Busch Lab

ZMP

A8WIP4_DANRE

Ensembl ID:
ENSDARG00000025949
Description:
Novel protein similar to vertebrate interleukin-1 receptor-associated kinase 1 (IRAK1) [Source:UniPr
Human Orthologue:
IRAK1
Human Description:
interleukin-1 receptor-associated kinase 1 [Source:HGNC Symbol;Acc:6112]
Mouse Orthologue:
Irak1
Mouse Description:
interleukin-1 receptor-associated kinase 1 Gene [Source:MGI Symbol;Acc:MGI:107420]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa15573 Essential Splice Site Available for shipment Available now
sa41119 Nonsense Mutation detected in F1 DNA Not yet available
sa21195 Nonsense Available for shipment Available now
sa34296 Essential Splice Site, Missense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa15573
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101527 Essential Splice Site 29 685 None 18
ENSDART00000137975 None None 553 None 11

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 8 (position 8140035)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 7584672
GRCz11 8 7603403
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TTCACTCGGGTTATGGACTCRCTTTCAAACTCAGACKGGATATCWTTCGG[T/C]AAGATTCATGGCKTTGTGTTTGTTTTTGTATCACAATKGTGCTGTGTTCA
Long Flanking Sequence:
AATGTGAAAAAGGAAATGGAAAATGTGAGTAATTTAGACGTGATGGCGAAGGAATTTACGAGCTCTTCTACTATGGCGAAGGGGAGTATTATGAATATTAATAAACGTAATATGATGTAGGTCTGACGTTAGTAAGTAGGCGGTGCTCATGTGTAATGTCTTTGCGCTACCTCATGAATAGTAATTAGTTAACAAGCATGAATATTCATGAACCAGGCATTTCGCCATTGTGATTTGTTTGTGACTCAAAAGAAGAAAGCGACCACCGAAAAGTAGCAGCCACAAGCAGGAAAAACCCCCGCAAGAACCACGTAAAAATAATATCTAAAAGTCTTATACACTAAAGGAGAAGAGAAAAGTTAGTGAAAACGCGGAGGGTTTGGGAAAATGTCAGGAACAGAGTTTGACAAGGTGTTACTGTACAATTTATCCGCGTCTGTTATGAATGACTTCACTCGGGTTATGGACTCGCTTTCAAACTCAGACTGGATATCTTTCGG[T/C]AAGATTCATGGCTTTGTGTTTGTTTTTGTATCACAATGGTGCTGTGTTCATTTATTTAAAGTTTAACCTAACTCCAGTGGATATGTTGATTAGCACACTTGCTAACATCAACTGTAAACTCGCTTAACGTTAGCCATCTCTTCGCTTAGCTTAGTCGAAAGGTGAAATATTTTCTTTTTAAAGCGAATGTTTATTTAAAGTGCAGATTAGTGTTGATTTATTTGCCCTGGTCTGGTTAATAGTTAGTTTGATAGTTTTTAGTAATTCGTAATAGTTTTTTATGTGTCAGTGTGGGTATTGTTTTGTATTCATAAGTTACTTTTATTATTATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGAAATTACACCTTTAATTGAGTTTGTTTTATGACTTAAATAATTTCAACTTTGATTTATCATGTTATTAGTCAGATCTCAGCATCTAACCTGAATGAATGAACACAACAAGAATATAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41119
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101527 Nonsense 71 685 2 18
ENSDART00000137975 None None 553 None 11

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 8 (position 8132605)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 7577242
GRCz11 8 7595973
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACAATTGGGGTTGTCGCAATGGGACAGTTGGAGCACTGCTGAAGATTCTT[G/T]AGGGACTCCAGTGGTTCAGAGCTCGTGATATCATTCTCAAAGCACAACTA
Long Flanking Sequence:
ATGGGGAGAACATGCAAACTCCACTCCGAAATGCCAACTGATCCAGCCAGAACTCGAACCAGTGACCTTCTTGCTGTGAGGCGACAGTGCTACCACTGAGCCACCATGACACCCGTTATATTAATCAGATGATGTCCTTTCACAGCTGTCTTGCTGCCAGTCAATCGTTGTTTTGTTGATCATGATTTTGAGGATAAATAATAAATGAAGTCCTTCACAACAAGAACGCAGTAATCTCAGATCAGTTCATCCAGATATTTTAATCTGAACTTGTTTGAAGAACTAAATTAGCTATTCAGTTTTGGATAGAATTCCCATTCAATTTCATAACACTCTCATTTTGCTTGCCAATTAAAGTATTTTATGTCCTTGCAGCTTCACAAATCATATCAGATCAGACTGAACTACGCCTTTTGGAGCAAAGCCCTCGACGGACGAGTAACCTCATGCACAATTGGGGTTGTCGCAATGGGACAGTTGGAGCACTGCTGAAGATTCTT[G/T]AGGGACTCCAGTGGTTCAGAGCTCGTGATATCATTCTCAAAGCACAACTATGTAGGTTTTTTTTCTTCTTCCTTTTTTTGATTTTTTTACCACATCTATGTGCCAAGCAGGTTATCAGTTGGGTTTTGTGGTTATCACGTTACTCGCTTTATAATCTAAAGTTTCACATTCCATGGTTCAAGAAAGAACTATGCTGTCAGTCAGATGTGAAATTTCTCAGTTGTGCTTATATTTCCCACGTTCTTATTTGGTTTACTTGTTTACTGCTTGTGATCCGTCAATGTATATTTTAAAACCTGTTTGTTGTTAACTTTCATCAAAATGAATTGACTTGTTCTGCCTGTAAATCTGAACTCAAATCTGTAGAAAGGCATTTCAGCAATCAATACTGATACCTATATTATGAAAATAAATATACTAACAGTATATGTATTTATACACTGGCTTGTCACATCAATTAAAAAAATGTAGATTTTTAAATCCATATTCACTGATTAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa21195
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101527 Nonsense 261 685 11 18
ENSDART00000137975 Nonsense 140 553 5 11
Genomic Location (Zv9):
Chromosome 8 (position 8126516)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 7571153
GRCz11 8 7589884
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCACAGGTACAGACATCCCAACATTATGGACTTTGTTGGCTACTGTATTT[C/A]AGGACAAACTTACTGTGTCATATATGTTTATATGCCCAACGGCTCTTTAG
Long Flanking Sequence:
AGGACGGAAGTGGACAAACTCTCTCAGTAAGAAGCTCTGCCTGTCCGTCTGTCGCTCCTGTGGCTCTTGCTTCCTTCTCTTGTGCTTTTAAATCTGAAGTCTTTCCTGTTTTCTCTTGATCAGCTTTTTGTAAGCTTGGCTGAGATTCATTTCTGTTTGTTCAACAGACTCGCAGAAAGGGATTTCCCCGCTTGAAATTTTGATTACTCTTTATGCACATCACCACACCTCTTCATGACCCAAAAAATGAGTCTCCAGCCCACTCTTCAAAACTTTTTCTGTGGTTAGTTTGAATCTTTTTGTCATCTTAGTGGGTCATTTGTTTCCCCTGACACTTCAGCCAACACTTTCAAGCCTTGCTTTCCTCAGCTATTGTAAAGCCTAAATGTTTAGAATAATTTATAATTAATAGTTTGACACTTTTTTTTTTTAATTACTCCCTGTTTTATTCCACAGGTACAGACATCCCAACATTATGGACTTTGTTGGCTACTGTATTT[C/A]AGGACAAACTTACTGTGTCATATATGTTTATATGCCCAACGGCTCTTTAGATGACCGGCTGCGCAATGAGGTAATTTGCATTTCCATTCATTCGTTTTCCTTCGGCTTAGTCTCTAATTCAGAGGTCGCCACAACGGATTGAACCACCAACTATTCCAGCATATGTTTTACATGGCGGATAAACCGCCAATCACAACCCACTACTGGGAATTACCCATACACTCTCGCATTCACACACACTATGGCCATTTTAGTTTATTCAGTTCACCTAGAGCACATGTCTTCGGACTGTGGGGAACACCAGAGTAGAGGTCTGCGCAGGACAGATTTTTAAGTTTTGCTCCTGCCCGCACCCGCAATGTTTTATTCCACACCTGACCGCTCCTGCTGTATATTCAGCCTTTGTTCACCTGCTGCCCACTTAGAATCATTTTCTGCCCAACCGTTCCCACTAAATTTAGATCTGGTTTCCAAAATCTCCTGTTTAAATCGGGTACTAG
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa5467
Status:
Allele not cryopreserved
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101527 Nonsense 441 685 15 18
ENSDART00000137975 Nonsense 318 553 9 11
Genomic Location (Zv9):
Chromosome 8 (position 8113858)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 7558495
GRCz11 8 7577226
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GATGATGGGAGAAGCTTCAGCAAAGCGAAGCACTCTCGAGATTTGTCCTA[C/A]GGTCAAACAGCAGAGCACATCTGCAAAAAACATCTGGATCSTCGACTGAC
Long Flanking Sequence:
GCTCTGGCACACCTCTTTCTAATTGGGCCAAGGCCTGGTCAACTGAAGTGGGCCTGTGCCACATTCGGAGCATTTACACTTGTCAAACGAACCGGGAAATAAATGCGCATGAGCACGGTTCGGATAGCCTAGAGTGAGTACGCCCTAAACTGAATATCGAGTAGGGGGCAGAGCTTTAATTAGTGAACCTTTCCCTTATAGGAAATTAACAATAAGAGAGGAATATTGTGGCTGAACCCGTCAAACGGACATCATCAGAGAAAGACCGCCACTCCAGTTAATGATTACCAAACCAAACATTTTTTTCAGTGGATGAACTTGCACAGATAACTTGTTCACCTAACAAATAACAATGTGCACTAGCAAAATTAATAATGTGTGAAATTTGAGCTTTGACACAGACTTAAAAGTTTTTATTTCTCACAGAAAGACCTGGTAACAGAGGAGGAAGATGATGGGAGAAGCTTCAGCAAAGCGAAGCACTCTCGAGATTTGTCCTA[C/A]GGTCAAACAGCAGAGCACATCTGCAAAAAACATCTGGATCGTCGACTGACCGCTAAAGATGCACCTGCAACTCATGGGTCAGCGGACATCGCTCGGCTGGCATGTCAGTGTTTAGAGCGGAGGAGGAAGAAGAGACCTCGCATGACAGATGTAGGAGAACCGGTTCAATGATGATTGTATATTTGATTATGACTTGAATATCTGTTTTATTAAAGTCTGCATGAACTGAAAGCTGCAACAGTTTTTTTTTTCATATTGTGAAGCAGTTCCTGGTGAAACAAAATATTAAATGAGAATACAGTGGGCGTGGCTTTGTACTTCTACTGCAAGCTTATTGGATGTAGAAAAATACAGACTTTTCATTCAGAAAAAGGTTTCGAGAGAGTTAGCCAACAACAAAAAAAAAAAACTTGTGGCTTTTTGGCTCACAAATTAAGATCAAAAACAAGATATTATTATCAAAAATAATAACAATTCTTCATGTTATTATATTTCAGTAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34296
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site, Missense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101527 Essential Splice Site 632 685 None 18
ENSDART00000137975 Missense 518 553 11 11
Genomic Location (Zv9):
Chromosome 8 (position 8111231)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 7555868
GRCz11 8 7574599
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTCCTCTCTAATTCTCATCTTAATATTATTATCCACAGGTTTTTCTGGAC[A/T]GAATGTTATCATCAACCCCGCTAGGCAGCGATTGGTACAGAAAATGGAGC
Long Flanking Sequence:
CAGTTGATTTTGAATGAATCGAGTGAGGCAGTGATTCAATGATTCATTCACAAAGACTGTCAACATTGTTCTAAGTGAATCAGCTATTTTGAAAGAAGTGTTTAAATAATTGATGCAGTGAATCAAACCTCTCAAAGTAATATTATTCATTCAAATAATAGTTTGAATGAATGGTTCAGTGCTTTGAATCAATCTACATTGTAAAAATCGCAATAGAAATAAAGATGAATGGAATCACTCATAAAGACAGTGACTTGCCTATAGCTTAAGTTGGTTTTAGTGTCACATTTATCCAAGAAAGGCCTGGCACAAAACACCCTTGGCTAAATATTTTATCATAATTATCAAATCAAAAAAAGTGCCTTATGTTTAACAAGGCTGCAAATATTTATACTTTAAAAATTCTTTATTATTCCACAAAAGTGTTGATGTCTTTTACTATTTGCTTTGTTCCTCTCTAATTCTCATCTTAATATTATTATCCACAGGTTTTTCTGGAC[A/T]GAATGTTATCATCAACCCCGCTAGGCAGCGATTGGTACAGAAAATGGAGCTTTATGAAGAAGGGAGGATTTTAACTTCTGATTTGTTGTCGTCAGGCGCCTCACTATGTAAGTGCTGAAACTGACAGTCAGATGACATTACTGCTGTTATGGGGGACAGTTTTTTTTAAGAGTTTTTATGGGAATACGAGTCATTTTCAGCTCAGTTATCATGATTGCTTCTGTTTAGGTAACATCTGATTGGCCTGTGGCAAATGTTTGTAGCTTTTTAGGCATCGCACAAGTCAGAGATACCAGGGGTCTGTTTTTTCGTAGCTGGATTACTCAGTTAGCTGGATTTGGTTATTGACGATTTGACATGATCCAGGATCGTTTAGTTCTTCAAAACTCATGCGAGAGTTGTTGTCATGGCAACAGTTCTGGTAGCTCAAACCTGCTCTGAAGCAGGTTTATTTCATACAAAAAGGATTAGATTGGGTCAGTTCAAGCAAAGATAATACT
Associated Phenotype:
Not determined