Busch Lab

ZMP

si:ch73-72b7.1

Ensembl ID:
ENSDARG00000086109
ZFIN ID:
ZDB-GENE-100921-23
Human Orthologue:
UNC5C
Human Description:
unc-5 homolog C (C. elegans) [Source:HGNC Symbol;Acc:12569]
Mouse Orthologue:
Unc5c
Mouse Description:
unc-5 homolog C (C. elegans) Gene [Source:MGI Symbol;Acc:MGI:1095412]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa8687 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa38449 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa5282 Nonsense F2 line generated Not yet available
sa38448 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa40361 Nonsense Mutation detected in F1 DNA Not yet available
sa30857 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa8687
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 Essential Splice Site 49 509 1 8
ENSDART00000131473 Essential Splice Site 175 620 3 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8879132)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6944062
GRCz11 5 7435217
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGTGCTGAACGGCGGATTTCAGCCTGTCAGCATCAAACAAGCACGATCAG[G/A]TGACMCCTTCACACCTCWCTGCAYTGAAAACAAATCACTCACTGGNNNNN
Long Flanking Sequence:
TTAGATAGGTAGGCAAGTGCACACACACACACACACGCACACACACACATACACTACAGCTAATTTAGTTCATCCAATTCCCCTATAGTCCATGTGTTTGGACTGTGGAGGAAACCCCCACCAGCAAGGGGAGAACATGCAAACTGGCCCACACAGAAATGCCAACTGGCCCTGCAGAGACTCAAACCAGCGACCTTCTTTCTGTGAGGTGACAGTGCTAACCACTGAGCCACTGCTTTGCCCCATAATTCATCAGGTGGCACTTTAAGTGTTATTTATTTATTCATTTATTTATGTGTGTTCTGCAGCGGCTCCGGGTGGAGACGAGGTGGCGCTGTACGTGGGCATCATCATGGCGGTGCTCATGTGTCTGATAGTGTCTGCAATCGTGGCTCTCCTGGTTTATCGCAGGACTCATCGCCGCTTTCACTCGGACATCATCGACTCGTCGGTGCTGAACGGCGGATTTCAGCCTGTCAGCATCAAACAAGCACGATCAG[G/A]TGACCCCTTCACACCTCACTGCACTGAAAACAAATCACTCACTGGATTCACTACAATTTTGCAAGCATGTTTATGCTCACCAAAGCTGCCTAGATGAAAAGTTCCTGATTTAATACCGTATAGAAAGTTCAGTAGAACAGCATTTACTTTGAGTTAAGCATCTAAAGACTGATATAGTACACTGAAAAAAGGATTTATTGGATTTACTCATTTTTTTAAAGGTAAGTGGTTGCAAACAATTAATATGGGCTGAATTTTAACAAACAAATTAAAGTGTTTAAAGAGCCCCTATTATGGGTTTTTGAGAATGACCTTTCATGTAGTGTGTAACACAGCTCTAAGGGAAATGAAATATCCAGCTAAGGCTTAAATCTGAAAGTGGACAGTTTTGAAAACTATTGATTCATCTATAAAAGAGTCGACTCATAGTGCTTCAAATGAATCGTCTTGATGACCACAACGATACGAAACTTAAGCCCTGCCCAATTGTTGCTCGCGCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa38449
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 Essential Splice Site 198 509 3 8
ENSDART00000131473 Essential Splice Site 324 620 5 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8866104)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6957090
GRCz11 5 7448245
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTCGAGTGTATGAGATGTATGTGAGCTTACAGAGGACAGAAAGCATGAGG[T/G]AAGACAAAAACACACAACCCACTTACTAAACACACATTCAGGATTCACAG
Long Flanking Sequence:
AACTTGTTAAACTAAGTTAATCCTGTTCTAACTTAATTTTATAAGTTACGCCAGCTGTTTTAAATCAGTTTTACATAATATAAGTTCAATGGACTCATTAGGTTAATTTAATTCAGTTTAGAAAATTTAAGCCAACAAGGACTTTTTTTTTTTACCATGTAGGACATACATATGCTGTAGCAGGGGTCACAAACCCTGTTCCTGGAGAGCTACCTTCATGCACATTTCAGTTGCAACCCTCACCAAACACACCTGTTTGTAATTATCAAGTGCTGCTTTAGGTACTATTAATTGGTTCAGGTGTGTTTGATCAGGGTTGGGACTGAATTCTGCAGGAAGGTAGCTCTCCAGGAACAGGGTTGGTGACCCCTGCTGTAGTACATGTCTATATCTGTCTAATGTGTGTTTCAGGTGTGAGTCTGTTGGTTCCAGCTGGTGCGATTCCTCAGGGTCGAGTGTATGAGATGTATGTGAGCTTACAGAGGACAGAAAGCATGAGG[T/G]AAGACAAAAACACACAACCCACTTACTAAACACACATTCAGGATTCACAGTGGGTTATTAAATGTTTATTTAAGTCACTATTAAAAAATCAAATCTGTCTGCTTTGTGAACGGTGAACTATACTACTGTATCTGCAGAACATATCATCAAACTAAAGGGATAGTTCACGCACACATTTAAATTAACTCGCCATTTACTTCCCCTTTTGTATTTTTTCTTATTCTAATAAACGCTGAAGAAGATGATTTGAAGAAAGCTGAAAATCTGTAACCCTTTACTTCGATAGTAGGGAACGTGTTACTGTTCTAATTACACTTTTGAGGAACAGTAATGTAACTAATTAGATTTTACATTTGTGTAATTTGATTACAGTTACCAAAGTCAGCGTTACTTGTGTTATAAATATAGATTTCAGAATATACAAAACAATATTTGCAGATTCTTGCTTAACATCACTCACAAATCACGTTTTCCACTGCACCGTCAGTTAATGGTTCTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa5282
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 Nonsense 375 509 6 8
ENSDART00000131473 Nonsense 501 620 8 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8855136)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6968058
GRCz11 5 7459213
KASP Assay ID:
554-3501.1 (used for ordering genotyping assays)
KASP Sequence:
ACCACAACTTGAGACTGTCAGTCCACGATATCCACTGCCAGTGGAGGAGC[A/T]AACTTCTGACCAAATACCAGGTACAACACAACACACTCACCACCTTCACT
Long Flanking Sequence:
TATTATTATTATTGTAAATGCTGCAGACTTTTATTATTTTGGTGATTTAGTAATTTAGTAAAATATAATTATACAAATAAAAACCCTAATCCTAACAAATTCATTTGCCTATTTTTAATCTGTTCTTATCATCAGTTATTTTAATTACTTTTATTACAATATTATAAGTTAATTTTTTTGTAACATATGTTATATAATTGTCCAAATGTTGTGAATTATTTTTGTTAATCTGAATACATTTAAGCTTCTTTGTACAGTAAATGTCCTGGTTATATGGGAGGTTGGGAAGTTTGTGTTGTTTTTACACCAAACTCTTTATAATAAAAAAGTGGTGTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTATGGTCAGGAGGTGCTGCAGATAGAAAAACAGATGGGTGGCAAACTGCTGGATGAACCAAAGTCTCTGAACTTCACTTATAGCAACCACAACTTGAGACTGTCAGTCCACGATATCCACTGCCAGTGGAGGAGC[A/T]AACTTCTGACCAAATACCAGGTACAACACAACACACTCACCACCTTCACTGAAGTAAACAGTATGAATATAAATATTAGTAGCAACATTCAGTGTTTTGTGTATTGTTCCATTCAATATAACTTAAGGTATTATTTAGGAAGTGTTTTTTTTTTTTTTAGAAAAGGATTGGAGGGTACTCAGTGTCCTGAAATACATTTTGTAAATTATTTTAATAGTTGAAATGCTTATATATTTTATATTAAATTATTTAACTCAATATTGATTTGTTCAAATTACGATATTTGTTATTATGTACAAAATTAATATTGATGTTGTCATTACAGGATTTTGTTATTAATAACATTTGAAAACTATTAGTTGTTAATTTTAGATATTATTATTATTATTATTATTATTATTTCTATTAATATTACTATTATTATTACTTCTATATTATTATTATTATTATTAATAATAATATCAAAGTAATAATAATAATAGTAATATTAATAATAATAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa38448
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 Essential Splice Site 381 509 None 8
ENSDART00000131473 Essential Splice Site 507 620 None 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8855114)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6968080
GRCz11 5 7459235
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCACGATATCCACTGCCAGTGGAGGAGCAAACTTCTGACCAAATACCAGG[T/C]ACAACACAACACACTCACCACCTTCACTGAAGTAAACAGTATGAATATAA
Long Flanking Sequence:
GCAGACTTTTATTATTTTGGTGATTTAGTAATTTAGTAAAATATAATTATACAAATAAAAACCCTAATCCTAACAAATTCATTTGCCTATTTTTAATCTGTTCTTATCATCAGTTATTTTAATTACTTTTATTACAATATTATAAGTTAATTTTTTTGTAACATATGTTATATAATTGTCCAAATGTTGTGAATTATTTTTGTTAATCTGAATACATTTAAGCTTCTTTGTACAGTAAATGTCCTGGTTATATGGGAGGTTGGGAAGTTTGTGTTGTTTTTACACCAAACTCTTTATAATAAAAAAGTGGTGTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTATGGTCAGGAGGTGCTGCAGATAGAAAAACAGATGGGTGGCAAACTGCTGGATGAACCAAAGTCTCTGAACTTCACTTATAGCAACCACAACTTGAGACTGTCAGTCCACGATATCCACTGCCAGTGGAGGAGCAAACTTCTGACCAAATACCAGG[T/C]ACAACACAACACACTCACCACCTTCACTGAAGTAAACAGTATGAATATAAATATTAGTAGCAACATTCAGTGTTTTGTGTATTGTTCCATTCAATATAACTTAAGGTATTATTTAGGAAGTGTTTTTTTTTTTTTTAGAAAAGGATTGGAGGGTACTCAGTGTCCTGAAATACATTTTGTAAATTATTTTAATAGTTGAAATGCTTATATATTTTATATTAAATTATTTAACTCAATATTGATTTGTTCAAATTACGATATTTGTTATTATGTACAAAATTAATATTGATGTTGTCATTACAGGATTTTGTTATTAATAACATTTGAAAACTATTAGTTGTTAATTTTAGATATTATTATTATTATTATTATTATTATTTCTATTAATATTACTATTATTATTACTTCTATATTATTATTATTATTATTAATAATAATATCAAAGTAATAATAATAATAGTAATATTAATAATAATAATAATAATAATAATAATTTATTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40361
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 None 483 509 8 8
ENSDART00000131473 Nonsense 608 620 10 10
ENSDART00000131156 None 483 509 8 8
ENSDART00000131473 Nonsense 608 620 10 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8844403)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6978791
GRCz11 5 7469946
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATCAGAAACAAACTGTGCAGCAGTCTGGACGCACCACACACACGCGGAAA[C/T]GACTGGAGGAAACTGGCTCACAAACTACAGCTCGACAGGTCATTGCACAT
Long Flanking Sequence:
TTCAAGATACTTCTATACAGCTTAAAGTGGCATTTAAAGGCTTCACTAGGTTAATTAGGTTAACTAGACAGGTAAGGGTAATTAGGCAAGTTATTTTAATGGTTTGTTCTGTAGACTATCGGAAAAAATATATAGCTTAAAGGGGCTGATAATTTTGACCTGAAAATGATTTTTTTAAAATGAAAAACTGCTTTTATTCTAGTTGAAATAAGACTTTCTCAAGAAGAAAAAATATTATCAGACATACCGTGAAAATGTCCTTGCCCTGTTAAACATCATTAGGGAAATATTTAAAAAAAGAAAAAAAATGAAAAGGGGGTGTAATAATTCTGACTGTATATATGTGTGTGTGTTGTACAGGATGTCCAAAGCATCGACACATCACTGATGGATCCCGGCAGCAGCATCACGGTTCTGTCGGGTCCGAGCGCCTTCAGGATCCCAGTGAGCATCAGAAACAAACTGTGCAGCAGTCTGGACGCACCACACACACGCGGAAA[C/T]GACTGGAGGAAACTGGCTCACAAACTACAGCTCGACAGGTCATTGCACATGCTGATTTTCTTCTTAAGAGGTCTCGTTTGATCAAACACACAGTAGTATTGTGAATTGTTGTTGCAGTGCAAAATGGCACTTCACATACACTGAACTACAAAAAATAAATGAATAAATAGCAAATATACAGTTGAATTATCAGCCCCTCTGTATATATTTTCCCCAATTTCTGTTTAACAGAGACACATTTCTAAACATAATAGTTTTCATTACTCATTTCTAATAATGTCCTTGCCATGATGACAGTAAATAATATTTGACTACACAGTAAAAAATAAATCCGTAATATTTATGGTAAAAAACCTGCAGCTGTGGTTGCCAATATTTTACTGTTAAAAATACTGTACAAACCGTAAAAGTAATTTCTAATTTTTACAGTAAACTACCGTATTTCATTAATTTATAGATGTAATATGTCTGTATTTTGAACTACCAACACCTACACATCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa30857
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000131156 None 483 509 8 8
ENSDART00000131473 Nonsense 608 620 10 10
ENSDART00000131156 None 483 509 8 8
ENSDART00000131473 Nonsense 608 620 10 10

The following transcripts of ENSDARG00000086109 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 8844403)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 6978791
GRCz11 5 7469946
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATCAGAAACAAACTGTGCAGCAGTCTGGACGCACCACACACACGCGGAAA[C/T]GACTGGAGGAAACTGGCTCACAAACTACAGCTCGACAGGTCATTGCACAT
Long Flanking Sequence:
TTCAAGATACTTCTATACAGCTTAAAGTGGCATTTAAAGGCTTCACTAGGTTAATTAGGTTAACTAGACAGGTAAGGGTAATTAGGCAAGTTATTTTAATGGTTTGTTCTGTAGACTATCGGAAAAAATATATAGCTTAAAGGGGCTGATAATTTTGACCTGAAAATGATTTTTTTAAAATGAAAAACTGCTTTTATTCTAGTTGAAATAAGACTTTCTCAAGAAGAAAAAATATTATCAGACATACCGTGAAAATGTCCTTGCCCTGTTAAACATCATTAGGGAAATATTTAAAAAAAGAAAAAAAATGAAAAGGGGGTGTAATAATTCTGACTGTATATATGTGTGTGTGTTGTACAGGATGTCCAAAGCATCGACACATCACTGATGGATCCCGGCAGCAGCATCACGGTTCTGTCGGGTCCGAGCGCCTTCAGGATCCCAGTGAGCATCAGAAACAAACTGTGCAGCAGTCTGGACGCACCACACACACGCGGAAA[C/T]GACTGGAGGAAACTGGCTCACAAACTACAGCTCGACAGGTCATTGCACATGCTGATTTTCTTCTTAAGAGGTCTCGTTTGATCAAACACACAGTAGTATTGTGAATTGTTGTTGCAGTGCAAAATGGCACTTCACATACACTGAACTACAAAAAATAAATGAATAAATAGCAAATATACAGTTGAATTATCAGCCCCTCTGTATATATTTTCCCCAATTTCTGTTTAACAGAGACACATTTCTAAACATAATAGTTTTCATTACTCATTTCTAATAATGTCCTTGCCATGATGACAGTAAATAATATTTGACTACACAGTAAAAAATAAATCCGTAATATTTATGGTAAAAAACCTGCAGCTGTGGTTGCCAATATTTTACTGTTAAAAATACTGTACAAACCGTAAAAGTAATTTCTAATTTTTACAGTAAACTACCGTATTTCATTAATTTATAGATGTAATATGTCTGTATTTTGAACTACCAACACCTACACATCT
Associated Phenotype:
Not determined