Busch Lab

ZMP

tnks

Ensembl ID:
ENSDARG00000077650
Human Orthologue:
TNKS
Human Description:
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Source:HGNC Symbol;Acc:11941]
Mouse Orthologue:
Tnks
Mouse Description:
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Gene [Source:MGI Symbol;Acc:MGI:13

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa18265 Essential Splice Site Available for shipment Available now
sa16785 Essential Splice Site Available for shipment Available now
sa37282 Nonsense Mutation detected in F1 DNA Not yet available
sa8904 Nonsense Mutation detected in F1 DNA Not yet available
sa25154 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa25155 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa18265
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Essential Splice Site 277 1280 3 28
ENSDART00000132653 Essential Splice Site 256 1252 3 27

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 21 (position 18773611)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 19909100
GRCz11 21 19945736
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CAAGTCTGCCCTGGACCTGGCCGACCCGTCCGCGAAAGCTGTCCTCACAG[G/A]YAAGTGCCACATTYTGTSTTTTATCAGTGTTTTGATCTTCAGCTGAACGC
Long Flanking Sequence:
GGAGGATTGGAGACAGTTATAGATAGACGCTGCTCTCGAGGTGCTCTCCGTTACTTCAGTCTCAAAAGCAGAGAGCGCTGCTGCCGAACGCCTCTGCTTCTTTCTCTCTGGGGCAGCGTAGAGGATCGGAAGACATGCTTTGATATTCAACTCTCATACACACGAGTTCACATGCCCGGACATAGTCTCTCTTTGAGTAACATGGGCTTTTTCCCCCCGTCTCACTGCAGTGTGTGTTTTTCCGCGCGGGCTGTTTTCGTTGCTGCTCCTGGTGCGCTGGTGTGCGATGTGTGTTTATGTCTGCACCATGCCGAGGCAAGCGCTCCCAGTCAGCGGCGCCAACGGCCCCAGCAACAGCCTCTGCCTGCCTGAGTTACGATACTGCTTGTGTTTTCCCTGCACAGTTCTACTCCAGCACGGCGCCGATCCCAACATCCGCAACACCGACGGCAAGTCTGCCCTGGACCTGGCCGACCCGTCCGCGAAAGCTGTCCTCACAG[G/A]TAAGTGCCACATTCTGTCTTTTATCAGTGTTTTGATCTTCAGCTGAACGCAGTTTGCCTTTGTCTGCTACTCTGATAGTGTCTGCACGGCTTTGAAACGGAGCAGCATTGTTATGCATCTGTATCTCCACGTTTGGTGTGTTTGTGTAAAGTGAGACTGTTGTTGTCCTTGAGCGCTTCTCTGCCTGCGTGCTCTCTCTTCTCTAGTAGGGATGGGCGGTTGAATATTAAGAGTATTGAATATTAAGATACTGATCGCTGTCTTAATATTGAATGTTGAGATACTTTGTTTGGATTTTGTCTGTGTGTTTTAGTAATTGTTTTGCATTGTTTATAGCTTTAATAGTTTTGCATTTTTGGAGGACATTTATGACCCTGCACTACAAAAGCTGTCATAAGTGTCTATAGTTTTTAGATTTGAGATTTATACATCACCTTAAAGGTTAAATAAAAATTTGATTGATGTATGTTTTATTCGGATTGGACAATATTTATCATAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16785
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Essential Splice Site 278 1280 None 28
ENSDART00000132653 Essential Splice Site 257 1252 None 27
Genomic Location (Zv9):
Chromosome 21 (position 18773612)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 19909101
GRCz11 21 19945737
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AAGTCTGCCCTGGACCTGGCCGACCCGTCCGCGAAAGCTGTCCTCACAGR[T/C]AAGTGCCACATTYTGTSTTTTATCAGTGTTTTGATCTTCAGCTGAACGCA
Long Flanking Sequence:
GAGGATTGGAGACAGTTATAGATAGACGCTGCTCTCGAGGTGCTCTCCGTTACTTCAGTCTCAAAAGCAGAGAGCGCTGCTGCCGAACGCCTCTGCTTCTTTCTCTCTGGGGCAGCGTAGAGGATCGGAAGACATGCTTTGATATTCAACTCTCATACACACGAGTTCACATGCCCGGACATAGTCTCTCTTTGAGTAACATGGGCTTTTTCCCCCCGTCTCACTGCAGTGTGTGTTTTTCCGCGCGGGCTGTTTTCGTTGCTGCTCCTGGTGCGCTGGTGTGCGATGTGTGTTTATGTCTGCACCATGCCGAGGCAAGCGCTCCCAGTCAGCGGCGCCAACGGCCCCAGCAACAGCCTCTGCCTGCCTGAGTTACGATACTGCTTGTGTTTTCCCTGCACAGTTCTACTCCAGCACGGCGCCGATCCCAACATCCGCAACACCGACGGCAAGTCTGCCCTGGACCTGGCCGACCCGTCCGCGAAAGCTGTCCTCACAGG[T/C]AAGTGCCACATTCTGTCTTTTATCAGTGTTTTGATCTTCAGCTGAACGCAGTTTGCCTTTGTCTGCTACTCTGATAGTGTCTGCACGGCTTTGAAACGGAGCAGCATTGTTATGCATCTGTATCTCCACGTTTGGTGTGTTTGTGTAAAGTGAGACTGTTGTTGTCCTTGAGCGCTTCTCTGCCTGCGTGCTCTCTCTTCTCTAGTAGGGATGGGCGGTTGAATATTAAGAGTATTGAATATTAAGATACTGATCGCTGTCTTAATATTGAATGTTGAGATACTTTGTTTGGATTTTGTCTGTGTGTTTTAGTAATTGTTTTGCATTGTTTATAGCTTTAATAGTTTTGCATTTTTGGAGGACATTTATGACCCTGCACTACAAAAGCTGTCATAAGTGTCTATAGTTTTTAGATTTGAGATTTATACATCACCTTAAAGGTTAAATAAAAATTTGATTGATGTATGTTTTATTCGGATTGGACAATATTTATCATAGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37282
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Nonsense 373 1280 8 28
ENSDART00000132653 Nonsense 345 1252 7 27
Genomic Location (Zv9):
Chromosome 21 (position 18859620)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 19995109
GRCz11 21 20031745
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTTCCTCTACACAATGCCTGCTCATATGGACACTATGAGGTTACAGAAT[T/A]GCTGCTGAAGGTAAGGACAAAAAAACGAAGTGGGAGTACTTTTGAGTGTT
Long Flanking Sequence:
CGGCATTTATATCTCTGTTTTTTTACCCCCAGCTATATTTGAATGCATTTCCTCCTCTCTCTCTTATAGTCCACTCCCCTGCATCTGGCAGCCGGATATAACCGAGTCCGAATAGTTCAGCTTCTGCTTCAACATGGCGCTGATGTTCATGCTAAAGATAAAGGGTAGGTCTGCTAATGTCTCAATTTGATTTCCTATATTTTTTAACATTCAACCAAAGATGCTTTTTCCATTCGCTTTTCAATTTTTTTCACTCTTGTAAAAGCTTTGGTTCATTAGCCTTCTATACATTTCTTATAATGAAAACCTCTGTATCATTTGTAAATAATGTTTTTCTCTCTCTCTCTCTCTCTGTGTGTGTGTGTGTGTTTGTGTGTGTGTGTGTGCTTGCTTTTTTGTGTGTGCTTGTGTGTGTGTATGCGCGCTCCATCTTGTCATCAATAGGGGTCTTGTTCCTCTACACAATGCCTGCTCATATGGACACTATGAGGTTACAGAAT[T/A]GCTGCTGAAGGTAAGGACAAAAAAACGAAGTGGGAGTACTTTTGAGTGTTCGCTGTTTGGAAGACAAACAACTTTGTTCCAGTTGAGCAGCATGACCTAACCAGACACAATGCATTAAAGCAATTTTTTTAAAGCAAATAAAAACTGTAATTCAGATTGTTTTTTTGTTTGACCAGCTACAACTGCAATAAGACATTTTTTCAGTCACATGATTTCTGTTTTGTCACACAGGCTTCTGTGTATTTTCATTGATACCTAAATATTGCAATACAAATCTTATATTTGAATATAAAACAAGTTCTTATTTGCAATAATCGTTATCAATTCTAGTGCATAAATACTCATCACATCACATCTAGATAGCTTTGACCCCATGCCTTAGGTTATTTTTTAAGACAATCACCTATTGCACCTTTAACAAAATGTTTTTTGTAGTTTTAGTTTACCTCAGCTTTAACAAATAAATCATAACTCTATTGCTCACTTTTTTTTCTGTTTGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8904
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Nonsense 490 1280 11 28
ENSDART00000132653 Nonsense 462 1252 10 27
Genomic Location (Zv9):
Chromosome 21 (position 18870287)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 20005776
GRCz11 21 20042412
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GCCTCTGTCCTGTATTTCAGCACTGTGCKGTCGTTTCACCTCACCCAAAA[C/T]GAAAACAGGTCACTGAACTGCTGCTGCGGAAAGGAGCCAATGTCAATGAG
Long Flanking Sequence:
TCCACCTAAAACTCAGACAAGCACAGAAACACAACACACAATTCTACCAAAAGCAAAATATACAGTAAGAAAAAAACTTTCTCAAAAAGAATAAAGCTTTTATTATTTATTTTTACTGTTCAATTTACTGCTTACGTTTTGTCTCTGTTTCTTCAACTTAAGCTAAACTTTTAATTTGATGGGTTGTTGTAAAGATGCTGTGTATACAAGTGTATCACAAAGCAATTTGCAGATGAACCTTGTGTGTTCATGTCCTCATAGTGTGAGACGACAGACATTAAAAACAAGCATAATACAGTAGAACATGTGTGTGCTCAGTGTATTCCTTGATTTTGTGAGTCTATTTACATCAAATAATTCACACAGCTGCTAATTTGCAGAATGTTCACAATGTTTTCTTTCATGAAATTTTTCCTAATGGTGAATAAATGTTTTAAAAGCACTAAGAGAGCCTCTGTCCTGTATTTCAGCACTGTGCGGTCGTTTCACCTCACCCAAAA[C/T]GAAAACAGGTCACTGAACTGCTGCTGCGGAAAGGAGCCAATGTCAATGAGAAGAACAAAGAGTGAGTGAAAGTGAATGGATTGTTCTGGATTTACGAATGTTTTTACCTTGAAGACTTATAGCAAGGTGTTTCTGTCCTTGTCGTGATCTTCTCTGTTGGTCTGTTGTGCAGCTTCATGACGCCTCTCCATGTGGCAGCAGAACGAGCGCACAACGACATCCTGGAGGTTCTGCAGAAACATGGGGCCAAGGTACACAGCTGTTCCCACATCAGCAGGCGCTCCACATGTTCATTTGAGCTGCCACACACACACATTTACAAACCTGACACCTCACTTCACTTTCACAACTCACTGTACAGTCAGCTTGAAATGAGACACTGTTTTTAATGCACCTGTCAATTTTGGGCTTTTTGGCATCTCATCAAATGTTTTGTCTGTCTAGTGTACAGAAAACTGTGGAGGCACTAAAGTATGTCATGCACATGATGTGTCTAGTGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa25154
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Essential Splice Site 537 1280 13 28
ENSDART00000132653 Essential Splice Site 509 1252 12 27
Genomic Location (Zv9):
Chromosome 21 (position 18892540)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 20028029
GRCz11 21 20064665
KASP Assay ID:
554-7621.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACTTTCAGACTGCTTACTTCCTTCTCCATCTCTTTTGTTTGTTTGTTTGT[A/T]GATGAATGCTGTTGACACACTGGGTCAGACGGCTTTGCACCGGGCGGCTC
Long Flanking Sequence:
GAATGCATTTACACAGTAATTACAACTGATTAAAACTATGCCCCAAGTTGGGTCAAAGGAGGTTAGGCTTGCATTGTTTAGGCAGCATTATTTTGATCAGTCACTTTAAATTAATTAGCAGCTTTAAATTAAGCATATGCAAAAAAACACCTCTTGATATAAAGGGTTCACATTATATGCAATTCACATTCTCAATAAAGCGTATTTTTGCTGAGAGTTTGAAAGTCACAAGTTTCAGACGGAATAATGAACTGCAATCATGCCATACACTAAACCGCACACAGTAGCTCCCTTTTTTTTCTCTCTCTCTCTGTGCGGTGTTGATAGTCTTTGAAGGAGCATAGACGTTTCCCAGGGGCTCGTCTGATTAATTCATATTTGTGTTCATTTCAAAAGAGGTCTGGTTTGCTTACAGCGCCGTCTCACTCTGTGTTCTGCGTTCAGATGTGCACTTTCAGACTGCTTACTTCCTTCTCCATCTCTTTTGTTTGTTTGTTTGT[A/T]GATGAATGCTGTTGACACACTGGGTCAGACGGCTTTGCACCGGGCGGCTCTGGCTGGACACTTACAGACATGCAGATTGCTGTTGAGTTATGGAGCCGATCCTGCCATCGTCTCTCTGCAGGGCTTCACAGCCGCCCAGATGGGCAATGAAGCTGTACAGCAGATCTTAAACGGTAGGGATTGAATCTGGGGTTTGGGTTTGTTTATATGAGCTTAGATGTTATACGTGAACAGTTATGGAAATGCACAGTAATGTATGCTCATGTCTGTTAGAAAACATTCCAGTAAGGAACTCAGATGTGGATTATAGACTCTTAGAGGCAGCAAAAGCTGGAGACTTGGACACTGTGAAGGTGAGAGATGCTTTTATTTGGGTTTAATATTAAGATGGTTCATTTGTTGTCCAGCAGTTAAGGAGTAAATAGGGGTTTGGAGGTGAGAAAGTAATTCTCTAGAAAGAGAAATTGTCCTTATTTATTATTATTTTTTTTGCAATAATA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa25155
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000111694 Essential Splice Site 537 1280 13 28
ENSDART00000132653 Essential Splice Site 509 1252 12 27
Genomic Location (Zv9):
Chromosome 21 (position 18892541)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 20028030
GRCz11 21 20064666
KASP Assay ID:
554-7701.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTTTCAGACTGCTTACTTCCTTCTCCATCTCTTTTGTTTGTTTGTTTGTA[G/T]ATGAATGCTGTTGACACACTGGGTCAGACGGCTTTGCACCGGGCGGCTCT
Long Flanking Sequence:
AATGCATTTACACAGTAATTACAACTGATTAAAACTATGCCCCAAGTTGGGTCAAAGGAGGTTAGGCTTGCATTGTTTAGGCAGCATTATTTTGATCAGTCACTTTAAATTAATTAGCAGCTTTAAATTAAGCATATGCAAAAAAACACCTCTTGATATAAAGGGTTCACATTATATGCAATTCACATTCTCAATAAAGCGTATTTTTGCTGAGAGTTTGAAAGTCACAAGTTTCAGACGGAATAATGAACTGCAATCATGCCATACACTAAACCGCACACAGTAGCTCCCTTTTTTTTCTCTCTCTCTCTGTGCGGTGTTGATAGTCTTTGAAGGAGCATAGACGTTTCCCAGGGGCTCGTCTGATTAATTCATATTTGTGTTCATTTCAAAAGAGGTCTGGTTTGCTTACAGCGCCGTCTCACTCTGTGTTCTGCGTTCAGATGTGCACTTTCAGACTGCTTACTTCCTTCTCCATCTCTTTTGTTTGTTTGTTTGTA[G/T]ATGAATGCTGTTGACACACTGGGTCAGACGGCTTTGCACCGGGCGGCTCTGGCTGGACACTTACAGACATGCAGATTGCTGTTGAGTTATGGAGCCGATCCTGCCATCGTCTCTCTGCAGGGCTTCACAGCCGCCCAGATGGGCAATGAAGCTGTACAGCAGATCTTAAACGGTAGGGATTGAATCTGGGGTTTGGGTTTGTTTATATGAGCTTAGATGTTATACGTGAACAGTTATGGAAATGCACAGTAATGTATGCTCATGTCTGTTAGAAAACATTCCAGTAAGGAACTCAGATGTGGATTATAGACTCTTAGAGGCAGCAAAAGCTGGAGACTTGGACACTGTGAAGGTGAGAGATGCTTTTATTTGGGTTTAATATTAAGATGGTTCATTTGTTGTCCAGCAGTTAAGGAGTAAATAGGGGTTTGGAGGTGAGAAAGTAATTCTCTAGAAAGAGAAATTGTCCTTATTTATTATTATTTTTTTTGCAATAATAA
Associated Phenotype:
Not determined