Busch Lab

ZMP

nbr1

Ensembl ID:
ENSDARG00000077297
ZFIN ID:
ZDB-GENE-030131-9112
Human Orthologue:
NBR1
Human Description:
neighbor of BRCA1 gene 1 [Source:HGNC Symbol;Acc:6746]
Mouse Orthologue:
Nbr1
Mouse Description:
neighbor of Brca1 gene 1 Gene [Source:MGI Symbol;Acc:MGI:108498]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa30960 Nonsense Mutation detected in F1 DNA Not yet available
sa42042 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa45462 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa11901 Essential Splice Site Available for shipment Available now
sa22111 Essential Splice Site, Missense Available for shipment Available now

Mutation Details

Allele Name:
sa30960
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114556 Nonsense 36 1014 2 23
ENSDART00000133048 Nonsense 36 989 2 21

The following transcripts of ENSDARG00000077297 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 28785350)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 27122959
GRCz11 12 27214319
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTAATCTTACTGTGCCTTCTTTACATTTTCTGTTTATAACTTTTAGATT[A/T]AAACTACTTTCGGCTTGAGCCATTTTCAAGTGAAATATTTTGACGAGGAC
Long Flanking Sequence:
CATCAAACGCTTCCGTTGACTCTGGCTCACAGACATGAACCTCCCCGTCACTGTCAAAGTGAACTTTAGGGGCAACGTGAAGAAATTTCCAGTCTTGGACACGAACAAAGCACAGTGGGAGACTGTGGAGGCCTGGGTAAGGAGTCATTAAGCCTTGCTGGGTGGCGTTTATGTGGGGACGTTTACATTTCTTGGTCCTACAAGGCCGTAGCTGAGGCCTACATAAACAAACCTTTAACCGGATGCTAAAAACGAATAACGTACAGGCAAATTCTTTAATCCTGTCATAGAAAATATGTCTTAACATGTATTTTAGCTGGGTCTTCTTTTAAAATCCACAGTGATGTAAATTGCAGCAATATCTATTATTTGCTCTTGACCTTTCTGTTCGGCCATAAATCAGATGACAGCTTCTAAATAAACACTAACGATGTAAAATATCGTTCTCGTTTTAATCTTACTGTGCCTTCTTTACATTTTCTGTTTATAACTTTTAGATT[A/T]AAACTACTTTCGGCTTGAGCCATTTTCAAGTGAAATATTTTGACGAGGACAACGAAGAGGTAAATAATAACAGTTTAATTACGGGTTTATATCATCTTTGCATTTTTGTTTAATATATTACATTGATGGATATGAGTTAAAAGTTGTTACAGATCTATTGTTTTATTTTTCATTACAGGTGTGCATAAACAGTCAAGGTATGTATATGATTTTATTAATTGTTTTCACTAAATAACTCGAAATGTTGAAATATTATTAAAATGAAAATTAATGTTTGTATATATATATATATATATATTTTTTTTTTATTTTTATTTTTATTTTTATTATTATTATTTTTTTATTATTATTTGACAACATCACAGATGAATATACAGAAGCTCTAAAGGTAAGAACATCAAACAATTCAGTTTTGTGTGTGTGTGTGTGTTTGTATTTATAAGCCAAATCTGAATAAGGCCCATGCTGTATTAAATTATTATTATAATGATCATAATTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa42042
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114556 Essential Splice Site 55 1014 2 23
ENSDART00000133048 Essential Splice Site 55 989 2 21

The following transcripts of ENSDARG00000077297 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 28785410)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 27123019
GRCz11 12 27214379
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCGGCTTGAGCCATTTTCAAGTGAAATATTTTGACGAGGACAACGAAGAG[G/T]TAAATAATAACAGTTTAATTACGGGTTTATATCATCTTTGCATTTTTGTT
Long Flanking Sequence:
GAACTTTAGGGGCAACGTGAAGAAATTTCCAGTCTTGGACACGAACAAAGCACAGTGGGAGACTGTGGAGGCCTGGGTAAGGAGTCATTAAGCCTTGCTGGGTGGCGTTTATGTGGGGACGTTTACATTTCTTGGTCCTACAAGGCCGTAGCTGAGGCCTACATAAACAAACCTTTAACCGGATGCTAAAAACGAATAACGTACAGGCAAATTCTTTAATCCTGTCATAGAAAATATGTCTTAACATGTATTTTAGCTGGGTCTTCTTTTAAAATCCACAGTGATGTAAATTGCAGCAATATCTATTATTTGCTCTTGACCTTTCTGTTCGGCCATAAATCAGATGACAGCTTCTAAATAAACACTAACGATGTAAAATATCGTTCTCGTTTTAATCTTACTGTGCCTTCTTTACATTTTCTGTTTATAACTTTTAGATTAAAACTACTTTCGGCTTGAGCCATTTTCAAGTGAAATATTTTGACGAGGACAACGAAGAG[G/T]TAAATAATAACAGTTTAATTACGGGTTTATATCATCTTTGCATTTTTGTTTAATATATTACATTGATGGATATGAGTTAAAAGTTGTTACAGATCTATTGTTTTATTTTTCATTACAGGTGTGCATAAACAGTCAAGGTATGTATATGATTTTATTAATTGTTTTCACTAAATAACTCGAAATGTTGAAATATTATTAAAATGAAAATTAATGTTTGTATATATATATATATATATATTTTTTTTTTATTTTTATTTTTATTTTTATTATTATTATTTTTTTATTATTATTTGACAACATCACAGATGAATATACAGAAGCTCTAAAGGTAAGAACATCAAACAATTCAGTTTTGTGTGTGTGTGTGTGTTTGTATTTATAAGCCAAATCTGAATAAGGCCCATGCTGTATTAAATTATTATTATAATGATCATAATTTAAAAAAAAATCTCAAGGCTTTAAAAATAAATTTATTTTTATTTAGAGTGCGTTTAAACAAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45462
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114556 Essential Splice Site 270 1014 9 23
ENSDART00000133048 None None 989 None 21

The following transcripts of ENSDARG00000077297 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 28789989)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 27127598
GRCz11 12 27218958
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTAGAGCGATGATTGTATATATATGTTAAGGGAATTGAATTCATTTTTC[T/G]GTGTTGTTTTCAGGTTTCTGAGGCGGGGTGACAGGACGGTGAGAAAGGCG
Long Flanking Sequence:
AAATGATGTCCTGAGGAGCAGATTCACATTTACATTTAGAGAAGATGGAGGGGTAGAATTTATTAAGCTTAACCCTACAATAATGAATCTGGTGTACTATTTTATATTAAATTAGTTGGTGTCTTGAGTTAATAGAACAAGTGTTTATGGTATTAGTAATTTAAAATTTATTTAAGATTACAATTCAGAAGTACTCTTCCAATCTCACACTATTTGAGAAAATGAATGACCGTTCAATATGAACTCTTCCCTCCTCCTATGTGCAGTGTTTGTCCATCTTGCATCTTATGCGAGCCATGCAGTCATAAACACGATCCCAGCCACAACCTAAAGAGAACAAGGACTCCTCTGTCTGTCCCTGAACGTGGAGTTACCCCTGAACCCAGGTAGGCCAAAATAAACACTTGGTGCTCAAGATGTTGTGAATTTTCTGCTTGACCTAACGTGTTGTTTAGAGCGATGATTGTATATATATGTTAAGGGAATTGAATTCATTTTTC[T/G]GTGTTGTTTTCAGGTTTCTGAGGCGGGGTGACAGGACGGTGAGAAAGGCGGAGAGGCAGCGTCTAAAAGCAGAGCGGAGGCAGCTGAAGGCTGAGGTGAAGGAGATCAAGAAGAAGCTGAGGCTGGAGAAGAGAGGTCTGCTGTGGAGTGGAGCCTCCAACGGGACCAGCACCTCAGGCCTTGCCCCCGCTCCCGCCCCGTCTCTAGGTGCAGGACCAGCCCCAGCTCCGGCCCTGTGCCCAGACCCTCAAACTTCCAGTCCAGAGTAAGGGCCACACTGAGAGGGGTCAGGGCTGGGTGACCTCCCTACCCAGCCCAGAACAAACATTATCAAGATTTATCACATTGTCTGTTATAGTTGAGTTATCGCTGGCAAATGGATGGAACTACCTCAAAATAGCACCCGCTGCCTTTATGTATTACGTCCTTTTTTGTACTTTTTTGATATGAACTTCAAGGAAAAGACAGACGCTGAAACAAAGCTGTTCTGATGATCCTCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11901
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114556 None 274 1014 9 23
ENSDART00000133048 Essential Splice Site 268 989 None 21

The following transcripts of ENSDARG00000077297 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 28790001)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 27127610
GRCz11 12 27218970
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ATTGTATATRTWTGTTAAGGGAATTGAATTCATTTTTCTGTGTTGTTTTC[A/C]GGTTTCTGAGGCGGGGTGACAGGACGGTGAGAAAGGCGGAGAGGCAGCGT
Long Flanking Sequence:
GAGGAGCAGATTCACATTTACATTTAGAGAAGATGGAGGGGTAGAATTTATTAAGCTTAACCCTACAATAATGAATCTGGTGTACTATTTTATATTAAATTAGTTGGTGTCTTGAGTTAATAGAACAAGTGTTTATGGTATTAGTAATTTAAAATTTATTTAAGATTACAATTCAGAAGTACTCTTCCAATCTCACACTATTTGAGAAAATGAATGACCGTTCAATATGAACTCTTCCCTCCTCCTATGTGCAGTGTTTGTCCATCTTGCATCTTATGCGAGCCATGCAGTCATAAACACGATCCCAGCCACAACCTAAAGAGAACAAGGACTCCTCTGTCTGTCCCTGAACGTGGAGTTACCCCTGAACCCAGGTAGGCCAAAATAAACACTTGGTGCTCAAGATGTTGTGAATTTTCTGCTTGACCTAACGTGTTGTTTAGAGCGATGATTGTATATATATGTTAAGGGAATTGAATTCATTTTTCTGTGTTGTTTTC[A/C]GGTTTCTGAGGCGGGGTGACAGGACGGTGAGAAAGGCGGAGAGGCAGCGTCTAAAAGCAGAGCGGAGGCAGCTGAAGGCTGAGGTGAAGGAGATCAAGAAGAAGCTGAGGCTGGAGAAGAGAGGTCTGCTGTGGAGTGGAGCCTCCAACGGGACCAGCACCTCAGGCCTTGCCCCCGCTCCCGCCCCGTCTCTAGGTGCAGGACCAGCCCCAGCTCCGGCCCTGTGCCCAGACCCTCAAACTTCCAGTCCAGAGTAAGGGCCACACTGAGAGGGGTCAGGGCTGGGTGACCTCCCTACCCAGCCCAGAACAAACATTATCAAGATTTATCACATTGTCTGTTATAGTTGAGTTATCGCTGGCAAATGGATGGAACTACCTCAAAATAGCACCCGCTGCCTTTATGTATTACGTCCTTTTTTGTACTTTTTTGATATGAACTTCAAGGAAAAGACAGACGCTGAAACAAAGCTGTTCTGATGATCCTCTGTGCACTCAAAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22111
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site, Missense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114556 Missense 699 1014 17 23
ENSDART00000133048 Essential Splice Site 692 989 16 21

The following transcripts of ENSDARG00000077297 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 28792643)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 27130252
GRCz11 12 27221612
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCCAGTTCCTGTGTCAAAGCCAATCATAACAGATGAACCTGTCTTTCCAG[G/A]TCTGCATGCCTTTTTTTTTTCTTGGTCACTGTTACTTAGGGTGCTTTTAC
Long Flanking Sequence:
GATTTTTAGATCTGTTAAAGGCTTTTGTGAATGAATGTCTTCCTGAACTGATTATGAACGTGTTACTAGTGACCTTTTATGTACTGACACGACTTATTCTCTGTTAGTCCTGCAGCCTCAGAGACAAAACGAGCTTCTGGATGTTCCAGGCAATGAGGAAGGAGACGAAGACATCAGTGGCACTCAGTTTGTGTGTGAGACTGTGATTCGCTCTCTGACTCTTGAGGAGGAACCAGAACGCAAACCTCAACGCAGAGCACGGCCCAGCCTGAGGAGGCATGATGGTGAGCTTCTGCTGGAATTCTGCTCACAAAAAAACAGATATTTGACTGGCCTTATTTTGTTTTTGTTCATTTTGCCTTCCTATTTTGCAGTTCCAGATCCTGTTCGCTTAAAGGAGAGATCAGTGCCGGTGAAGAATGACAGACCAGTCATAAACAGGCCTGAGGCTCCAGTTCCTGTGTCAAAGCCAATCATAACAGATGAACCTGTCTTTCCAG[G/A]TCTGCATGCCTTTTTTTTTTCTTGGTCACTGTTACTTAGGGTGCTTTTACACTTGGTTTAATTGCCTGGACCATACCAAAGTTCGATTGTCCTCCCCGGCCACCTTCTCGGTTGGTTTGTGTTCACACTTTCTTTTTTCCTTCTGAACCCCGTTACGCTTGCTTCATCAAGCTGCTGTGGTGTGTACAGCCTTTGGTTTTGGACATACAGAAAAGCAACTCGCGTCCATCTGTCGCAATATTATTATAAAAGTTCAGAACATAACGCAATGTTTTTGGAGGAGACAAGCAGACATTATCACTATGCTTGCCCTGGCTTAGTCCTGCTTGTCACCAAGGTACAGTACGTGATACACACACATACACACACACGAATGAACGTTATGAAATGCTGTTGATGGATCCATTATTTGGTACGATTGCATTCATATCAGAAGTGAAGCGGACCAGGACCGTACCCCAGACCACCTCTTTCAGCTGGACTCTGGTATATTTTGTGAG
Associated Phenotype:
Not determined