Busch Lab

ZMP

myha

Ensembl ID:
ENSDARG00000071435
ZFIN ID:
ZDB-GENE-060531-50
Human Orthologues:
MYH6, MYH7
Human Descriptions:
myosin, heavy chain 6, cardiac muscle, alpha [Source:HGNC Symbol;Acc:7576]
myosin, heavy chain 7, cardiac muscle, beta [Source:HGNC Symbol;Acc:7577]
Mouse Orthologues:
Myh6, Myh7
Mouse Descriptions:
myosin, heavy polypeptide 6, cardiac muscle, alpha Gene [Source:MGI Symbol;Acc:MGI:97255]
myosin, heavy polypeptide 7, cardiac muscle, beta Gene [Source:MGI Symbol;Acc:MGI:2155600]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa8392 Nonsense Mutation detected in F1 DNA Not yet available
sa40476 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa7568 Missense Mutation detected in F1 DNA Not yet available
sa30619 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa8392
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000046048 Nonsense 161 1106 4 25
ENSDART00000122669 Nonsense 145 364 3 10
Genomic Location (Zv9):
Chromosome 5 (position 33885536)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 31647768
GRCz11 5 32247921
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACCCCTACAAGTGGCTCCCAGTGTATGACGCAGAAGTGGTTGCTGCCTAC[A/T]GAGGCAAAAAGCGTATGGAGGCTCCACCCCACATCTTCTCTGTCTCTGAC
Long Flanking Sequence:
TGCTATGTGGTTGATGACAAAGAGCTGTACGTCAAGGGAACAATCAAGAGCAGAGACGGTGGCAAAGTCACCGTTATTACACTTGACACTAAGGAGGTGAATTTTTACATTTCATGTAAATTAGATGAATTTCAATTAATTGCAATAACACAGACTTAATAAATCTATTATTGACTGGATGACTTTTATAGGAGAGAGTTGCTAAGGAGGAAGATGTCCACCCAATGAATCCTCCCAAGTTTGACAAGATTGAGGACATGGCCATGATGACCCATCTCAATGAACCCTCTGTGCTGTATAACCTCAAAGAGCGTTATGCAGCATGGATGATCTACGTAAGTTCTGAAACAACCTACAACAGCACTTCAAGACATTTAGTCTGTGTGTTTGCCATCTGACCACTTCTCTCCTCATTTCAGACCTACTCTGGACTGTTCTGCGCCACTGTAAACCCCTACAAGTGGCTCCCAGTGTATGACGCAGAAGTGGTTGCTGCCTAC[A/T]GAGGCAAAAAGCGTATGGAGGCTCCACCCCACATCTTCTCTGTCTCTGACAACGCCTATCAGTTCATGTTGACTGGTGAGATCTCATTTACAAGATCTGACTTACACACAAGTTCACATTCATCATTTTAACAAAACAATTGCTAAAACATTATTACCTTTGCATTTACAGACAGAGAGAACCAGTCTGTCCTGATTACGTATGTATCTAATCTAATAGAGATGCTGAGAACAGGTTTATTTTCCTCTCGTGCAAATTCTACATGTCTTATCATTTTCTGTCTTCGTGTCTCTCATAAACCAGTGGAGAATCTGGTGCTGGAAAGACTGTGAACACCAAACGTGTCATTCAGTACTTTGCCACCGTTGCAGTTCAGGGCGGTGACAAGAAGAAAGAGCAGACTCCAGGCAAAATGCAGGTATGCAATAAAAAAATATACTAATTAAATTATACTTATCTTAAATACATATAAAACTAAAAAAAAAACAAAAAAAAAAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40476
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000046048 Essential Splice Site 186 1106 5 25
ENSDART00000122669 Essential Splice Site 170 364 4 10
Genomic Location (Zv9):
Chromosome 5 (position 33885706)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 31647938
GRCz11 5 32248091
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCATCATTTTAACAAAACAATTGCTAAAACATTATTACCTTTGCATTTAC[A/T]GACAGAGAGAACCAGTCTGTCCTGATTACGTATGTATCTAATCTAATAGA
Long Flanking Sequence:
TTGACTGGATGACTTTTATAGGAGAGAGTTGCTAAGGAGGAAGATGTCCACCCAATGAATCCTCCCAAGTTTGACAAGATTGAGGACATGGCCATGATGACCCATCTCAATGAACCCTCTGTGCTGTATAACCTCAAAGAGCGTTATGCAGCATGGATGATCTACGTAAGTTCTGAAACAACCTACAACAGCACTTCAAGACATTTAGTCTGTGTGTTTGCCATCTGACCACTTCTCTCCTCATTTCAGACCTACTCTGGACTGTTCTGCGCCACTGTAAACCCCTACAAGTGGCTCCCAGTGTATGACGCAGAAGTGGTTGCTGCCTACAGAGGCAAAAAGCGTATGGAGGCTCCACCCCACATCTTCTCTGTCTCTGACAACGCCTATCAGTTCATGTTGACTGGTGAGATCTCATTTACAAGATCTGACTTACACACAAGTTCACATTCATCATTTTAACAAAACAATTGCTAAAACATTATTACCTTTGCATTTAC[A/T]GACAGAGAGAACCAGTCTGTCCTGATTACGTATGTATCTAATCTAATAGAGATGCTGAGAACAGGTTTATTTTCCTCTCGTGCAAATTCTACATGTCTTATCATTTTCTGTCTTCGTGTCTCTCATAAACCAGTGGAGAATCTGGTGCTGGAAAGACTGTGAACACCAAACGTGTCATTCAGTACTTTGCCACCGTTGCAGTTCAGGGCGGTGACAAGAAGAAAGAGCAGACTCCAGGCAAAATGCAGGTATGCAATAAAAAAATATACTAATTAAATTATACTTATCTTAAATACATATAAAACTAAAAAAAAAACAAAAAAAAAAAAACACATACACTACTGAATTTGTGATATCCCTGCAAAAAGTGTTGTAATGCAAAATTAATGAAACCCATTCATACAACACAGGGCTCTCTTGAGGATCAGATCATTGCTGCCAACCCTCTGCTTGAGGCTTATGGTAATGCCAAGACTGTGAGAAATGACAACTCCTCTCGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa7568
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > A
Consequence:
Missense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000046048 Missense 736 1106 19 25
ENSDART00000122669 None None 364 None 10

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 33889011)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 31651243
GRCz11 5 32251396
KASP Assay ID:
554-4016.1 (used for ordering genotyping assays)
KASP Sequence:
GAATTCAGGTGTTCTTCAAAGCTGGTCTKCTGGGTACTCTTGAGGAGATG[C/A]GTGATGAGAAACTGGCTAGTCTGGTCACAATGACYCAGGCTCTCTGCCGT
Long Flanking Sequence:
GACGGTGTTGATAACATCATGCTGTTACTTATAGGTCTTATGGAGAACTTCCTAGTTATCCACCAGCTGAGGTGTAACGGTGTACTGGAGGGTATCAGAATCTGTAGAAAGGGTTTCCCAAGCAGAATTCTTTATGCCGACTTCAAGCAGAGGTAAATGGGACCTTCTGAAAGCATAATTAACTTTAGGAATTACTTAATTACAAGATCTTAACAATTTTCATAAATGTTCAACAGATACAAGGTGTTGAATGCCAGTGTTATCCCAGAGGGACAGTTCATTGACAACAAGAAGGCCAGTGAGAAACTCCTGGGATCTATTGATGTTAATCATGATGAGTACAGATTTGGACACACAAAGGTTCATATTTTAATTTACAGTTTTAAGAGATTCAGTGATCAGTGTAGTTTACATTAGGCATCAATTTCTTTTCCTTTTCTCTATTTACATGAATTCAGGTGTTCTTCAAAGCTGGTCTGCTGGGTACTCTTGAGGAGATG[C/A]GTGATGAGAAACTGGCTAGTCTGGTCACAATGACTCAGGCTCTCTGCCGTGCTTATCTGATGAGGAGAGAGTTTGTGAAGATGATGGAGAGGAGGTGAGGGAAAGCATGAGTTATAATTGTGTGAATGGTAAAAAGTAATAATTATGGCATTTAATGATGAACTATTCACAGGGAGTCCATTTACACCATCCAGTACAACATCCGCTCATTCATGAATGTCAAACACTGGCCATGGATGAAGGTTTACTACAAGATTAAGCCTCTGCTGAAGAGTGCTGAGACTGAGAAAGAACTGGCAAACATGAAAGAGGACTTTGTCAAATGCAAAGAAGATCTTGTCAAGGCTGAAGCTAAAAAGAAGGAGCTGGAAGAGAAGATGGTGGCACTGCTGCAAGAGAAAAATGATCTGCAGCTGGCAGTGGCTTCTGTGAGTATTCTTAATTTAATAAACTCAATCTCATCTCCATTAAAATTAGTTTGCAATGATATAACAATGTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa30619
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000046048 Essential Splice Site 934 1106 None 25
ENSDART00000122669 None None 364 None 10

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 5 (position 33889845)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 31652077
GRCz11 5 32252230
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATACAGTATATATTGTAAAATAACTAAGCGTATTTGAAATCAAATCACAC[A/T]GGTTAAGAACTTGACAGAGGAAATGGCATCTCAGGATGAGAGCATTGCCA
Long Flanking Sequence:
ATCTTGTCAAGGCTGAAGCTAAAAAGAAGGAGCTGGAAGAGAAGATGGTGGCACTGCTGCAAGAGAAAAATGATCTGCAGCTGGCAGTGGCTTCTGTGAGTATTCTTAATTTAATAAACTCAATCTCATCTCCATTAAAATTAGTTTGCAATGATATAACAATGTGTTTTCCTAACAGGAAGCTGAAAATCTCTCAGATGCTGAGGAGAGGTGTGAGGGTCTGATCAAGAGCAAAATCCAGCTTGAGGCTAAACTCAAAGAGACAACTGAGAGACTGGAGGATGAGGAAGAAATCAATGCTGAACTGACAGCCAAGAAGAGAAAACTGGAGGACGAGTGCTCTGAGCTGAAGAAAGACATTGATGACCTGGAGCTCACCTTGGCTAAAGTGGAAAAGGAGAAACATGCCACTGAGAATAAGGTTGGAGACAAAGGCTCTTTGACTTATATATACAGTATATATTGTAAAATAACTAAGCGTATTTGAAATCAAATCACAC[A/T]GGTTAAGAACTTGACAGAGGAAATGGCATCTCAGGATGAGAGCATTGCCAAGCTTACAAAGGAGAAGAAAGCCCTCCAAGAGGCACATCAGCAGACTCTGGATGATCTTCAGGCTGAGGAGGACAAAGTCAACACCCTGACCAAATCCAAGACAAAGCTTGAGCAGCAAGTTGATGATGTGAGCTCTATGTTAAATATGTCTAGAATTGATTTATAATTTTTGCTTTTGAATATATTGAATTAAATATGTTATAAACATCATTGTCATATAGCTTGAGGGTTCCCTTGAACAAGAAAAGAAGCTCCGTATGGACCTGGAGAGAGCTAAGAGAAAGCTTGAAGGAGATCTAAAATTGGCCCAAGAGTCTATCATGGACCTGGAAAATGACAAGCAGCAGTCTGAAGAGAAAATTAAAAAGTAAAAAATATATAAATACTTTAACAAAACATTCCACAAACTTGCTGTGTACAAACTATTGATACTTGATCACCCACAGGAA
Associated Phenotype:
Not determined