Busch Lab

ZMP

dyrk1aa

Ensembl ID:
ENSDARG00000063570
ZFIN ID:
ZDB-GENE-050302-29
Description:
dual specificity tyrosine-phosphorylation-regulated kinase 1A [Source:RefSeq peptide;Acc:NP_0010741
Human Orthologue:
DYRK1A
Human Description:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A [Source:HGNC Symbol;Acc:3091]
Mouse Orthologue:
Dyrk1a
Mouse Description:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Gene [Source:MGI Symbol;Acc:MGI:13

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa27522 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa15575 Nonsense Available for shipment Available now
sa21625 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa27522
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100073 Essential Splice Site 75 734 None 11
ENSDART00000141723 Essential Splice Site 75 226 None 5
ENSDART00000144722 Essential Splice Site 71 222 None 7

The following transcripts of ENSDARG00000063570 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 210310)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 73478
GRCz11 10 73478
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGTACTGATGGACACTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGC[A/C]GGTAACTGCTGATATGGTGATGCTGCAGAGGCGGATGCCTCAGTGTTTCC
Long Flanking Sequence:
TGTGTGTGTGTGTTTGAAGGATGCTAACACGTGTCCAGTGTCGTCTTGTGACAGCAGCACAGTCTGCCATTTTGGTGCGGGTGTTTTGGGATGTTCTGTAAGCCGATCGGCTCGAGTTTCACTGGAGCGTTTGCTGCTTAAATGTGGAGGGCAGGCTGATGTTCATGTGTGTTTTGCAGGAGGAGAGACCTCAGCATGCAAACCCTCCTCTGTCCGGCTGGCCCCCTCGTTTTCTTTCCACTCGGCTGGTGTGCAGATGGATGCGCAGACGCCCCATTCTCACCCGCCGTTCAGTGATGCTCACCCACAGGGCGCCGCTGACCAATCCGCTGCTGCGCTGCCCTACAACCCGCAGGCCCCGCAGCCCAGCGCCACCCAGGTACACACACTCGCGCACACACACACACACACACACACACACACACACAGGCGTACAATAAGAGCACATTCGGTACTGATGGACACTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGC[A/C]GGTAACTGCTGATATGGTGATGCTGCAGAGGCGGATGCCTCAGTGTTTCCGGGATCCAGCGACGGCACCCTTAAGAAAACTCTCCATCGAGCTGATCAAAACATACAAACACATCAATGAGGTGTGGAGCTGTTCCTCTAGCGCTTCATCACACACACACACTAAAGCTCAGCTGGAGTATGGGCAATGACAGAATATATGACGCACTCTCCACCAGCGAGAGGCACATTGAGCTGTTCATCAGATCTAGAGGACTGTAGTGTCGCTATCAGGCATGCACAACACTGAGAGAGTGTGTGATGATGTTGACTATGGCCATTACGATGCTACTTATGACCTTTCCCTGGATCTGTGTTTGTCAACCATGTTTCTCGAGGACCACCAGTTCTGCACATTTCCATGTCTTCTTAACCGAACACACCTGATTCAGATCATCAGCTCATTAGCAGAGGCTGAAACATGTGGGAAAGACAACAGAGACATCCAAAACATGCAGTGCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15575
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100073 Nonsense 621 734 11 11
ENSDART00000141723 None None 226 None 5
ENSDART00000144722 None None 222 None 7

The following transcripts of ENSDARG00000063570 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 220539)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 63550
GRCz11 10 63550
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACCACCACCATCAYCACCACCACCCGCCGCCRCATGGACAGGGCCCTGCC[C/T]GACCTCGACCCCGGCTCTACTCTCCGTCCCACAGCGCCTCCACGCAGGAC
Long Flanking Sequence:
GTTTTGCTGTCGTGGCAATGACTGAACTGCCCTACAGTGGAGCATTAGAGAGTCAACAGCGCTGTTCATCAGGGATCAGGGGGTTCACTGAGGGAATCTGGGTTTGCTTCTAAACAAGCCACCATTTTCCCACACAGAGGAGGGAGAAGATCCACACATCTCTTTCCTAGCCTCCTTGTTGTGTTTTACATGACAGTGACACACTTTTATTGTGAAGTGCAGTGGTGACGTGCATGTTAATGTGTGTGTGTGTGTGTGTGTTAATGTGTGTGTGTGTGTGTGTGTTAATGTGTGTGTGTGTGTGTCCTTCTCAGGCAAGACAGGCGTTTGTGCCGGCGCTGGGCTGGGTTGGAGACGGACTCCAGCAGGCGTCAGGAGAGACTCACCCCGTACAGGAGACCACTTTCCACGTGCCCCCACACCAGCCCAAAGCCCTGCACCCCCACCAACACCACCACCATCATCACCACCACCCGCCGCCGCATGGACAGGGCCCTGCC[C/T]GACCTCGACCCCGGCTCTACTCTCCGTCCCACAGCGCCTCCACGCAGGACTCAATGGAGGTGACGCACGGACACCTGTCCATGACCTCGCTGTCTTCCTCCGCCTCGTCCTCCTCCACCTCCTCCTCCTCCACCGGCAACCATCACTACGCCTACCAGAGCCGCCCGCTGCCCCACGGCCTGGGCTTCGGCCACAGCGGCAGCATGACTCTGGGCCTGGGTGCCTTCTCCAACCCGCGACAGGAGACGGGCGTGGCAGGCGTAGGTCTGCGGCCGGGTCTGGAGCGCGAGGAGTCCCCGATGGCGGGTGTATGTGTGCAGCAGAGCTCCGTGGCCAGCTCCTGACCCGCCTGAGGAGGCCGATTCACGCGCCCGTCCATACTGGAGCTGAGCGGAGCTGGAGCCAAGCGGAGCCAGCACTCCTGCGGCCGTGGACGTTAACTTCGGTCTGCAGCTCTGACGCTGCCGGAGCCCAGCGCTCGCCCGCCGCCGCCACCGCAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa21625
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100073 Nonsense 623 734 11 11
ENSDART00000141723 None None 226 None 5
ENSDART00000144722 None None 222 None 7

The following transcripts of ENSDARG00000063570 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 220545)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 63544
GRCz11 10 63544
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCATCATCACCACCACCCGCCGCCGCATGGACAGGGCCCTGCCCGACCT[C/T]GACCCCGGCTCTACTCTCCGTCCCACAGCGCCTCCACGCAGGACTCAATG
Long Flanking Sequence:
CTGTCGTGGCAATGACTGAACTGCCCTACAGTGGAGCATTAGAGAGTCAACAGCGCTGTTCATCAGGGATCAGGGGGTTCACTGAGGGAATCTGGGTTTGCTTCTAAACAAGCCACCATTTTCCCACACAGAGGAGGGAGAAGATCCACACATCTCTTTCCTAGCCTCCTTGTTGTGTTTTACATGACAGTGACACACTTTTATTGTGAAGTGCAGTGGTGACGTGCATGTTAATGTGTGTGTGTGTGTGTGTGTTAATGTGTGTGTGTGTGTGTGTGTTAATGTGTGTGTGTGTGTGTCCTTCTCAGGCAAGACAGGCGTTTGTGCCGGCGCTGGGCTGGGTTGGAGACGGACTCCAGCAGGCGTCAGGAGAGACTCACCCCGTACAGGAGACCACTTTCCACGTGCCCCCACACCAGCCCAAAGCCCTGCACCCCCACCAACACCACCACCATCATCACCACCACCCGCCGCCGCATGGACAGGGCCCTGCCCGACCT[C/T]GACCCCGGCTCTACTCTCCGTCCCACAGCGCCTCCACGCAGGACTCAATGGAGGTGACGCACGGACACCTGTCCATGACCTCGCTGTCTTCCTCCGCCTCGTCCTCCTCCACCTCCTCCTCCTCCACCGGCAACCATCACTACGCCTACCAGAGCCGCCCGCTGCCCCACGGCCTGGGCTTCGGCCACAGCGGCAGCATGACTCTGGGCCTGGGTGCCTTCTCCAACCCGCGACAGGAGACGGGCGTGGCAGGCGTAGGTCTGCGGCCGGGTCTGGAGCGCGAGGAGTCCCCGATGGCGGGTGTATGTGTGCAGCAGAGCTCCGTGGCCAGCTCCTGACCCGCCTGAGGAGGCCGATTCACGCGCCCGTCCATACTGGAGCTGAGCGGAGCTGGAGCCAAGCGGAGCCAGCACTCCTGCGGCCGTGGACGTTAACTTCGGTCTGCAGCTCTGACGCTGCCGGAGCCCAGCGCTCGCCCGCCGCCGCCACCGCAGCGTTTC
Associated Phenotype:
Not determined