Busch Lab

ZMP

nrxn2a

Ensembl ID:
ENSDARG00000061454
ZFIN ID:
ZDB-GENE-070206-5
Description:
neurexin 2a [Source:RefSeq peptide;Acc:NP_001073439]
Human Orthologue:
NRXN2
Human Description:
neurexin 2 [Source:HGNC Symbol;Acc:8009]
Mouse Orthologue:
Nrxn2
Mouse Description:
neurexin II Gene [Source:MGI Symbol;Acc:MGI:1096362]

Alleles

There are 7 alleles of this gene:

Allele Name Consequence Status Availability
sa32351 Nonsense Available for shipment Available now
sa45740 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa16817 Essential Splice Site Available for shipment Available now
sa18390 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa32351
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087657 Nonsense 455 1670 9 24
ENSDART00000087660 None None 642 None 7
ENSDART00000132583 None None 648 None 7
ENSDART00000141629 Nonsense 455 1670 10 24

The following transcripts of ENSDARG00000061454 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 21 (position 27473300)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 28042211
GRCz11 21 28078906
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTCTCTCTCCCTGTCCCAGGTGGTCTACACCAATAATGAGTTCAGACTA[G/T]AGCTCTCCCATCTGGCGGAATTGCGTGACCCTAAGGTTACCCTCCATGGC
Long Flanking Sequence:
CACATGTGACAGAAACAAAAAACCAACCTTAAGGGGACACAGTCAGCATGCAGGAATGTTATTTTAGGAGCAGTTTTGTCATACGGTGGCACGTGTGGGCTAGACATCATATCATACATTGAGATTTTTCAGTTGACGTCACTTAATGAATGCGCTGTTTATGCGCGCGATTCAGAAAAGCACTTAGCCGCGGCATCGTCAGAGCTAATGTTAGCGTAGGATGATTCATCATATTAATGAAACAGAATATCGATTAGCCGAGGGTTGCTGTAGTGCTCTGGATGATGTCTCTCGGTTTATGTGATCCACTCATGCTTTTGAGTATTTAAAGAGACTGCCGTGTTTACTGACTTGAAAACCGTGCCCTCTAGGTACACACATCAGCTGGGGTTTGTTTGTACCAGTGGGCAGCATACTACTCCATTCCCTCCTGTTAGCATTTAAGCTTTTTTTCTCTCTCCCTGTCCCAGGTGGTCTACACCAATAATGAGTTCAGACTA[G/T]AGCTCTCCCATCTGGCGGAATTGCGTGACCCTAAGGTTACCCTCCATGGCGATTTGACCTTCCGCTGCGAGGACGTCGCTGCATTGGACCCAGTCAGTTTCGACGCGCCCACTGCTTATGTAACCCTCCCGCGCTGGAATGGCAAGAAAGCTGGCTCTGTGTCCTTCGATTTTCGAACCACCGAGCCCAACGGACTGCTGTTGTTCAGTCACGGGCGGCCGCAGGGTTCAAAAGATCACAGACCAAGGGTGGACTTCTTCGCCATGGAACTGCTGGATGGATTCCTCCACCTGCTCATGGACATGGGCTCCGGGAGCATCAAGATTAAAGTGGGGAACAAGAAGGTCAATGATGGAGAATGGTGCCACGTAGACTTCCAGAGAGAGGGCAGGAAAGGTCAGGATATTGCAAGATCAGCACACACATTATTGCTAAACCTGCTCTCGCTTTGATTCCTACTCTGACGCTTTCCTCTTAATCTCTGCCGTTAAAGCACTGCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45740
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087657 Essential Splice Site 783 1670 11 24
ENSDART00000087660 None None 642 None 7
ENSDART00000132583 None None 648 None 7
ENSDART00000141629 Essential Splice Site 783 1670 12 24

The following transcripts of ENSDARG00000061454 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 21 (position 27469106)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 28038017
GRCz11 21 28074712
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGCGCCTGGAGCTGGACGGGGGAAGAGTCAAGCTTACCGTCAACCTCGG[T/C]AAAACCACCAGACTCGAGGCTCTTCCCAAAACACATTTCACTCTCATTCC
Long Flanking Sequence:
GATATACTGTAGCTGTTATTACTGTTACTGTGACCATGTAACTTAAAATGAAATGTCTTAATAGCAGTAGCAATTAGTTACATTTTATTTGGATTCAAATACAATGCAAATCCCTGAGTTTATTAAAGAGTAATTAAAACTGAATAAAAATATTGATAATGTTTACATTTACTTTGCTTTTTAACATTATATAAACATAAAAAAATACTGTTTGAAAAATGCATACAAAAATATATCTTTTAATTTTGCATCCTAGTGTTTGCTGACCTGTAGTGTCTTGTTCTGCCTCTTTCAGAGTCTGCAGTGTTGAGTTACGACGGCAGCATGTTTCTGAAAGTCCTGATGCCTCACGCAGCTCACAGCGAGGCCGAGGACGTGTCTCTGCGCTTCATGTCTCAGAGGGCTTATGGTCTGCTCATGGCCACCACCTCCAAAGAGTCCGCCGATACCCTGCGCCTGGAGCTGGACGGGGGAAGAGTCAAGCTTACCGTCAACCTCGG[T/C]AAAACCACCAGACTCGAGGCTCTTCCCAAAACACATTTCACTCTCATTCCTCCATCTTTATCTCTTTCTGCTCTTCTTCTTCTTCTCTCTCTCTCTCTCTCTCTTTCTTTCTCGCTCTGTCTTTCTCTCTCCACCTGTGCAGCCTTCAATGGCTTTCACTTCTGCAGCTTTCAGAGCAGACAGCCAGAGAGACCAGATCATTTAGTGTCAAACACATTGAGTTAAACTAGGGGAGACTGAGGGGAAATTATATTGTTTTACCTTTTGAATTTTTCTATAACTTTATAATGTTTAAATATAATATAATATAATATAATATAATATAATATAATATAATATAATATAATATAATAATATAAATCTCTGTATTTTAAAAGGTCAACTTCAAAGTAAGAATATGATATGAATCCTGCACAGTATTCTTAGTTTTTATTATTATTAAATTGCTTACATAATGAGGCTGAGTAGTTTTGTCTTTAGGAATAATATGCAAGCAATTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16817
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087657 Essential Splice Site 962 1670 15 24
ENSDART00000087660 None None 642 None 7
ENSDART00000132583 None None 648 None 7
ENSDART00000141629 Essential Splice Site 962 1670 15 24

The following transcripts of ENSDARG00000061454 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 21 (position 27445497)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 28014408
GRCz11 21 28051103
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TCAACTCTGGGGATGGCAGTGACTTTATCGTGATYGAGCTTGTAAAAGGG[T/A]AAGTGTGAGTTTTAATTGAACAATTTTAACAAATAATACAGGGTTTCTGT
Long Flanking Sequence:
CTCTGAACTGAACATCAAAAGCTGTACTTGCCTTGGGATGGGCTCAGGCAGCACGCCATTCCCTCATATCATCTGCTCCCAGACCTGACTAATCGAGCGTGTTTGGTTCTGCCACAGGCCAGATGAGCGGAGCACACACGCAGCTGGAGTTCCACCACATAGAGACGGGCATCATGACTGAGCGCCGCTTTATCTCAGTCATGCCATCCAACTTCATCGGCCACCTGCAGGGCCTCTCTTTCAACGGCATGCCTTACCTAGACCAGTGCAAGAATGGTGACATCTCCTACTGTGAGCTCAACGCCCGCTTCGGCATGCGCCGCATAGTGGCCGATCCGGTCAGCTTCCGAAATCGAGCCAGTTATGTGGCGCTGTCCACCTTACAAGCCTACGCCTCCATGCACCTCTTCTTCCAGTTCAAAACAACCAGCCCTGATGGTCTGATTCTCTTCAACTCTGGGGATGGCAGTGACTTTATCGTGATTGAGCTTGTAAAAGGG[T/A]AAGTGTGAGTTTTAATTGAACAATTTTAACAAATAATACAGGGTTTCTGTGCTTCTTCAAAAAGTGAAGTTCATTTATAATTTTTTTAGAGGAGCACCTGCTTATGATTGACCACAGCTGGTCCAGCATTAGCTATTAAATGATTTACCAATCAGATGAATCCAAACGTACATAAATAACCAGATTTTCTTACCTTAGTCATCTTCATCTAGAAGAATCCCCCCCATCCACAGTTCCTCCTGCCCCTCTTACCGAGAATAATCCAGAATAGGCTAGCACATCAGCTAAGTGGTTAGCACTGTTACCTCACAGCAAGGTTTGAGTCCCGACTGGGCTGGGTGTTTCTGTGGGAAGTTTACATGTTCTCCTCATACTCACATGGGTTTCCCTCAGGTACTCAGTATAAGGGATTTAAATAAACCAAATTGGCACAGTATATTGGTGTTTTAGTACTCAGCATTCACCGCATAAACATATGCTGGTTTAGTTGGTGGTTCATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18390
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087657 Nonsense 1080 1670 17 24
ENSDART00000087660 None None 642 None 7
ENSDART00000132583 None None 648 None 7
ENSDART00000141629 Nonsense 1080 1670 17 24

The following transcripts of ENSDARG00000061454 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 21 (position 27407096)
Other Location(s):
Assembly Chromosome Position
GRCz10 21 27976007
GRCz11 21 28012702
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GACTTTCAGACCTGATTGCAGATGCTCTGCACCGTGTKGGCCAAGTGGAG[C/T]GAGGATGTGAGGGTCAGTATACTGATGCTCTGAGGCAATCATGACAACAT
Long Flanking Sequence:
AGAATAGTATCCCAAAATATATTTATTGCATCATATTGAGAGATGCACAGACACTTTTTCTCTCATATTAGTTTTTCCACTGGCATTCACTCTAAAATGGCATATTAAATTTAGCAACAGAAGCCTGGAATACAGTAATGACATAAGAAATTACAAATGTTTTGAAATAAAACATGATGTGAACTTTTTATGATTTACTTATGACTTATTTTCGTGTTTTCATTTATTGACTCCAGACTGTTAAGTTATATATGAAATATGGCTTAACTTTTTTCAATTGATTTAGCTGGCTATTATTAACCATTCCTTACTGTATCTTTATTTTCTTCTGCTCTATAGGAGAGCTGTACATTGGAGGTGTGGGGAAGAGCATGTACAACAGTCTGCCAAAGCTCATTGCATCGCGGGATGGTTATCAGGGCTGCCTGGCCTCAGTTGACCTGAATGGCAGACTTTCAGACCTGATTGCAGATGCTCTGCACCGTGTGGGCCAAGTGGAG[C/T]GAGGATGTGAGGGTCAGTATACTGATGCTCTGAGGCAATCATGACAACATATGAGCCTTAAATCAAATTATATTTCTGGCATGCTCAATTAAAGACTATGCAGTACACAAGATGAACATTATTGTCTAGCAAAATGCTACCAATTTCATTGTTAGTACTTGAAATGCCCAATTTAATCGCATCAGCTTTGAGAGTGCTAAACCTAAAAAATATGTTTGCTGTTTGTTCAAACTGATTATTTAAACTGAGCTGAAACAACACAATTCTTGAGATGTTTTGGAGACAACTTACTTGTTTTATGTTCAATCAACTTAAAGTAAAAATAAAAAAAATAAGTTAACCCAGCAATTTTTACAGTGTAAGCTGTAAAACAAAATGCTGAGTTCCACACAATTCATTCAGGTTGTCCCAACATAAATCAATTAAGTTAACTTAATCTCAAGAATTAGGCTCAGGATGTATAAACTCAAGAATTGTGTTTTTACAAAGGTAACACAGTC
Associated Phenotype:
Not determined