ZMP
wwp2
Ensembl ID:
ZFIN ID:
Description:
NEDD4-like E3 ubiquitin-protein ligase WWP2 [Source:RefSeq peptide;Acc:NP_001092918]
Human Orthologue:
WWP2
Human Description:
WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:16804]
Mouse Orthologue:
Wwp2
Mouse Description:
WW domain containing E3 ubiquitin protein ligase 2 Gene [Source:MGI Symbol;Acc:MGI:1914144]
Alleles
There are 4 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa44346 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa19371 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa44346
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087364 | Nonsense | 627 | 866 | 17 | 23 |
| ENSDART00000136640 | Nonsense | 627 | 866 | 19 | 25 |
| ENSDART00000139582 | None | None | 46 | None | 4 |
| ENSDART00000141473 | None | None | 276 | None | 8 |
The following transcripts of ENSDARG00000061345 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 25 (position 35860687)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 25 | 34292019 |
| GRCz11 | 25 | 34796977 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCGTTGTATCATGGGAAGTTCATTGACACAGGCTTCACTTTGCCATTCTA[C/A]AAGCGGATGCTGAACAAGAAGCCCACGCTGAAAGACCTGGAGTCCATCGA
Long Flanking Sequence:
TTTAAGCAAATTAATAATATATAAATAAATAAACAAATAATAAACACACACCCACAAAAACATTTATTTATTTTAATATTTACAGTTTTTACTTTAATAAACTTTTAAAAATAAATTTAAATGTGTGACTGACATTTATTATGTAAAATACTATGAAATATTTTAATGCAAATAAAATGTAACATGTTTTTTTAAAGAAATGTTGTCTTTGTTCAATATTTTTATTATTTTTATTTTTATTATTATAACTATATATCTTTTGGCTTATTTAATATTTTATGGCTCCTCTCACCTCAGTATAAATTCATTGAACAGTTTTTATAACAAGAAAACATTCATAAATGTAGATTTTTAATAATTTCGATGTTAATTGCATTACATTGATTGCATTAAAATATACGTAGAGTATTATTATGACTCTTGCTTTTACCTTTGCTTGTCTCTCTACAGGCGTTGTATCATGGGAAGTTCATTGACACAGGCTTCACTTTGCCATTCTA[C/A]AAGCGGATGCTGAACAAGAAGCCCACGCTGAAAGACCTGGAGTCCATCGACCCAGAGTTTTACAACTCCATCATGTGGGTCAAGTGAGTATCAATATTCATTTTACCATTATATGTATTCAGTAATCCAGTGCTCAGCATAAATGAGTACACCCCTCTTTGGAAAATGAATAGTTTGATCCATTTCTCACTAAATATAGCCAGTAGATTTTGGCGCATTCAAACAAAACAGTTTTATTAAACAGTAATATCCAATAAAATAATAGCATTTTATATGTTCACAGAGAGAATGATCTGGAAGAGTGCGGCGTGGAGCTTTACTTTGCTCAGGACATGGAGATTTTGGGCAAGGTGACGACACACCAGCTGAAGGACGATGGAGAAAATGAACTGGTCACTCAGGACAACAAGGAGGAATATATCGGGTACTTTTTATAGAACTTTGATAGCATCATTGTCCTTAAAGGTTTCATGAAATTAAAGAAATGTTTTTGTAGATGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa19371
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087364 | Essential Splice Site | 834 | 866 | 22 | 23 |
| ENSDART00000136640 | Essential Splice Site | 834 | 866 | 24 | 25 |
| ENSDART00000139582 | None | None | 46 | None | 4 |
| ENSDART00000141473 | None | None | 276 | None | 8 |
The following transcripts of ENSDARG00000061345 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 25 (position 35865140)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 25 | 34296472 |
| GRCz11 | 25 | 34801430 |
KASP Assay ID:
2261-7175.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCATAGACAAAGTGGGGAAGGAAACATGGCTGCCTAGAAGTCACACTTGG[T/G]GAGGCTCAAAAAAACAAAAAACAACAACAACTATTAAAACATGCCTTCAT
Long Flanking Sequence:
TTTCTTTTTCTTTAGAAAATCACAATGGTCAAAATGCCAAGTGTTTTTGTTTGTTTGTTCACATTTATTGTATTTGAAAATCAGGGATATCTCTCTAAATATTGTTTTCTTGACCTATCTGAGGTTAAAGCATTGGTATTGTATTGTCTATAAATAAACATGACTTTTTTTTTTGCTTACAATTTAGAAGTATTTGTGAAGCGATAGCACATTTTACTCAAAACGTGACTCTTAATTGTAAATCCAGAGAATTTCCAAGTGTTCTGAAGTGGGATTTTTTTTCATTTCTGTATATAAACATCAAATAATTTGTGTATTCGATTAATGGAACTATTAATAAAGCATAATAGAGTTACTACACAGAAAAAAAAAGTTTGATCAGCTTATCCAAACTCTAAATGTGCATTTATTGATCTCGTTTTTTAGGAAGCAACGGTCCACAGAAGTTCTGCATAGACAAAGTGGGGAAGGAAACATGGCTGCCTAGAAGTCACACTTGG[T/G]GAGGCTCAAAAAAACAAAAAACAACAACAACTATTAAAACATGCCTTCATTGACCGGTGACTTATTTGTTCCTTCTGTCATTCTCAGCTTTAATCGCCTGGATTTGCCTCCGTATAAAAACCTGGAACAGCTCCGAGAAAAGCTTCTATTCGCCATCGAGGAAACTGAGGGATTTGGACAAGAGTGATGGAGGGAAACATTTCCACCAGGCCATTTATACCACTAATGTGGAGTGAACGGCAGATTTACACTTCAGTTACTAGTTTACCTAAAAACAAAACCCTAAATATTATTTATTCAGCCTCACGTCATTTCAAACCGACACACTGTTCTGTTTCTGTGCACAATTAAAATTGTTATGCTGATTTTATGAAAATTCGACACGTTTTGAGGGAAGTTTGAACTCGGGGGTCGTTTACAGTACGACGTTTTCAAAAATGAGGAAACATTTCATGTATTTTGGCTGTTCGTTTAGGTGATAATAGCATTTTTTTTGACTG
Associated Phenotype:
Not determined