Busch Lab

ZMP

ROCK1

Ensembl ID:
ENSDARG00000058993
Description:
Rho-associated, coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:10251]
Human Orthologue:
ROCK1
Human Description:
Rho-associated, coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:10251]
Mouse Orthologue:
Rock1
Mouse Description:
Rho-associated coiled-coil containing protein kinase 1 Gene [Source:MGI Symbol;Acc:MGI:107927]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa2058 Nonsense F2 line generated Not yet available
sa5712 Nonsense F2 line generated Not yet available
sa39747 Splice Site, Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa2058
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081976 Nonsense 597 1359 16 33
ENSDART00000081976 Nonsense 597 1359 16 33
Genomic Location (Zv9):
Chromosome 2 (position 3020598)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 3027623
GRCz11 2 2869522
KASP Assay ID:
554-3139.1 (used for ordering genotyping assays)
KASP Sequence:
GCAKAAACCGGGAGCTGCAGGAGAAGATTCGCGCCGCAGAAAGTGTCAAA[C/T]AACAGCTGGAGAAAGAGCTGCTGCAGCTGCAGACCACGCTGGACACCGAG
Long Flanking Sequence:
CCCTAAACGACTGATAGCCCCGCTTTAAACAACTGATAGCCCCACCCTAAATAACTGATAGCCCCACCCTAAAGGACGGTTAGCCCTGCCCTAAACGACTGATAGCCCCGCCCTAAACGACTGATAGCCCCACCCAAAATGACTGATAGCCCCACCCTAAACGACTGATAGCCCCGCCCTAAACAACTGATAGCCCCACCCAAATTGACTTATAGCTCCGCCCTAAAAGACTGATAACCTCACTGGAACTGTAAATCCTCATTTTTGGCTCTTCTATCTTTATATTGAGGCCTGTTTTTGTACCACGTGACATTCAAACAACATCTCACACACAACATTGTCATCCACAGCTGGGGGAAGCCAACGATCTTCTGCGCGCTGAGTCAGACACAGTGATGCGCCTGAGGAAGAGCCACACAGAAATGGGCAAGACTATGAGCCAGCTGGAGAGCATAAACCGGGAGCTGCAGGAGAAGATTCGCGCCGCAGAAAGTGTCAAA[C/T]AACAGCTGGAGAAAGAGCTGCTGCAGCTGCAGACCACGCTGGACACCGAGAGACGGAGCTGCAGCCAAGGCTCAGAGGAGATCCGAGAACTGCAAGGTGAGACACCTCAGTTCAGTTTATCTTTATTTCACTGGCGCTTTTACAATGTAGATTGTGTCAAAGCAGCTTAAGACAGAAGTTCTAGTAAATGTAAACAGAGTCAGTTCAGTTTTCAGAGTTGAAGTTCAGTTTAATTCAGGTCAGTGTGGTTTAAATTTCACTGCTGAAAGTCCAAACACTGAAGAGCAAATCCAGTGATGCACAGCTCCAAAAGTGCCAAACCAAGCAAGCCAGTGGAGACAGTGGCGAAGAAAAAACTTCACCAATTGACCAAAGTGAAGGAAAAACGGATACCAATAGTTTTAGACTTGTTTGGTTTGTTTACTATAATAAACTTTGGTGTAGACCAGGGGGGTCAAACGTACGGCCGGATCAGACCCGCAAACAAATTAATTGCGGCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa5712
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081976 Nonsense 597 1359 16 33
ENSDART00000081976 Nonsense 597 1359 16 33
Genomic Location (Zv9):
Chromosome 2 (position 3020598)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 3027623
GRCz11 2 2869522
KASP Assay ID:
554-3139.1 (used for ordering genotyping assays)
KASP Sequence:
GCAKAAACCGGGAGCTGCAGGAGAAGATTCGCGCCGCAGAAAGTGTCAAA[C/T]AACAGCTGGAGAAAGAGCTGCTGCAGCTGCAGACCACGCTGGACACCGAG
Long Flanking Sequence:
CCCTAAACGACTGATAGCCCCGCTTTAAACAACTGATAGCCCCACCCTAAATAACTGATAGCCCCACCCTAAAGGACGGTTAGCCCTGCCCTAAACGACTGATAGCCCCGCCCTAAACGACTGATAGCCCCACCCAAAATGACTGATAGCCCCACCCTAAACGACTGATAGCCCCGCCCTAAACAACTGATAGCCCCACCCAAATTGACTTATAGCTCCGCCCTAAAAGACTGATAACCTCACTGGAACTGTAAATCCTCATTTTTGGCTCTTCTATCTTTATATTGAGGCCTGTTTTTGTACCACGTGACATTCAAACAACATCTCACACACAACATTGTCATCCACAGCTGGGGGAAGCCAACGATCTTCTGCGCGCTGAGTCAGACACAGTGATGCGCCTGAGGAAGAGCCACACAGAAATGGGCAAGACTATGAGCCAGCTGGAGAGCATAAACCGGGAGCTGCAGGAGAAGATTCGCGCCGCAGAAAGTGTCAAA[C/T]AACAGCTGGAGAAAGAGCTGCTGCAGCTGCAGACCACGCTGGACACCGAGAGACGGAGCTGCAGCCAAGGCTCAGAGGAGATCCGAGAACTGCAAGGTGAGACACCTCAGTTCAGTTTATCTTTATTTCACTGGCGCTTTTACAATGTAGATTGTGTCAAAGCAGCTTAAGACAGAAGTTCTAGTAAATGTAAACAGAGTCAGTTCAGTTTTCAGAGTTGAAGTTCAGTTTAATTCAGGTCAGTGTGGTTTAAATTTCACTGCTGAAAGTCCAAACACTGAAGAGCAAATCCAGTGATGCACAGCTCCAAAAGTGCCAAACCAAGCAAGCCAGTGGAGACAGTGGCGAAGAAAAAACTTCACCAATTGACCAAAGTGAAGGAAAAACGGATACCAATAGTTTTAGACTTGTTTGGTTTGTTTACTATAATAAACTTTGGTGTAGACCAGGGGGGTCAAACGTACGGCCGGATCAGACCCGCAAACAAATTAATTGCGGCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39747
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Splice Site, Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081976 Splice Site, Nonsense 1202 1359 30 33
Genomic Location (Zv9):
Chromosome 2 (position 3042986)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 3050011
GRCz11 2 2891910
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CACAAGGTGACGTTTACCGAGCAGAGACTGATGAAATCCCAAGAATATTC[C/T]AGGTCAGTTTTTGAATATATTTTCTAATAATAAAGGTCATAAAATGCCCC
Long Flanking Sequence:
TTGTCTGCTGTTTAAAAACCAGCCTAGAGCGCCGTCTGCTGTTAAACACTAGCCTAGAGCGCCGTCTGTTGATAAAAACAAGCCTAGAGCGCCGTCTGCTGTTAAACACTAGCCTAGAGTGCCATCTGCTGTTAAGCATTACACTGGAGGGCCGTCTGCTGTTAAACACTAGCCTAGAGCGCTATCTGCTGTTGAACACTAGCCTAGAGCACTGTCTGCTCTTAAACATTAGCCTAGAGCACTGTCTGCTTTTAAAACTATCCTAGAATGCCATCTGCTCTTAAACACTAATCTAGAGCACCGTCTGCTGTTAATCACCAATCCAATCCATGTTATCAGTTATTTCATTCATTCCTGTTTGTAAAATGCAATGATTTACTTGCTACTATATTAAAATGTATGTGTTTTTGTGTTCACATCACAGTAAACTTTTCCATGTGCGTCCTGTCACACAAGGTGACGTTTACCGAGCAGAGACTGATGAAATCCCAAGAATATTC[C/T]AGGTCAGTTTTTGAATATATTTTCTAATAATAAAGGTCATAAAATGCCCCATAATGATATAATCACCATATGCGTGCTATTTAAAGAGTGTGTTAGTGATTTGGTGGTCCACAATCCGTGTACACGTTGCTTATTACACACACAGGGAGGCACAGCAGCACACAACCTTAAGTCTGCCATGTAAATAACAAATCTGCTTGGCAAGATCCCAACTCACTCGTAAAGGGAATGGGAGATCAAACTCTGATGGGTTTAATGCACATTACTCTCAAAAACACACCCATTACTGATTAAGAGAATAAAGACAACCCCTTTAGGTTATGCGCTGGGTAGGCAGACTGTTTTTCACACCGTTAAAACAGCAAAAGTGGATTCAGATATACCCTAACTGTGCATCTCTAAAATAGATCATTAAAATGAGCTTCACAACCTTTGATATCTTCACCTGAATCTGCAAATTGAATGAGAGTGTTTGTGGTTTAGATCCTGTATGCTAATGA
Associated Phenotype:
Not determined