Busch Lab

ZMP

LOC566708

Ensembl ID:
ENSDARG00000058503
Human Orthologue:
FLT3
Human Description:
fms-related tyrosine kinase 3 [Source:HGNC Symbol;Acc:3765]
Mouse Orthologue:
Flt3
Mouse Description:
FMS-like tyrosine kinase 3 Gene [Source:MGI Symbol;Acc:MGI:95559]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa15012 Essential Splice Site Available for shipment Available now
sa24498 Essential Splice Site Available for shipment Available now
sa37884 Nonsense Mutation detected in F1 DNA Not yet available
sa44134 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa15012
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081357 Essential Splice Site 35 956 None 24
ENSDART00000147759 None None 439 None 12

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 22321487)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 21568365
GRCz11 24 21713539
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GAAGGACGGTTTAACTGAAGCTCATCCGCGATGCGACACTGATGGATCGG[T/C]AAAGTTTCTTCTTTCTAATCAGCCCYYAGTACAACTGTCTGTCTGGAACT
Long Flanking Sequence:
GTCCTCTGCAGATGCTGGCCGACTAATACTGAACCTGAAACGTTTAAAGAAGTGTGTGTGTGTGTGTTTGTGTATATGTGTGAGTGTGAGTGTGAGTATGTGTGTCACTTACAGGCTGAAGTGAAAGTCTTCTTGCCTCTGTTCGCTGTCCATCCTATTTCACGGTCTGACAAGAGTCGGGGAACAAACTGTTATGTATTCACGCAATGCATCTTGGAATCAAGCTCTTGCTGGGTAAGTGAGGCAAAACTGTTTATTTACTTGCGGCAAAAACTGCAGTAATTCGTCCGTTTTAATGGCTTGTCTTATGCAGAATATTGTTTGTTATAAATATATTCAAGACTGAAAGTCTAGTCTGTTGAATAGTGTTTTTTGTTTTATTTCTTTCTGTCACATTTGTATTGTTTTCTCTTTTACCGTAGTGCTGCTCGTGCTGCACTGGAGCTCGTTGAAGGACGGTTTAACTGAAGCTCATCCGCGATGCGACACTGATGGATCGG[T/C]AAAGTTTCTTCTTTCTAATCAGCCCTCAGTACAACTGTCTGTCTGGAACTGTGAGACTCATTTACAGCTGGTGTTTAGCGTCACCCACGGAATAAACTGAGATTACAGATGCCTCGTTACATTAAACTAAATGTTACAAGGTGTTTGGTGCCGCCTCAGTTTGAAAACGTGATTTCTAAAGCACCTATTTAAAATATGCTAAACCTAATACATATCCATTTGTTTACTGTATGTGGTATCATGGCTGATAATTTAACAAGCTATAAAGTGCAAGTAGTGAGCATTTGTCAATGAAGAGCTCATAATTTAACATCAAAAAGTCACTTATGTAACTTATTAAGAAAGCACACTTTCAAGGAATAGTTCACTGCAAAATATAAAATTACTCATTTTTTAATCTACTTATGCTTCAAGTCGATATGAATTTTTCTGTCAAACACAAAAGAAGATATTTTGAAGAATGTAATAATAAACTTACTTCTCATCATTTAGCCAGTTAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24498
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081357 Essential Splice Site 597 956 15 24
ENSDART00000147759 Essential Splice Site 184 439 5 12
Genomic Location (Zv9):
Chromosome 24 (position 22311485)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 21558363
GRCz11 24 21703537
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GATCAGCAAGCCGGGTGTTTCTGTTCAGGTAGCGGTAAAAATGTTAAAGG[G/A]TAAGTAATGACAAATCTGTTATGAATATTTAAATAAGATAAAATAAATAA
Long Flanking Sequence:
ACATTACTATGAGAAATTACCATTTTTATAAAGGGTAATGCGTTATTTTGATGGCTCCTATTGCATGTTTTATTTGCAAAAAGTTGCATTGCAAATGCCAATTACTTCTCATTTGAGTATTAGTAGACTGTCTGCTTAATATAGGTTGATATGCTCCTTCAACAGATATTTAACTGACTATAAGTAACTTTGCAAGTACATGTCAACTTACAACAACCTTAAACCCAACCTAACAGTCTACTTATAATCTAATGAGAATTTGTTGGCATGTAGATGCAATAAACCTTAAAGTCAACAAAATGCGTTAAAGGGACCATCAAAATAAAGTGATACTATAATGTAATCAGTCATTAACTACCATTTTGAAGTAACTTACCCAATACTAATTTCCACAGGGAATGAACTTGGATCTGGTGCTTTTGGGATGGTTGTTCAGGCTACAGCATATGGGATCAGCAAGCCGGGTGTTTCTGTTCAGGTAGCGGTAAAAATGTTAAAGG[G/A]TAAGTAATGACAAATCTGTTATGAATATTTAAATAAGATAAAATAAATAACAACCTGTGCTTTGTATGCTTGGCGGATTAAACAGAGAAGCACCAGGCAGTGGAGAAGGAAGCTCTGATGTCTGAACTGAAAATGCTGACTCATATTGGACACCATGAGAACATTGTCAACCTGCTTGGTGCTTGCACGGGATCAGGTAAGATTTGGAGAGGCCTTGGGTTTGATAATTATATTATCAGTTGGAGACACACACCTATATGCAGATGTAGATAAAAATTAGAGAACCACTTATAAAGGCTTATTTTTTTTCAGACGTAGTGCAATCGACTTCCAATTTTAGAGTTTAGATAAATGTTTTGAAGAAATTTAAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAATGAATAGGAAGTGAGCAACTTTAAATGGTGTGATCTTGATCTTGGCCTTTTCCACAGTTCACGGACTGACAAGTTTCTTAGCCAAACCTTGATGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37884
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081357 Nonsense 613 956 16 24
ENSDART00000147759 Nonsense 200 439 6 12
Genomic Location (Zv9):
Chromosome 24 (position 22311355)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 21558233
GRCz11 24 21703407
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAACAGAGAAGCACCAGGCAGTGGAGAAGGAAGCTCTGATGTCTGAACTG[A/T]AAATGCTGACTCATATTGGACACCATGAGAACATTGTCAACCTGCTTGGT
Long Flanking Sequence:
TCTGCTTAATATAGGTTGATATGCTCCTTCAACAGATATTTAACTGACTATAAGTAACTTTGCAAGTACATGTCAACTTACAACAACCTTAAACCCAACCTAACAGTCTACTTATAATCTAATGAGAATTTGTTGGCATGTAGATGCAATAAACCTTAAAGTCAACAAAATGCGTTAAAGGGACCATCAAAATAAAGTGATACTATAATGTAATCAGTCATTAACTACCATTTTGAAGTAACTTACCCAATACTAATTTCCACAGGGAATGAACTTGGATCTGGTGCTTTTGGGATGGTTGTTCAGGCTACAGCATATGGGATCAGCAAGCCGGGTGTTTCTGTTCAGGTAGCGGTAAAAATGTTAAAGGGTAAGTAATGACAAATCTGTTATGAATATTTAAATAAGATAAAATAAATAACAACCTGTGCTTTGTATGCTTGGCGGATTAAACAGAGAAGCACCAGGCAGTGGAGAAGGAAGCTCTGATGTCTGAACTG[A/T]AAATGCTGACTCATATTGGACACCATGAGAACATTGTCAACCTGCTTGGTGCTTGCACGGGATCAGGTAAGATTTGGAGAGGCCTTGGGTTTGATAATTATATTATCAGTTGGAGACACACACCTATATGCAGATGTAGATAAAAATTAGAGAACCACTTATAAAGGCTTATTTTTTTTCAGACGTAGTGCAATCGACTTCCAATTTTAGAGTTTAGATAAATGTTTTGAAGAAATTTAAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAATGAATAGGAAGTGAGCAACTTTAAATGGTGTGATCTTGATCTTGGCCTTTTCCACAGTTCACGGACTGACAAGTTTCTTAGCCAAACCTTGATGAAATGGATTTTCACTTTAGGTTTAGGTCAGGAATCTGGGCTGGCTATTTTATCTTTTCAATTATTTCAGCTTTAAAGAAATGATTTACCATTTGTTTCGTGGATCTTGAATGAGTGAGCGACTTTAGCCGCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa44134
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081357 Nonsense 870 956 22 24
ENSDART00000147759 Nonsense 396 439 11 12
Genomic Location (Zv9):
Chromosome 24 (position 22303836)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 21550714
GRCz11 24 21695888
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGTGAACAACACTTTCTACAGAATGATTGAAAGTGGATATCACTTGGAG[C/T]AGCCCTATTATGCAGCAGAATCTGTGTAAGTGCCTCTAGTTTTTTTTTAT
Long Flanking Sequence:
ACAGCATGCCAAACCTGCTGTTATTATCAAGCTATATTTAAGTGAGAACTCTTGAAGTAAAAGTTTTTTTTCAGTTTGATGTAGAGAAAACATCAGAATGCACTTTTTTGTGTACTATTTTGTAACTCATTCTTGATTTCAGTCAGTATATTACACAATATATATTTTTCAAGGTTGTGTCTTCACAATGCGTGTTTTCTCCTGTACTGAACTGTAAATCTCCTCTTCAGCAGCTTGTATATCAAAATTGATTGTGGAAATGTAAAGAGATGCCCTAAATCTGCTCTGTAAAAACAATTGAATCTAATATTGAAAAAATAAAGAGTTAAACAAGATTTTTGTTGCTGATCCGATCCAACCTTCAGACAACTATGAATGTTTTTTTTTATTATTATTTTGTATTCATTAGACATTCATCTCTTTCAGGAGTCACCCCATATCCTGGTGTGACTGTGAACAACACTTTCTACAGAATGATTGAAAGTGGATATCACTTGGAG[C/T]AGCCCTATTATGCAGCAGAATCTGTGTAAGTGCCTCTAGTTTTTTTTTATTTTTAAAAAATGAATGAGTAGTAGTGCTACCCACGGTGTCGCCCATAATCAAATACTAATACACTGTAAAAACTATTAGTAACTTTACATTAAAAATATTGAGTAAATCATTTGTAACTCAGAACTGTTAGATTGGCTTAACTTCGATTTTATAATTATGCTCCTACACTGTAAAAAGTGATTAGTTACTTAAAGCAAGTAAACCGATTGCTTTAAAAGAAACAAGTTGACTTTACAAAAATAAAGTTAACCTATTGTAACTTGGAACTGTAAAGTTGACTTAATTTTTATATATATGCTTGTAATTACTTTTTTTAAGTCAACTAATGCGTTTGTACAATGTCAGACTATTTTAGCACGTCTGTTTTCAAATATTTGGTGCTTCATTAAGTCTATAAAATCTACAATTATTGCCTGTATTAACTTAGGAGACACACTGAAGTCTAGAAG
Associated Phenotype:
Not determined