ZMP
si:dkey-31b16.12
Ensembl ID:
ZFIN ID:
Human Orthologue:
MLH3
Human Description:
mutL homolog 3 (E. coli) [Source:HGNC Symbol;Acc:7128]
Mouse Orthologue:
Mlh3
Mouse Description:
mutL homolog 3 (E coli) Gene [Source:MGI Symbol;Acc:MGI:1353455]
Alleles
There are 9 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa37705 | Nonsense | Available for shipment | Available now |
| sa15701 | Essential Splice Site | Available for shipment | Available now |
| sa24334 | Essential Splice Site | Available for shipment | Available now |
| sa24335 | Nonsense | Available for shipment | Available now |
| sa226 | Nonsense | Confirmed mutation in F2 line | Not yet available |
| sa9704 | Nonsense | Available for shipment | Available now |
Mutation Details
Allele Name:
sa37705
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Nonsense | 645 | 1133 | 1 | 12 |
| ENSDART00000143694 | Nonsense | 645 | 1171 | 1 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24878904)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24665024 |
| GRCz11 | 23 | 24591565 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCAGAGATTCAAACTTCCTTAAACGGGACCTTTCATCTTTCCCACCCTCA[C/T]AAGACTCATGCTTTAAAGAATTAGAAAAAACCCTCTTAGATGAAGATGTT
Long Flanking Sequence:
AGATTTCACTTCCAGAAGCACAAGATAGTTTGCAGAAATTCTACACCCCAAATAAAACCTCTCCAAAAAAGAGAAGGATGCCGTTAAATGACACCGAAGAAGAAAAACATGTTTTTTATGGTGGTCCCTCAAAGACATTTAAAGCTACACCACCTCGTAAATTAACCCTGTCTTTTGAAACGGGATCTCTTGACAAGTTCAAAAGGTTGTTTGGGAAAGAGGCTGAGAAAAAACAACCAAGCACAGAAAAAACAAGCCTTCTAAATCCAAATCCCAATGACCGCTTTGTAGGATCTACATCGTGTTTGGATGATCTACACCATCCAGTATTGAGGAACAGTTCAGGTCATCCTACTACACACAGATCTACTGAATCTTCATCGCTGAACAAGAAAAACAAAATATCATTAGCTGCCAAATGTTCCTATTTAAAACAGGACAAAGAGCTCTGCAGAGATTCAAACTTCCTTAAACGGGACCTTTCATCTTTCCCACCCTCA[C/T]AAGACTCATGCTTTAAAGAATTAGAAAAAACCCTCTTAGATGAAGATGTTTTATTTGGATCATCTGGAATTGTTGATTCTGTTGACTTTCCTCTTATTGAACAGGACACAGCATTACCATCTGTTGCAGAAGAATCGCACCTCTTCAACAACAATGTGACTTTCTTTATTGGAAATGAGAGCAGTGTTGATGAAGCCAGCGTTGCCTCTCAGCGTGATCCTCAACACAGCATTGCAGGAAATGAAGGTCAGACTACAAACGAAAGTGTTGAATCAATCCCAGTGTCCAACAGCTGGTTGGCTCATTACGATAGCTGGTTAGGAAAGCTGGTTTATATCAATCAAGTAACAGGGCTCAGCAAGTACAACTCTCCCCCTATGGAGGAGACTCAAGTGCCATGTACCACAGATGTCACTAACATGGCGGTCAGTGTTATTTCAAAAGCAGGTGCGGGAAATGCAGTGAGACGTTTTTGGATCAGTAATGTGCAGATGTCTTTT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa15701
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Essential Splice Site | 827 | 1133 | 2 | 12 |
| ENSDART00000143694 | Essential Splice Site | 854 | 1171 | 1 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24879535)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24665655 |
| GRCz11 | 23 | 24592196 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GCCCAAGCCCAGAGCAGAAAGAGCCTTTAACTCMGGGAYAGACAGCAGAG[G/A]TACAGCTCTAGACTGACATAAGGCCTGAAATCAGCTTTTCGGTGCACTTT
Long Flanking Sequence:
AGAATCGCACCTCTTCAACAACAATGTGACTTTCTTTATTGGAAATGAGAGCAGTGTTGATGAAGCCAGCGTTGCCTCTCAGCGTGATCCTCAACACAGCATTGCAGGAAATGAAGGTCAGACTACAAACGAAAGTGTTGAATCAATCCCAGTGTCCAACAGCTGGTTGGCTCATTACGATAGCTGGTTAGGAAAGCTGGTTTATATCAATCAAGTAACAGGGCTCAGCAAGTACAACTCTCCCCCTATGGAGGAGACTCAAGTGCCATGTACCACAGATGTCACTAACATGGCGGTCAGTGTTATTTCAAAAGCAGGTGCGGGAAATGCAGTGAGACGTTTTTGGATCAGTAATGTGCAGATGTCTTTTATTATAAACAGCTTCTCTTTGCTCTTAGGCTTTGAGTACAGGTGTTATCCATTTCAATCAGACATTGTACTTCCCTTTCTGCCCAAGCCCAGAGCAGAAAGAGCCTTTAACTCAGGGACAGACAGCAGAG[G/A]TACAGCTCTAGACTGACATAAGGCCTGAAATCAGCTTTTCGGTGCACTTTAACTAATTGTTTTTTTTGTTACTCTTTAAGAGGATGCCCAAGCTCCCGATTCACTGTCGACTTTATTCTCAGAATGGCACAACCCTGTGTTTATACGACCACCAGAGGTAAAAAGTACTGAGTAAAATAGTGTGTGTATTAGGGTTGTCATGATACCATCAATTCAGACCAAGACACTATACCAGCTAAAGTATGACAATATCAAGTAGTACTGTAGTATCGATACTGCAGTAATTCATTACTCAAATCAGTTAGAAATACTATATTTTACAGTATATGTCATAACGCTTAAATTCAATTCAGAATTCCCTTATTATTGAAAATGTATTATTTGTACACACTTTCTCTGTTTATTTTTGTATACACTGTCACTCTTTTGTTGATATTACAATAATAATAATAATTAAATATATAAATCATTGATCACGCCGTATGATCTGTCATGACAGC
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa24334
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Essential Splice Site | 828 | 1133 | 3 | 12 |
| ENSDART00000143694 | Essential Splice Site | 855 | 1171 | 2 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24879615)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24665735 |
| GRCz11 | 23 | 24592276 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATCAGCTTTTCGGTGCACTTTAACTAATTGTTTTTTTTGTTACTCTTTAA[G/A]AGGATGCCCAAGCTCCCGATTCACTGTCGACTTTATTCTCAGAATGGCAC
Long Flanking Sequence:
AGCGTGATCCTCAACACAGCATTGCAGGAAATGAAGGTCAGACTACAAACGAAAGTGTTGAATCAATCCCAGTGTCCAACAGCTGGTTGGCTCATTACGATAGCTGGTTAGGAAAGCTGGTTTATATCAATCAAGTAACAGGGCTCAGCAAGTACAACTCTCCCCCTATGGAGGAGACTCAAGTGCCATGTACCACAGATGTCACTAACATGGCGGTCAGTGTTATTTCAAAAGCAGGTGCGGGAAATGCAGTGAGACGTTTTTGGATCAGTAATGTGCAGATGTCTTTTATTATAAACAGCTTCTCTTTGCTCTTAGGCTTTGAGTACAGGTGTTATCCATTTCAATCAGACATTGTACTTCCCTTTCTGCCCAAGCCCAGAGCAGAAAGAGCCTTTAACTCAGGGACAGACAGCAGAGGTACAGCTCTAGACTGACATAAGGCCTGAAATCAGCTTTTCGGTGCACTTTAACTAATTGTTTTTTTTGTTACTCTTTAA[G/A]AGGATGCCCAAGCTCCCGATTCACTGTCGACTTTATTCTCAGAATGGCACAACCCTGTGTTTATACGACCACCAGAGGTAAAAAGTACTGAGTAAAATAGTGTGTGTATTAGGGTTGTCATGATACCATCAATTCAGACCAAGACACTATACCAGCTAAAGTATGACAATATCAAGTAGTACTGTAGTATCGATACTGCAGTAATTCATTACTCAAATCAGTTAGAAATACTATATTTTACAGTATATGTCATAACGCTTAAATTCAATTCAGAATTCCCTTATTATTGAAAATGTATTATTTGTACACACTTTCTCTGTTTATTTTTGTATACACTGTCACTCTTTTGTTGATATTACAATAATAATAATAATTAAATATATAAATCATTGATCACGCCGTATGATCTGTCATGACAGCACCAAACTACGACTCGTATGCAGACAGTTCAAGTAAAAGTAAAATAAAGTGGTCTATTAATTATTTTTGGCACAAATGTA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa24335
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Nonsense | 850 | 1133 | 3 | 12 |
| ENSDART00000143694 | Nonsense | 877 | 1171 | 2 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24879681)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24665801 |
| GRCz11 | 23 | 24592342 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCGATTCACTGTCGACTTTATTCTCAGAATGGCACAACCCTGTGTTTATA[C/T]GACCACCAGAGGTAAAAAGTACTGAGTAAAATAGTGTGTGTATTAGGGTT
Long Flanking Sequence:
TCCCAGTGTCCAACAGCTGGTTGGCTCATTACGATAGCTGGTTAGGAAAGCTGGTTTATATCAATCAAGTAACAGGGCTCAGCAAGTACAACTCTCCCCCTATGGAGGAGACTCAAGTGCCATGTACCACAGATGTCACTAACATGGCGGTCAGTGTTATTTCAAAAGCAGGTGCGGGAAATGCAGTGAGACGTTTTTGGATCAGTAATGTGCAGATGTCTTTTATTATAAACAGCTTCTCTTTGCTCTTAGGCTTTGAGTACAGGTGTTATCCATTTCAATCAGACATTGTACTTCCCTTTCTGCCCAAGCCCAGAGCAGAAAGAGCCTTTAACTCAGGGACAGACAGCAGAGGTACAGCTCTAGACTGACATAAGGCCTGAAATCAGCTTTTCGGTGCACTTTAACTAATTGTTTTTTTTGTTACTCTTTAAGAGGATGCCCAAGCTCCCGATTCACTGTCGACTTTATTCTCAGAATGGCACAACCCTGTGTTTATA[C/T]GACCACCAGAGGTAAAAAGTACTGAGTAAAATAGTGTGTGTATTAGGGTTGTCATGATACCATCAATTCAGACCAAGACACTATACCAGCTAAAGTATGACAATATCAAGTAGTACTGTAGTATCGATACTGCAGTAATTCATTACTCAAATCAGTTAGAAATACTATATTTTACAGTATATGTCATAACGCTTAAATTCAATTCAGAATTCCCTTATTATTGAAAATGTATTATTTGTACACACTTTCTCTGTTTATTTTTGTATACACTGTCACTCTTTTGTTGATATTACAATAATAATAATAATTAAATATATAAATCATTGATCACGCCGTATGATCTGTCATGACAGCACCAAACTACGACTCGTATGCAGACAGTTCAAGTAAAAGTAAAATAAAGTGGTCTATTAATTATTTTTGGCACAAATGTAATTACCAAAGTATTGTTTACATACTTCAGCGGCACCGCCAGTATTTTGGAGCCATAGTATCGCGGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa226
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Nonsense | 900 | 1133 | 5 | 12 |
| ENSDART00000143694 | Nonsense | 927 | 1171 | 4 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24881849)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24667969 |
| GRCz11 | 23 | 24594510 |
KASP Assay ID:
554-0160.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGTTTTACCCTTAGGTCATCAATCAAGTAGACAAGAAGTTTCTTGCTTG[T/A]TTGATAAATACAGCAGGGCAGAACACCTCTGAAAGCAGTACGGATGAAGG
Long Flanking Sequence:
TTGGTGATTCCTATTATGAAATTCAACCGTAAGCTTGGCAAATAGCTTTTGGAGAAATAAATGTTTCCCTATTCAGACAGACTGCCCGAGCATGCTGCCTGAGAGGTGTTTCAAAGATGGCAGCTTAGTGAAATGACTTGCCTTAAAGGGACTTTAGCATAATGGAGACAGGTGATTGGTCATGTGAGTGTGATGTCTGCTATGCTAGAGATTATTCAGCAAATTAATTTCCATTTCGCATTATTCACATACTTTTTTTTGCACCACCTCTAATGAGCAGAAAAGCTTTTGTGAATTTACTGAGTTTAAAATTATTTATTTATTGTATTTTGAAAGGATCCATCACTTGTTTCTTCTGTAATTCTTTAAAATGGACATTAAATCAGGATGATTTAACCCAGCTACTGTCACAAATAGGACTTTCCTTTAAAATGAATGTAAAATTGCTTTCTGTTTTACCCTTAGGTCATCAATCAAGTAGACAAGAAGTTTCTTGCTTG[T/A]TTGATAAATACAGCAGGGCAGAACACCTCTGAAAGCAGTACGGATGAAGGTATTGTGGGCTGAAAATCACAATGTTAAATGATTATATAAATCTAAACTTTTGTCATTGCTTCTCCTGGCAGGGAATCTTCTAGTGCTGGTTGATCAACATGCTGCCCATGAAAGAGTTCGACTAGAGGGTTTAATAGCAGGTAAATGATAGTGATAGAAGTAGATAAAAAGTACTACATAAAAAGACATTTTATATATTAGATAATAGTTAATAGCACCAAATAATCATATTAAATTGTTTTCAGAAGGAGTTGAAACTTTTGCTTAACAGTCCTCGAATCAAATGACATTAAATGTATTAAATACAGTTATTTAAAAAAATACTGTTTTACTGTAGATGCTTTTATTAGCATAAGAGATTTTTTCAAAAACATTAATAACCTTTAGACCCCAAACTTAGCTTATAAGAATATAAAAACAAAATGAAGTTCATATAAAAGCATTAAAAA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa9704
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000078805 | Nonsense | 911 | 1133 | 5 | 12 |
| ENSDART00000143694 | Nonsense | 938 | 1171 | 4 | 11 |
Genomic Location (Zv9):
Chromosome 23 (position 24881880)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 24668000 |
| GRCz11 | 23 | 24594541 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACAAGAAGTTTCTTGCTTGTTTGATAAATACAGCAGGGCAGAACACCTCT[G/T]AAAGCAGTACGGATGAAGGTATTGTGGGCTGAAAATCACAATGTTRAATR
Long Flanking Sequence:
AGCTTGGCAAATAGCTTTTGGAGAAATAAATGTTTCCCTATTCAGACAGACTGCCCGAGCATGCTGCCTGAGAGGTGTTTCAAAGATGGCAGCTTAGTGAAATGACTTGCCTTAAAGGGACTTTAGCATAATGGAGACAGGTGATTGGTCATGTGAGTGTGATGTCTGCTATGCTAGAGATTATTCAGCAAATTAATTTCCATTTCGCATTATTCACATACTTTTTTTTGCACCACCTCTAATGAGCAGAAAAGCTTTTGTGAATTTACTGAGTTTAAAATTATTTATTTATTGTATTTTGAAAGGATCCATCACTTGTTTCTTCTGTAATTCTTTAAAATGGACATTAAATCAGGATGATTTAACCCAGCTACTGTCACAAATAGGACTTTCCTTTAAAATGAATGTAAAATTGCTTTCTGTTTTACCCTTAGGTCATCAATCAAGTAGACAAGAAGTTTCTTGCTTGTTTGATAAATACAGCAGGGCAGAACACCTCT[G/T]AAAGCAGTACGGATGAAGGTATTGTGGGCTGAAAATCACAATGTTAAATGATTATATAAATCTAAACTTTTGTCATTGCTTCTCCTGGCAGGGAATCTTCTAGTGCTGGTTGATCAACATGCTGCCCATGAAAGAGTTCGACTAGAGGGTTTAATAGCAGGTAAATGATAGTGATAGAAGTAGATAAAAAGTACTACATAAAAAGACATTTTATATATTAGATAATAGTTAATAGCACCAAATAATCATATTAAATTGTTTTCAGAAGGAGTTGAAACTTTTGCTTAACAGTCCTCGAATCAAATGACATTAAATGTATTAAATACAGTTATTTAAAAAAATACTGTTTTACTGTAGATGCTTTTATTAGCATAAGAGATTTTTTCAAAAACATTAATAACCTTTAGACCCCAAACTTAGCTTATAAGAATATAAAAACAAAATGAAGTTCATATAAAAGCATTAAAAAGTCTAATACACATCAGGTGAGATACATCAAA
Associated Phenotype:
Not determined