ZMP
appb
Ensembl ID:
ZFIN ID:
Description:
amyloid beta (A4) precursor protein b [Source:RefSeq peptide;Acc:NP_690842]
Human Orthologue:
APP
Human Description:
amyloid beta (A4) precursor protein [Source:HGNC Symbol;Acc:620]
Mouse Orthologue:
App
Mouse Description:
amyloid beta (A4) precursor protein Gene [Source:MGI Symbol;Acc:MGI:88059]
Alleles
There are 4 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa327 | Nonsense | F2 line generated | Not yet available |
| sa34693 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa41475 | Nonsense | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa327
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000077894 | None | None | 362 | None | 11 |
| ENSDART00000077901 | Nonsense | 142 | 694 | 4 | 17 |
| ENSDART00000077908 | Nonsense | 142 | 751 | 4 | 17 |
| ENSDART00000100684 | Nonsense | 142 | 660 | 4 | 17 |
| ENSDART00000122679 | None | None | 362 | None | 12 |
| ENSDART00000122787 | None | None | 83 | None | 3 |
| ENSDART00000125536 | Nonsense | 142 | 694 | 4 | 16 |
Genomic Location (Zv9):
Chromosome 9 (position 36026372)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 35245883 |
| GRCz11 | 9 | 35055068 |
KASP Assay ID:
554-3359.1 (used for ordering genotyping assays)
KASP Sequence:
TCAGCGATGCCCTCCTCGTCCCAGATAAGTGCAAGTTCTTGCACCAGGAG[C/T]GAATGGACATGTGCGAGAGTCATCTACACTGGCATACAGTGGCCAAAGAG
Long Flanking Sequence:
TCTGTTCACTCGAACAACAATTTGTACCTTGTTTTGACTCCCACAGGTATACCCAGACCTCCAGATCACTAATGTAGTGGAGGCCAACCAGCCTGTCAGCATCCAGAACTGGTGCAAAATGGGTCGCCGCCAGTGCCGCAGTCACACGCACATTGTTGTTCCCTACCGTTGCCTGGGTATGTATGTGTGTGTTCACATAAAGAAAATCCTTCAACGTGACACTTACATCAGAACACTCTGCCACTCCTGGGGTATTAACCTGGATTTGTGGAACATTAAACTAATGCTTTTAGCACGGCTCTTGTTCGATTTCCTATCATCATTCTGCATCAGCTAAGATGAGATTCATTAAAACACCATCAAAATTTGCTCAGGATGCTTTACACATCAGCAGAAATCTATTTGAGCACCTGCTGAGCAAATGTTTGTTTATTTCAGTTGGGGAGTTTGTCAGCGATGCCCTCCTCGTCCCAGATAAGTGCAAGTTCTTGCACCAGGAG[C/T]GAATGGACATGTGCGAGAGTCATCTACACTGGCATACAGTGGCCAAAGAGGTCAGCGATCGCACCACATCACATTTACACTTTCACGTATTAATAACAGAAAAGTCAGATCAGATTTCTGTTTCTGGAACCGGCACCTATTTTAGTTTAGATCAATCTTTTGTGCTGCTGAAAATATGTTTGAAGGGACGGTTCATCTAAAAATAAAAATGACCTCATCATTTGCTCTCCCTCATGAGGTTTTAAATCTTTATGAGCTTCTTTCTTCTATTAAACACAAAAGAAGATGTGTTTTAAAATGCTGGTTGCTGGCACACATTGACTTTCATAGTAGGAAAACTATTGCTATGGAAGTCACTGGATGCTAGCATTTTTCAAAATATTTAATATATATACTGTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATAAGACTATATGTTTTGTTTAGGGATATATGTTTAGTTTAA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa34693
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000077894 | Nonsense | 102 | 362 | 4 | 11 |
| ENSDART00000077901 | Nonsense | 434 | 694 | 10 | 17 |
| ENSDART00000077908 | Nonsense | 491 | 751 | 11 | 17 |
| ENSDART00000100684 | Nonsense | 434 | 660 | 10 | 17 |
| ENSDART00000122679 | Nonsense | 102 | 362 | 5 | 12 |
| ENSDART00000122787 | None | None | 83 | None | 3 |
| ENSDART00000125536 | Nonsense | 434 | 694 | 10 | 16 |
Genomic Location (Zv9):
Chromosome 9 (position 36004688)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 35224199 |
| GRCz11 | 9 | 35033384 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAGCTAAAAATAATCCTGTCTCATACAGCCTCGGCAGGTGCTGAATCTGT[T/A]GAAGAAGTATATCCGTGCGGAGCAGAAGGACCGTCAGCACACTCTCAAAC
Long Flanking Sequence:
GCATTGTTGAGGATTTTGGATTTTGTTGGCCTATAAAATTGAAACCACGCTTCTTCGCCCCCAGCTGGCAGAAATTTTTTGACATTTTATTTATTAGACATGCTTATTTATTGCTTTTATTGTACGTGTTTTTTTGTTTGTTTGTTTTTTATCAGGTAATAGATTTTATTTATATAAAAGAAAGTTGTCTATAGAAATGAATAGTAATGAAATCATTCCGGAAATGTTCCCAATATTTACTGGTATTACTGTGTGAAAGTGGCTATTGTCTACATGAATACATAAAACTAGTTAAAATTGTGTTCTTTGCCCCCAAAAAACTACAAATCTTAATTTCATATCAGTTATGACTGTAAATTATATATAGAATACCTAGTAAATGTTGCCATAAATATAGCCTGTGCTTCTGATGTGATATTCAAACATAAATAAATAAACAAATTATAACATAAGCTAAAAATAATCCTGTCTCATACAGCCTCGGCAGGTGCTGAATCTGT[T/A]GAAGAAGTATATCCGTGCGGAGCAGAAGGACCGTCAGCACACTCTCAAACACTTTGAACACGTGCGGGAGGTCGATCCCAAGAAGGCTTCACAGATTCGGCCATTTGTAAGCTCCTGTCAAGCTGTTCGTTCCTGCTTTAATTATGATTTGTGTAAATGCTTTAGAACTTGATTTTGAGCCCCTGTGCTTTTAGGTGATGACCCACCTACGTGTGATTGAGGAACGCATGAACCAGTCTTTGGGTTACCTCTATAAAGTGCCTCAAGTGGCTAATGATATCCAGGATCAAGTGGGTGAGTTTTTTTAATCGCACTTCAGAGGCTCAAACTGTGCTGGAAATGGAATATGTTGTCACATAACATCATTTTATTTTGTTTTATTTTTAATGTTTTATTTTTTTGTTACTCAAAACTGTTTTACTGTACTTTTGTATATTTTTTGTGTAAAGCATTTTGAGAATTAAGTTTTAAAGGCGATATATATATATAAGTGATGTAAG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa41475
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000077894 | Nonsense | 121 | 362 | 4 | 11 |
| ENSDART00000077901 | Nonsense | 453 | 694 | 10 | 17 |
| ENSDART00000077908 | Nonsense | 510 | 751 | 11 | 17 |
| ENSDART00000100684 | Nonsense | 453 | 660 | 10 | 17 |
| ENSDART00000122679 | Nonsense | 121 | 362 | 5 | 12 |
| ENSDART00000122787 | None | None | 83 | None | 3 |
| ENSDART00000125536 | Nonsense | 453 | 694 | 10 | 16 |
Genomic Location (Zv9):
Chromosome 9 (position 36004632)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 35224143 |
| GRCz11 | 9 | 35033328 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGTATATCCGTGCGGAGCAGAAGGACCGTCAGCACACTCTCAAACACTTT[G/T]AACACGTGCGGGAGGTCGATCCCAAGAAGGCTTCACAGATTCGGCCATTT
Long Flanking Sequence:
GCCCCCAGCTGGCAGAAATTTTTTGACATTTTATTTATTAGACATGCTTATTTATTGCTTTTATTGTACGTGTTTTTTTGTTTGTTTGTTTTTTATCAGGTAATAGATTTTATTTATATAAAAGAAAGTTGTCTATAGAAATGAATAGTAATGAAATCATTCCGGAAATGTTCCCAATATTTACTGGTATTACTGTGTGAAAGTGGCTATTGTCTACATGAATACATAAAACTAGTTAAAATTGTGTTCTTTGCCCCCAAAAAACTACAAATCTTAATTTCATATCAGTTATGACTGTAAATTATATATAGAATACCTAGTAAATGTTGCCATAAATATAGCCTGTGCTTCTGATGTGATATTCAAACATAAATAAATAAACAAATTATAACATAAGCTAAAAATAATCCTGTCTCATACAGCCTCGGCAGGTGCTGAATCTGTTGAAGAAGTATATCCGTGCGGAGCAGAAGGACCGTCAGCACACTCTCAAACACTTT[G/T]AACACGTGCGGGAGGTCGATCCCAAGAAGGCTTCACAGATTCGGCCATTTGTAAGCTCCTGTCAAGCTGTTCGTTCCTGCTTTAATTATGATTTGTGTAAATGCTTTAGAACTTGATTTTGAGCCCCTGTGCTTTTAGGTGATGACCCACCTACGTGTGATTGAGGAACGCATGAACCAGTCTTTGGGTTACCTCTATAAAGTGCCTCAAGTGGCTAATGATATCCAGGATCAAGTGGGTGAGTTTTTTTAATCGCACTTCAGAGGCTCAAACTGTGCTGGAAATGGAATATGTTGTCACATAACATCATTTTATTTTGTTTTATTTTTAATGTTTTATTTTTTTGTTACTCAAAACTGTTTTACTGTACTTTTGTATATTTTTTGTGTAAAGCATTTTGAGAATTAAGTTTTAAAGGCGATATATATATATAAGTGATGTAAGTGATGATTATTATTATGAAGAATTATGAAATGCTGTGTTTTGTGCAGCGGTGCTGG
Associated Phenotype:
Not determined