Busch Lab

ZMP

aplp2

Ensembl ID:
ENSDARG00000054864
ZFIN ID:
ZDB-GENE-061009-28
Description:
amyloid-like protein 2 [Source:RefSeq peptide;Acc:NP_001116484]
Human Orthologue:
APLP2
Human Description:
amyloid beta (A4) precursor-like protein 2 [Source:HGNC Symbol;Acc:598]
Mouse Orthologue:
Aplp2
Mouse Description:
amyloid beta (A4) precursor-like protein 2 Gene [Source:MGI Symbol;Acc:MGI:88047]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa29087 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa29086 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa29087
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077125 Essential Splice Site 312 764 6 17
Genomic Location (Zv9):
Chromosome 18 (position 42834763)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 44424654
GRCz11 18 44418108
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTCATGCCGGAGAAACAGGACGATGACAAAACTCTGCAGGAAGTAGAAG[G/A]TCAGTCTCACGCTGTTTCCTTCATTTATTGCCTTACTGCCACAGTGAGTT
Long Flanking Sequence:
CTCCTCCAAGACTGCCACAGCATCTGCTCAGAATACGGCCTGGTCTAGGATTATAGAGACCTCAGGATAATAAAACCAGACTAAAATAAGCATCGATATATACGTTTATTTTTTTCTAAATTTGAATTTTAACACTGTTTTGAAGCACATTAGTTTATATATATCCTTAAAACTAACAGACTGAAACTGAAATCTACATTTTTTATTTGTTTAACAGCTTCCCTTTAAAAAGGCAGATAGACCCAAAAACATCACTATCACGTGAAATGTAAAAAATGTTTTCTTTTATCTTAGTGAGCCTGTTGCCATCGATCCTCCCACTCAGGAAGACACAGCAGAGGAAGAGGAGGAGCAGGAGGAGGATGGAGATGAAGAGGACTATCACTACATCTACGAGGATGAGGAGGAGGACAGAGACAGCGAGGAGAAGGATGTTAAGAAAGAGAAAGCTGTCATGCCGGAGAAACAGGACGATGACAAAACTCTGCAGGAAGTAGAAG[G/A]TCAGTCTCACGCTGTTTCCTTCATTTATTGCCTTACTGCCACAGTGAGTTCAATTACAGCAGCTCGTTTGCTTCAGATCTTTGCTCCTGTTCACCATAAGGTTATTGACTTTTTTTTTTAAAGTAAGACTTTGTTTTGTTGTATAGGAATGTTTATGGGTCAAAGATGAGACGTGTTATTCTAGCATCAAAAATGTAGAATTAAATTTTTTCTGTTTTTAATGTTGTATTCTGTGCAGAAATTAGGCTACTTTTTACCATGATTTACAGAAGATGTCCATTTTAATGTAATTTAGGGTAACATTAGTTTAAATAATATATATTAAGGTATTAGCTGTGATTCAAATATAAAAAATGTTAAAGACTCTAAAGGTCAGAGTGCAGCAACCAAATACTGATTTAAATTAATTTAAATCTTTATACTTTGTCATTGTCTTTCAACCCATTTGGGTTTAAATGTTGTTAATCTTTTAAAATATAATCCAATCCGTTGGAGCTCTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa29086
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077125 Nonsense 402 764 8 17
Genomic Location (Zv9):
Chromosome 18 (position 42825501)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 44415392
GRCz11 18 44408846
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGACCCCAGCAGATGATAAAGAGCACAGCCGCTTCCAGAAAGCCAAGGAG[C/T]AACTCGAGATCAGACACCGCAACCGTATGGAGAGGGTGAGTGCAGTGTCA
Long Flanking Sequence:
GGTTAAAATGAATTTTTAAATGTAACGCAAGTTACTTTTTATTTGAATTAGTTTGCTTCTAATAAAAAAAAAAAAATTGCTGAATTAAAATTAATATTGAATCACGATGATAGAATGCAATCAAAGAACACATCAAAGAAAAGTGATTTTACTAATAAGACAAAATGTATAAAAGTAGCAAGCACATTGCTTTAAGCTTTCATTAATCTGTATAAACGGCTTGTGTAACTCTGGGGTCAGGTAATTCTCAGAAGATTACATTATACTGAATTATCATTTTTTATGTTATTTGTTTTAAAACGTAACGAAAGAGTTGTCAGTTTGAGCAGTACAGTGCAGCCTGGCTCATATTTGAATCCAAGTTTCAGTGTTTATCATCACTCTCTTTCTGTTTTCCCTCAGCCGTCCCGCCGACCCCTCAGCCCACAGATGATGTGGATGTGTACTTCGAGACCCCAGCAGATGATAAAGAGCACAGCCGCTTCCAGAAAGCCAAGGAG[C/T]AACTCGAGATCAGACACCGCAACCGTATGGAGAGGGTGAGTGCAGTGTCACTTTAATTTTTCGGATATTCTGCATGCAACGTCAAAATTGTTATCCCCCTATGAATATATATCTTTTATATTTCCCAAATTATGTTAAACAGAAATTGGGGGAAAATATACGGGTGGGAGGGGGGTATTAATTATGACTTCAGCTGTATATGGTTATTATTCGTTCTCTATATTAAAACACAAACCAAATATACAGGTTAGTTTTTGCTGTAGTTGTAATTTTTTTAAAACTGAAGAATGAGAGCTTTTGGCCTTTAGTGAAACATGTTGGAGACTCTGTCCTGGTTTGGAGCTGCATTTCTTTCAGTGGCAATATAGTAAACAATAATGATCTTAAACACACGACTATTGCAGTGAAATCATCTGGTGAAACACTCATGAAATGGCCTGCCCAGAATCCAGACCTGAATATTATAGAGACAGTATGGAATCACATGAATTTATTTGACA
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa4051
Status:
Allele not cryopreserved
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077125 Nonsense 756 764 17 17
Genomic Location (Zv9):
Chromosome 18 (position 42784102)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 44373993
GRCz11 18 44367447
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GAACGTCACCTGAGCAAGATGCAGAACCACGGCTATGAAAACCCCACTTA[C/A]AAATACCTGGAGCAGATGCAGATTTAGCCATCATGCGGCRCWGTGGAGCT
Long Flanking Sequence:
TATATATATATATATATGTATATATATGTATGTATGTATGTATGTATGTATGTATGTATATGTGTGTATATGTATATATATGTATGTATGTATATGTGTGTATATATGTGTATACCTGTATATATATGTATGTCTATATATGTGTATGTATGTGTATATATACATGTATGTATGTATATTTATATATGTATATATATATGTATGTATATGTATGTGAATATATATATATATATATATATATATATATATATATATATATATATATATTAGACAGCACATTTCACACATGAGTATAATAGTTCAGAATATTCATGTTTGTACTATATATTAGTAATAATGAATTAATCTTTCTTTTAAAACCATTTAAGGGGGTCATTTTAAATAACTGATCATGCTTTTGATGTTAAACCTTCTTTTGCTTTTCAGGTTGATCCCATGCTCACTCCAGAAGAACGTCACCTGAGCAAGATGCAGAACCACGGCTATGAAAACCCCACTTA[C/A]AAATACCTGGAGCAGATGCAGATTTAGCCATCATGCGGCGCTGTGGAGCTGAGAGGGGTGAACATACTACTGACCAATATAAAACTGCTCTCAAATCATTTCATGCATTTGAAATGCATATCCTGGTTCATTTAAAGAAAAAAAAACTACAACAACACAATGGGTTATTAATACTACTACTTCTAATACTGCTACTGTTGTACCATGGAGCGCAATTTTTAGGCTCTTGTAACTTTTTATTTTCGTTAAAAAGCAACGGTTTTAAATCAGGAGAACGTGATTCTGCAAATTGATTTTGGAATTGGAGCGTATTATTATTTTAATATGGTTTTAAATGTTCATTTGATAACGTTTGATTTTAGTATATAGAGGTACAGCAAAGCAAAGGCGAAACAATCAATATATAAAGACACACAGCAGTTTGTCTACACCATCGCTGGCCGCCGGATATACTTCTTTTAAATAGATCGCTTGTATATGAAGGTTATTTGTAACAACTT
Associated Phenotype:
Not determined