Busch Lab

ZMP

c6ast4

Ensembl ID:
ENSDARG00000052578
ZFIN ID:
ZDB-GENE-050626-100
Description:
six-cysteine containing astacin protease 4 [Source:RefSeq peptide;Acc:NP_001020351]
Human Orthologue:
ASTL
Human Description:
astacin-like metallo-endopeptidase (M12 family) [Source:HGNC Symbol;Acc:31704]
Mouse Orthologue:
Astl
Mouse Description:
astacin-like metalloendopeptidase (M12 family) Gene [Source:MGI Symbol;Acc:MGI:3046414]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa18882 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa27001 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa34127 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa18882
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000074463 Essential Splice Site 137 265 6 9
ENSDART00000144341 Essential Splice Site 137 265 7 10

The following transcripts of ENSDARG00000052578 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 40028462)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 38365102
GRCz11 7 38636360
KASP Assay ID:
554-6145.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATATCAATGTCTGTGTGACACATAAATGTTGACATTATGTTCATCTTACA[G/T]GTGCTACTCTTACGTTGGCCGTCAGGGTAATGTCCAGACAGTATCTCTGG
Long Flanking Sequence:
CTGAAGAGAGGTGTTAAAACTGAACACAGAACATAGAAAGATGTATACTTTGTTGTTGGGCAGAGAATTCGTAGAAAAAGAGGAAGTATGTCGAAGGTGCGGCCAATGGAGGACTGAACAATGACTGACAAGTGACGTTACACCAAAACTCCACCTGTTAAGATCGGTGGTGTATATATGCTGAAGTCAGGAAATGTATGTTAGTTGCGAACCTCTTGAATGTAATTCTCGTATTGCATTGGGGTAATGTAACCCAGAGCTCTGTCATCGAATTATTCATTTGTATCCAATAAATTACTAATATTTTTGTCATTGAAGAAAAACCTCTCCTGACCTTTTCTCTTGAACACGCATGGAGTTGGCTTGATATTCCAACAATGTTTCACAGTAATGATGACAAGAAATGAGAACTGTTTTCATTTATTTTCAATATTATTGAGAAACATTAACATATCAATGTCTGTGTGACACATAAATGTTGACATTATGTTCATCTTACA[G/T]GTGCTACTCTTACGTTGGCCGTCAGGGTAATGTCCAGACAGTATCTCTGGCCCGAAGTGGCTGTCTTTACCACAGCACTGTTCAGCATGAGCTGCTCCACGCCCTGGGCTTCAACCATGAACAAACCCGCAGTGACCGTGACAATCACATCCAGGTCATCTGGGAGAACATCCTTGATGGTAATGTTCAGTCACAGAACACTTTGAGGAGAGCCCATACTCTTATGTAGTGTGTTTACTGATTTGGATGTGTTTTGTTTTCTCATCAGACATGAAGTACAACTTCAATAAAATCAACACCCTGAACCAGGGAACTCCTTATGACTACAAGTCTGTGATGCAGTACGAGAGGTGGGTGAGCTCAAGATTAACTTTTTTCAAAAGTCTCCCAGATTGTAATCTAACTGTCACTTGCTTTCAGGTATGCTTTCTCCAAGAACGGATATCCCACTATGATTCCCATTCCCAACAATAACGCTGAGCTGGGCAAGTCCACTCAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa27001
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000074463 Essential Splice Site 196 265 6 9
ENSDART00000144341 Essential Splice Site 196 265 7 10

The following transcripts of ENSDARG00000052578 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 40028282)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 38364922
GRCz11 7 38636180
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CAGTGACCGTGACAATCACATCCAGGTCATCTGGGAGAACATCCTTGATG[G/A]TAATGTTCAGTCACAGAACACTTTGAGGAGAGCCCATACTCTTATGTAGT
Long Flanking Sequence:
CTGAAGTCAGGAAATGTATGTTAGTTGCGAACCTCTTGAATGTAATTCTCGTATTGCATTGGGGTAATGTAACCCAGAGCTCTGTCATCGAATTATTCATTTGTATCCAATAAATTACTAATATTTTTGTCATTGAAGAAAAACCTCTCCTGACCTTTTCTCTTGAACACGCATGGAGTTGGCTTGATATTCCAACAATGTTTCACAGTAATGATGACAAGAAATGAGAACTGTTTTCATTTATTTTCAATATTATTGAGAAACATTAACATATCAATGTCTGTGTGACACATAAATGTTGACATTATGTTCATCTTACAGGTGCTACTCTTACGTTGGCCGTCAGGGTAATGTCCAGACAGTATCTCTGGCCCGAAGTGGCTGTCTTTACCACAGCACTGTTCAGCATGAGCTGCTCCACGCCCTGGGCTTCAACCATGAACAAACCCGCAGTGACCGTGACAATCACATCCAGGTCATCTGGGAGAACATCCTTGATG[G/A]TAATGTTCAGTCACAGAACACTTTGAGGAGAGCCCATACTCTTATGTAGTGTGTTTACTGATTTGGATGTGTTTTGTTTTCTCATCAGACATGAAGTACAACTTCAATAAAATCAACACCCTGAACCAGGGAACTCCTTATGACTACAAGTCTGTGATGCAGTACGAGAGGTGGGTGAGCTCAAGATTAACTTTTTTCAAAAGTCTCCCAGATTGTAATCTAACTGTCACTTGCTTTCAGGTATGCTTTCTCCAAGAACGGATATCCCACTATGATTCCCATTCCCAACAATAACGCTGAGCTGGGCAAGTCCACTCAGATGAGCCAGAATGACATCACCAGGCTTAACAGACTCTACCAGTGCTGTGAGTCAGACATTTATTTACATTTCCATAGATAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAACATGGACATACAGTATGTATATATTTATTTTTACTTTTGTATGTTTAACAGTTAAGTGTGGAGAATTTTAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34127
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000074463 Essential Splice Site 197 265 7 9
ENSDART00000144341 Essential Splice Site 197 265 8 10

The following transcripts of ENSDARG00000052578 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 40028195)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 38364835
GRCz11 7 38636093
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TACTCTTATGTAGTGTGTTTACTGATTTGGATGTGTTTTGTTTTCTCATC[A/T]GACATGAAGTACAACTTCAATAAAATCAACACCCTGAACCAGGGAACTCC
Long Flanking Sequence:
TCGAATTATTCATTTGTATCCAATAAATTACTAATATTTTTGTCATTGAAGAAAAACCTCTCCTGACCTTTTCTCTTGAACACGCATGGAGTTGGCTTGATATTCCAACAATGTTTCACAGTAATGATGACAAGAAATGAGAACTGTTTTCATTTATTTTCAATATTATTGAGAAACATTAACATATCAATGTCTGTGTGACACATAAATGTTGACATTATGTTCATCTTACAGGTGCTACTCTTACGTTGGCCGTCAGGGTAATGTCCAGACAGTATCTCTGGCCCGAAGTGGCTGTCTTTACCACAGCACTGTTCAGCATGAGCTGCTCCACGCCCTGGGCTTCAACCATGAACAAACCCGCAGTGACCGTGACAATCACATCCAGGTCATCTGGGAGAACATCCTTGATGGTAATGTTCAGTCACAGAACACTTTGAGGAGAGCCCATACTCTTATGTAGTGTGTTTACTGATTTGGATGTGTTTTGTTTTCTCATC[A/T]GACATGAAGTACAACTTCAATAAAATCAACACCCTGAACCAGGGAACTCCTTATGACTACAAGTCTGTGATGCAGTACGAGAGGTGGGTGAGCTCAAGATTAACTTTTTTCAAAAGTCTCCCAGATTGTAATCTAACTGTCACTTGCTTTCAGGTATGCTTTCTCCAAGAACGGATATCCCACTATGATTCCCATTCCCAACAATAACGCTGAGCTGGGCAAGTCCACTCAGATGAGCCAGAATGACATCACCAGGCTTAACAGACTCTACCAGTGCTGTGAGTCAGACATTTATTTACATTTCCATAGATAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAACATGGACATACAGTATGTATATATTTATTTTTACTTTTGTATGTTTAACAGTTAAGTGTGGAGAATTTTAAATTTACTTTTGCCCATTTATCCGTCTTTTAGGAGCAGCACAAATTTAAAAGGATCCAAAGTCTCACTGATGTTGCTGAACAACCATC
Associated Phenotype:
Not determined