Busch Lab

ZMP

notch1b

Ensembl ID:
ENSDARG00000052094
ZFIN ID:
ZDB-GENE-990415-183
Description:
neurogenic locus notch homolog protein 1 [Source:RefSeq peptide;Acc:NP_571377]
Human Orthologue:
NOTCH1
Human Description:
notch 1 [Source:HGNC Symbol;Acc:7881]
Mouse Orthologue:
Notch1
Mouse Description:
Notch gene homolog 1 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:97363]

Alleles

There are 10 alleles of this gene:

Allele Name Consequence Status Availability
sa1187 Essential Splice Site F2 line generated Not yet available
sa26617 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa26616 Nonsense Mutation detected in F1 DNA Not yet available
sa11236 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa1187
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000050855 Essential Splice Site 44 2465 2 34
ENSDART00000050856 None None 1817 None 22
ENSDART00000130888 Essential Splice Site 2 2436 2 34
Genomic Location (Zv9):
Chromosome 5 (position 68766852)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 65099074
GRCz11 5 65778189
KASP Assay ID:
554-1096.1 (used for ordering genotyping assays)
KASP Sequence:
AAAACGGAGGCACATGTGAACCAACTGCAGACGGGAGAGGAGAATGCAAG[T/A]AAGTGATAAGATTCTCGACTGCATGATATTGCTGTGTCTGATACCCAGAA
Long Flanking Sequence:
TATTTCATGTTTAAGGCAATACAAATAACATATTCTTTGGCATAATAGTGAAAGTGCTAAACCTACACACATTTTAGAAGAAAATTTCAGGTTTTTGCATCCGAACTCAACTCACTTTTTAAATTAGGATGACTGCTTTTGGTCATTTATAATAGACTGTAAACAAATGCTGGGTTCCTTTACAATCAATTTGTGTCGGGACATCATGAAGCTATTAAGTTAGCTAATTAGTTTTCACAAATTGAAGTGGATTGGATATAAAACAATTAACTTATCCCCAAAACAACTAAAACATTGTGTTGTTTCAGCTCATTTTAAATAAGTAGTTTGAACAGACGGCAAACATCTTTTTTTTGTGTGTAGTTTGAGATCAAAACATCATGTAATGCTCAACAGAAATGAGTTATCCTGTTTCTGCATTTCCAGGCCTGGAATGTTCAGAAAAATGCCAAAACGGAGGCACATGTGAACCAACTGCAGACGGGAGAGGAGAATGCAAG[T/A]AAGTGATAAGATTCTCGACTGCATGATATTGCTGTGTCTGATACCCAGAAGGAGTCAAACATATTGTTGATTGAATAGCACACACATACAGTAGCTAAGGAGATTTTTAAAAGTTAAAGAGATAGTTCACCTCAAAATGATGTTTACTCACACTTGACTTGTTCCAAACCAGTTTAAGTTTCTATTTGACACTAAAGAAGGTATTTTGAAGAATTTTACACCGTAAAAAAATGTTTGGTTCCAAATAATCAATTTATCTTGGGACAACATGAAGGAATTAAGTTAAGGTAATTAATTTTTACAAATTCAGGTGGATTGAACTTAAAACATTCAAGTTGTCCCAGAATAAAACCTCAAGGATTGTGTTGTTCCAGCTCAATTTAAATAAGTAGTTTTGCCGTAAACATATTTTATGAGTGAAGAAACCTGTAACTGACACCATAGTGTTTGTTTTTCTTATAGTTGTCAATGGTTTCAACATTCTTCAAAACAGTGGCGAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa26617
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000050855 Essential Splice Site 539 2465 11 34
ENSDART00000050856 None None 1817 None 22
ENSDART00000130888 Essential Splice Site 470 2436 10 34
Genomic Location (Zv9):
Chromosome 5 (position 68714956)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 65047178
GRCz11 5 65726293
KASP Assay ID:
2259-6806.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTGGAGGAATGAAGCTGGAGGAATTATTGTAATGACCTTCTTTTTTTGT[A/T]GGATTTTCGGGGAGCCAATGCCAGTTCGACATTGACGAGTGCGCTAGTAC
Long Flanking Sequence:
TGTCCCATAAGTCTATACCCTGATGGATTTGTAGCCGTTAATGTGTTCAGACTGTATATTTGAGCAGCAGACGTCTTTAGTGAGGGATTAAAATAACTGGGGGAGAAAGCACAAATGCTGGGGGTCCCTGAGCGACGGGGAGCTGCTGAATAGCATGGGGTCAGGGGTTGCGCGGGGCTCTTTTTGGTGGGACAGGCTCGAAGAGGGGGGCGAAGGCTGGATGGAAGAATGCACATTGTGATGGAAAACTTCCACGGGACAAAGGAGGCAACCGGCATGGCTTGGCGTTCCTATGAATAGACAGTTCCTCTTTGTCTGGTGCCCTTGGTCAGGAGGGTTTTTTACCGCCATTTTACCCCCTCTTCTCCCACTCTCAGAAAAAAATAAGCTTGAAAACCTGAGAGAAAAAGCATGCAGCTGGGTATTAATGAATGCTGCTGTATAGAGGAGTGTGGAGGAATGAAGCTGGAGGAATTATTGTAATGACCTTCTTTTTTTGT[A/T]GGATTTTCGGGGAGCCAATGCCAGTTCGACATTGACGAGTGCGCTAGTACTCCTTGTAAAAATGGGGCCAAGTGTATGGATGGGCCCAATATGTACACCTGCCAGTGCACTGAAGGTATGAAGATGCCATCAGCTTCTAATTAGTACTAAAAAGTATTAAAGAAATGGAAAAATTATTTTTTTGGCTATTTGGGGGGGGGGTATACATATTTTCAAATATTTCACAAATTATGTTTAACAGAGGAACACATTTTTCACAGTATTTCCTATAATATTTTTTCTTCTGGAGAAAGTCTGATTTGTTTTATTTCGGCTAGAATAAAAGCAGTTTTTAATTTTTATTTCAATATTTAATTCTCTTTGAATATCACACTAACTAACTGTACAAAAAAAAAAAAAAAAAAAAAAAACTACTAACACTTTCCTTCTTAGACTTTACAGACCTGAAACTTGCCTTTAGTACTTATTCATTGTTGCTCTTATAGTTGTGTAAATTGCTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa26616
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000050855 Nonsense 1088 2465 20 34
ENSDART00000050856 Nonsense 439 1817 8 22
ENSDART00000130888 Nonsense 1059 2436 20 34
Genomic Location (Zv9):
Chromosome 5 (position 68696569)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 65028791
GRCz11 5 65707906
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTTTATACTGTGACGTTCCCAGTGTTTCCTGCGAGGTGGCCGCCAAACAG[C/T]AAGGTTTGTTTATATGAATGGGCCTATTACAGTTAAAGTCAAATTTATTC
Long Flanking Sequence:
TAATGTTAATTAATGCATTTACTAACATGAACAAACAATGAGCAATACATTTACTACTGTATTTGTTCATGTTAGTTTACGTAAAATAAAGTTGTTCATTGTTAGTTTGTTAACTCATGGTGCATTAGCTAATGTTAACAAGCATGGACTTGGATGTTAATTATGCATTAGTAAATGTTCAATTATGATTATTAATTGCTGTACATGTGTTGTTCATGATTAGTTCATGTTAGTAAATGCATTAACTAATGAACCTTATTGTAAAGTGTTACTATATATATATATATATAATTTTTTGAGTGTGGATACACTAGTTAAATCATTGACATGGATGAACTGTTGTCTTGCAGGAGCTGGTGAACTGGTGTAAACCGTCTCCCTGTAAGAATGGAGGGATCTGCAGACAGAGCGGCACGAGATACAGCTGTCAGTGTCAGACAGGCTGGACTGGTTTATACTGTGACGTTCCCAGTGTTTCCTGCGAGGTGGCCGCCAAACAG[C/T]AAGGTTTGTTTATATGAATGGGCCTATTACAGTTAAAGTCAAATTTATTCGCCCTTCTGGGATTTTATTGCCAAATGATGTTTAATAGAGCAAGGCAATTTTCACAGTATGTCTGATAATATTTTTTCTTCTTATTTGTTTAATTTCGCCTTGAATAAAAGCAGTTTTTAATTGTTTTAAAACCATTTTAATGCCAGTATTATTAGCCCCCTTAAGCAATATTTTAATTTCGATTATTATGTATATGTCTAATTAACCTAACCTGCCTTATTAACCTAGTTAAGCCTTTAAATGTCACTTTAAGCTGTATAGAAGTGTCTTGAAAAATATCTAGTCAAATATTATTTACTGTCATCATGGCAAAGATAAAATAAATCAGTTATTAGAGATGAGTTATTGAAACTATTATGTTTAGAAATGTGTTGAACAAAAAAAATCTCTCTGTTAAACAGAAATTGGGGAAAAATATACAAAATATACCCCTTGTTACTCAGCACTGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11236
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000050855 Nonsense 1149 2465 21 34
ENSDART00000050856 Nonsense 500 1817 9 22
ENSDART00000130888 Nonsense 1120 2436 21 34
Genomic Location (Zv9):
Chromosome 5 (position 68695835)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 65028057
GRCz11 5 65707172
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CCRTGCCAGAACGGAGCAACTTGCACCGACTACCTGGGCGGATACTCCTG[T/A]GAAGTMAGTCAAGAGGATCTGGAAGTTRGCAATCATCTTCACTGTGAATG
Long Flanking Sequence:
TTATTATGTATATGTCTAATTAACCTAACCTGCCTTATTAACCTAGTTAAGCCTTTAAATGTCACTTTAAGCTGTATAGAAGTGTCTTGAAAAATATCTAGTCAAATATTATTTACTGTCATCATGGCAAAGATAAAATAAATCAGTTATTAGAGATGAGTTATTGAAACTATTATGTTTAGAAATGTGTTGAACAAAAAAAATCTCTCTGTTAAACAGAAATTGGGGAAAAATATACAAAATATACCCCTTGTTACTCAGCACTGGTTTCTGCTCAGCCTGTTCAGTGTTTGAGATGTTTGTTTCTCCTGATTTCCAGGTGTTGATGTGGTCCGGCTGTGTCGTAACTCTGGCCAGTGTCTGGACGCTGGAAACACACACTATTGTCACTGTCAGGCCGGATACACGGGCAGCTACTGTGAGGAGCAGGTGGACGAATGCATTCCCAATCCGTGCCAGAACGGAGCAACTTGCACCGACTACCTGGGCGGATACTCCTG[T/A]GAAGTAAGTCAAGAGGATCTGGAAGTTGGCAATCATCTTCACTGTGAATGGTCCCTTTTCACATATCCGGGTTTCTTAGTTGCGGAAGTCGTCATAGTTGGGTAAACTTAGAGCATGGTAAACGGGAGAGAACAACAAATATTTTTTACAATCCTATTTGCTGAAATAATAACAGAAAAACTCCATAAGGATGTTATAAAGGTGTTCTGACAAAGTAAAAAAAAATAGTGTGTCAGCCAGAAGAGAGAATAACGTCAAATCACCTAACAGCAAGAAGGTCGCTGGTTTGAGTCCCAGCTGGGTCAGTTGACATTTTTGTGTGGAGTTTGCATGTTCTCCCCATGTTGATGTGGGTTTCCTCCGGGTGCTCCGGTTTAACCCACAGTGCAAAGACATGCGCTATAGGGGAACTACCAACCTACGTCACACATGATGTCACACGGGTTCAACCACACAAAGTGGTTACAAAAAAAAGACCGGTTCCAATAGCAAACATGTTG
Associated Phenotype:
Not determined