Busch Lab

ZMP

cyfip1

Ensembl ID:
ENSDARG00000044345
ZFIN ID:
ZDB-GENE-030131-8557
Description:
Cytoplasmic FMR1-interacting protein 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q90YM8]
Human Orthologue:
CYFIP1
Human Description:
cytoplasmic FMR1 interacting protein 1 [Source:HGNC Symbol;Acc:13759]
Mouse Orthologue:
Cyfip1
Mouse Description:
cytoplasmic FMR1 interacting protein 1 Gene [Source:MGI Symbol;Acc:MGI:1338801]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa14676 Essential Splice Site Available for shipment Available now
sa20750 Nonsense Available for shipment Available now
sa40737 Nonsense Mutation detected in F1 DNA Not yet available
sa10367 Nonsense Available for shipment Available now
sa2288 Nonsense F2 line generated Not yet available
sa45259 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa14676
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Essential Splice Site 70 1253 4 31
ENSDART00000104233 Essential Splice Site 70 1257 3 31
ENSDART00000122199 Essential Splice Site 70 476 4 15
ENSDART00000124610 Essential Splice Site 70 1014 4 26
ENSDART00000130905 Essential Splice Site 70 511 4 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37620275)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37694033
GRCz11 6 37671927
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GTTGCATAAACGCRTRTAAGTGTAATGATGAACTGTTTGCTGTRCATTAC[A/T]GAATGACATGTTAGAAGAAGGTCAGCAGTATGCWGTGATGCTGTACACGT
Long Flanking Sequence:
TTTTTTAGCTTGACTTGTTCACTGATCCAAAATATTTTAAATGTTTTTCAAAATAAAATATATTGCATTCAATGGGGGGAAACGTTTTTTTTTTTTTTTTTCCCAAAACATTTAAAAAGAATATATTTTAGAACAGTATTCACAATACCGAGATACTGTGATATATTTATACAAGGTTATCTTACTGTCAAAATCTTTTACTGGCCCATGCCTAGCTGCAAAACCAGAATATCATGGAATTTTGTTAATCTTTTGGATAAATAAATAAGTAGGATTATCACTGTATATAATTATAATTACTTATATTTGTGCTGATAATTGATAATTATGCATAATTATTTGAATAGCTTAATTGAAAAATTGACAATATTAAACGTTTTTTCATTCAGTTTTTTTTTATGTGGCTTTATTTTGCACATCTTGTATGTAAAAGAAGTCTGTGTGCATTCAGTTGCATAAACGCGTATAAGTGTAATGATGAACTGTTTGCTGTGCATTAC[A/T]GAATGACATGTTAGAAGAAGGTCAGCAGTATGCTGTGATGCTGTACACGTGGAGGTGCTGTTCGAGAGCTATTCCTCAGGTAATTTAGTAAATCCCAAAGCATTTTACATTCAAACTCAAGACCACCATCATCACCAACAACCAGTCTATAGTTTTGATCCTCCTCATCATCTGTTCCTGTCACAGGTGAAGTGTAATGAACAACCCAACAGAGTGGAGATCTACGAGAAGACTGTGGAGGTGCTCGAACCCGAAGTCAACAAACTAATGAACTTCATGTACTTTCAGGTAAAGCCTAACACTATTTCCTGCATCAGAATACTGGATATTATAATGTGCATTAATACTTCTGCTTCTCTTTCAGAGGACAGCAATAGATCGCTTTTGTGGTGAAGTGCGTCGTCTCTGTCATGCAGAGCGGAGGAAAGACTTTGTGTCTGAAGCTTATCTGCTCACTCTGGGAAAGTTTATCAACATGTTTGCGGTGCTGGATGAACTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20750
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Nonsense 79 1253 4 31
ENSDART00000104233 Nonsense 79 1257 3 31
ENSDART00000122199 Nonsense 79 476 4 15
ENSDART00000124610 Nonsense 79 1014 4 26
ENSDART00000130905 Nonsense 79 511 4 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37620306)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37694064
GRCz11 6 37671958
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACTGTTTGCTGTGCATTACAGAATGACATGTTAGAAGAAGGTCAGCAGTA[T/A]GCTGTGATGCTGTACACGTGGAGGTGCTGTTCGAGAGCTATTCCTCAGGT
Long Flanking Sequence:
ATATTTTAAATGTTTTTCAAAATAAAATATATTGCATTCAATGGGGGGAAACGTTTTTTTTTTTTTTTTTCCCAAAACATTTAAAAAGAATATATTTTAGAACAGTATTCACAATACCGAGATACTGTGATATATTTATACAAGGTTATCTTACTGTCAAAATCTTTTACTGGCCCATGCCTAGCTGCAAAACCAGAATATCATGGAATTTTGTTAATCTTTTGGATAAATAAATAAGTAGGATTATCACTGTATATAATTATAATTACTTATATTTGTGCTGATAATTGATAATTATGCATAATTATTTGAATAGCTTAATTGAAAAATTGACAATATTAAACGTTTTTTCATTCAGTTTTTTTTTATGTGGCTTTATTTTGCACATCTTGTATGTAAAAGAAGTCTGTGTGCATTCAGTTGCATAAACGCGTATAAGTGTAATGATGAACTGTTTGCTGTGCATTACAGAATGACATGTTAGAAGAAGGTCAGCAGTA[T/A]GCTGTGATGCTGTACACGTGGAGGTGCTGTTCGAGAGCTATTCCTCAGGTAATTTAGTAAATCCCAAAGCATTTTACATTCAAACTCAAGACCACCATCATCACCAACAACCAGTCTATAGTTTTGATCCTCCTCATCATCTGTTCCTGTCACAGGTGAAGTGTAATGAACAACCCAACAGAGTGGAGATCTACGAGAAGACTGTGGAGGTGCTCGAACCCGAAGTCAACAAACTAATGAACTTCATGTACTTTCAGGTAAAGCCTAACACTATTTCCTGCATCAGAATACTGGATATTATAATGTGCATTAATACTTCTGCTTCTCTTTCAGAGGACAGCAATAGATCGCTTTTGTGGTGAAGTGCGTCGTCTCTGTCATGCAGAGCGGAGGAAAGACTTTGTGTCTGAAGCTTATCTGCTCACTCTGGGAAAGTTTATCAACATGTTTGCGGTGCTGGATGAACTTAAGAACATGAAGTGCAGCGTCAAAAATGACCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40737
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Nonsense 98 1253 5 31
ENSDART00000104233 Nonsense 98 1257 4 31
ENSDART00000122199 Nonsense 98 476 5 15
ENSDART00000124610 Nonsense 98 1014 5 26
ENSDART00000130905 Nonsense 98 511 5 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37620470)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37694228
GRCz11 6 37672122
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTCTATAGTTTTGATCCTCCTCATCATCTGTTCCTGTCACAGGTGAAGTG[T/A]AATGAACAACCCAACAGAGTGGAGATCTACGAGAAGACTGTGGAGGTGCT
Long Flanking Sequence:
TTTTACTGGCCCATGCCTAGCTGCAAAACCAGAATATCATGGAATTTTGTTAATCTTTTGGATAAATAAATAAGTAGGATTATCACTGTATATAATTATAATTACTTATATTTGTGCTGATAATTGATAATTATGCATAATTATTTGAATAGCTTAATTGAAAAATTGACAATATTAAACGTTTTTTCATTCAGTTTTTTTTTATGTGGCTTTATTTTGCACATCTTGTATGTAAAAGAAGTCTGTGTGCATTCAGTTGCATAAACGCGTATAAGTGTAATGATGAACTGTTTGCTGTGCATTACAGAATGACATGTTAGAAGAAGGTCAGCAGTATGCTGTGATGCTGTACACGTGGAGGTGCTGTTCGAGAGCTATTCCTCAGGTAATTTAGTAAATCCCAAAGCATTTTACATTCAAACTCAAGACCACCATCATCACCAACAACCAGTCTATAGTTTTGATCCTCCTCATCATCTGTTCCTGTCACAGGTGAAGTG[T/A]AATGAACAACCCAACAGAGTGGAGATCTACGAGAAGACTGTGGAGGTGCTCGAACCCGAAGTCAACAAACTAATGAACTTCATGTACTTTCAGGTAAAGCCTAACACTATTTCCTGCATCAGAATACTGGATATTATAATGTGCATTAATACTTCTGCTTCTCTTTCAGAGGACAGCAATAGATCGCTTTTGTGGTGAAGTGCGTCGTCTCTGTCATGCAGAGCGGAGGAAAGACTTTGTGTCTGAAGCTTATCTGCTCACTCTGGGAAAGTTTATCAACATGTTTGCGGTGCTGGATGAACTTAAGAACATGAAGTGCAGCGTCAAAAATGACCACTCCGCCTACAAGAGGTAAACCACGCACTGCTTTCTGCATTTAGTTCTGTCTCTAATAAGAGGATTCCTCTAGATGGCAGTCATGTTACATCTGGATATTAAAGCAAACATGTTTTAGGTGCTCTGTTGACATTAAATAAACATGCAGAACTATGAAATAATTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10367
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Nonsense 580 1253 16 31
ENSDART00000104233 Nonsense 584 1257 16 31
ENSDART00000122199 None None 476 None 15
ENSDART00000124610 Nonsense 580 1014 16 26
ENSDART00000130905 None None 511 None 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37645902)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37719660
GRCz11 6 37697554
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AACAATGCTGGAGTCTCTGGTCGCAGATAAGAGCGGATCAAAGAAGACCT[T/A]GCGCAGTAGTCTRGAGGGGCCGACCAYTCWKGACATCGAGAAGTTTCATC
Long Flanking Sequence:
TTTTTTTATAGCTACAAATACATATTTGGATAGTTGTTTCCCAAAATGCTATACTGGTCATAATTCTGCCACACTGCAGGACAGTTTGACCCAAACAATGACCTTGTAAATTTGAACACAGTACTGCGCGGACACACATTCACCCACATTTCCAGATGGAATCCAAGGACACAAATACAGACAACCCAACCTTTTTGATGCCTGTCGGAGATGTCTAGGGAAGCTTTGACACCTGTTTGCCCTCCATCAGCATGTTAATGCACTCAGAATAATGCAGAAGAGAACCCCCCCACCTGCGGCGGGATGACCAGTGCAGAATAGGAATGTGAATTTGTCTGTGTCGAGAGCTTTGATAACCATGCATATGTAAAGAACAAACTTTGCATCGGACTTGCTGTCCTTTCATCTGAGTCTTTTTTTCTGTTCCTCTATGTAGCTGTATATGGTCAGAACAATGCTGGAGTCTCTGGTCGCAGATAAGAGCGGATCAAAGAAGACCT[T/A]GCGCAGTAGTCTGGAGGGGCCGACCATTCTGGACATCGAGAAGTTTCATCGCGAATCCTTTTTCTACACTCATCTGCTCAACTTCAGTGGTAAGGAACAGGTTGAACACTTGCCCTCATCATTCTTAGATTTAATCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTACAGCTGTTAAAGATTTTTTTAGGATTAGCATATTATTGTACAACTAGACTTTTTTTTAAAATACCACTATACAATAAATGTGGCCTGAAAGTATGGACAGTTAAGCTACATTTAAATGTCACTGCTTTATGAATGGTAAACGGCATTTATTTATTTTTTGCTAATTAAAGTAGATAGAATTTTCCATACTTAAAAAAAAAGCCTAAAAAAGAATTGCAAAATTTTTTGGATATACCACTTGATTTCAAATTGTATTAATTCCAGACTGTCGGAAAAGTAAGAGAAGTCAATCCAGCAGACTCATTTCAAGCAGAATTTATTTAGACATATTAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa2288
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Nonsense 919 1253 24 31
ENSDART00000104233 Nonsense 923 1257 24 31
ENSDART00000122199 None None 476 None 15
ENSDART00000124610 Nonsense 919 1014 24 26
ENSDART00000130905 None None 511 None 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37663785)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37737543
GRCz11 6 37715437
KASP Assay ID:
554-2555.1 (used for ordering genotyping assays)
KASP Sequence:
ACAGCCTCTACCGCAACTTTGTGGGACCTCCACATATTAAGGCTATTTGC[A/T]GACTTCTGGGATACCAGGGAATCGCTGTGGTGATGGAGGAGCTGTTAAAA
Long Flanking Sequence:
GACACTTCTATACATCTATACAGCTTAAAGTGACATTTAAAGGGTTAACTAGGTTAATTAGGTTGAATAGGCAAGTTAGGGTAATTAGGCAAGTTATTGTATAATGATGGTTTGTTTTGTAGACTATTGGAAAAAAACTGCTTAAAGGGGCTAATCATTTTGCCCTTAAAATGGCTTTTAAAAAAATAAAAACTGATTTTATTTTGGCCGAAATTAAACAAATAAAACTTTCTCCAGAAGAAAAAATATTATCAGACATACTGTGTAAATGTCCCTGGACTGTTAAACATCATTTGGGAAATATTTAAAAAAGAAAAATAAATTCAAAGGGGGGGCTAATAATTCTGACTTTAACTGTATATGAGATTTTATATTTGTTCATAATAAACTGCTTCATTTTCTTGTTTTTCATGATTATTTAGGCCTTGAATTTGGCGTACAGCAGCATATACAGCCTCTACCGCAACTTTGTGGGACCTCCACATATTAAGGCTATTTGC[A/T]GACTTCTGGGATACCAGGGAATCGCTGTGGTGATGGAGGAGCTGTTAAAAGTTGTCAAAAGCCTGGTAAGATTTTTCATATAAATACAGACATTTGAGGATGTTTTAAAGACATGAGCATATAATCGTTTTTATCTACACCAAATTCCTTATTTCACGAATATCAAACCTGTCATTTATAAGAATCTTAACACATTATTATCGTTATTAGAACTAATTATTACACAACTAAAGTTTTCAAGAAGAAAGTCTGTCATTTTCCAGATGTACGGGCACTGGTAAACATTATTGTCTTCTTGTTCAGCTTCAAGGCACCATCCTTCAGTATGTGAAGACATTGATGGAAGTGATGCCCAAGATTTGCCGTCTGCCTCGCCATGAGTATGGCTCACCAGGTGAATAATATACTCCGAAACAATCCTTTTATTTTTTGTTGACCCAAGTGAGCAACTTGACCCTGTGCAAATACCAGCAAGTAGTAGATAAGCACTGAATTATGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45259
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000065127 Essential Splice Site 1014 1253 None 31
ENSDART00000104233 Essential Splice Site 1018 1257 None 31
ENSDART00000122199 None None 476 None 15
ENSDART00000124610 None 1014 1014 None 26
ENSDART00000130905 None None 511 None 15

The following transcripts of ENSDARG00000044345 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 6 (position 37665403)
Other Location(s):
Assembly Chromosome Position
GRCz10 6 37739161
GRCz11 6 37717055
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGAGGTTGGAAACGCATTGCTCTTCTGCCTTCTGACTGAACAGAGCTTGG[T/A]GAGAAAACACAACATCTCCATTCACATGATTGAACTTTAAGGTGATTAAA
Long Flanking Sequence:
CGTGACTCACATTCTTTAATGATTCGTCTGAAAGCCGTCATGATGGCAAACCTTGCATAGAAGAAAGCGGTCAATTTTGACAATTAGCACTTAGTAGGATGAACTAAATTCCGGGTTTTCAAAAGTGTGTGTAGTTTTTGGTGTACAGTAGGCTATCTTTGGGACATCTACGTTGCAAAATGAACCATGTTTAGTTACTTTACTTCTTAATCAAATATTTTCTGGTGATCCTTGGCCAATAAAAGCTGCAAATGAGTTCAGATTTTGTGTTGTAAACTTGAATGTCTGACCACATCCTGATTTTAGACATTGATTTTGGAAATGCTAATCTAGGAGCAGTAAATACAATTTCTGTTTACCGGATGCAGGTATCCTGGAGTTCTTCCACCACCAGCTGAAAGACATTGTGGAGTACGCTGAGCTGAAGACTGTGTGCTTCCAGAACCTGAGGGAGGTTGGAAACGCATTGCTCTTCTGCCTTCTGACTGAACAGAGCTTGG[T/A]GAGAAAACACAACATCTCCATTCACATGATTGAACTTTAAGGTGATTAAAGTGATTGCCTTTAAAGGGGTGGTCCAGAGTGTATTTTTAAGGCTTGGTTGTGTCTATAAGATGCAAAGCAATGTGTGCTCATGCTTCACTTGTAGAAAATCAGTTTTTTCATATATCTTACTTTGATACTACACAGCTACTCTGCTAACATAGAAACGACTATCATATTCCCTAGTTCCTGCGAAAGGCCCACCCTCAAGAGGCTGTGATTGGTCAGCTAACATAATGTGCTGTGATTTGTGGATCGTCTCCATGTCACACCCCTACAAGCATGCACTTTTGCTTCGTGTAAACTGTAAGCCGTATAAGTTTGTGCCTGACTCAAACAGAACATAAAGAGCAGCATTTTCCATTGGTTACATCCTTGTTTATGTTCTCACTACAACATACCCTCAACGCTAGAAACTGTGCACGTAATTGATCAATTTTAACAAAGAAAAACACTTACAG
Associated Phenotype:
Not determined