ZMP
tp53
Ensembl ID:
ZFIN ID:
Description:
Cellular tumor antigen p53 [Source:UniProtKB/Swiss-Prot;Acc:P79734]
Human Orthologue:
TP53
Human Description:
tumor protein p53 [Source:HGNC Symbol;Acc:11998]
Mouse Orthologue:
Trp53
Mouse Description:
transformation related protein 53 Gene [Source:MGI Symbol;Acc:MGI:98834]
Alleles
There are 4 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa20404 | Nonsense | Available for shipment | Available now |
| sa1114 | Essential Splice Site | Available for shipment | Available now |
| hu888 | Essential Splice Site | Confirmed mutation in F2 line | Not yet available |
| sa20405 | Nonsense | Available for shipment | Available now |
Mutation Details
Allele Name:
sa20404
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000051549 | Nonsense | 48 | 374 | 4 | 11 |
| ENSDART00000135934 | Nonsense | 47 | 369 | 4 | 11 |
The following transcripts of ENSDARG00000035559 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 5 (position 25756440)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 5 | 23583705 |
| GRCz11 | 5 | 24087505 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCTGTGTTTGCCAGGAGTACTTGCCGGGATCGTTTGACCCCAATTTTTTT[G/T]AAAATGTGCTTGAAGAACAGCCTCAGCCATCCACTCTCCCACCAACATCC
Long Flanking Sequence:
TATGACTTTCGTGTTTATAATTTCACAGCAATGGCGCAAAACGACAGCCAAGAGTTCGCGGAGCTCTGGGAGAAGAATTTGATGTAAGTTCGCAAGGGTCGCACTCCTGATACACAACGCTCCTCTTTTTCCTGCCTCTCTAAATTTCCCCGTATTTTTGTTAGCAGCCATGTCAGGTTGCTATAATGTACCTGTCTTAATATTTTTGGTGTTTGCTTGTTTAAGATGCATCTGTCGAACGTATTGTTTATCTGGAGTTCTTTGTATGAGCTTCAACAGATTAATACTAATTTCTCTCTCTTCCTTTTCAATTGTCTCAGAAGTATTCAGCCCCCAGGTGGTGGCTCTTGCTGGGACATCATTAATGATGAGGTATTTAAAAAAATAATCTCAAACACCCAGAAATCTCTATTTTCCTCTTTTGGTTTTCAGTGTTGAACTTTTGTTTGTTCTGTGTTTGCCAGGAGTACTTGCCGGGATCGTTTGACCCCAATTTTTTT[G/T]AAAATGTGCTTGAAGAACAGCCTCAGCCATCCACTCTCCCACCAACATCCACTGTTCCGGAGACAAGCGACTATCCCGGCGATCATGGATTTAGGCTCAGGTTCCCGCAGTCTGGCACAGCAAAATCTGTAACTTGCACTGTGAGTCAAAAGCGCATACACACACATACTTTCACAAATTTAATGGAAAGAGACATTTCAGTATAGTTGATCAATCTAGTAATCTTAAATTAAACATTCATAATCCATAATGAAAATATCACAAAACTGTATGTAGAAATCTGTTTGCATATGTGCCATGGTTTGCTCATAATCTGTGTAAATTATTCAGAAATAAAATTAGGGTTAGTGACAAATATGACTGATAATATACTGTATAAGTGTATGTGCAAAGTGGTTATATGATGGTAGTAAGATGGCTAACTTCAGTATGTAGCATATAGTAGTCTAAATGTGGACATGTAGCTGAAGTCATGCAGAGATGCAGGTTGTTCTTACTGG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa1114
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000051549 | Essential Splice Site | 95 | 374 | 5 | 11 |
| ENSDART00000135934 | Essential Splice Site | 94 | 369 | 5 | 11 |
The following transcripts of ENSDARG00000035559 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 5 (position 25759271)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 5 | 23586536 |
| GRCz11 | 5 | 24090336 |
KASP Assay ID:
554-1016.1 (used for ordering genotyping assays)
KASP Sequence:
TTAAGTGCTAAACTATAACAACTGGGTGAAACTTATTTTTTTGTAATTGC[A/T]GTATTCACCGGACCTGAATAAACTCTTCTGTCAGCTGGCAAAAACTTGCC
Long Flanking Sequence:
TATTGATGAGACAAATTTTTATTCACTTTAAAGGGAAAGTTGACAAAAACCTAAAAATGGTTTTACCCAACCGTCACTTACAGTTTAAACTTATTTGAATATCTTCTGTAGACCACAAAAATTAAAATAAATAAATGAATAAATACTGGCCATTGTCATTTTTCGTATTCTTTTACTATGGATATCAGTGGCCACCAATTTTAAACTTTCTTCAAAATATCTATTATGTTAACAAAAAACAGCAACGTTGGAGCCACTTGAGGTTGAGTAAATTTTAATTTTGGGGTGAACTATCTCTTTAAAGCACCAGTACTAAGGAATACCCCAGTCAATAATATCTCATATTTAATCTGCTTTCTCATTAATTTTAGTCATGATTCTTACATTAACTTGTTTAGTTTCTACCGATACTAATAAAAACTGCTTGGATGGATTATTGAACTTTTTTTTTTAAGTGCTAAACTATAACAACTGGGTGAAACTTATTTTTTTGTAATTGC[A/T]GTATTCACCGGACCTGAATAAACTCTTCTGTCAGCTGGCAAAAACTTGCCCCGTTCAAATGGTGGTGGACGTTGCCCCTCCACAGGGCTCCGTGGTTCGAGCCACTGCCATCTATAAGAAGTCCGAGCATGTGGCTGAAGTGGTCCGCAGATGCCCCCATCATGAGCGAACCCCGGATGGAGATAGTACAGACATTTTTTTTTCCATATCCATTCTTGCATCATTCTAGGCCTGCACTATTAATTGATTTTAAACCAAAATGACGATTTGAAAAGGTGTGTTTTTTTTTTGTTGTTTTTTGCCAGAAACTGTGATTATTTTGTTTATTACTATGGCGAGGGAGGCAAGTGTGTGTAATTAAAACGATCCAACTAATGTTAGTTAAAAAGCAAACAACCGTTACAGCAGACCCCCAAACCAATATGTGGAGATGAAATGAAAGCTGCTAACTTCATTTCTGCTCTGCTTCTCTCGTTCACTCTCTTGTTTTGGCTGTTACA
Associated Phenotype:
Normal
| Stage | Entity | Quality | Tag |
|---|---|---|---|
| Larval:Day 5 ZFS:0000037 |
whole organism ZFA:0001094 |
quality PATO:0000001 |
normal PATO:0000461 |
Mutation Details
Allele Name:
hu888
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000051549 | Essential Splice Site | 277 | 374 | 9 | 11 |
| ENSDART00000135934 | None | None | 369 | None | 11 |
The following transcripts of ENSDARG00000035559 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 5 (position 25762707)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 5 | 23589972 |
| GRCz11 | 5 | 24093772 |
KASP Assay ID:
554-0030.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAAAAATATTTTGCCTTATAATAGGAGGGTAATGTGAATCTAACCTGGCA[G/T]GTTTGGTGAAAGAATCTTCTTCAGCTACATTACGACCTGAGGGGAGCAAA
Long Flanking Sequence:
GTCATATGTTGTATTTCCTGTGTGATGTCGCAGGCCAGACATTTGCCTTCTGCAGGCTGGCACTCTTCTGGACTGAATGAAGATAGATCTTCCTCTATATCAGCATCTGCTACAACTTTTTTGGCACTGTTACTCATGTTAAGTGATTTTGCTGTAAACAAAACGGTTCCTGGAGTTCAAAACATCTCTCGTGATTTAACATACCAATCAATTGGACTCATCTCGCATTTGAATCCATTTTCATCTGGCTCATGCTCAATTGTTACATCCTGCTTTTTTGTCCCACAGAGGTCAGTTGCTGGGCCGGAGGTCTTTTGAGGTGCGTGTGTGTGCATGTCCAGGCAGAGACAGGAAAACTGAGGAGAGCAACTTCAAGAAAGACCAAGAGACCAAAACCATGGCCAAAACCACCACTGGGACCAAACGTAGTAAGTTTGCTGCTACACTGCTGAAAAATATTTTGCCTTATAATAGGAGGGTAATGTGAATCTAACCTGGCA[G/T]GTTTGGTGAAAGAATCTTCTTCAGCTACATTACGACCTGAGGGGAGCAAAAAGGCCAAGGGCTCCAGCAGCGATGAGGAGATCTTTACCCTGCAGGTGATTGTCTTATTAATACTATTTTTTAAAACGGTTTAGCAACAAATATGTGTTTAGCCACACATTATTTAAATGCTTTTAAATTTGTTTTGAATAAAATTTATTTGCAGTTTAGACTAGAGCTGCACAATTAATCGAAAAAAAGATCACAATCTCGATTCAGCCCCCTAGGCGATCTTGATCCAGCATTTCTACGATTCTGTCAATAATATTTTCAAGTTCAGGAGAAAAGCAAAGGCCGCACAAGTCTTCATTGTTTTACGTACGTTGTTCAGCAACGTGGACACCCCCAAATGGGTTTGAAAGAGTCACATGCTGTATTTATAAGATATAATCACCTCAATAACCTCAAATATGTAGTTTCTGTCTATATGTAATGATGTATTCACGGCCGCAAAATCACAT
Associated Phenotype:
Normal
| Stage | Entity | Quality | Tag |
|---|---|---|---|
| Larval:Day 5 ZFS:0000037 |
whole organism ZFA:0001094 |
quality PATO:0000001 |
normal PATO:0000461 |
Mutation Details
Allele Name:
sa20405
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000051549 | Nonsense | 339 | 374 | 10 | 11 |
| ENSDART00000135934 | Nonsense | 334 | 369 | 10 | 11 |
The following transcripts of ENSDARG00000035559 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 5 (position 25765573)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 5 | 23592838 |
| GRCz11 | 5 | 24096638 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GACAGTCTGGAGTTAAGTGATGTGGTGCCTGCCTCAGATGCTGAAAAGTA[T/A]CGTCAGAAATTGTAAGTTCTCAATTCCACTGTACAATTTGTGTGTGTGTA
Long Flanking Sequence:
TACACCAGTGGTAAGGTCAGGAGGTGGTATTATTGGACGTATTATAAGAAGTGCATCTGATTGTTTTTGCATGGCACACTCTATGAAGGCTTGTTCTGCAGGACATAATTCCACATTATGCAATACTGTTTTTGCATTAATAAAGATTTTGAGGCTTCACAAAACCTTTGCTGTTAATTAAAAATGCAAATGTATTTATTTATTACCTTCAGTATTTGAGATGACCTAAGAAGTAAATTTAGCAGTTCTAACTTTATTTCTAAGCCAAATTTAAGTTTTCGTTTGTGTTATTGCTCATCCCTGCTCTTACTTTAAACTTGACATTGTGGACTGCAAATATTGTTGGACTTTTAATAAATCCCTAGTGGTTTGTGTACGCATCACCATAACATTTGTTTCTCCATTCAGGTGAGGGGCAGGGAGCGTTATGAAATTTTAAAGAAATTGAACGACAGTCTGGAGTTAAGTGATGTGGTGCCTGCCTCAGATGCTGAAAAGTA[T/A]CGTCAGAAATTGTAAGTTCTCAATTCCACTGTACAATTTGTGTGTGTGTAATCAAACCATTTATCCAATTTATTTAATACAACACCTGTCAGCAGAGCTAATTTGACATTTACAAACTTCACAATTCTTTCATTCTTTTTCTTTCAGCATGACAAAAAACAAAAAAGAGAATCGTGAATCATCTGAGCCCAAACAGGGAAAGAAGCTGATGGTGAAGGACGAAGGAAGAAGCGACTCTGATTAAGGTGATGGGATGCTAAGAGAGAAAGAAACTGGGAGTTTTGCTCTTTTTGGACTGCCTTTTTTGCTTTTATTACACCAAAAAAAAAAGCTTGTCACAGGGGTCATTTGGGGAACTGCGATACATGTGATCCATTAGTCCTGTTTGTCATGTTTCTTCTTGTTCACTCCACTGGGACCTTTGTTGCTGGACACTGATTTTGCAGTGTTTTACCAGCACTGGCGAGGGCTAAGACTAGCCTGACGTTTTACAGACCCGT
Associated Phenotype:
Not determined