Busch Lab

ZMP

apaf1

Ensembl ID:
ENSDARG00000021239
ZFIN ID:
ZDB-GENE-000616-4
Description:
Apoptotic protease-activating factor 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9I9H8]
Human Orthologue:
APAF1
Human Description:
apoptotic peptidase activating factor 1 [Source:HGNC Symbol;Acc:576]
Mouse Orthologue:
Apaf1
Mouse Description:
apoptotic peptidase activating factor 1 Gene [Source:MGI Symbol;Acc:MGI:1306796]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa16025 Nonsense Available for shipment Available now
sa14399 Essential Splice Site Available for shipment Available now
sa10293 Nonsense Available for shipment Available now

Mutation Details

This allele has been removed from public view.

Allele Name:
sa5258
Status:
Allele not cryopreserved
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000019165 Essential Splice Site None 1261 2 27
ENSDART00000113507 Essential Splice Site None 464 2 11
ENSDART00000127261 None None 1264 None 27

The following transcripts of ENSDARG00000021239 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 16913574)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 17856414
GRCz11 4 17845390
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GCCCTTGCATAAGCAAATAAAATGCTTTATTTGTTTATTCTCTCCCACTT[A/T]GTTTCATGCATCCCGCTTCGTTGCACTAAGTAAATCAAAATTAAGTGCAG
Long Flanking Sequence:
TGCAGTTTTGACTTGACTTTAAATTATATTTGATGTTAGAATTGAGACAAAGTCAGACTTCTGTAATGAAATATTGAATATACAGATTGCATTTCAGAACAATGTTGTATCACCCTACAAACTGAAAAAAGTGAAGTTTTAATGTTTTGAGAGTTGGGATTTTTAAAGTTTCTCATTTTGTTTGACGTTTGAGTTTTGCATCTCAGTTTCTTTTCTCTGAATTGAGGCAATTGTCTGAACTGACAAAAAAAATATTGCATGAAACATTTCTTTAGAATTCCAAGTGTCTCAATTCACTCACAGGTTCTTTTGATTCAGTCCCTGCTTCATCAGGGGTCACCACAGCTAAATGAGCTTCCAATGACATAGCAATTCAGATTTTGCTATTTTTATTTTTAGTTCCATAGAAACGTCAGTTCTGCACTGCTCTGAGTTGACAGAAATAATATGGCCCTTGCATAAGCAAATAAAATGCTTTATTTGTTTATTCTCTCCCACTT[A/T]GTTTCATGCATCCCGCTTCGTTGCACTAAGTAAATCAAAATTAAGTGCAGTGTTTCTCAGACGAGCACTGCGGCTTATGTGGAGATGGAGGAACGTGCCCGCAGCCGCCTGCTGCGCTCCAAAGCCACTCTGGAGCAGGACATCAAAGCCTCCTACCTGATGGACCACATGATCAGCGATGGCGTTCTAACCAATGATGAGGAAGCAAAAGTGCTCAGCAAGGTCTCTGATGTTCATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATAATACATATACATACACACGCACACACATTCACACACACGTGTGCATTGTATGTACAAAAATAAATGAATAAAAAATTAAATGTGTATACATGTAAATCTAAGCTGAACTGAAGCAGTTTTAATTCACTAGAACTTCTATATTAAGCTGCTTTGAGACAATCTGCATTGTAAAAGCGCTGTAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16025
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000019165 Nonsense 129 1261 4 27
ENSDART00000113507 Nonsense 129 464 4 11
ENSDART00000127261 Nonsense 130 1264 4 27

The following transcripts of ENSDARG00000021239 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 16914489)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 17857329
GRCz11 4 17846305
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CGATTCTGAGTGTAGGAGGTGTTCCTCAGAGACCTGTGGTGTTCGTGAGT[C/T]GACCTCCACTGCTCAATCTGATCCGGGAGATGCTGTACCRGCTGCGGGAC
Long Flanking Sequence:
TCTAAGCTGAACTGAAGCAGTTTTAATTCACTAGAACTTCTATATTAAGCTGCTTTGAGACAATCTGCATTGTAAAAGCGCTGTAGAAATCAAGATGAATTGAATTAATTTTTGCAAAGCACTAATAAAAAGTGAATATGTGTGAAATTTTCCCATTTTTGTTTCTCCAGGCCACTAGAAAAGAGCAGGCCGTGGCTCTGCTTGAGACCCTGTTGAGGAAAGACAATCGTGCCTACATTTCCTTCTACAACGCCCTGATCAGGGAGAGTTATGGAGATCTGGCCAGTCTCCTTCACAGTGATTTGCCTCTGCTCAGCCCTGAGGGAGAGAAGAGCTTCGCTGATGGAGTCTCTCCCTCTGGTAAAAGCTCAGTTGTGTTTGAACTTGTTTTTTCAAGTGGCTTTATGTGTGAGGTACTAGAGGTTTTCTTTGCTTTGGTTTCAGTCCAGGCGATTCTGAGTGTAGGAGGTGTTCCTCAGAGACCTGTGGTGTTCGTGAGT[C/T]GACCTCCACTGCTCAATCTGATCCGGGAGATGCTGTACCGGCTGCGGGACACACCGGGCTGGGTAACTGTATTTGGCATGGCTGGCTCAGGGAAGTCTGTGATGGCTGCCGAGGTTGTTCGAGATCGTTCACTCATTAAGGGTAATGATGTGTTGTTTATTTACATTTATCCAAACGTTTAGTACATTTTTTTTTTTTTTAAATAAAGATTTTATTCTATTTGTAATTTGTTTTCGGATTTATTTTAATTGAGGTTTTATTGTGTTCATTTTAGTTTGCGTCATGTATTTATATTATTTTATTTTATATTTGGTTGAAATGTTATTTGTTTTATTGTTAAACTAAGGTTTTATTTCAAAGTGTTTTTATTAGTAATTTTTAGTTTGTTTTTTTTCATTTGTTTATTATAGTCTTTTGTATTTTTAATTTTATTTAATGGTTTTTATTTGTAGCTTTAAGTTTAAGAATTATCTCTGTTTTTGTATTTATATTTTACTTAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14399
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000019165 Essential Splice Site 176 1261 5 27
ENSDART00000113507 Essential Splice Site 176 464 5 11
ENSDART00000127261 Essential Splice Site 177 1264 5 27

The following transcripts of ENSDARG00000021239 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 16915194)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 17858034
GRCz11 4 17847010
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AAAATGCACAGAGTACAGTGTACGTGAATGTATTTTTGTCTCTRTTCTCC[A/T]GAGTGTTTTCCTGATGGTGTTCACTGGCTGTCTGTGGGTCAGTGTGAGCG
Long Flanking Sequence:
AAAGATTTTATTCTATTTGTAATTTGTTTTCGGATTTATTTTAATTGAGGTTTTATTGTGTTCATTTTAGTTTGCGTCATGTATTTATATTATTTTATTTTATATTTGGTTGAAATGTTATTTGTTTTATTGTTAAACTAAGGTTTTATTTCAAAGTGTTTTTATTAGTAATTTTTAGTTTGTTTTTTTTCATTTGTTTATTATAGTCTTTTGTATTTTTAATTTTATTTAATGGTTTTTATTTGTAGCTTTAAGTTTAAGAATTATCTCTGTTTTTGTATTTATATTTTACTTATTTTAATTTTGTTGTAGTTACGATTTTTTTGGCTTTGTCTGAATTTGCTTTTATAAAAAAACATTGCATTTAAAAAAAAAAAAAAAAGTTTGAGCAAACATTTTTTAATTTTTTTAAGTTTATTTAATTTTATTCTTTAAGACCAAAGGACTAAAAAAATGCACAGAGTACAGTGTACGTGAATGTATTTTTGTCTCTGTTCTCC[A/T]GAGTGTTTTCCTGATGGTGTTCACTGGCTGTCTGTGGGTCAGTGTGAGCGGGCAGACCTGTTGGTTAGGATGCAGTCTCTGTGCTTTCGTTTGGAGCAGTGTCAAAGTTCAGACACCAGTCAGCGGCCACCCAGCACTGTGGAGGAGGCCAAAGAGCGCCTGCGCTTCCTAATGCTCCGCAGATTCCCCAGGTCAGTTCGCTTGGAAGAACATAGTACATCATGGAATAGTGTTTCCTGGTCCAAGCCTTTATTAATTTAAATAAAAAAAAATTAACTATTAATTAAAAGTAGCTGCTACTGGGTCATAACCGCACATTAAAGTGGATCTTACAAAATCATGGTCTACCTACCGTCTGTGGACTTGCTACACCTCAGAGCTTCATATTTTAACTATTCATCAAAGGTGAATCACTACAGTACCTGAGATTAGGTGTGGATGAAAACATACTTTAAGATCATGACGTTCAATAGTAATACAGAATACTCTGAGCTAAAAAT
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa26275
Status:
Less stringent filtering
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000019165 Essential Splice Site 731 1261 15 27
ENSDART00000113507 None None 464 None 11
ENSDART00000127261 Essential Splice Site 732 1264 15 27

The following transcripts of ENSDARG00000021239 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 16919928)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 17862768
GRCz11 4 17851744
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAGAGTCCTGCTGGCCACCTGCTCAAATGACAAATTCACTAACACCAAGG[T/G]GATGCTTTTTTTTTTTTTGTTTCTTAAATCTTTACTTTAGTAATATTAGA
Long Flanking Sequence:
GTGTCCTGCTGTTCGTTCTGACGCTGTGATTATTACCGTATGCCACTGCCAAATTTGTTTATTTGTTCTGTCTAGGTGTTTAAATCAACCTCTGGAGAGAAGCTTCTGGAGCTTCAGGCTCATGAGGAAGATGTTTTATGCTGTGCCTTTTCCCCTGATGACCGGCATATAGCAACATGTGCCAGTGACAAGAAGGTGAAGGTCAGTGGTGTCCATTTGTGGGTCATTTTTATGTATTTGATTTTTATGAATTAACTTTTTTGAGCATCTGTAATACAGAGCATTTATCGTTTGACATTTATATTTCATGGTGCACTGTCATGCATGATTTTTATTTATGTTTTTGGGTTTTTTTTAGTTGTGGAATGTTGAGCGAGGTGTTCTTATCAGAGAGTTTGAAGTTGAACACGAGGAGCAGATCAACCACTGCCAGTTCACCAACACAGGCCGAAGAGTCCTGCTGGCCACCTGCTCAAATGACAAATTCACTAACACCAAGG[T/G]GATGCTTTTTTTTTTTTTGTTTCTTAAATCTTTACTTTAGTAATATTAGAATAATTAGTTTTTATAATTATAATAATCAAAAGAAATGGTATAAAAAGCATAAGTATCTAACAGTAACAGTAGTAGTATGATGTGGATGTTATTATCAATAATTAATTAATAAATACCTAAAGAAACCTTATTTGTTAGATTTTGTACTGAGTGGTCGTTTTGAAAATTAATAATGAATACTAATTTAATAATAAAATATTCAGTCTTTAAACTAATAATTATTGTTATTATTACATGATGGCTACATTTATGTTGTATGAACAGTAATTGTTTTAACGCTAGTAATTGTGTTTAATTAAAATTGATTCAAAGTCCTGATTTGTTCAATATGTTCAAGTTAATTCAGTAGTGGTATCAGTGAAGGCGTTTTATTTCCCAATATTCATTTTTGGGGAAAAAGTGAAGTTTTTAATTTCTTTTTAGAATCATCGGTACATCATAGCGCAGGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10293
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000019165 Nonsense 886 1261 19 27
ENSDART00000113507 None None 464 None 11
ENSDART00000127261 Nonsense 887 1264 19 27

The following transcripts of ENSDARG00000021239 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 16923329)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 17866169
GRCz11 4 17855145
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AACTTCGAAAGCAGTAAGAAGAAAGCCGAATGCAGTGGTCATCTGAGCTG[G/A]GTTCACTGTGTGCAGTTTTCACCCGACGGCTCACTCCTGCTGTCCTCCTC
Long Flanking Sequence:
GCGTATTTAAAAACCTATTGCTGTATGCCAATAACTGTTCTAAGGTTTTTGAACATAACCAGTGTTTTATTTTAGATTTTATATATATTTTTTAGATTGAATTAATTTAAATAATTTTATTTTATTCATAAATCATGTATAATTTTTTCTAACGCTGTTACACAGTCCCTCTGGGATTTTGGAAGTCCTGTCCTTCTAAGATTAAAAAAATATTTATATGTAGTTTTGTTCTATTTTACAAACTTTTAGTGCTTTCACAGCAAAATACAATAATTGAAGCTAATAAAGCCATAGGTTTTGAAGAAAGTGATCATAAAATCAGTGATTGATTTTATTGTAGGGAAGCCATGTTTTTGTGTTTTTTGTTTTTTTTGTTAACTCTGGTTGAAGTAATTCTGGCTGGCATAAGTGTGGTGAAGTGCTAAGAAGTGTTGTTTATTTCAGCTGTGGAACTTCGAAAGCAGTAAGAAGAAAGCCGAATGCAGTGGTCATCTGAGCTG[G/A]GTTCACTGTGTGCAGTTTTCACCCGACGGCTCACTCCTGCTGTCCTCCTCTGATGATCAGACTATCAGGGTGAGTTGCTTTTACTCCCGTCTTCCCTGCGTTGTGTCAGTTGCATTACAGCGATCTTTTGAACAGCACTGACCTGTGATCATGAAGTGTTGAATGTTATCCAGTTGTGGGAGACGGACCGGGTTCACACTTCTTCTGCTGTGGCTCTGAAGAGGGACACTGATGTGCTGTTCTCTCACAGTGATGCTACGATCATCGCACCCGATAGCAGTAACAGATTACAGGTACTGGACACAAGGGACCAGTGCAATTAGTTGATGTACTGCCATTTTTACTAGGATTTTTTTGCTCATTTGATCTGTTTATTTTTGTTAAGAAATATTAAAATCGGTTCCTTTTTTTTATTTTTTATTTTTTAATGGTTCAATTATTTTACTGCCGTTCTCACATTTTAAAAGCGAGCATTTTAAATTTAACATTAATTCATATCA
Associated Phenotype:
Not determined