Busch Lab

ZMP

sesn1

Ensembl ID:
ENSDARG00000020693
ZFIN ID:
ZDB-GENE-040718-408
Description:
sestrin-1 [Source:RefSeq peptide;Acc:NP_001002660]
Human Orthologue:
SESN1
Human Description:
sestrin 1 [Source:HGNC Symbol;Acc:21595]
Mouse Orthologue:
Sesn1
Mouse Description:
sestrin 1 Gene [Source:MGI Symbol;Acc:MGI:2155278]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa14435 Essential Splice Site Available for shipment Available now
sa23741 Nonsense Available for shipment Available now
sa29391 Nonsense Mutation detected in F1 DNA Not yet available
sa44943 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa14435
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000062993 Essential Splice Site 56 488 2 10
ENSDART00000147448 Essential Splice Site 56 499 2 10
Genomic Location (Zv9):
Chromosome 20 (position 32264383)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 32322623
GRCz11 20 32225502
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TCCCCAGACCAGTGGGAAATGGACCAAGTAGATTTATACCAGAGAAAGAG[G/A]TGAGCGTTAACATCTGCCCCGCTTGCTCAAAGTTAACAKAAATCTGGCAA
Long Flanking Sequence:
ATACCAATGTAATTAATAACAATGTATTTTTTTGCACAATTTCTTGCATATCCCTATCTGATTCAGCAATTTTTCATGTTTATGTCACTGGTGCATTGCAAACTCAGCCAACCTTTGTTCATAAGGTATCTAGGCTGTTTTGAGTCATTCTCTTTGTGTCTTTGACAGTGAGAAGATGAATGATGTTCAAGATGAATGATCATTTGCTACTTATATTATAATGCATTTTTGGTTATGTATTATAAAGGATTTATTTACTACTAAATGCCGTAGAATATTCTAGAACCAGCCGTTGATGTTTGAGCTGAGGAAGGATGTTGTTTTTAAGAGCTCTGGTCTGATGCCAGAAATTCTTCGATACTAGTATAGCTTCATGCCAAGAGCTTCTCTGTGGTTTTCGATCATGTAATCATGTTTTTTTCAATCTTTTCTAGGATGTTGGAGTGCGAATCCCCAGACCAGTGGGAAATGGACCAAGTAGATTTATACCAGAGAAAGAG[G/A]TGAGCGTTAACATCTGCCCCGCTTGCTCAAAGTTAACATAAATCTGGCAACAATCATTTTTAATCAACAAATGGCACCTCTGTTATTTTTAATCGCACAAACAGCATTTATCATACACTTTAGTGAAGTTATTTTACCAGCACTGAATTCCTCAGGTTCACCGCGTCTCTACTCCCCTGTTGTCCCAGATACTTCAAGTCAGTAAATTGGATGAAAGGACACAGTCGATTTTTGAGGATGCCTTTGCAGTGCTTGGTCGCCTCGACAACATCTCCTTGGTCATGGGGTTTCATCCTCAATATCTGGAGAGCTTTCTTAGGACACAACATTACCTCCTTCAGATGGACGGTCCATTGTCTCTGCACTGCAGGCATTATATTGGAATAATGGTGAGGTTGCAGACGGTATTTTTTGTATGAAATTCAAAAACCCCAGTGGTAGCTTGTTCTAAATGCTTGTGTCTGTGTTCAACAGGCTGCTGCTAGGCACCAGTGCACGTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa23741
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000062993 Nonsense 68 488 3 10
ENSDART00000147448 Nonsense 79 499 3 10
Genomic Location (Zv9):
Chromosome 20 (position 32264605)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 32322845
GRCz11 20 32225724
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTCCCCTGTTGTCCCAGATACTTCAAGTCAGTAAATTGGATGAAAGGACA[C/T]AGTCGATTTTTGAGGATGCCTTTGCAGTGCTTGGTCGCCTCGACAACATC
Long Flanking Sequence:
GCATTTTTGGTTATGTATTATAAAGGATTTATTTACTACTAAATGCCGTAGAATATTCTAGAACCAGCCGTTGATGTTTGAGCTGAGGAAGGATGTTGTTTTTAAGAGCTCTGGTCTGATGCCAGAAATTCTTCGATACTAGTATAGCTTCATGCCAAGAGCTTCTCTGTGGTTTTCGATCATGTAATCATGTTTTTTTCAATCTTTTCTAGGATGTTGGAGTGCGAATCCCCAGACCAGTGGGAAATGGACCAAGTAGATTTATACCAGAGAAAGAGGTGAGCGTTAACATCTGCCCCGCTTGCTCAAAGTTAACATAAATCTGGCAACAATCATTTTTAATCAACAAATGGCACCTCTGTTATTTTTAATCGCACAAACAGCATTTATCATACACTTTAGTGAAGTTATTTTACCAGCACTGAATTCCTCAGGTTCACCGCGTCTCTACTCCCCTGTTGTCCCAGATACTTCAAGTCAGTAAATTGGATGAAAGGACA[C/T]AGTCGATTTTTGAGGATGCCTTTGCAGTGCTTGGTCGCCTCGACAACATCTCCTTGGTCATGGGGTTTCATCCTCAATATCTGGAGAGCTTTCTTAGGACACAACATTACCTCCTTCAGATGGACGGTCCATTGTCTCTGCACTGCAGGCATTATATTGGAATAATGGTGAGGTTGCAGACGGTATTTTTTGTATGAAATTCAAAAACCCCAGTGGTAGCTTGTTCTAAATGCTTGTGTCTGTGTTCAACAGGCTGCTGCTAGGCACCAGTGCACGTATCTGGTCAACCTGCACGTGAATGACTTCCTGCAGGTCGGAGGTGATCCGAAGTGGTTGAATGGTCTGGAAGAAGCCCCACGGAAGCTGCAGGCTCTCGGGGAGCTCAATAAGATCCTGGCCCACCGCCCCTGGCTGCTCACCAAAGAACACATTGAGGTATGACTTCAGCCTCACGGTCACTCGTGGAAACTCGCCAACAGTTGTTATGCAACTGTAATGAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa29391
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000062993 Nonsense 145 488 4 10
ENSDART00000147448 Nonsense 156 499 4 10
Genomic Location (Zv9):
Chromosome 20 (position 32264921)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 32323161
GRCz11 20 32226040
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCAGTGCACGTATCTGGTCAACCTGCACGTGAATGACTTCCTGCAGGTC[G/T]GAGGTGATCCGAAGTGGTTGAATGGTCTGGAAGAAGCCCCACGGAAGCTG
Long Flanking Sequence:
ATAAATCTGGCAACAATCATTTTTAATCAACAAATGGCACCTCTGTTATTTTTAATCGCACAAACAGCATTTATCATACACTTTAGTGAAGTTATTTTACCAGCACTGAATTCCTCAGGTTCACCGCGTCTCTACTCCCCTGTTGTCCCAGATACTTCAAGTCAGTAAATTGGATGAAAGGACACAGTCGATTTTTGAGGATGCCTTTGCAGTGCTTGGTCGCCTCGACAACATCTCCTTGGTCATGGGGTTTCATCCTCAATATCTGGAGAGCTTTCTTAGGACACAACATTACCTCCTTCAGATGGACGGTCCATTGTCTCTGCACTGCAGGCATTATATTGGAATAATGGTGAGGTTGCAGACGGTATTTTTTGTATGAAATTCAAAAACCCCAGTGGTAGCTTGTTCTAAATGCTTGTGTCTGTGTTCAACAGGCTGCTGCTAGGCACCAGTGCACGTATCTGGTCAACCTGCACGTGAATGACTTCCTGCAGGTC[G/T]GAGGTGATCCGAAGTGGTTGAATGGTCTGGAAGAAGCCCCACGGAAGCTGCAGGCTCTCGGGGAGCTCAATAAGATCCTGGCCCACCGCCCCTGGCTGCTCACCAAAGAACACATTGAGGTATGACTTCAGCCTCACGGTCACTCGTGGAAACTCGCCAACAGTTGTTATGCAACTGTAATGAGCATCGAGATGTTTTATAATGCTGTTACACGATACTGTGAAGTATGAAAACTGATCAGGTTTCAGTAGATAGGATTTAAACGAGCTTAAATGGGGTTATTTTATTAGCATTTAATGTTTTAGATACATGGTGCTATTAATTCATGATAAACACATGCAGATAGTGATTTGAACGCATCACTTCTGTGATGAGCATGTTCATTTCAGTATAAGTTAAATTTATGTTAATTTAATATTAATTTCTGAATAAAAATGTATTCTGTTTGGTTTTTGGTGAAAAAAAGTTGAGACTTTCACAAAAGAAGTCTCAGTAAAACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa44943
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000062993 Nonsense 323 488 7 10
ENSDART00000147448 Nonsense 334 499 7 10
Genomic Location (Zv9):
Chromosome 20 (position 32266500)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 32324740
GRCz11 20 32227619
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGTTTGCTCAACAGAAGATGAGGAGTGTGTGCCATCCAGAGATGTTTCG[C/T]GACACTTTGAAGACCCTAGTTATGGCTATAAAGACTTCTCCAGGAGAGGA
Long Flanking Sequence:
TCAAATTTCAGTACAACGTACATTACGTTTGTGTTGATCTAGACTCCTGTATGCATGTTTTAGGTGTCAGAATCATCTGGTGAGGTGGAAGTGCTCATGGAGAGGATGAAGCAGCTTCAGGAATGTCGTGATGAAGAAGAAGCCAGCCAGGAGGAAATGGCCACTCGTTTTGAGAGGGAGAAGACGGAGTGTATGCTGGTGGTCACCTCTGGTAAGTAGATGCTTCCACTAAAATGTTTCATATCAGTACGTTAGACATTACTCCAAGCCTGTTTTCCTCATCTATTTATTTGATAAAAAAAACGATAAAATTGTGAAATACAATTAAGATGAAAATGATTAATGTCTATTAATGTATTTAAATCCCAAAGTCGCTCAGAAATCTGAATATGCTGATTTCCTGTTTTATTGGGATTAATTATTACTGGTACTCAATCACAATAAATCATCGTGTTTGCTCAACAGAAGATGAGGAGTGTGTGCCATCCAGAGATGTTTCG[C/T]GACACTTTGAAGACCCTAGTTATGGCTATAAAGACTTCTCCAGGAGAGGAGAACATGTACCAACTCTCAGAGTGCAGGTGAGAGGAAGGGACATCATCTTTGCCTTTGACTACCAAAGAAAAATTAGGATTACATTAACAGCCCTATGTTTTGTGCCCTTAACAGGACTACAGTTGGGAAGATCATGGATTTTCCCTCGTGAATCGGCTGTATTCGGATTTCGGCCAACTTCTGGATGAAAAGTTTCAGATCGCGTTCAATCTGACATACAACACAATGGCAACACATCAGGGTGTGGACACTTCCATGCTCCGCAGAGCCATCTGGAACTACATCCACTGCATGTTCGGGATTCGGTCAGTCATTCTACTGCTCACTGTTTTACAAACGTTTCATAGATTCAGTCATGCTGTAAGAATTACTGTATATATTAGTTACTATATATATTACACAATCATGCTTTAAGAATTACTATATATATATATATATATATATATATA
Associated Phenotype:
Not determined