Busch Lab

ZMP

TYK2

Ensembl ID:
ENSDARG00000020326
Description:
tyrosine kinase 2 [Source:HGNC Symbol;Acc:12440]
Human Orthologue:
TYK2
Human Description:
tyrosine kinase 2 [Source:HGNC Symbol;Acc:12440]
Mouse Orthologue:
Tyk2
Mouse Description:
tyrosine kinase 2 Gene [Source:MGI Symbol;Acc:MGI:1929470]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa31356 Essential Splice Site Available for shipment Available now
sa13280 Essential Splice Site Available for shipment Available now
sa2092 Essential Splice Site F2 line generated Not yet available
sa5732 Essential Splice Site F2 line generated Not yet available

Mutation Details

Allele Name:
sa31356
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000055124 Essential Splice Site 67 1174 2 25
Genomic Location (Zv9):
Chromosome 3 (position 46532054)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 48541607
GRCz11 3 46493941
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AATAAGTAAATAAATAAATAAAGATATCTAAAATGCTTTCTCTTTTCCTC[A/T]GGGATCACTCCAGTCTGTCATGCCTTGTTTGCACTGTATGACCCTGCTTC
Long Flanking Sequence:
TTTTCACATTCATATCCCTTTAAGGACATTGTGACGCTACAATCAAGTTCAGACGCAGTGTTTATTGCAATATAGAATAACTTCCTCAGAATGGGACTTTGTAACTTCACAGCATTCAAGGAAGTGTAAAGTGTTAAAAAGTTTTAAAAGACTGTCCCCCCCCCCCACAGTTTTATTGTAAACACACCTTAATGTCATTGACCCAGGTGCTGGACTCAATGTATGATGTATAGACGAGGACGTTCTAGGAGATCAAAGAAAGCAGGGACGTCCAAAGGACAGAGTGAAGGTCCTGGTGTCCATGTGTTTCTGTTCTGGACCAAAGATGGAGAACGATGCCTGTCTTACAAGAAGGGTGAGGTGACTGCTGAAGATCTCACCACTGAAGCAGCAAAGGCTGTGGGTAGGTTTGGGTGTGGATGCCAGTAAGAGATTTAAAATCAATAAATAAATAAGTAAATAAATAAATAAAGATATCTAAAATGCTTTCTCTTTTCCTC[A/T]GGGATCACTCCAGTCTGTCATGCCTTGTTTGCACTGTATGACCCTGCTTCATTGTGCTGGTACAGTCCAAATCACAACTTTAATGCAGAGAACCAGTCGGGCCTGTTACTGCATTTTCGTTTGAGGTGAGTGTGAAGGCGTGTAGAGATTGTTGGATTGGTATGCGTGCATAAAAGCGTGATGCGACAGTGAAAGAAAGCTGTAATCATCAATGGAAACTCTTTTGTAGATTTTACTTTCATAAGTGGCATGGATTAGGTGAAAATGCACCAGAAGTGGGCCGCTATGCATTACGGACCTCAGCTGGGACACAGCAGGCGACATCTCATTTGCTGGAGCTGAGTGCCCTGGAATACCTGTTTGCTCAGGTGATTTTTTTTTTACAGTCTCTCAAAGTAATTCAAAGAGGTTTCCTGAAACCCTTTAGTTTCATTGCCTTCATTTCTTTGTTGTTTGAAGAGAAAACATTGCAGCGTCTGAACAGGTTCAGGCTATTTAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa13280
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000055124 Essential Splice Site 757 1174 14 25
Genomic Location (Zv9):
Chromosome 3 (position 46562910)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 48572463
GRCz11 3 46524797
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TGTAAAGCTCAGTGACCCAGGCATTTCTCTGTCAGCTCTATCTCAAGGAG[G/A]TAAGCTCGTGTTGTTATTCTCACGTGCTCTAGATCGAATCGAGCACATCC
Long Flanking Sequence:
TGGCGCATCAAGCACCGCCGTCGCCGCGGCATGAATGGCGGTACAAGGAACACATTGAAGTAGTAACATCTGTATGTGGTTAATTTGTGATTAATTTGATTAACCGCCACACTGTGTGACTAATTACATTTAATATTTTAATCGCACAAGCCAAACATGAGCACAACATCTTCTCACTTCTGTAATGTGAAACAATACATTTAATCAGTAAAGTAAACTAATTCACAAATATCTCTGATGTTACATTTTAAAATCAAAAGAATTTCTGATTTTAACACATGTTGTTTACATTAGGAGAACTACATTTAATGTTATTGTCAGCTGCATCATTAAAAACAACTACCATCATATATGTGCTTTGCAGGAGACCAAGCGTTTAGTGCATGGAAATGTCTGTGGCAAGAACATCCTGGTGGTCCGGAAAGGTTTAGAGGAGGGCACGTCTCCTTTTGTAAAGCTCAGTGACCCAGGCATTTCTCTGTCAGCTCTATCTCAAGGAG[G/A]TAAGCTCGTGTTGTTATTCTCACGTGCTCTAGATCGAATCGAGCACATCCTGTACCCCATCTCTGTATCATTTCTCTAGTTACCTCTCTACTATTTACTTCATCAGGTTCTCTCGTGGTTGAGAGAACAGGAAGCCAACCACTTCCTCATAGTGATGTTTGCTTCCTTTAGATCATATTTACAGCAGTGAAGCAGCTGTCCAGAGAACATAAATAATAAATAAGTCATGAATGTTGTGCCGTTCTTTGAGGTCAACCTATAATATTATCAAGGTCTTTACAACAAAAAGATGATAAGCATCTCAATAATAAGCAGTAATAAGCTGTATTATGTCTTCTTTGGACCTCCTCATCAGAATTCATGTTTGAATAGACATAGCAGATTATAGATTTGAAAGTAAACCAATAGTATCTGGATTGGATGCAGACTTGGATTTGCAACCTGAGACTGCATATTTCAGAGATGCAATGTCTGACACAATGCACTCAATGCATCTGGTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa2092
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000055124 Essential Splice Site 892 1174 19 25
ENSDART00000055124 Essential Splice Site 892 1174 19 25
Genomic Location (Zv9):
Chromosome 3 (position 46574847)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 48584400
GRCz11 3 46536734
KASP Assay ID:
554-2623.1 (used for ordering genotyping assays)
KASP Sequence:
AAGCGTCTTCTACAAGCGTTACCTGAGGAAGATTCGGGATCTGGGAGAGG[T/C]CAGTTTACCGCCTGTTCTGCGGTCAGCTCTTACTGTCATTTGTCCGTTTC
Long Flanking Sequence:
TAGATTTTATAAAAAACATACACATCATATTGAAAATATGATATATTTGATATAGTTTTTTCATTAAAAATACAATAATAAATGATAATTTGATAACTATTAGGCATCTGTCAATGAAAATGTCAAATCATATCAAAATTTGATACATTTATGATGCTTTTTTTATTTATCATTATTGACATTTTTGTCCATTTATTGTTGTTTGTTTAGGTCTTTAACTTATAAAACCCTGCAGAAACAACCACAGAACAATGTTTTCCCTTTTAAATCGCACTATAAAATATTTGGATGTCTCCAAGCTTATCAGCCAGCATATTGCCTAAAAAGCAGAGTATTATTTTTCAGTATTGAGCAGAATGTGTGTTGTTTGTGTAACTGATATGTGATTTGTCTTCTTCCAAAAGATCCAGACATTTCATCGGAGTGCGAGTCTCTTCCAGACAAAGACCCAAGCGTCTTCTACAAGCGTTACCTGAGGAAGATTCGGGATCTGGGAGAGG[T/C]CAGTTTACCGCCTGTTCTGCGGTCAGCTCTTACTGTCATTTGTCCGTTTCATCTGATACTCTGCTTTCAGGGTCACTTTGGAAAGGTGATGCTGTACGTCTATGACCCTCACAATGACGGGACGGGCGAGTATGTGGCGGTGAAGGCCTTAAAGCAGGAGGGCGACGGCAGCAGTCTCCATGTTTCCTGGATGAAGGAGATCGAAATCCTCAAATCGCTTTACCACAACAACATTGTCAAATATAAAGGCTGCTGTACTGAAATGGGTAAGAAAAAAAATCTGTGTTGCTGACATTTGTGGGGGTTTTATCTGTAGAGTTGTTTTATGGCTATAGAGAGCAACAGTGCGGTTCTAAAAGTAAAAAAAAAACAACATAATATACACTCACCGGCCTCTTTATTAGGTACACCTGTCCAACTGCTTGTTAACACAACTTTCTAATCAGCAACTCAAAGCATTTAGGCATGTAAACATGCTCAAGACGATCTGCTGCAGTTCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa5732
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000055124 Essential Splice Site 892 1174 19 25
ENSDART00000055124 Essential Splice Site 892 1174 19 25
Genomic Location (Zv9):
Chromosome 3 (position 46574847)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 48584400
GRCz11 3 46536734
KASP Assay ID:
554-2623.1 (used for ordering genotyping assays)
KASP Sequence:
AAGCGTCTTCTACAAGCGTTACCTGAGGAAGATTCGGGATCTGGGAGAGG[T/C]CAGTTTACCGCCTGTTCTGCGGTCAGCTCTTACTGTCATTTGTCCGTTTC
Long Flanking Sequence:
TAGATTTTATAAAAAACATACACATCATATTGAAAATATGATATATTTGATATAGTTTTTTCATTAAAAATACAATAATAAATGATAATTTGATAACTATTAGGCATCTGTCAATGAAAATGTCAAATCATATCAAAATTTGATACATTTATGATGCTTTTTTTATTTATCATTATTGACATTTTTGTCCATTTATTGTTGTTTGTTTAGGTCTTTAACTTATAAAACCCTGCAGAAACAACCACAGAACAATGTTTTCCCTTTTAAATCGCACTATAAAATATTTGGATGTCTCCAAGCTTATCAGCCAGCATATTGCCTAAAAAGCAGAGTATTATTTTTCAGTATTGAGCAGAATGTGTGTTGTTTGTGTAACTGATATGTGATTTGTCTTCTTCCAAAAGATCCAGACATTTCATCGGAGTGCGAGTCTCTTCCAGACAAAGACCCAAGCGTCTTCTACAAGCGTTACCTGAGGAAGATTCGGGATCTGGGAGAGG[T/C]CAGTTTACCGCCTGTTCTGCGGTCAGCTCTTACTGTCATTTGTCCGTTTCATCTGATACTCTGCTTTCAGGGTCACTTTGGAAAGGTGATGCTGTACGTCTATGACCCTCACAATGACGGGACGGGCGAGTATGTGGCGGTGAAGGCCTTAAAGCAGGAGGGCGACGGCAGCAGTCTCCATGTTTCCTGGATGAAGGAGATCGAAATCCTCAAATCGCTTTACCACAACAACATTGTCAAATATAAAGGCTGCTGTACTGAAATGGGTAAGAAAAAAAATCTGTGTTGCTGACATTTGTGGGGGTTTTATCTGTAGAGTTGTTTTATGGCTATAGAGAGCAACAGTGCGGTTCTAAAAGTAAAAAAAAAACAACATAATATACACTCACCGGCCTCTTTATTAGGTACACCTGTCCAACTGCTTGTTAACACAACTTTCTAATCAGCAACTCAAAGCATTTAGGCATGTAAACATGCTCAAGACGATCTGCTGCAGTTCA
Associated Phenotype:
Not determined