Busch Lab

ZMP

msh2

Ensembl ID:
ENSDARG00000018022
ZFIN ID:
ZDB-GENE-040426-2932
Description:
DNA mismatch repair protein Msh2 [Source:RefSeq peptide;Acc:NP_998689]
Human Orthologue:
MSH2
Human Description:
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [Source:HGNC Symbol;Acc:7325]
Mouse Orthologue:
Msh2
Mouse Description:
mutS homolog 2 (E. coli) Gene [Source:MGI Symbol;Acc:MGI:101816]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa31876 Nonsense Available for shipment Available now
hu1886 Essential Splice Site Confirmed mutation in F2 line Not yet available
sa6253 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa22101 Essential Splice Site Available for shipment Available now
sa11438 Nonsense Available for shipment Available now
sa24911 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa31876
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Nonsense 218 936 4 16
Genomic Location (Zv9):
Chromosome 12 (position 26428168)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24800609
GRCz11 12 24921828
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTATAATCATGCTTAATAAATACTTGTGGTTGTTGATGATTCAGGTGGTG[C/T]AGCGTGGTGGCATTCTCCTCACAGACAGGAAGAAGTCAGAGTTCACAACT
Long Flanking Sequence:
TTTGTGTAAACCATGATACACTACAATCTAAATCTATGTTAATAAAAAATAAACATGACTTGAAAAAAAAAAGATTCTTTAAAGTAGAAAGCATTCAATACTAAAAGTGAAGACTATTTTTTATAATGTAATAATGCTACAAGTAATTCAAAAGCTATTTCAAATTTAAAAGTGTTATTTTAAATGTATTGTTTTAAACTGTAGAATGCTGAAAAATATATGAGATTCCCACTGAGCACCAATTTAACATATTACAAGGATTTCTGAGAAATAACTGCTAAGAAAATAGTGTATTAGCGATACCTTACTTATAAGAGGTGAATACTTAGTTTTAATTTAACGATAGAACATTTTACAATGTTTTTAATCAAACAAATAAATACCATTGGCAAGCATAAAAAATAAACATCATAAATCTGAATGTTTTGCATCCTTTGACATGTAGTATATCTATAATCATGCTTAATAAATACTTGTGGTTGTTGATGATTCAGGTGGTG[C/T]AGCGTGGTGGCATTCTCCTCACAGACAGGAAGAAGTCAGAGTTCACAACTAAAGACATTGTGCAGGATCTGAATCGGCTACTGAAGGCCCGTAAAGGAGAGACTGTGTCCAGCGCTGCCCTGCCTGAGATGGAGAAAAAGGTTTGGGGATCTGCCACTAGTGATAGGAGAAACTATGCTTTTCAAAGCTTCAAAACAATTGAATGAAAAGATTTCTTTTTTGAAGCTTTTGAAACATCGTGTCCAAGGGACACCTTGTGGTCATAACATTTAAATGCAGAAAACCCTCAGGCAAAACTTGTTAGTTGACTTTTTCAAACATTGCAAGCTTTTAAATTAAAAGTATAATATATAAATGCACTTAGCCTAAATTTCCCTAATTTCTCTAATTTCATCAAATATTAAGTGTCCTTAATAGTATGTGTACAACCCAACCCGACTATTAACCATTCCTTTTCATTTTACAAATGTCGCATCAAAACATCTACAGAATAATAAAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
hu1886
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Essential Splice Site 314 936 5 16
Genomic Location (Zv9):
Chromosome 12 (position 26427255)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24799696
GRCz11 12 24920915
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGTACATGCGCCTGGATAATGCTGCTGTACAGGCTCTCAATCTCTTTCAG[G/A]TTAGTGCTCATTTAAAAACGAGAAATAGGCCATTTCTTCAGCTAAGGCTA
Long Flanking Sequence:
AATAGTATGTGTACAACCCAACCCGACTATTAACCATTCCTTTTCATTTTACAAATGTCGCATCAAAACATCTACAGAATAATAAAATGGATCAGTGATTAGGTAAAAACTTTCTTAGAACTATATTTCGAAGCTTACCAAAAATTTTAAAACTGTAAAGATGTGACAACCTTTTTTACTGAAATCATGTGATCCTGCAGATTTGCTTTGCTCAGAAACAACTGATTCAATGCTAAAGATTCATTAAGGTTTTGAAGCTTCAGAATGCAGCATTTGCAACCCATTTAAAAATCAGTGTTCAGTTTGAGGGGGTTTTGCCTGGAGATTTAATCATAATATCACCTTTTCAGATTGCAATGTCTTGCTTAGAAGCAGTCATCAAATACCTGGAGCTTCTCGCAGATGAGGCCAATTTTGGGTCTTTCAAGATGACCACCTTTGACCTCAACCAGTACATGCGCCTGGATAATGCTGCTGTACAGGCTCTCAATCTCTTTCAG[G/A]TTAGTGCTCATTTAAAAACGAGAAATAGGCCATTTCTTCAGCTAAGGCTACAATCTATTCTTTGTTTCTGTTATTTTTCAGGGTTCCTCTGATGATGCTACAGGCACTCACTCTCTGGCTGGACTTTTGAACAAATGTCGGACTCCACAAGGACAGCGACTGGTCAACCAATGGATCAAACAGCCTCTCATTGACAAAAACAAGATAGAAGAAAGGTGAGACTTTTGACACAAGCTCGTTTAAGTCTGTATTAATCCATGGTTTATGTAATAGTAATGTCTTTTTAAGACCTCTGTAATATAGTCTTTATATTTAAGTGATATTTCAAATGATTGTGCACAGATACATAAATCAAAATGTTGTTATGCGTGTTATAAATAATGTACTTTTTTCCCATAATGAGACCCTTTATTTTAAAAGTGGATGTCATTTAAAAAGAAATGCGTTTATAACTGAATTTATGTTAATGTAGTCAATATGGCATAAGTTTTGAAATCTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6253
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Essential Splice Site 314 936 5 16
Genomic Location (Zv9):
Chromosome 12 (position 26427254)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24799695
GRCz11 12 24920914
KASP Assay ID:
554-4612.1 (used for ordering genotyping assays)
KASP Sequence:
GTACATGCGCCTGGATAATGCTGCTGTACAGGCTCTCAATCTCTTTCAGG[T/C]TAGTGCTCATTTAAAAACGAGAAATAGGCCATTTCTTCAGCYAAGGCTAC
Long Flanking Sequence:
ATAGTATGTGTACAACCCAACCCGACTATTAACCATTCCTTTTCATTTTACAAATGTCGCATCAAAACATCTACAGAATAATAAAATGGATCAGTGATTAGGTAAAAACTTTCTTAGAACTATATTTCGAAGCTTACCAAAAATTTTAAAACTGTAAAGATGTGACAACCTTTTTTACTGAAATCATGTGATCCTGCAGATTTGCTTTGCTCAGAAACAACTGATTCAATGCTAAAGATTCATTAAGGTTTTGAAGCTTCAGAATGCAGCATTTGCAACCCATTTAAAAATCAGTGTTCAGTTTGAGGGGGTTTTGCCTGGAGATTTAATCATAATATCACCTTTTCAGATTGCAATGTCTTGCTTAGAAGCAGTCATCAAATACCTGGAGCTTCTCGCAGATGAGGCCAATTTTGGGTCTTTCAAGATGACCACCTTTGACCTCAACCAGTACATGCGCCTGGATAATGCTGCTGTACAGGCTCTCAATCTCTTTCAGG[T/C]TAGTGCTCATTTAAAAACGAGAAATAGGCCATTTCTTCAGCTAAGGCTACAATCTATTCTTTGTTTCTGTTATTTTTCAGGGTTCCTCTGATGATGCTACAGGCACTCACTCTCTGGCTGGACTTTTGAACAAATGTCGGACTCCACAAGGACAGCGACTGGTCAACCAATGGATCAAACAGCCTCTCATTGACAAAAACAAGATAGAAGAAAGGTGAGACTTTTGACACAAGCTCGTTTAAGTCTGTATTAATCCATGGTTTATGTAATAGTAATGTCTTTTTAAGACCTCTGTAATATAGTCTTTATATTTAAGTGATATTTCAAATGATTGTGCACAGATACATAAATCAAAATGTTGTTATGCGTGTTATAAATAATGTACTTTTTTCCCATAATGAGACCCTTTATTTTAAAAGTGGATGTCATTTAAAAAGAAATGCGTTTATAACTGAATTTATGTTAATGTAGTCAATATGGCATAAGTTTTGAAATCTGTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22101
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Essential Splice Site 426 936 7 16
Genomic Location (Zv9):
Chromosome 12 (position 26426117)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24798558
GRCz11 12 24919777
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCTGTGGGGCAACTGCCCAATGTGGTGCTGGCACTGGAGAGATACAGTGG[T/C]AAGCAAAACAACAACTTTATCAATAATCGATAACATTAAGCCTGAGAATC
Long Flanking Sequence:
CTCACTGATTCTGACTGGACAACTTTTGTTGCTATTGTTATGCTCAATATACTTGTATATCAGTACGATAATAGTTATATAATTAGTACAATACAATTAGTATAATAATGATTGCAGTGATTTTGATTGTTTACATTTACAATTTCACATTATGGATAGTTTTCTGATCAAACCTCTGAATTGCAATCATAATGAAATCTTTACTTCAGTTTCACAGCATAATTTAAGATATCGTTTTCTCTTTGAATCGAACTTTTGTAACATGCAATGAGACTATACCTTTGCTTGTACATGCTTAGACTGGACCTTGTGGAGACATTTGTGGAGGACTCGGAGCTAAGGAAAAGTTGTCAAGAGGATCTACTTCGTCGCTTTCCTGACTTAAATCGGATGGCAAAGAAGTTCCAGCGTCAGAGCTCCAATTTACAGGACTGTTACCGGGTCTATCAATCTGTGGGGCAACTGCCCAATGTGGTGCTGGCACTGGAGAGATACAGTGG[T/C]AAGCAAAACAACAACTTTATCAATAATCGATAACATTAAGCCTGAGAATCCTTATAGTTTTAAGGTTTAATTCACTCATCAAGGATTCTTTCTTGACTTGTTTGACTTTCTTTCGTTTATTGAACTGAAAGAAAGATATTCTGAAGAATGTTGGAAACAAGCAGCCAATGACGTCCATTGTATCTTTTGTTCCTACTATGAATGTCAATGGCTGTTTTTATCCGATATTCTTCAGAATATCTTGAGGTTGTTTGGTCAGTAGTAAAAAGTAATCTATAAGTTTAAAAAAACGAGTTAACTATTTCCTTTTTGGGTGAACTATCCTTTAAAGCCGGGGTCCAAACTCAGTGTGCGGGAGAGTTTAGCTCCAACTTGCTTCAACACAGCTGCCAGGAAGTTTCTTGTATATCTAGTAAGAGCTTGATTAGCTGGTTGTAGCTAAACTCTCCAGGGCCGAGTGTAAAAAACCCCTGCCTTAAAGAACGATGCTTTTTATGGGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11438
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Nonsense 451 936 8 16
Genomic Location (Zv9):
Chromosome 12 (position 26425110)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24797551
GRCz11 12 24918770
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CAGCATTCATCTCTCCACTAAACGACCTCATCTCAGACTTCTCCAAATTT[C/T]AGGAGATGATTGAAACCACACTKGACATGAACCAGGTCTGCTCTTGTCTT
Long Flanking Sequence:
GAGTGATTTTAATGTGTTAACAGCAATGTAAAGTTACAAATACTCAAATGACTGTAATTGAGTATTTATTTTTCCTCAGGAATTGAAGTTTTAAAAATGTAAAGCGTTAAAAGGGTCCAAGATGATGTCAAATCTTTATGCTCAATGACCCATGATGACTGAAGTTGCCAAATGACCTTAAACAAAAACTACATGCACTACAGAATATTACTTTTTCACACACATGCAAACACATGCATGTAAACACATAAGCCATTCACAGCGTAACACTCACTACTCTTGAGTACTTTTAAAATGGTTACGTTTTACTCATACTTGCGGTATAATTTAAAACAGATAATTTACTTGCGCTACATTTTTGGGCAAGTTATGTTACTTTTACTTGAGTGATTTTTCAGTACTCTTTCCACCACTCTGTGTTAACAGGAAAACATCAGGTCCTCCTGCATGCAGCATTCATCTCTCCACTAAACGACCTCATCTCAGACTTCTCCAAATTT[C/T]AGGAGATGATTGAAACCACACTGGACATGAACCAGGTCTGCTCTTGTCTTCTATCTTAGGGTTTTGCTTCTGTTTACATTTTATTCACTTATACAACAACCATTTGCTTTTATAAAACAAAGAAAACTAGTGTATTGCACTTTCATCTCAGTCTGCATTTCAGTAGAAATGTCATTGAAATACAAACTAAGTCAGAACGAAAAAAGTATTCTGTTTTGTTGGCAGATCATTTAGGGTATTGATAAGGTGTTCCTAAAATTTGCACAACGGACTGACATTTCCACATCCCTAAATAGGACACTGCACAAAATGAAAAGTGATTGGTTCGTTAAACTGTCACTCATGTAGCATCATGGGTGGTCCTTGACCATACATAGCAGACAAATTGTCCAGACTCCAGACCTGATGGCTATAGAAGACTTAAGTGCAGCGTGATAAACAGGCTTTGAGAACAATCTGTTGTCTAATCTTTCTAATACTGTTGTGTTATTGTCCAGGTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24911
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000002465 Essential Splice Site 876 936 15 16
Genomic Location (Zv9):
Chromosome 12 (position 26412924)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 24785365
GRCz11 12 24906584
KASP Assay ID:
554-7300.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTGGGGAGGAAGCAGGACCCAAAGCCAAGAAACGCTGCATGGAGAAACAG[G/A]TGAGAGGTGTTATTGAAAGAAACTTGGCATTTGCTGTGCAGCTCATTGGA
Long Flanking Sequence:
TTGACGGCATAATTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATAAAACCATGTACACATTTATAGACATCAAGCCTTGTGTTACTGTAAGTTTAAAACATTTCCATTTCTCCACCATATCTATAGTAAATAGCCTAAATTGGCAACTTCACTGATTTATGGTTGCAAGGTTTCTAAATATTACGTGATACCTTTTTACCTACGTCTGAAGTGCTTGAAGCGTGACCCGTTTTTTTTTTTTTTTTTTTTTAGCTGTACTGATATATGTGGTTGATTTGACTTAGGTGTGTGTGACCAGAGCTTTGGGATTCATGTGGCGGAGCTTGCTAGCTTCCCCAAACATGTAATTGCAAATGCGCGGGAGAAGGCTTTGGAGCTTGAAGAATTTCAAGACATCTCCAGTGTTGGGGAGGAAGCAGGACCCAAAGCCAAGAAACGCTGCATGGAGAAACAG[G/A]TGAGAGGTGTTATTGAAAGAAACTTGGCATTTGCTGTGCAGCTCATTGGAGTTAATAAACTGATATATGCTGTCTTGTCAATTTACCCACAGGAGGGAGAGAAGATCATTGAGGCTTTTCTGGCTAAGGTTAAATCAATGCCTGTTGATGGGATGTCTGACAAGGCTGTCAAAGAGGAGCTGCGCAAACTCAAGGCAGAGGTCATCAGCCAAAACAATAGCTTCGTCAATGAGATAGTGTCACGCTCTGGCAAGGTCAAACTCAGTTCAGCCTGAGGGTTAGAAGTTCAACGTTTCTGTAAAACTGTTTGTGGCATAATGGAAATGGATACAATCTATAGTAGATTAGAAAAAGGTTCCATTTTAATACTGTCTCTTTGGTTTCAGCTGTTGTTTTTTGGGGGGTTATATTGTAGACCACATTCTTGTGCGTTTTTCAACATAAATCATCCAACAGACTAAATATTTTCTAAATCAGATTTGTGTGTGTGTGTGTGTTGT
Associated Phenotype:
Not determined