Busch Lab

ZMP

msh6

Ensembl ID:
ENSDARG00000011666
ZFIN ID:
ZDB-GENE-020905-3
Description:
DNA mismatch repair protein Msh6 [Source:RefSeq peptide;Acc:NP_878280]
Human Orthologue:
MSH6
Human Description:
mutS homolog 6 (E. coli) [Source:HGNC Symbol;Acc:7329]
Mouse Orthologue:
Msh6
Mouse Description:
mutS homolog 6 (E. coli) Gene [Source:MGI Symbol;Acc:MGI:1343961]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
hu1811 Nonsense Available for shipment Available now
sa12638 Nonsense Available for shipment Available now
sa22382 Nonsense Available for shipment Available now
sa15374 Nonsense Available for shipment Available now
sa15299 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
hu1811
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018840 Nonsense 474 1369 4 10
ENSDART00000143175 None None 109 None 3
ENSDART00000143315 None None 234 None 3
ENSDART00000146105 None None 129 None 4
Genomic Location (Zv9):
Chromosome 13 (position 49394373)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 48075665
GRCz11 13 48366695
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACTCTGGCTTCCCTGAAATCGGCTTCGGCCGCTTCTCAGACGTACTTGTG[C/T]AAAAAGGCTACAAAGTAGCTCGCGTAGAACAGACTGAAACTCCAGATATG
Long Flanking Sequence:
CCACAGAAAAGCCTACTAAATCAAAGAGCAAACCAGAAACTCCAAAGCGAGCGCCTGCAGCTCTGCCATCAGTGTCGACTGATGCCAAATCTCGACTTTCTGCTTTCTCTGCACCAGATAACTTTGATAGTCAGAATAGTGCAAATGGGACCGAGGGCGGATCGACCGTATGGGACCACGAGAAACTGGAGTGGCTGCAGGACGGCAAGAGAAAAGACGCACAGCGTAAACGTCAGTCTGACGAAAACTACGATCCCACAACTCTATATGTGCCCGAAGACTTCCTTAACAGGACGACGCCTGGAATGCGCCGCTGGTGGCAACTTAAATCTGAGATGTTTGATACTGTTCTGTTTTACAAAGTTGGTAAGTTTTATGAACTCTACCACATGGATGCAGTCATTGGCGTCAATGAACTTAATCTTACCTTCATGAAAGGTACCTGGGCCCACTCTGGCTTCCCTGAAATCGGCTTCGGCCGCTTCTCAGACGTACTTGTG[C/T]AAAAAGGCTACAAAGTAGCTCGCGTAGAACAGACTGAAACTCCAGATATGATGGAGGCACGATGCAAGAAACTGGCACGTCCCACTAAATTTGATAAAGTTGTCAAAAGAGAGGTTTGCCGAATTATCACGCGAGGCACTCAAACGTATAGCGTGCTTGATGGCGCCCCTTCTGAAACTCAAAGCAAGTATCTGTTGAGCATTAAAGAAAAGAGTGAAGAGGATAGCACAGGTCATGGTCATATCTACGGAGTTTGTTTCATTGACACATCAGTGGGGCGTTTTCACATCGGTCAATTCCAGGATGACCGACATTGCTCCCGTTTGCGTACTTTAGTGGCACACTATTCCCCTGCTCAAGTTATTTTTGAGAAAGGAAACCCTTCAATTGAGACATTAAAAATCTTTAAGGCCATCGTGGCATCATCTCTACAAGAAGGCCTGAATGCTGGTTCCCAATTTTGGGATGCCCAGAAAACCCTCAAGGTACTTGCAGAGGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12638
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018840 Nonsense 911 1369 4 10
ENSDART00000143175 None None 109 None 3
ENSDART00000143315 None None 234 None 3
ENSDART00000146105 None None 129 None 4
Genomic Location (Zv9):
Chromosome 13 (position 49393062)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 48076976
GRCz11 13 48368006
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TCAAGACTGAAAACGAAGATGGTCTTTTCCCTGACCTTTCTCCAGAGCTC[A/T]AACGTTGGGATACTGCTTTCGACCATCAGAAAGCTCGCACTACAGGTGTC
Long Flanking Sequence:
TCGAAATCCTTCAGAATAGCTCGACTGGAGGTCCTGAGGGAACACTACTTGAACGACTGGACACATGTTGCACTCCTTTTGGCAAGAGGCTGTTGAAACAATGGATTTGTGCCCCTCTTTGTAATCCATCCTCCATTGGTGATCGCTTGGATGCTCTGGAGGACCTAATGGGCGCTCCATCCCAAACATCCGAAGTCACAGACCTGCTCAAGAAGCTTCCAGATTTGGAAAGGCTACTTAGTAAGATCCACAGCATGGGTACTCCTTTAAAAGGACAAGACCATCCGGACTCCAGAGCCATTCTGTACGAAGAGGTAGTTTACAGCAAACGTAAGATTGCAGATTTTCTCGCAGCACTTGAGGGATTTAAAGTTATGAAAGAAATCGTGTCGATCATGGAGCCTGTCGGCGAAGACCTCAAATCCAAACTACTGCGCCAAGTGGTGCTCCTCAAGACTGAAAACGAAGATGGTCTTTTCCCTGACCTTTCTCCAGAGCTC[A/T]AACGTTGGGATACTGCTTTCGACCATCAGAAAGCTCGCACTACAGGTGTCATCACACCAAAAGCTGGCTTCGATCCAGAATACGACCAGGCCTTAAATGGAATAAAAGAGTGCGAGAGAGACCTGCAGGACTACTTGGATCGACAGAAAAAGCGATTGGGCTGTAAGAATCTATCCTACTGGGGAACGGGAAGAAACCGATACCAACTGGAAGTTCCAGAGAGTGTTTCTGAAAGAAGCCTACCGGAGGAGTACGAGGTCAGGTCTACTAAAAAGGGCTGGAAGCGATACTCCACCAAGGATATCGAGCGAATGTTTTCAGAGCTACAGAGCTGGGAAGACAAGAGAGATGCAGCGCTGAAGGACTGCATGAGGAGACTCTTCTACAACTTTGACAAGAATTACAAGGACTGGCAGACGGCTGTGGAGTGCATGGCAGTGCTCGGTAAGAAAAATTGACTACATCTACTTTCAGCTATGTTGCTTGTTTGAAGTTCACCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22382
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018840 Nonsense 938 1369 4 10
ENSDART00000143175 None None 109 None 3
ENSDART00000143315 None None 234 None 3
ENSDART00000146105 None None 129 None 4
Genomic Location (Zv9):
Chromosome 13 (position 49392979)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 48077059
GRCz11 13 48368089
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCTCGCACTACAGGTGTCATCACACCAAAAGCTGGCTTCGATCCAGAATA[C/A]GACCAGGCCTTAAATGGAATAAAAGAGTGCGAGAGAGACCTGCAGGACTA
Long Flanking Sequence:
AAGAGGCTGTTGAAACAATGGATTTGTGCCCCTCTTTGTAATCCATCCTCCATTGGTGATCGCTTGGATGCTCTGGAGGACCTAATGGGCGCTCCATCCCAAACATCCGAAGTCACAGACCTGCTCAAGAAGCTTCCAGATTTGGAAAGGCTACTTAGTAAGATCCACAGCATGGGTACTCCTTTAAAAGGACAAGACCATCCGGACTCCAGAGCCATTCTGTACGAAGAGGTAGTTTACAGCAAACGTAAGATTGCAGATTTTCTCGCAGCACTTGAGGGATTTAAAGTTATGAAAGAAATCGTGTCGATCATGGAGCCTGTCGGCGAAGACCTCAAATCCAAACTACTGCGCCAAGTGGTGCTCCTCAAGACTGAAAACGAAGATGGTCTTTTCCCTGACCTTTCTCCAGAGCTCAAACGTTGGGATACTGCTTTCGACCATCAGAAAGCTCGCACTACAGGTGTCATCACACCAAAAGCTGGCTTCGATCCAGAATA[C/A]GACCAGGCCTTAAATGGAATAAAAGAGTGCGAGAGAGACCTGCAGGACTACTTGGATCGACAGAAAAAGCGATTGGGCTGTAAGAATCTATCCTACTGGGGAACGGGAAGAAACCGATACCAACTGGAAGTTCCAGAGAGTGTTTCTGAAAGAAGCCTACCGGAGGAGTACGAGGTCAGGTCTACTAAAAAGGGCTGGAAGCGATACTCCACCAAGGATATCGAGCGAATGTTTTCAGAGCTACAGAGCTGGGAAGACAAGAGAGATGCAGCGCTGAAGGACTGCATGAGGAGACTCTTCTACAACTTTGACAAGAATTACAAGGACTGGCAGACGGCTGTGGAGTGCATGGCAGTGCTCGGTAAGAAAAATTGACTACATCTACTTTCAGCTATGTTGCTTGTTTGAAGTTCACCCTCAAATGACTAGTTTGATTTATGCTTGATTTTTGATTTTGCGCATGATTTATGCTTAAAGCATCTTAGGTAGGCATGGGCCAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15374
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018840 Nonsense 1004 1369 4 10
ENSDART00000143175 None None 109 None 3
ENSDART00000143315 None None 234 None 3
ENSDART00000146105 None None 129 None 4
Genomic Location (Zv9):
Chromosome 13 (position 49392782)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 48077256
GRCz11 13 48368286
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TGAAAGAAGCCTACCGGARGAGTAYGAGGTCAGGTCTACTAAAAAGGGCT[G/A]GAAGCGATACTCYACCAAGGATATCGAGCGAWTGTTTTCAGAGCTACAGA
Long Flanking Sequence:
CCATCCGGACTCCAGAGCCATTCTGTACGAAGAGGTAGTTTACAGCAAACGTAAGATTGCAGATTTTCTCGCAGCACTTGAGGGATTTAAAGTTATGAAAGAAATCGTGTCGATCATGGAGCCTGTCGGCGAAGACCTCAAATCCAAACTACTGCGCCAAGTGGTGCTCCTCAAGACTGAAAACGAAGATGGTCTTTTCCCTGACCTTTCTCCAGAGCTCAAACGTTGGGATACTGCTTTCGACCATCAGAAAGCTCGCACTACAGGTGTCATCACACCAAAAGCTGGCTTCGATCCAGAATACGACCAGGCCTTAAATGGAATAAAAGAGTGCGAGAGAGACCTGCAGGACTACTTGGATCGACAGAAAAAGCGATTGGGCTGTAAGAATCTATCCTACTGGGGAACGGGAAGAAACCGATACCAACTGGAAGTTCCAGAGAGTGTTTCTGAAAGAAGCCTACCGGAGGAGTACGAGGTCAGGTCTACTAAAAAGGGCT[G/A]GAAGCGATACTCCACCAAGGATATCGAGCGAATGTTTTCAGAGCTACAGAGCTGGGAAGACAAGAGAGATGCAGCGCTGAAGGACTGCATGAGGAGACTCTTCTACAACTTTGACAAGAATTACAAGGACTGGCAGACGGCTGTGGAGTGCATGGCAGTGCTCGGTAAGAAAAATTGACTACATCTACTTTCAGCTATGTTGCTTGTTTGAAGTTCACCCTCAAATGACTAGTTTGATTTATGCTTGATTTTTGATTTTGCGCATGATTTATGCTTAAAGCATCTTAGGTAGGCATGGGCCAGTATAAAATTCTTACGGTATGATAACCTTGGATAAAAATATCACGATATTGTGCTCACTGCTCTAAAATATATTATTTTTAAATGTCCGTGTAAAAAAATAATAAAAATAAAAAGTTTTCCTTTAAACACAATATATTTTATTTTTTGAAAGATTTTAAATATTTTGGAACAGTAAACATGTCAGGCAGAATCATGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15299
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018840 Essential Splice Site 1343 1369 9 10
ENSDART00000143175 None None 109 None 3
ENSDART00000143315 None None 234 None 3
ENSDART00000146105 None None 129 None 4
Genomic Location (Zv9):
Chromosome 13 (position 49385372)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 48084666
GRCz11 13 48375696
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AGAAGGCCCGCGACTTCGAAAGGAGCACCGTATCTCTCCGCATATTCAAG[T/A]ACGTCTCTTYATCAACATGTTTTACATCGTGATCWTTTYATTGCCTTAAA
Long Flanking Sequence:
TAACCGAAAGCGGGGAGTGTCATGGCCCTTTAATAAACATTTACCAGACGCCATATATTAACATAAACGTTGGGGCTGCATCTCACATCACAATACAATCTCATATCCTGATAACATAGTATATTATGGTATAATACCTTGCTGTAAACTCAATCAAATTACAGTTTCACACATTTATAAAAAAATGTACTCAAAAATGATTTAATATGTGATTTAAAACACAGGTCACCAACCTTTTTCCATCCCTGACCTCAGCCTTGCCTATTTATTAAAGCGATGTCCGTGTGTTTTGTTGTCAGGCCTGTATGGTGGAGAATGAGTGTGAAGACCCCAGTCAGGAGACCATCACCTTCCTCTACAAGTTCATCAGAGGAGCGTGTCCTAAAAGCTACGGCTTTAATGCGGCTCGCTTGGCAAACATCCCGGAGGACGTGATCCAGAGCGGACACAAGAAGGCCCGCGACTTCGAAAGGAGCACCGTATCTCTCCGCATATTCAAG[T/A]ACGTCTCTTCATCAACATGTTTTACATCGTGATCATTTTATTGCCTTAAAAAAGACAGCTCACGCCAAAATCTGTAAAACATGTAGGAGTTTCTTCTGTTGAACACTAAAGGAGATATTTTGAGGAATGTTGGAAAGCGATACCCATTGACATCCATAGTAGACAGGAAGAAAATACTATGGGAGTGAATAGGTGCATCCCAAATCGCATACTTATGCACTATTCTACGCCATTTTGTAGTATTAATAGTGTAAGTAAGTAGTGCATTCACACTGAAAATGCTATAAATAATAAGTGCACTTTAATTAAGCTGATGATGCTCCTATTCAACCGTTAAAAAGAAGTGTGTAATGTCGGACACTTCACACACTCAACAGCTAAGGGTGTCACGATCCTCCAAATCCTCGATTCGATTACATTTTCGATTCTAAAGTCACGATTCGATTCGATTATGAATAATTAATTAATTAATGACCAATTAATTATTTGTAGCCTACCGT
Associated Phenotype:
Not determined