Busch Lab

ZMP

iars

Ensembl ID:
ENSDARG00000007955
ZFIN ID:
ZDB-GENE-030131-6325
Description:
isoleucyl-tRNA synthetase, cytoplasmic [Source:RefSeq peptide;Acc:NP_956190]
Human Orthologue:
IARS
Human Description:
isoleucyl-tRNA synthetase [Source:HGNC Symbol;Acc:5330]
Mouse Orthologue:
Iars
Mouse Description:
isoleucine-tRNA synthetase Gene [Source:MGI Symbol;Acc:MGI:2145219]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa27708 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa21826 Nonsense Available for shipment Available now
sa41755 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa27708
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Essential Splice Site None 1270 1 35
Genomic Location (Zv9):
Chromosome 11 (position 1357459)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1365832
GRCz11 11 1392420
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTCAGTTGCATCATTTCCGCTGTCTCTGTTCACCGGCGACGGCCAGCATG[T/C]GAGTGTGATCTGACACTTCATCTTAATATAAAACTTTCTCAAACACACAC
Long Flanking Sequence:
ATCTGTTATCACATGCCTGACAGGACTTTTATTTTTATTTCATTTTAATAACGTCATCATTACCAGTTAAAGGGACAGTACACCCCAAAATAAAATAAAACGCATCATTATTTACTGAACTATTATGTGTTTCTTTCTCCTGTTAAAAGCAAAACAATATTCTAAATAATGCTGGGGAAATCCGTAATTGATATACACATTAGAAACAAAATACTATAAGAGTCATAAGCTCTTTTTCCAGCATTTTTCAATATAACTTGTTTTGTGTTCAACAGAATTAAGAAACTCATAAATATTTACAACCACTCGAGTGTGAGTAAATAATGAGGACATTTTATTTTTTGGATGAACTGTCCCATCATCACTGAAACTAAAATTAAAGAGCGTTCCCCTGTGGCTTTTATTATGTAAACTTTGGCTTGTATTTTGTCCAGTAGCTCAGGCGTTTCAGTCAGTTGCATCATTTCCGCTGTCTCTGTTCACCGGCGACGGCCAGCATG[T/C]GAGTGTGATCTGACACTTCATCTTAATATAAAACTTTCTCAAACACACACATATATAACTTACAGACACACACACATATACACAAACACACACTGCCTGCTCCGTGTCTATAGACTCGCTCATATATAGGCGAACTCGGTGATTAGCGGCTAGCTGAGACTGTAGCTGCTGCTCTATTACTGTAGTCTGATACTGTCTAATAATAAACAGTTATTAATCAGCATATGAGCGTGTATGATTGACACACATCAGTCAGTTTGAGTCTATTAGCCAGTTTGTATTCTGTTTATGCAGCAGAACACAGATATGACAGCACTATGATGTTAGTTCAGTGCTCCAAATATATATATNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTATATATATATATATATATATATATATATATATACATCCATATATATATA
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa27707
Status:
Less stringent filtering
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Essential Splice Site 278 1270 8 35
Genomic Location (Zv9):
Chromosome 11 (position 1348040)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1356413
GRCz11 11 1383001
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGACTCGTCGCTCTCTTCAAGTCTGACTCTGAATACACCATTCTGGAGCG[G/T]TGAGTGCACACACACATGTACAGCGGGGACAATAAGGGTTTTGATAAGTG
Long Flanking Sequence:
CAATCCATCCATCCATCCACCCATCCAATCCATCCCATTCATCAAATCCTTCCCAATCCATCCATCCCATCCCATACGTTCCAGTCCATCTATCCTAATTCACGCCATCCCATCCATCCATCTGTCCATTCATCCATCCAAATCATGTTTCGTATTTTTTGGATGGATGAAAGTATATATTAAAAAAATTACTCCCAACTAAATGTCATATAATCCAAAAAGCAAAACAAACTGGTCTCCAAAATGAGCTCTTCCTCTATGATTAAAGACGCTTGCTTATTATTATATTGCACTCATTACATTCACACCTACAGCTTTAATGTTTGAGGCCGGTTTACATATTATGTTTTATTTTGCTCACCAAGACTGCATTGATTTGATCAAAACACAAATATTGCCGTGTGTTTGTCAGACAACAGCTCACAGAAGATCTACATCATGATGGAGGCCAGACTCGTCGCTCTCTTCAAGTCTGACTCTGAATACACCATTCTGGAGCG[G/T]TGAGTGCACACACACATGTACAGCGGGGACAATAAGGGTTTTGATAAGTGGTTTGTCCCAAAGTTTGCATAATCCTTCCCAATCCATCCATCCCAATCCTCCCCAATATAAACTAAATGTTAGGAAAGTGTGTGCGTGTGTGTGTGTGTGCGTGTGCTTTTTTTGTAAATGTGTGTGTGTGTATGTTAAAGTGAGAGTGTGTGTGGTGTCTTTTAATGTGTGTGTGTTTGTGTGTTTGTGTGTGTGTTTTGTGACCGATTGTGGTGTGTGAAGTGTGTACTGAGCAGTATGTGTGTGCACGCGTTGAAGTGTGTGTGTGTGTATATGTATAATTGAGTGTGCGTCCTTTCAGAAGTGTTTTGTGACTGAGTGTGGTATTTGAAGTGTCCACTGAGCATTGCGTGTGTGTGTTTGTGCGTGCGTTGAAGCATGTGTATGAATGGTTTTTCGTCTGTGTGTGTGGTGTCTTTTAACCTATGTGTTATTTCTGTTTGTGTGTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa21826
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Nonsense 409 1270 13 35
Genomic Location (Zv9):
Chromosome 11 (position 1335417)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1343790
GRCz11 11 1370378
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TAAATATTGAACAACTCGTTGGTTTGCAGGTCGGACACGCCGCTGATCTA[C/A]AAAGCAGTGCCCAGCTGGTTTATAAGGGTGGAGCACATGGTGGAGAAACT
Long Flanking Sequence:
CAATCATCCAGTCGGAGTGTTAGTCTTCAGTTAATGACTCACTGATTCAATCATCCTGTCGGAGTGTGAGTCTTCAGTTAATGACTCACTGATTCAAATGATCCAGTCAAGGTGCGAATCTTCAGTTAATGACTCACTGATTTAATCATCCAGTCGGAGTGCGAGTCTTCAGTTAATGACTCACTGATTCAATCATCCAGTCGGAGTGTGAGTCTTCAGTTAATGACTCACTGATTTAATCATCCAGTCGGAGTGTGAATCTTCAGTTAATGACTCACTGATTCAAATGTTCCAGTCGGAATGTGAATCTTCAGGTAATGACTCACTGATTCAAATGGTCACTAGGGGTCGGCATACTAGAGGTTTCCATGACAATCTTACATTTTGTCATCTGGCACAGTTAGTCCTGCCATGTGATGATATCATAAGTAATTTAATGTTTCAGATGTTTAAATATTGAACAACTCGTTGGTTTGCAGGTCGGACACGCCGCTGATCTA[C/A]AAAGCAGTGCCCAGCTGGTTTATAAGGGTGGAGCACATGGTGGAGAAACTTCTGGACAACAACAGCAAGTGCTACTGGTACTGAGAATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCTGCATGTTGATCAGATGCACATGCTTACAGCTCCTCTATAATCCGTCATCAGATTTGGGTTGGTCTTTTGTCATACATTGTAAAAGGCTATTCAGACTCTTGATGAAGTGTGATATGGTGATCTGCAAAGTAAGAGCTCGTCTTCGTTTCTCAGATGTGGTTTTAAAGTCTGTTGTGTTGGTTCTTAATGGTGCAGTAGGTAAGTTTGACACCCAGTGGTTGAACTAGGTATTGCACTTATGGATCAAAACAAAGGCAATCGCAGGTTGCCAGATTGAGGGCAGAATCAAATGATTTAAACCATGTTCTAAATAAGCTGCTTTTATTAAGAACACGGTTTAAATCATTCGCTCCTGCCCTCAATCTGGCAACCTGCGATT
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa27706
Status:
Less stringent filtering
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Nonsense 819 1270 24 35
Genomic Location (Zv9):
Chromosome 11 (position 1319264)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1327637
GRCz11 11 1354225
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGTGTGTGTGTGTGTGTGTCGCAGGGAGTCTCTGATTGACCAGCGTATT[G/T]AGAGTGCGGTGTCTCGGATGCAGTCGGTCATTGAGTTGGGTCGTGTAATC
Long Flanking Sequence:
GTGTGTGTGTGTGTGTGTGTGTTTCTCTCAGAGGTGACCTGCTGTCACAGACGTGGAGAACATCCAGAGGACACACACACACACACACACACACACTCTCTTCGTCTGATGGAAAAACATCATGTACTGATGCGCTCCCGCTGATAAACGCCTCAGATGGATGTTTTACAGTAGACATGATGTGATGCATGTAGAGTCGGCTCTATATCAATCTCCAAACCGCAGTAAAGCTTAAAAGCCTTCATCACCCCATGACTTATTTTACATGACCCAATCATCTCAGTTCGGGTTTCACTAAGCAGTTAAAAATGTGGCAAAAAACAATGGAAACCTAGGTAATGTCCCCACAATTCACAAAAACCAACATGTGTGTGTGCGTGTGTGTATATATTAGAGAGAGAACGACCTGTTGTAATGGTAGTCGTGTGTCTGTCCTATGACTGTGTTTGTGTGTGTGTGTGTGTGTGTGTCGCAGGGAGTCTCTGATTGACCAGCGTATT[G/T]AGAGTGCGGTGTCTCGGATGCAGTCGGTCATTGAGTTGGGTCGTGTAATCAGAGACAGGAAGACTCTGCCCATCAAGGTGAGTTTCTGCCTGATGATGGAGAGTGTGTGTGTGTTTTACTGCTGCTGATGGAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTCAGTATCCGCTGAAGGAGGTGGTGGTCATCCATCAGGACCCAGAGGCTCTCACTGATATCCAGTCCCTGCAGAACTACATCCTGGAGGTCAGAGACACTTTCTGCACACACATAGGTCCTGTAGACATTTCCTGTAGACTCCTCTCACACACACACTTTCTGGCAATACTTATGTCATACATTTCCCACACACACACTTCCTGCTTACACTTCCCACAGACACTTCCTGCAAACACTTTCTTCCCGTAGACACTTCCCGAACACGTTTCTTGCACACACTTCCTGCACACACTTCCTATTGACACTTCCTGCACACACTTCCTGCACACA
Associated Phenotype:
Not determined

Mutation Details

This allele has been removed from public view.

Allele Name:
sa27705
Status:
Less stringent filtering
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
n/a
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Nonsense 1100 1270 31 35
Genomic Location (Zv9):
Chromosome 11 (position 1306662)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1315035
GRCz11 11 1341623
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCGGCTCGGCGTGTGCGTTTGTGAACCTCAGAGTGTCGCTCAAAGATAAA[C/T]AGCAGGGTACGAGACGCTACACACACACACACACACACACACACACACAC
Long Flanking Sequence:
GTTGCATCTGTGTGTGCATGTCTATATGTATGTGTCTATATGTGTTTGTGCGTATGTGTGTATATGCACATCGGCATGTGTGTGTGTGTGTATGTTTATGTGCCTGCATGTGTGTGTTTTCTCTATGTATGTGTGTACTTATGTGTTTGTGCATGTCTCTATGCATACTTGTGTGCGCGTGCGTGCGTGTGTATGTGTGTAAGTGTAAATTTGTGTGATTTTGTGTGTACTTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGCACATGCATGCGCCTGTATGTTTGTGTATATGTGTGTGTAGATATGTGCATGTGTGTGTTCGTGCATTCATTCATTCATTCATGCGTGCGTTGTCGTGTGTGTGTGTTTCAGCTGAAGGGCTCAGATCTGGAGTTGACTATCGTGCGAGGCTCCTCCTCTTCCTCCGTCTGCAGGGCTCCTGTGAGCGGCTCGGCGTGTGCGTTTGTGAACCTCAGAGTGTCGCTCAAAGATAAA[C/T]AGCAGGGTACGAGACGCTACACACACACACACACACACACACACACACACACACACACACACACACAAACACACACACACACAAACACACCTGCAGGATCTGATCTGCAGCTCATCTTCTGTGTGTTCTGCTGTCAGACGGTGTGGTTCTGCTGGAGAACCCCAAGGGAGACAACAGACTGGACCTGGAGCAGCTGAAGAGGATCTGCTGCAGTGTGTTCGGCCTCAACGGAGCTCCAGTCTCCATATTCAACGGCAAGACAGGTGAGAGCTCCAAATATAACAGTGGAGCCTGTTCACATGTGTGTGTGTGTGTTTCTCCGCAGCAGAAGTTGTCATAGTTGGTGGGAGAGCACAACAGATCATTCATTTACAATCCTATTGCTGAAATAATGACAGAAAAATTTCACAAGGGTCTTATGAAGACTTTCAGAAAGAGGAAAACAATGGTGTAAGACCGATAACTAGGGGTGTAACGGATCACGGTTGATCTGTGATTCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41755
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004423 Essential Splice Site 1143 1270 32 35
Genomic Location (Zv9):
Chromosome 11 (position 1306398)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 1314771
GRCz11 11 1341359
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTGTTCGGCCTCAACGGAGCTCCAGTCTCCATATTCAACGGCAAGACAG[G/A]TGAGAGCTCCAAATATAACAGTGGAGCCTGTTCACATGTGTGTGTGTGTG
Long Flanking Sequence:
GCACATGCATGCGCCTGTATGTTTGTGTATATGTGTGTGTAGATATGTGCATGTGTGTGTTCGTGCATTCATTCATTCATTCATGCGTGCGTTGTCGTGTGTGTGTGTTTCAGCTGAAGGGCTCAGATCTGGAGTTGACTATCGTGCGAGGCTCCTCCTCTTCCTCCGTCTGCAGGGCTCCTGTGAGCGGCTCGGCGTGTGCGTTTGTGAACCTCAGAGTGTCGCTCAAAGATAAACAGCAGGGTACGAGACGCTACACACACACACACACACACACACACACACACACACACACACACACACAAACACACACACACACAAACACACCTGCAGGATCTGATCTGCAGCTCATCTTCTGTGTGTTCTGCTGTCAGACGGTGTGGTTCTGCTGGAGAACCCCAAGGGAGACAACAGACTGGACCTGGAGCAGCTGAAGAGGATCTGCTGCAGTGTGTTCGGCCTCAACGGAGCTCCAGTCTCCATATTCAACGGCAAGACAG[G/A]TGAGAGCTCCAAATATAACAGTGGAGCCTGTTCACATGTGTGTGTGTGTGTTTCTCCGCAGCAGAAGTTGTCATAGTTGGTGGGAGAGCACAACAGATCATTCATTTACAATCCTATTGCTGAAATAATGACAGAAAAATTTCACAAGGGTCTTATGAAGACTTTCAGAAAGAGGAAAACAATGGTGTAAGACCGATAACTAGGGGTGTAACGGATCACGGTTGATCTGTGATTCATATGATTAATACATATTTTTACTTGTAGATTAATCCTAAACTTGTAATGATTGCAGAGAGATCGCCTCCTCTTTTTTTTAAAAGCAGCCAATAGCTGTTTATTTCATCATCGCTCAGCCAGTAAGAGTGCTTGAGCTCAGGTGAATCAAATGTCTTGAAGGGGGCGGGGCATGTCAGACACTAGAGAGCATTTGATTGGTCAGAAGATTTGATGAGACACTAAAGTATGACGTGACATAAATAAAAACCATAGATATATACATT
Associated Phenotype:
Not determined