Busch Lab

ZMP

map2k2a

Ensembl ID:
ENSDARG00000006609
ZFIN ID:
ZDB-GENE-041027-1
Description:
mitogen-activated protein kinase kinase 2a [Source:RefSeq peptide;Acc:NP_001032468]
Human Orthologue:
MAP2K2
Human Description:
mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol;Acc:6842]
Mouse Orthologue:
Map2k2
Mouse Description:
mitogen-activated protein kinase kinase 2 Gene [Source:MGI Symbol;Acc:MGI:1346867]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa37498 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa1721 Nonsense Available for shipment Available now
sa3186 Nonsense F2 line generated Not yet available

Mutation Details

Allele Name:
sa37498
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000010048 Essential Splice Site 28 397 None 11
ENSDART00000129402 Essential Splice Site 28 285 None 8
Genomic Location (Zv9):
Chromosome 22 (position 20723020)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 20377696
GRCz11 22 20402674
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TAACCCCCACTGGAGAGGGACAGTCAACCAACATTGATGCAGCAGCAGAG[T/A]AAGTATTTATTTAGCTATATCAGTGCCTTTATGTACCTGCACACGTCTCA
Long Flanking Sequence:
CCTTTTTTCTTGGGGGAAATTTCAACTTCTGTTTTCGCGGCTCCTCCGAGCCAAACTATTTCGGACAGCGTTTCTCGCCCGGTCCTGAGGCTGTGAACGATAGGCCTAACTTGTCTTTTGCCGCCTTTTGTCTGTGGGAGCGCTCGCGAGTCAGAGGCCGTGCCGGAGAGACATTCCAGCGATGCACGCGCTTAAATAAACTGCATTTCCTGCACTTTTACCTCTGAGCCACTCGCTTTTTCATTTGACACTTTAATTTCACCTGGAGCAGCTTTTGAGAGCATGATTGGGTGTTGAAATTTGGGGCTTGCTAATCTCAGAAACTTCCACTACAAGGGTTTGTGTATCAGTTTGAAGTATTGGATGTCAGTAGAGACAACCTGGTTGCTTTCTTTGAAATTGATAACTTTGCAAGTATGGCACCAAAAAGAAGACCAGTCCCCTTGATTATAACCCCCACTGGAGAGGGACAGTCAACCAACATTGATGCAGCAGCAGAG[T/A]AAGTATTTATTTAGCTATATCAGTGCCTTTATGTACCTGCACACGTCTCACCTGGTCGTCTTTTTGTCTTTAGGGCCAACCTGGAGGCCTTGCAGAGGAAGTTAGGTGAGCTGGATTTGGATGAACAGCAGAGGAAGCGCCTCGAAGCTTTCCTCACCCAGAAAGCCCAGGTGGGCGAGCTCAAGGATGAAGATTTCGAACCCATATGTGAACTTGGCGCTGGTAATGGTGGAGTGGTTCATAAAGTCCGTCACAAACCCTCGAGACTGGTTATGGCCAGGAAGGTAAGCGATAAAGGATCTTATGCACCTGCTAAGGGCTAGGCAATTTGGCAAAATTCATATCATGATCTAATCTCATGTTCTGATAACAATATGCATTATAATATACTACAGTTTCTGTAAATCCAATCAGTTAATAGTTTATACACAACATATATTGACCACACTTAAAGAATTATTTCTTTAAAAGATTATACACGTTTGTAAAGTGCTTACTCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1721
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000010048 Nonsense 91 397 2 11
ENSDART00000129402 Nonsense 91 285 2 8
Genomic Location (Zv9):
Chromosome 22 (position 20722758)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 20377434
GRCz11 22 20402412
KASP Assay ID:
554-1667.1 (used for ordering genotyping assays)
KASP Sequence:
ACTTGGCGCTGGTAATGGTGGAGTSGTTCATAAAGTCCGTCACAAACCCT[C/A]GAGACTGGTTATGGCCAGGAAGGTAAGCGATAAAGGATCTTATGCACCTG
Long Flanking Sequence:
CTGGAGCAGCTTTTGAGAGCATGATTGGGTGTTGAAATTTGGGGCTTGCTAATCTCAGAAACTTCCACTACAAGGGTTTGTGTATCAGTTTGAAGTATTGGATGTCAGTAGAGACAACCTGGTTGCTTTCTTTGAAATTGATAACTTTGCAAGTATGGCACCAAAAAGAAGACCAGTCCCCTTGATTATAACCCCCACTGGAGAGGGACAGTCAACCAACATTGATGCAGCAGCAGAGTAAGTATTTATTTAGCTATATCAGTGCCTTTATGTACCTGCACACGTCTCACCTGGTCGTCTTTTTGTCTTTAGGGCCAACCTGGAGGCCTTGCAGAGGAAGTTAGGTGAGCTGGATTTGGATGAACAGCAGAGGAAGCGCCTCGAAGCTTTCCTCACCCAGAAAGCCCAGGTGGGCGAGCTCAAGGATGAAGATTTCGAACCCATATGTGAACTTGGCGCTGGTAATGGTGGAGTGGTTCATAAAGTCCGTCACAAACCCT[C/A]GAGACTGGTTATGGCCAGGAAGGTAAGCGATAAAGGATCTTATGCACCTGCTAAGGGCTAGGCAATTTGGCAAAATTCATATCATGATCTAATCTCATGTTCTGATAACAATATGCATTATAATATACTACAGTTTCTGTAAATCCAATCAGTTAATAGTTTATACACAACATATATTGACCACACTTAAAGAATTATTTCTTTAAAAGATTATACACGTTTGTAAAGTGCTTACTCTTTTATATGTGATCAAATGTTTGAAATAAAATGTAGAAATATTATTAAGATATAAAGCACTTTTCAAAAACTAATGATTACAAGTCCAACATGAGAATAAATAGAGTAAAATAAAATGCCAAATGTAAACCTTGTACTTTCAAGATTGCAAATTTTTTTTAAAGATGCTGTTATTCATGTTTCTGTCAACATTTTCATAATGGCATGTTAGATTGAGCTTGTATAAATTATTTAATAAAAAGTGTCACCGGCTAGGGCTGTGC
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa3186
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000010048 Nonsense 178 397 5 11
ENSDART00000129402 Nonsense 178 285 5 8
Genomic Location (Zv9):
Chromosome 22 (position 20716796)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 20371472
GRCz11 22 20396450
KASP Assay ID:
554-3174.1 (used for ordering genotyping assays)
KASP Sequence:
CTTCATTGATGATATCYATAACGCTCTCGCTCCACAGGTACTCAGAGGTT[T/A]GGCGTATCTTCGGGAGAAGCACCAAATAATGCACAGAGGTACGCACAAAG
Long Flanking Sequence:
GAAGTAGAGAGGACAACCTGCTCTTCTTGTTCTTGGCTAAAAGCTGAACCCAAAGGATGGTACGTAGACTCCATCGTAACATGTCTGCCGGTATTACACATAGACCACAATATAATAAAGCTGTGAACACACCCATGGATGTGCAAACTCCCTTTTAAGTCAGAGTCAGCAAAACATGCAGGTTTTTCAACACTCGTTTAGCCATTTTCTGCCAAATGAATAGGGTCAAACTAGCGTTTCGCTTTTAATCCTGACAAAGTACAAACACTTGGGCATGAAGACCAAACAAAGGTGCTGAGATCTGTTTATGCATGCGTCCATAATGTTTATTGAATGTGCATTTCATCTTTTGGTAATTAGAAAGCAGAAGTTGTTTTGTAAAGACCAGACCATGTAGCGCATGCTGTAAATTCAGGAAGCCAGATACCACACTAGCCGTTGACAGATAAACTTCATTGATGATATCTATAACGCTCTCGCTCCACAGGTACTCAGAGGTT[T/A]GGCGTATCTTCGGGAGAAGCACCAAATAATGCACAGAGGTACGCACAAAGCAACATTCCTTACTAATATCTTAGGAAACGTACATGTACATACACGCGCTGGAGGGCGGCAGGAAGTAGCCCCCTAATGCAGCCATTGAAATTGCATAAGAAGCTTAAAAATGATTATTATAGAGAGATTAGGCCTCACAAGGTCTTTACTGAAACTAACCAGAGACCTTCATCTCTGCAGTAATTGTTAATCTGAGATTAAACAACACTGTCATTAAAGAAGTTAGGTGTTCCAGTTTACATGTGAAACAACCGTCTTCTACTGTTATTTTTTTTAAATATAACATTATTCATTGAATTAAATATTATCAAAACATTAGGTATTCTTTTTCTAATAAATTTTAAAGGGGTTAACCCAACATACATTTTTTTGTCTTCTGAATTATTGAATTAATATGAATTACTTCTTTTGAACACATTAGTTTAAAAAATTTTTGGAAACAAGTAGCT
Associated Phenotype:
Not determined