Busch Lab

ZMP

tcf7l2

Ensembl ID:
ENSDARG00000004415
ZFIN ID:
ZDB-GENE-991110-8
Description:
transcription factor 7-like 2 [Source:RefSeq peptide;Acc:NP_571334]
Human Orthologue:
TCF7L2
Human Description:
transcription factor 7-like 2 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:11641]
Mouse Orthologue:
Tcf7l2
Mouse Description:
transcription factor 7-like 2, T-cell specific, HMG-box Gene [Source:MGI Symbol;Acc:MGI:1202879]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa35328 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa35327 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa103 Nonsense Available for shipment Available now
sa22132 Nonsense Available for shipment Available now
sa2624 Essential Splice Site F2 line generated Not yet available

Mutation Details

Allele Name:
sa35328
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000005562 Essential Splice Site 161 477 4 15
ENSDART00000009237 None None 438 None 14
ENSDART00000031408 Essential Splice Site 161 610 4 14
ENSDART00000121527 Essential Splice Site 161 597 4 15
ENSDART00000122972 None None 235 None 6
ENSDART00000123318 None None 426 None 13
ENSDART00000125046 Essential Splice Site 161 268 4 7
ENSDART00000128703 Essential Splice Site 145 181 4 5
ENSDART00000133854 None None 118 None 4

The following transcripts of ENSDARG00000004415 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 32758000)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 30955997
GRCz11 12 31070899
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTAGACAAGCACTTAAAGATGCCAGGTCACCTTCTCCAGCACACATCGTT[G/T]TAAGTAACACTCATGAGTCATTGCATTTACAAAGCTCTTTGTTCTACAGC
Long Flanking Sequence:
ACAAAAAAACTCGACACAGAATTGTTAAAAACCTACTGCCAGCTAGCGTTTTGGAAGGGTTACTGCAGAGCAACACCAAAGTATAAATGCAGAAGTATAAATGCACGACTATGTACAAGGCTGGCGCCGTGGATCACGTTGATCACTCGATGCAGAAGTATAAACAGCCTTAAGATGTCAATTAATCATTAGTTTCAACTGTCAAGGATTTCCACCTCATGCATCATTCGACCTCAGATCTTTTTGACATAATTTATTTTTGTTTACTTTTTTTTTTCATGTCACAGTCACTTTTTATTTGGGATATTTTAGCTCTTATGTTGTGTTTCCCTTTGTTTTCTGCATTATTAACATGTTTTTCTTTTGTTTTTCTCCATTCTTTTCTTTCTGCCATCCAGTATCTACAGATGAAATGGCCCCTGCTAGATGTTCAAGCAGGAAGTCTTCAGAGTAGACAAGCACTTAAAGATGCCAGGTCACCTTCTCCAGCACACATCGTT[G/T]TAAGTAACACTCATGAGTCATTGCATTTACAAAGCTCTTTGTTCTACAGCACAGTCCATGAAAATTTCCTGTATCCTGTGTATTTGGTGCTTTGGGACCTTACGCTCCTCTCCTAACTCACAGCTGTCAATGGGATGACCTATAAGTAACTGTAAATCCGATTGCGTTGGAAAATTATATGTCATATGGGCGCTTTTGTTTTTTAATATGGCTTTTTTATGGAAACAAGAGGGTGAGATATCCACATGTGTAGCTCAGAAGAGTTTTCTCCCCAATTCTTATGCTGTAAAGTGGCAGAGGACAAACCATCCTTACAGTGGAGACGGATAATTAACACCCATGCTAAGCTTGGTTCAGGGAATGAGTGTGTGGAGTAGGGATGCTATGTTTATTTTGTTTTATGTGCTGGATCCGCTGGTGCTGTTATACATGTGTTTAACGCTAAATTTATCACTCTTCAAGGTTAGCCATGCTTCTGGGCAGAAATAATGTTACAGTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa35327
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000005562 Essential Splice Site 162 477 5 15
ENSDART00000009237 Essential Splice Site 128 438 4 14
ENSDART00000031408 Essential Splice Site 162 610 5 14
ENSDART00000121527 Essential Splice Site 162 597 5 15
ENSDART00000122972 Essential Splice Site 128 235 4 6
ENSDART00000123318 Essential Splice Site 128 426 4 13
ENSDART00000125046 Essential Splice Site 162 268 5 7
ENSDART00000128703 None None 181 None 5
ENSDART00000133854 Essential Splice Site 11 118 2 4

The following transcripts of ENSDARG00000004415 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 32691226)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 30889223
GRCz11 12 31004125
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTCTTGTTCTTCTTCCCACCCCCTTCCCTCTCTTTTTCTGTTTCTTGCTA[G/A]TCTAATAAGGTCCCCGTGGTACAGCACCCTCACCATGTGCACCCGCTCAC
Long Flanking Sequence:
TAGGTAATTGAAAATGGGGCCTGTGCCACTTAAGAACACAAAGAGCAGATTACATAGCTAAAACCAATTTGACCAAAATGCAGAAATGGATTTTCTCTCTTCCCTCCCACCCCTCCTCTCTTATCTTTTATAATGCAAACCCTTTCCAAAAGCAGACCCTGAAGGAAGAGGAAGGGGTGCGAGAACGAGACATGGGTAACCCAGAGAAAAAGGAGGGAGTGTGCTTAGATTGACTGTCATTTGGTTCATTAGGTGGTTTCTGTGGTTGCAAACGTGAAACACAATGAAATCAAGCACTGTGCGGATCCAATGACTGTTTGAATCAATGTAAACTGTTTTTAATTACAAACCACATTGTTCTGAGAATCGGCCTGTGGTTTGTGATGAATGCATAGTTGAAATAGAGGCGCCGGTGTTGCCCCAACCCAAACATATATTAACAGCCTCTTCTTCTTGTTCTTCTTCCCACCCCCTTCCCTCTCTTTTTCTGTTTCTTGCTA[G/A]TCTAATAAGGTCCCCGTGGTACAGCACCCTCACCATGTGCACCCGCTCACACCTCTGATCACCTACAGCAATGAGCACTTCACGCCTGGGAACCCCCCTCCACATCTACAGGCAGACGTGGACCCCAAAACAGGTACATATGCATGCACGTCTTCCTTTACATTCATGAATTTCAAAACAGGCAGGACGAAACCCAAGGCTAACCTTCAGGCCTGGCTAACTAACGGCTACAGTGTGTGATCTCGCTTGTAGCACTGCATTCATAGCTACCTGGCAAGATGCACTGAAGCGTTTCAGAGTCGTCTTGGCTCAGGGCCAAGGTTGCGCCCCTCCTTTTGTGTGCATGTTGAGATGGAGCTGTTGACCTGGGTCGGTTAAGCCTGTGGAGCCACTTGACTCATGGGAGATGTAGACAGGGACTTCTGTTATTTAACTGCCAGATACCAAAACCGCTGTTTGTTTTTATTCTAAAGCGTGATAACATTAGCAATTTCAGCAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa103
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000005562 Nonsense 376 477 10 15
ENSDART00000009237 Nonsense 337 438 9 14
ENSDART00000031408 Nonsense 376 610 10 14
ENSDART00000121527 Nonsense 376 597 10 15
ENSDART00000122972 None None 235 None 6
ENSDART00000123318 Nonsense 337 426 9 13
ENSDART00000125046 None None 268 None 7
ENSDART00000128703 None None 181 None 5
ENSDART00000133854 None None 118 None 4

The following transcripts of ENSDARG00000004415 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 32676376)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 30874373
GRCz11 12 30989275
KASP Assay ID:
554-0075.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATTTGATGGATGTCTGTGTGTTTCTCTGTGTACAGTGGCACGCTCTGTCA[C/T]GAGAGGAGCAGGCCAAATACTACGAATTAGCCAGGAAAGAACGACAGCTT
Long Flanking Sequence:
CCTCCTTCTCATTTGCAGGAAACATCAGGATGCGAAAAAGGAGGAGGAAAAGAAGAAGCAGCCGCACATAAAGAAACCTCTGAACGCGTTCATGCTTTATATGAAGGAAATGAGAGCCAAAGTGGTGGCGGAGTGCACACTGAAAGAGAGCGCAGCTATCAACCAGATCCTAGGCCGAAGGGTGAGTGTCACACACTACTGGGCCAAACTACTGTAGCAGAAGGCCATCTCATACTTCTAAGACCACAGATTGCTGTATACCCCAGATCAAGAGGACATTTTTTAACTCATGGTGGTTGGAAACCCCAAGTTCACTCAACAATTAAAATTTACTCACTATTTACTCTCCCTCAAGTGGTTCCAAACATTTATATATTTCTTTTTCTCTCAGACTTTTCATTTTTGAGTGAACTATCCCTTTAAATATCAATATCTCTGTAATGGCTGTGGATTTGATGGATGTCTGTGTGTTTCTCTGTGTACAGTGGCACGCTCTGTCA[C/T]GAGAGGAGCAGGCCAAATACTACGAATTAGCCAGGAAAGAACGACAGCTTCACATGCAGCTGTACCCCGGCTGGTCGGCACGAGACAACTATGTAAGTTTTTAAGTTTTCAACATGTAACAATCTGGATTCCTTCCCTAGGGGGTCACATTTAAGCCCATGCAGATGCGTATACAAATCATGACAAACAGCCTTAGGAGGAAGCTAAAGCACATGTGGCTGGCTGTTCTTGACCGGTTTAGCTGCTGGAAGACAAAATTTTCCGTCAGTTGACTGTACATGCGCTTTCCCTCAGATCTGTGCTGTGCGATTTTCCTCTGCTTTCATTAGTATTCCACTGGTTCACCTAAAAAGAGAAAGGCGAGCTGAGATCAGAGTAATTAAATAACCACAGGGCCTAAACGCCTCGTAGCTTTGATGAAAGAGGACATCGCTCTCCGCCGGCAGAAATGTGGAATGAGCGCACCGTTTACTGTTTCGCTGGAGTTTTGCGCCTGACAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22132
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000005562 Nonsense 400 477 10 15
ENSDART00000009237 Nonsense 361 438 9 14
ENSDART00000031408 Nonsense 400 610 10 14
ENSDART00000121527 Nonsense 400 597 10 15
ENSDART00000122972 None None 235 None 6
ENSDART00000123318 Nonsense 361 426 9 13
ENSDART00000125046 None None 268 None 7
ENSDART00000128703 None None 181 None 5
ENSDART00000133854 None None 118 None 4

The following transcripts of ENSDARG00000004415 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 32676302)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 30874299
GRCz11 12 30989201
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAATTAGCCAGGAAAGAACGACAGCTTCACATGCAGCTGTACCCCGGCTG[G/A]TCGGCACGAGACAACTATGTAAGTTTTTAAGTTTTCAACATGTAACAATC
Long Flanking Sequence:
AACCTCTGAACGCGTTCATGCTTTATATGAAGGAAATGAGAGCCAAAGTGGTGGCGGAGTGCACACTGAAAGAGAGCGCAGCTATCAACCAGATCCTAGGCCGAAGGGTGAGTGTCACACACTACTGGGCCAAACTACTGTAGCAGAAGGCCATCTCATACTTCTAAGACCACAGATTGCTGTATACCCCAGATCAAGAGGACATTTTTTAACTCATGGTGGTTGGAAACCCCAAGTTCACTCAACAATTAAAATTTACTCACTATTTACTCTCCCTCAAGTGGTTCCAAACATTTATATATTTCTTTTTCTCTCAGACTTTTCATTTTTGAGTGAACTATCCCTTTAAATATCAATATCTCTGTAATGGCTGTGGATTTGATGGATGTCTGTGTGTTTCTCTGTGTACAGTGGCACGCTCTGTCACGAGAGGAGCAGGCCAAATACTACGAATTAGCCAGGAAAGAACGACAGCTTCACATGCAGCTGTACCCCGGCTG[G/A]TCGGCACGAGACAACTATGTAAGTTTTTAAGTTTTCAACATGTAACAATCTGGATTCCTTCCCTAGGGGGTCACATTTAAGCCCATGCAGATGCGTATACAAATCATGACAAACAGCCTTAGGAGGAAGCTAAAGCACATGTGGCTGGCTGTTCTTGACCGGTTTAGCTGCTGGAAGACAAAATTTTCCGTCAGTTGACTGTACATGCGCTTTCCCTCAGATCTGTGCTGTGCGATTTTCCTCTGCTTTCATTAGTATTCCACTGGTTCACCTAAAAAGAGAAAGGCGAGCTGAGATCAGAGTAATTAAATAACCACAGGGCCTAAACGCCTCGTAGCTTTGATGAAAGAGGACATCGCTCTCCGCCGGCAGAAATGTGGAATGAGCGCACCGTTTACTGTTTCGCTGGAGTTTTGCGCCTGACAAACGGCCCCACCGCCCAGCCTGTCAACTCTCCTTGGAGTCTGACCACGTGTCTTGACTCTCCTAGTCAAAGTTCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa2624
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000005562 Essential Splice Site 422 477 11 15
ENSDART00000009237 Essential Splice Site 383 438 10 14
ENSDART00000031408 Essential Splice Site 422 610 11 14
ENSDART00000121527 Essential Splice Site 422 597 11 15
ENSDART00000122972 None None 235 None 6
ENSDART00000123318 Essential Splice Site 383 426 10 13
ENSDART00000125046 None None 268 None 7
ENSDART00000128703 None None 181 None 5
ENSDART00000133854 None None 118 None 4

The following transcripts of ENSDARG00000004415 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 12 (position 32675341)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 30873338
GRCz11 12 30988240
KASP Assay ID:
554-2443.1 (used for ordering genotyping assays)
KASP Sequence:
GGGGAAAAAGAAGAAGAGAAAAAGGGAAAAGCAGGCAGGAGAGGGCAATG[G/A]TAAGTGTGCTGCAATTATCTCTCATATTAAAGCAGACCCATCATCTGTCA
Long Flanking Sequence:
GAGTCTGACCACGTGTCTTGACTCTCCTAGTCAAAGTTCCTCAAACGGAGCAAGCTGATCGCTCTGCTCGGACTTGACCTCGGCCTCGGCGCAATCAGCATCGTTTTCGAGAAAGGACTAACGCAACAGAAGTTCTCCTTCTCCGCTCTCCCCCCTCCAGTAAACCGAGCTGTTCAAAGAAACCTCAAGAGCTTCCAATCGTTTCACAAAGAAAGGAAAACTAAGCAGCGAGACAACAAGGAATAAACAAAAGAAGAGAAATAGGACGAAGGGAAAGATAGGGAAAGTTCTGTTCTGTCCTGCAGTGGCAGCTCGAACCTTCAGGCTGTTGCATGAATAAATAAATCAGTAAAAACATTGGGCTCTCTTGTTCATTTCATGTCTTGGTCTTTTTTGCAGTATAATAACTAATGTTCCTGTCTATTTCTCTTTTCTGGCGGGTAACTATCAGGGGAAAAAGAAGAAGAGAAAAAGGGAAAAGCAGGCAGGAGAGGGCAATG[G/A]TAAGTGTGCTGCAATTATCTCTCATATTAAAGCAGACCCATCATCTGTCACAAGTGTGACATCTCAAAGATGAAAGTCCAGCCTTTTTTTTTTAATCTCTTTTTTGTGCCTGCCTCATTTTGTATATAGCTATGCTACCCAATGCAATATTTACACGATAGACTGCTTGTTATCCCCTTCCCCTCCCCTTGCCCCATGTCGAGCATTAATAACATTGAATATGCATGACCCCCCACCTCCTCCCCTCCCACCAGCTGGCCCCCCCACCCCTTTGCCCTGCCCCCCTCCAGCATTTATTGTACTGTGATATGTATGTTTTGAGAGTGTGAGCGTTAATCACACTTGTGACTGATTGCCAGCCTCTGAATGTGCCGCCCATGCTTGTGTCACTGTGCTTATGTGGTCGTAACTTTGGGCCGTGCCTGCTGCATGCTCTGATACATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTATATAGTGATAATATGTATAA
Associated Phenotype:
Not determined