Busch Lab

ZMP

meis1

Ensembl ID:
ENSDARG00000012078
ZFIN ID:
ZDB-GENE-020122-1
Description:
homeobox protein Meis1 [Source:RefSeq peptide;Acc:NP_571968]
Human Orthologue:
MEIS1
Human Description:
Meis homeobox 1 [Source:HGNC Symbol;Acc:7000]
Mouse Orthologue:
Meis1
Mouse Description:
Meis homeobox 1 Gene [Source:MGI Symbol;Acc:MGI:104717]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa9839 Nonsense Available for shipment Available now
sa19051 Nonsense Mutation detected in F1 DNA Not yet available
sa35409 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa9839
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000102576 Nonsense 91 388 3 13
ENSDART00000125383 Nonsense 91 463 2 11
ENSDART00000102576 Nonsense 91 388 3 13
ENSDART00000125383 Nonsense 91 463 2 11

The following transcripts of ENSDARG00000012078 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 5242785)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 5437563
GRCz11 13 5566149
KASP Assay ID:
2260-5983.1 (used for ordering genotyping assays)
KASP Sequence:
TCTTTTATTCCAGGCACCCCTTGTTCCCTCTTCTWGCACTGATTTTTGAG[A/T]AATGTGAATTAGCCACTTGCACACCTAGAGAACCCGGTGTTGCTGGGGGC
Long Flanking Sequence:
ATCTAGGTCCACTATTTGAACCATGGTTAAATTGCACGCTTGGCCTAGACTCAACTTGAGCATTTTAGGTGCTCTGACCTTGTAGTCCGCAGTTCATATTGACCGCTGTCTTTGATAATACGTTTAGGAATTCAAGTTGCAAGTGATTTGATACAGTGTACGCACAAGTAACAAGCTTGTTATAATTAATGTCACAACTAAATTATCAACACGAGCATATACGTGTAAACAAGCAATTGCTATCAACGTGGCGCAAGGGTACGCAAGTGTTTTTTTTTTTTTTTGTTTACTGACATAAATCATATTTAGTTTATGAAATCTTAACTTTTCAATTACAAATCAGATTGCAGTAAAGGTTTCAGAACTGACCCCTTTTACAATTAGAATGAGTTGTGAAGTGTTATTAAAAGTTATGTTAATCCAGAGTTTCCCTCAAACTGACCTCTATACTCTTTTATTCCAGGCACCCCTTGTTCCCTCTTCTAGCACTGATTTTTGAG[A/T]AATGTGAATTAGCCACTTGCACACCTAGAGAACCCGGTGTTGCTGGGGGCGATGTGTGTTCATCAGAGTCTTTCAATGAGGATATAGCAGTGTTTGCAAAACAGGTCAGAAACTGATTTATTCCGCAAAAAGTTTTTGCACATTTTTACTGTTGCGTTTACATACTCTTTGTAACTGGAAATCTTTATAGCCTACATGTGTTAAAAAAACAATGTTTGAGCAACGCATTTAAATAGATTTTGTGTTTTTTTTAAGAACTATTTTTTTTTCTCACAATTTTTAATTATTTACATGCATATCGTCTCAGATTCGAGCAGAAAAGCCGCTATTTTCGTCAAATCCTGAGCTGGATAATTTGGTGAGTGTATTATTATATTTACAATTATTAGCATTGCTATTATTTTGCCTGTTAAAGTTCCAATCTAAAACTTATTTTAATTATTTAAATATCCAAAAAGTTTTCTTTACACAAAATAGTTTGATTATTTTTGTTTTTGACA
Associated Phenotype:
This allele has been associated with this phenotype by genetic linkage analysis and may not be causal.
See FAQs for more info.
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 eye
ZFA:0000107		 quality
PATO:0000001		 normal
PATO:0000461
Larval:Day 5
ZFS:0000037		 heart
ZFA:0000114		 quality
PATO:0000001		 normal
PATO:0000461
Larval:Day 5
ZFS:0000037		 mandibular arch skeleton
ZFA:0001227		 quality
PATO:0000001		 normal
PATO:0000461
Larval:Day 5
ZFS:0000037		 swim bladder
ZFA:0000076		 aplastic
PATO:0001483		 abnormal
PATO:0000460

Mutation Details

Allele Name:
sa19051
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000102576 Nonsense 91 388 3 13
ENSDART00000125383 Nonsense 91 463 2 11
ENSDART00000102576 Nonsense 91 388 3 13
ENSDART00000125383 Nonsense 91 463 2 11

The following transcripts of ENSDARG00000012078 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 5242785)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 5437563
GRCz11 13 5566149
KASP Assay ID:
2260-5983.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCTTTTATTCCAGGCACCCCTTGTTCCCTCTTCTAGCACTGATTTTTGAG[A/T]AATGTGAATTAGCCACTTGCACACCTAGAGAACCCGGTGTTGCTGGGGGC
Long Flanking Sequence:
ATCTAGGTCCACTATTTGAACCATGGTTAAATTGCACGCTTGGCCTAGACTCAACTTGAGCATTTTAGGTGCTCTGACCTTGTAGTCCGCAGTTCATATTGACCGCTGTCTTTGATAATACGTTTAGGAATTCAAGTTGCAAGTGATTTGATACAGTGTACGCACAAGTAACAAGCTTGTTATAATTAATGTCACAACTAAATTATCAACACGAGCATATACGTGTAAACAAGCAATTGCTATCAACGTGGCGCAAGGGTACGCAAGTGTTTTTTTTTTTTTTTGTTTACTGACATAAATCATATTTAGTTTATGAAATCTTAACTTTTCAATTACAAATCAGATTGCAGTAAAGGTTTCAGAACTGACCCCTTTTACAATTAGAATGAGTTGTGAAGTGTTATTAAAAGTTATGTTAATCCAGAGTTTCCCTCAAACTGACCTCTATACTCTTTTATTCCAGGCACCCCTTGTTCCCTCTTCTAGCACTGATTTTTGAG[A/T]AATGTGAATTAGCCACTTGCACACCTAGAGAACCCGGTGTTGCTGGGGGCGATGTGTGTTCATCAGAGTCTTTCAATGAGGATATAGCAGTGTTTGCAAAACAGGTCAGAAACTGATTTATTCCGCAAAAAGTTTTTGCACATTTTTACTGTTGCGTTTACATACTCTTTGTAACTGGAAATCTTTATAGCCTACATGTGTTAAAAAAACAATGTTTGAGCAACGCATTTAAATAGATTTTGTGTTTTTTTTAAGAACTATTTTTTTTTCTCACAATTTTTAATTATTTACATGCATATCGTCTCAGATTCGAGCAGAAAAGCCGCTATTTTCGTCAAATCCTGAGCTGGATAATTTGGTGAGTGTATTATTATATTTACAATTATTAGCATTGCTATTATTTTGCCTGTTAAAGTTCCAATCTAAAACTTATTTTAATTATTTAAATATCCAAAAAGTTTTCTTTACACAAAATAGTTTGATTATTTTTGTTTTTGACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa35409
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000102576 Essential Splice Site 208 388 None 13
ENSDART00000125383 Essential Splice Site 208 463 None 11

The following transcripts of ENSDARG00000012078 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 5240841)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 5435619
GRCz11 13 5564205
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAAATCAGACAGTGAAGAAATTACGAGATCATCGGGGCCCCTTGATCAGG[T/C]ACGTGGTGGAGTCCATTTCTTTTCTGGCCATTCAGACCGTCTTTTGGGTC
Long Flanking Sequence:
TTGTAAATAGGTGGTAATGAAATAACTCCACGAAATTAAACAGTTTACCTTAAATGTCAGTCAAGCAGGTCATCTCTCTAATGGCCACAACCCCGGGAGCAGATGAATTTAACACGGGTGTTGAATACGGTGCAGCCCGTGAGTCGTCTTGTCAGTGTCAATTTTCTGCGATATCTTTATTTTGAAAGGGGGTAAAGTTATTTCACATTCTGGATGCGTCTGATAGATATCAGAGAAGGCCACTGGGAGAGGTTTTCCATGTCAATAAGAGTTCTGGATGCACTTGTCAAGTCGCTGTGATGACCCTTTGTGATTTCCCCCCCTCTTTTCCCGCTTTCCTTTGTATCTATAGGTACATGAACTTTGTGACAATTTTTGTCATCGGTACATCAGCTGTTTGAAGGGGAAGATGCCCATCGACTTGGTTATAGACGACAGAGAAGGAGGATCAAAATCAGACAGTGAAGAAATTACGAGATCATCGGGGCCCCTTGATCAGG[T/C]ACGTGGTGGAGTCCATTTCTTTTCTGGCCATTCAGACCGTCTTTTGGGTCACTTTCTCTGCCTCGCCGTCATTTGCATACGATTAAGGCTTTTAAATTCCATCGGATTGAAAAATTTGGAATAATGTGGCCCATTATTGCTTCATTACGGTTTGATCCCGGAACTGACCCGAGGAGATTAGCTCGTGAAAGCATTGCCATAAACTTGACCTGTTTCTTGTCGATTTTAATTTAGTCCTTTCCCTCGTCTTTTCTCTCGCCTGCCTTTTTTTTATCAAAGCAAATGGTTTGACAATCTATGGCATATATATGTTACTATTGCGAAGCAAATTGACTCAAATCTTTAGGAGACATTTAGAGATTTGGTGCTTTGGTGTTCTGCTGTTGTTCATGCTTCATTAGTTGCCTTGTCAGTGTTTTTCCTCAGACGAGAGCGCGCGTTGCTCAGTGCTTTGAATAGCATAGGCAGTGCGCGTTCGTGTTTGAGTACTACTGTGCAGT
Associated Phenotype:
Not determined