Busch Lab

ZMP

ercc4

Ensembl ID:
ENSDARG00000014161
ZFIN ID:
ZDB-GENE-030131-5533
Description:
DNA repair endonuclease XPF [Source:RefSeq peptide;Acc:NP_956079]
Human Orthologue:
ERCC4
Human Description:
excision repair cross-complementing rodent repair deficiency, complementation group 4 [Source:HGNC S
Mouse Orthologue:
Ercc4
Mouse Description:
excision repair cross-complementing rodent repair deficiency, complementation group 4 Gene [Source:M

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa35269 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa1408 Essential Splice Site Available for shipment Available now
sa42015 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa35270 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa6249 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa35269
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000015780 Essential Splice Site 185 886 4 12
Genomic Location (Zv9):
Chromosome 12 (position 21059047)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 19840891
GRCz11 12 19962765
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGCGTGTCATGAGAAACTTGTTTGTGAAGAAACTTTTTCTCTGGCCAAGG[T/C]AGGACAACTTCAATCAAGAAAATGTTCACCTTCAAATATTACTAAATATA
Long Flanking Sequence:
ACGGGTACTGAATGTGTTTGTGCGTGTTTCTGCTGAAGGAGTATTTGACGGAGCGGCTGCGAGCTGAAGGAGTCACTCATCTTCCTCAAACTGTGACCAGTGATGTGCAGAGTGCTGACAGATATAACGTGTACACTAAAGGAGGAGTGCTGTTTGTCACTAGCCGAATCCTAGTGGTGGATTTCCTGACTGACAGAATCCCTGCTCACCTAGTAACAGGTCAGAGAAAAGAAAACATATATTAAAATGCATCTGTATTCATTACAGCTGAGATGAAATGTGAATTGTTGTGTTCTTGAACAGGAATCCTGGTGTACCGGGCACATAATATCATTGAGTCTTGTCAGGAGGCTTTCATTTTGAGACTTTATCGTCAGAAAAACAAAACCGGCTTCATCAAGGCCTTTACAGATAAAGCCACATCCTTCTCTTCAGGATTCTGTAAAGTCGAGCGTGTCATGAGAAACTTGTTTGTGAAGAAACTTTTTCTCTGGCCAAGG[T/C]AGGACAACTTCAATCAAGAAAATGTTCACCTTCAAATATTACTAAATATATATAAATGTTTTGTTAACATTTGTTGCTAGATTGTTATCAAAGGTTTCCTAGAAAAAGATTTAAAAATATATATTTTGTTTGCTTTTTGATCTTTTTTTTTTTAAATAACATAAGTCATAAATTTTAATTTTTACCTTATTATTCTGACTTTATTTGACTGTATGTTTTAATGATTGACTTTTTGTCTTTAATTTCTACTTTTATCTCTCAATTAGGATTTAGTATGTCATGATTAGGACTTTATTTGAATGTATTTTTTTATAACTATGACTTAAATATATAAAAGCATATGAATTTTTAATATAATCACGACTTCTTAAAGAGCCCATATTATACATGAAATAGGGTCATATCTTGGTTGTAAGGGTCTCCAACAACAGTTTAATATGCATGCAAGGTCAAAAAACACTTTCATGGTCTTATAATCTGCATTTATTTTTACCTAATTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1408
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000015780 Essential Splice Site 315 886 6 12
Genomic Location (Zv9):
Chromosome 12 (position 21063676)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 19845520
GRCz11 12 19967394
KASP Assay ID:
554-1329.1 (used for ordering genotyping assays)
KASP Sequence:
CTGCTGGAGTCTTTGAGAACCAGCCAGAAAAGTTTTGGTAGTAATTCAGG[T/C]ACAGTCCGCTCGTCTGCTGCTTTAGTTGAGATAATTTTACAGCAAAAATG
Long Flanking Sequence:
GACCAAAAATTATATTTATTTTTCCTTTTTTTTTATAAAAAAATAATCAATAATGCAATTCGATCTTATTTTTACAGTAATTCCTGTTGTTGGTTTTGTTTGTTAATTCATTTTATAGTTAGATCAGGTCAGGTTGTGTTTAAAAGAAAAAAATAGAATAGAACAATTATATCTAAATAAAATTAATTAATTTCCTTAAATTGACAAATAAAATAATTGCATGAAGGAAAAAATACTTGATTTAATTGGGATTTTTTTTTATATTTGATGATTGTGAAATACTATAAAATTTCATACTAATAATTATTCTATCCTTAGACAATTCGTCATTACCTTGACCCACTGTGGCATCAGCTGGGGTCCAGGACCAAATCTCTTGTTCAGGACCTGAAGATTTTAAGAACCCTTCTTCTCTACCTCACTCAGTACGACTGTGTCACCTTCCTCAATCTGCTGGAGTCTTTGAGAACCAGCCAGAAAAGTTTTGGTAGTAATTCAGG[T/C]ACAGTCCGCTCGTCTGCTGCTTTAGTTGAGATAATTTTACAGCAAAAATGTCACCCGATTTATTTCTTTATTTTCAAATCAGGTTGGTTGTTCCTGGACTCAAGCATGTCTATGTTTGTAAATGCTCGCAGTCGTGTGTATCGCATTCAGGAGTCTAAGAAAAAACTGAAAGTTGGAGAGATTGAGCAGAAACAAAACCTAGGTACAATATGTTTCATGTTTTTCTCTGTTTACAAATGTGTTTTAAGTTTTAAACGTGTACATGGTATTTTCTTCATATTTATTTGTGTATAAAACTAGCGCCTCCGAAAAGAGAGCTTGTGCTTGAGAAGAATCCAAAGTGGGAAGCACTTACAGAAGTCCTACAGGAGATTGAGAAAGAAAACAGCAAATCTGAGCACGAACCAGGTAAAAATGTATTAAAAATGAAAATTCACTGTTTATTTACTCATCCTCAGATCATCCAAGGTTTTTTTCTTCTGAAAGAGATTTTTAGCCGA
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa42015
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000015780 Essential Splice Site 606 886 10 12
Genomic Location (Zv9):
Chromosome 12 (position 21067772)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 19849616
GRCz11 12 19971490
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TATCTTACAGCATTAAACAAAGAAAAGCAAGCGTTTGAGCACCTCATAAG[G/A]TTTGTCAAATATATCTCATTTAGCTGAGAAATTCAGTGGAATGTTCAGTG
Long Flanking Sequence:
AGTAAATTTATTTATTTACACATTTTACAAATGCAAACTTTTGTTTTGGATGTGATTCACTTATAATTGTAGATCAGTCTTTTGAGTAAAATGTGCAGTTTTGTTTTAGAAACTACTTGTAATGTCAAATCCTAAAATCTTCAGAATTTCAAATGAAAATATTTGCAATTAAAGCCTTTACACCATCATGTATTTTTTTATGATCCTTTGAAAAATCTTTGAAAAGTTTTTTTTTTTTTTTTTTGTGGAATACAAGTATTAATTTCTTACAAAAAGTGTATTGATTTAGAAATTCACATAAGTATTAACTTATTTATATAAATAAAAACTAAAAAACAATATCCACCACTTATAGAAATACTGTTTTTTTGTTGTTGTTGAGTTTCTCACGTTCTTTTCTGCTTTAGTGTGTATTTTCTCATATATGGAGGTTCAACAGAAGAACAGAGATATCTTACAGCATTAAACAAAGAAAAGCAAGCGTTTGAGCACCTCATAAG[G/A]TTTGTCAAATATATCTCATTTAGCTGAGAAATTCAGTGGAATGTTCAGTGGTGTTCATCTTATTAAAAGCTGTTGTTTTTCCTCTTTTAAATAGGGAAAAGGCCAGCATGGTTGTGCCAGAAGAAAGAGAAGGTAGAGAAGACACCAATCTAGATCTTGTCCGCAGTCAGGAACCTGCTAGTGCCGCCACAAACACCCGCAAAGCAGGTGAACCTCAGCAAATCAGCCTAAATATTAACACAAAGGGTTTTTTTTACGAGTGATGGAATTTCGGATCATAGAATTTTAAACCGTCTATTAAAGACATTGAAAGGGAATTTTATATTTCTGTTGTCCAAGTTATTGGGATATCTGCGATTTTGTTTGTTATTTTAAATTTTGCTTTCCATTTATCAAATGTTTTTTTCCTTGCATTTCCCTGTGCAGATGGGCTCTACCTATATCCAACTAGAATGTCATTTATTATAAAGCAATGCAGATGGCGCAGCAGGAATTTGAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa35270
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000015780 Essential Splice Site 606 886 10 12
Genomic Location (Zv9):
Chromosome 12 (position 21067773)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 19849617
GRCz11 12 19971491
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATCTTACAGCATTAAACAAAGAAAAGCAAGCGTTTGAGCACCTCATAAGG[T/G]TTGTCAAATATATCTCATTTAGCTGAGAAATTCAGTGGAATGTTCAGTGG
Long Flanking Sequence:
GTAAATTTATTTATTTACACATTTTACAAATGCAAACTTTTGTTTTGGATGTGATTCACTTATAATTGTAGATCAGTCTTTTGAGTAAAATGTGCAGTTTTGTTTTAGAAACTACTTGTAATGTCAAATCCTAAAATCTTCAGAATTTCAAATGAAAATATTTGCAATTAAAGCCTTTACACCATCATGTATTTTTTTATGATCCTTTGAAAAATCTTTGAAAAGTTTTTTTTTTTTTTTTTTGTGGAATACAAGTATTAATTTCTTACAAAAAGTGTATTGATTTAGAAATTCACATAAGTATTAACTTATTTATATAAATAAAAACTAAAAAACAATATCCACCACTTATAGAAATACTGTTTTTTTGTTGTTGTTGAGTTTCTCACGTTCTTTTCTGCTTTAGTGTGTATTTTCTCATATATGGAGGTTCAACAGAAGAACAGAGATATCTTACAGCATTAAACAAAGAAAAGCAAGCGTTTGAGCACCTCATAAGG[T/G]TTGTCAAATATATCTCATTTAGCTGAGAAATTCAGTGGAATGTTCAGTGGTGTTCATCTTATTAAAAGCTGTTGTTTTTCCTCTTTTAAATAGGGAAAAGGCCAGCATGGTTGTGCCAGAAGAAAGAGAAGGTAGAGAAGACACCAATCTAGATCTTGTCCGCAGTCAGGAACCTGCTAGTGCCGCCACAAACACCCGCAAAGCAGGTGAACCTCAGCAAATCAGCCTAAATATTAACACAAAGGGTTTTTTTTACGAGTGATGGAATTTCGGATCATAGAATTTTAAACCGTCTATTAAAGACATTGAAAGGGAATTTTATATTTCTGTTGTCCAAGTTATTGGGATATCTGCGATTTTGTTTGTTATTTTAAATTTTGCTTTCCATTTATCAAATGTTTTTTTCCTTGCATTTCCCTGTGCAGATGGGCTCTACCTATATCCAACTAGAATGTCATTTATTATAAAGCAATGCAGATGGCGCAGCAGGAATTTGAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6249
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000015780 Nonsense 708 886 12 12
Genomic Location (Zv9):
Chromosome 12 (position 21069931)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 19851775
GRCz11 12 19973649
KASP Assay ID:
554-5113.1 (used for ordering genotyping assays)
KASP Sequence:
CTGACATCTGCGTAGAGCGCAAAAGCGTCAGCGACCTCATTGGCTCCTTA[C/T]AGAGCGGACGCCTTTAYACACAGTGCCTCTCCATGACTCGATTCTACCGC
Long Flanking Sequence:
TTCTCAATTCACACTGCGTCTGTATTAAATAAGTAACTAGAAATTAGCATGTAATAGTGCGCCGCTTGAACCAAAAATGCTGAAAATGCTTGAAATGACAATAAAAGCCTGCTTGGCTTGAACTAATTCTCCTTTCACACAGGGTGTCAACCTTAAAAAGTAACTAGATATTAGCATGTAGTAGTGTGCGGCTTGAACCCAAAATGCAAGGGCTGATTTTACTCACAGTGTTCTGTTATCACTCACTTCTCACTTTTTGACCTTATAACTGTTTGTATCACTCTTTTAAACTGTTTTAACTTCAATTAGGGGGACTTGAAGAGGTTAAAGAGCCTCATCGGATCATCGTCGACATGAGAGAGTTTCGCAGTGAACTTCCTTCACTTCTGCATCGACGTGGTCTGGACATCGAGCCTGTCACCTTAGAGGTCGGCGACTACATACTGACGTCTGACATCTGCGTAGAGCGCAAAAGCGTCAGCGACCTCATTGGCTCCTTA[C/T]AGAGCGGACGCCTTTACACACAGTGCCTCTCCATGACTCGATTCTACCGCCGTCCTGTGTTGCTCATCGAGTTTGACCCCGCTAAACCATTCTCCCTGGTGGCCCGCAGTGACTTTCGGCAGGAGATCTCAGCCAACGATGTCACCTCCAAACTGACCCTTCTCACCCTCCATTTCCCCCGCCTTAGGCTCCTCTGGTGCCCTTCGCCGTATGTGACGGCAGAGCTGTTTCAGGAGCTCAAGCATGGCCGTACCGAGCCGGACGCCAGCACAGCTCAGGCAGTTACAGCAGAATCAGAGACTGTGACCGAATCTGCAGATCTGTACAATCCTGGACCTTACGACTTCCTGCTGCGTATGCCTGGAGTCAATGTGAAGAACTTCAAGAGTCTGATAAAACATGTTTCCTGCCTCGCTGATCTTGTGACATTTAGCCAGGAGACGCTCAGTGAGATTTTGGGCAGCAGCAGCAATGCCAGGATGCTTTATGAATTCATACAC
Associated Phenotype:
Not determined