Busch Lab

ZMP

dnmt8

Ensembl ID:
ENSDARG00000005394
ZFIN ID:
ZDB-GENE-050314-5
Description:
DNA (cytosine-5-)-methyltransferase 8 [Source:RefSeq peptide;Acc:NP_001018144]
Human Orthologues:
DNMT3A, DNMT3L
Human Descriptions:
DNA (cytosine-5-)-methyltransferase 3 alpha [Source:HGNC Symbol;Acc:2978]
DNA (cytosine-5-)-methyltransferase 3-like [Source:HGNC Symbol;Acc:2980]
Mouse Orthologues:
Dnmt3a, Dnmt3l
Mouse Descriptions:
DNA (cytosine-5-)-methyltransferase 3-like Gene [Source:MGI Symbol;Acc:MGI:1859287]
DNA methyltransferase 3A Gene [Source:MGI Symbol;Acc:MGI:1261827]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa43531 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa31049 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa617 Nonsense Available for shipment Available now
sa37156 Nonsense Mutation detected in F1 DNA Not yet available
sa8988 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa43531
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000031712 Essential Splice Site 370 997 7 23
ENSDART00000100320 Essential Splice Site 225 852 4 20
ENSDART00000031712 Essential Splice Site 370 997 7 23
ENSDART00000100320 Essential Splice Site 225 852 4 20
Genomic Location (Zv9):
Chromosome 20 (position 47274102)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 47095874
GRCz11 20 46999594
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCGGTGAGAAAGTTCTGACAGGAATCGCGCCGATACACCAAGAGTACCAG[G/A]TGAATATCTTAAAAATCTCTCCCTTCAGATATTTTTTGTGGCCTAAAATA
Long Flanking Sequence:
CTACATTTCAAGTCAATATTTACCTAAACACAAACATCAGTCCGTATTTCTGGAGAGGAGTTCAATACTGCATCTGCTTTCGATTTGCAGTGAAAATCCTGTGAGACACTACTGTGCCCTGTGTGTCTATATTTATCCTTGTTTTGATAGCATGTGTTCTTCTATACTAGGAGAAGAAGGTCCGCCTTGTTCAAATGAGTGACACAATGGACCACCAATCAGCAGTGGGCTCTCAGGAGGATGAACCAGCCATGATTCTTCCTACCATACCTCAGCAACAGCAGAAGAAGGTCCGCCTTGTTCTAATGAGTGACACAATGGACGACCAATCAGCAGTGGGCTCTCAGGAGGATGAACCAGCCATGATTCTTCCTGCCATACCTCAGCAACAGCACACTGACCCCGCCTCCCCAACGGTTGCCACAACGCCTGAGCCGCCTCCCGTCGCCTGCGGTGAGAAAGTTCTGACAGGAATCGCGCCGATACACCAAGAGTACCAG[G/A]TGAATATCTTAAAAATCTCTCCCTTCAGATATTTTTTGTGGCCTAAAATAACCACATTGTTAATTTATTATTATTTTTTTTATTATTATTATTTTTTTCATACATTTATTCATTAATTTTCTTTTCGGCTTTGTCCCTTTATTAATCAGGGGTTGCCACTGCGGAATAGACCGCCAACTTATCCGGCATATGTAAAATAAAATGAAAATAATAAAAATAATAATTTGAAAGGATTTTAATCGAATTTGATTAATCAATCTATCTGTATTTTAGACCTATTTGTGCAGTTAATTGCATCTAAAATAAAAGTGTGTTTACATAATCTATGCTAGTGTACTTTTGATATTTATTAAATATATAAATATATAAACAGGGACAGGCAAAATACAAATTGAAATGTATTTTAAAATAAAATACCAAATACCTCAGTATTACGTGCATCAAAATAAACTACAAAATACAGCAGCCACAACAAGGATCCAAATAAAATACTGTATTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa31049
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000031712 Essential Splice Site 370 997 7 23
ENSDART00000100320 Essential Splice Site 225 852 4 20
ENSDART00000031712 Essential Splice Site 370 997 7 23
ENSDART00000100320 Essential Splice Site 225 852 4 20
Genomic Location (Zv9):
Chromosome 20 (position 47274102)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 47095874
GRCz11 20 46999594
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCGGTGAGAAAGTTCTGACAGGAATCGCGCCGATACACCAAGAGTACCAG[G/A]TGAATATCTTAAAAATCTCTCCCTTCAGATATTTTTTGTGGCCTAAAATA
Long Flanking Sequence:
CTACATTTCAAGTCAATATTTACCTAAACACAAACATCAGTCCGTATTTCTGGAGAGGAGTTCAATACTGCATCTGCTTTCGATTTGCAGTGAAAATCCTGTGAGACACTACTGTGCCCTGTGTGTCTATATTTATCCTTGTTTTGATAGCATGTGTTCTTCTATACTAGGAGAAGAAGGTCCGCCTTGTTCAAATGAGTGACACAATGGACCACCAATCAGCAGTGGGCTCTCAGGAGGATGAACCAGCCATGATTCTTCCTACCATACCTCAGCAACAGCAGAAGAAGGTCCGCCTTGTTCTAATGAGTGACACAATGGACGACCAATCAGCAGTGGGCTCTCAGGAGGATGAACCAGCCATGATTCTTCCTGCCATACCTCAGCAACAGCACACTGACCCCGCCTCCCCAACGGTTGCCACAACGCCTGAGCCGCCTCCCGTCGCCTGCGGTGAGAAAGTTCTGACAGGAATCGCGCCGATACACCAAGAGTACCAG[G/A]TGAATATCTTAAAAATCTCTCCCTTCAGATATTTTTTGTGGCCTAAAATAACCACATTGTTAATTTATTATTATTTTTTTTATTATTATTATTTTTTTCATACATTTATTCATTAATTTTCTTTTCGGCTTTGTCCCTTTATTAATCAGGGGTTGCCACTGCGGAATAGACCGCCAACTTATCCGGCATATGTAAAATAAAATGAAAATAATAAAAATAATAATTTGAAAGGATTTTAATCGAATTTGATTAATCAATCTATCTGTATTTTAGACCTATTTGTGCAGTTAATTGCATCTAAAATAAAAGTGTGTTTACATAATCTATGCTAGTGTACTTTTGATATTTATTAAATATATAAATATATAAACAGGGACAGGCAAAATACAAATTGAAATGTATTTTAAAATAAAATACCAAATACCTCAGTATTACGTGCATCAAAATAAACTACAAAATACAGCAGCCACAACAAGGATCCAAATAAAATACTGTATTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa617
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000031712 Nonsense 811 997 18 23
ENSDART00000100320 Nonsense 666 852 15 20
Genomic Location (Zv9):
Chromosome 20 (position 47249374)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 47071146
GRCz11 20 46974866
KASP Assay ID:
554-0527.1 (used for ordering genotyping assays)
KASP Sequence:
GTCCCTGTAATGATCTGTCCATCGTCAACCCTGCTAGGAAAGGCTTGTTT[G/T]GTATGACACACGCCATTAGATCCATTTTCCTCACTAAAATCATAAGATTT
Long Flanking Sequence:
TTGGCTCTATCACTGTCTCTCCACTCAAACTGTGTGGTGAGCGCACTGGCGCCGTTGTCCTGTGGCTGCCGTCGCATCATCCAAGTAGATGCTGCACACGGGTGGTGGTGTCGAGAGACGCCCCTTATGATTGTGAATGCTTTGGGTGTACGGCCATACCCAATAAATGCACTATATAAATACGCATTACATTATAAAGGAGGTCATCAGTTTTCAGGATTAAAAGATCCGGGATCTGCCTAATCATCTTAGATCAATTAAAGAGGACCTATCATGCAAAAATCACTTGTATAAGGGGTTTAATAACGGTTTGACATAAGGTTGTGAATATAGCCAGGCTCTAATGGAAACAATTAATTAATGAAATATTTTATAACCCCATTTATCACACTTCTTGTTTGTCTCTGCAGATTCAGGAGTGGGGGCCGTTTGATCTTGTGATTGGTGGAAGTCCCTGTAATGATCTGTCCATCGTCAACCCTGCTAGGAAAGGCTTGTTT[G/T]GTATGACACACGCCATTAGATCCATTTTCCTCACTAAAATCATAAGATTTGTTTGTGCGTTTGTCTATAAACTTGTGTTAAATAAGTGTTTATGCGCAGAGGGAACCGGGCGCCTGTTCTTTGAGTTTTACCGGCTGCTTCACGAAGCGCGGCCTAAAGAAGGAGACGACCGCCCGTTTTTCTGGCTGTTCGAGAACGTGGTTGCAATGGGGGTCAGTGACAAGAAAGACATCTCACGCTTTCTGGAGGTGTGTAAATACACTACAACAACAAGCATATAAACTAAGGTTATAATAGTTTAGCATTTTTCATTGGTTTAGTTTTTATTTAGTTTAGATTTTTGTTTTTAATTTCAGTTACTTTTAGTTGGGTAGATCTGCTAGTTTTATTCGTTTTTAAATTTTGAAATTGCTTAGTTTTTGTTTAATTTGTAGTAGTTTTACTATTAGTTTTTTTTTTCCAAATAAGGATACTTGTTAGGTGCGAGATTCAAAATTGTC
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa37156
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000031712 Nonsense 826 997 19 23
ENSDART00000100320 Nonsense 681 852 16 20
Genomic Location (Zv9):
Chromosome 20 (position 47249230)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 47071002
GRCz11 20 46974722
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCGCAGAGGGAACCGGGCGCCTGTTCTTTGAGTTTTACCGGCTGCTTCAC[G/T]AAGCGCGGCCTAAAGAAGGAGACGACCGCCCGTTTTTCTGGCTGTTCGAG
Long Flanking Sequence:
GGTGTACGGCCATACCCAATAAATGCACTATATAAATACGCATTACATTATAAAGGAGGTCATCAGTTTTCAGGATTAAAAGATCCGGGATCTGCCTAATCATCTTAGATCAATTAAAGAGGACCTATCATGCAAAAATCACTTGTATAAGGGGTTTAATAACGGTTTGACATAAGGTTGTGAATATAGCCAGGCTCTAATGGAAACAATTAATTAATGAAATATTTTATAACCCCATTTATCACACTTCTTGTTTGTCTCTGCAGATTCAGGAGTGGGGGCCGTTTGATCTTGTGATTGGTGGAAGTCCCTGTAATGATCTGTCCATCGTCAACCCTGCTAGGAAAGGCTTGTTTGGTATGACACACGCCATTAGATCCATTTTCCTCACTAAAATCATAAGATTTGTTTGTGCGTTTGTCTATAAACTTGTGTTAAATAAGTGTTTATGCGCAGAGGGAACCGGGCGCCTGTTCTTTGAGTTTTACCGGCTGCTTCAC[G/T]AAGCGCGGCCTAAAGAAGGAGACGACCGCCCGTTTTTCTGGCTGTTCGAGAACGTGGTTGCAATGGGGGTCAGTGACAAGAAAGACATCTCACGCTTTCTGGAGGTGTGTAAATACACTACAACAACAAGCATATAAACTAAGGTTATAATAGTTTAGCATTTTTCATTGGTTTAGTTTTTATTTAGTTTAGATTTTTGTTTTTAATTTCAGTTACTTTTAGTTGGGTAGATCTGCTAGTTTTATTCGTTTTTAAATTTTGAAATTGCTTAGTTTTTGTTTAATTTGTAGTAGTTTTACTATTAGTTTTTTTTTTCCAAATAAGGATACTTGTTAGGTGCGAGATTCAAAATTGTCAGAATAAATATTTTATAATAAAATTTCAACCAAAGATACATTTTTTGAAACGTGTATCCAGAGCCTATTCATCAAAACCTGCAAATGTTTCTTGGACCTCAAAAATATAGGTTATACCATATGTCAAACAGTTCATATATAACT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8988
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000031712 Essential Splice Site 889 997 20 23
ENSDART00000100320 Essential Splice Site 744 852 17 20
Genomic Location (Zv9):
Chromosome 20 (position 47245196)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 47066968
GRCz11 20 46970688
KASP Assay ID:
2261-4918.1 (used for ordering genotyping assays)
KASP Sequence:
GCCGCACACAGAGCTCGATACTTCTGGGGGAACCTTCCTGGGATGAATCG[G/A]TAAGACTGCTTGTGTCTGAGAGTRGCTGCTATTTTACTAGCGTTCGAAAC
Long Flanking Sequence:
TCTCGTGTTTGGGACCCTTTCGAAAGGGTGCCGAAAAAGTGGTACGGTTTGGTTCAGTACGCCTTTTGACAGTGGAAACGGCCATAAAAGCGTACCAAACCGAACCGAACTGTACCACTCAGTGGAAACGGGCCATATAAGGCTTACAGTAGACTTATGTATTAAATACATTTACAAAGATGAAAACGAAGGAGGTTTTTGCTATAATTCTAGTTAGTTTCAATTAGTTTTGTGAGTACATGATACAGTTTCAGTTAGTTCTAGTTTTTATTTTTATTTCCATTTAAAATTGTAGTTTTTGTTTTTCCGTCTGTTTTCCTCAGCTATAATAACGTTGATTCAAACTGAAGTCATTTAATGAACCTTGAATTTCTTCTGAAATATCTCATTTATTGTTTACTCGTTTGTGTCCAGTGTAATCCAGTCATGATCGATGCTAAGGAGGTGTCAGCCGCACACAGAGCTCGATACTTCTGGGGGAACCTTCCTGGGATGAATCG[G/A]TAAGACTGCTTGTGTCTGAGAGTGGCTGCTATTTTACTAGCGTTCGAAACACATGTGCAATAGACATCAAAATGATCAACAGATTAGAAAAACTAATGAATAAAACAGTTTCTTCTCAATTGCTTTTCATTTGATGTGCTTGATCTCAACCACCCTCAATGGCAGAGCTGTGATTAAAAATGAAACGCTATTGGCTGTTTTTAATAGGCAGGAGCTACTCTATGCCCCGCCCTCAGTTCATTTTTCTGTTGAGATTACATCAAACATCAAATAAAAAGCGCACATTTTAAAGCACTTCGCGGGACCTTTTAAATAGAGCCCTTTGTGTTTCTCTTTTCAGGCCACTGACTGCTATGGTGAATGACAAACTCGATCTGCAAGACTGTCTGGAACATGGACGCACAGCTAAGGTGTGTGTTTGTGTTTGTATGTGTGTTCATTATTAAAGGTGCAGTATGTAAGTTTAACACCCAATGGTAGAACTAGGTATTGCACTCCTG
Associated Phenotype:
Not determined