ZMP

si:ch73-211l2.3

Ensembl ID:

ENSDARG00000075932

ZFIN IDs:

ZDB-GENE-030616-440, ZDB-GENE-081105-52

Description:

Novel protein similar to MHC class II alpha chain [Source:UniProtKB/TrEMBL;Acc:Q8MGS1]

Human Orthologues:

HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DRA, XXbac-BPG181M17.5

Human Descriptions:

Major histocompatibility complex, class II, DM beta [Source:UniProtKB/TrEMBL;Acc:A2AAT6]
major histocompatibility complex, class II, DM alpha [Source:HGNC Symbol;Acc:4934]
major histocompatibility complex, class II, DM beta [Source:HGNC Symbol;Acc:4935]
major histocompatibility complex, class II, DO alpha [Source:HGNC Symbol;Acc:4936]
major histocompatibility complex, class II, DP alpha 1 [Source:HGNC Symbol;Acc:4938]
major histocompatibility complex, class II, DQ alpha 1 [Source:HGNC Symbol;Acc:4942]
major histocompatibility complex, class II, DQ alpha 2 [Source:HGNC Symbol;Acc:4943]
major histocompatibility complex, class II, DR alpha [Source:HGNC Symbol;Acc:4947]

Mouse Orthologues:

H2-Aa, H2-DMa, H2-DMb1, H2-DMb2, H2-Oa

Mouse Descriptions:

histocompatibility 2, O region alpha locus Gene [Source:MGI Symbol;Acc:MGI:95924]
histocompatibility 2, class II antigen A, alpha Gene [Source:MGI Symbol;Acc:MGI:95895]
histocompatibility 2, class II, locus DMa Gene [Source:MGI Symbol;Acc:MGI:95921]
histocompatibility 2, class II, locus Mb1 Gene [Source:MGI Symbol;Acc:MGI:95922]
histocompatibility 2, class II, locus Mb2 Gene [Source:MGI Symbol;Acc:MGI:95923]

Alleles

There is 1 allele of this gene:

Allele Name	Consequence	Status	Availability
sa6103	Essential Splice Site	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa6103

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

G > A

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000006898	Essential Splice Site	100	234	2	4

The following transcripts of ENSDARG00000075932 do not overlap with this mutation:

ENSDART00000145799

Genomic Location (Zv9):

Chromosome 8 (position 47079978)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	8	44485292
GRCz11	8	44479198

KASP Assay ID:

554-3786.1 (used for ordering genotyping assays)

KASP Sequence:

CTACCTGGCTGTGCTTAGAGAGGTGTATGCCAGTTCACCTGAAGTACTTG[G/A]TAAGACAAAAATAGGGATAAAAATGAGTCACACTTYATGATAAGTTTGCA

Long Flanking Sequence:

TAGTGTGAGTACATAGAGAGTAAAGTTTCATTTTGGAGTGAACTATCCATTTAAAGCTGCTTGCTTTTCAGTAACACATAACTAATGATACCGTAAATGATTTCACACTTGTTAAATGAGATTTCATAGATAATCAAGTTGATAAATAAGATTATACTCATGTATGCTTCATGTAAATATATTAAAAATGCTATTCCTTAACAAAAATAATAATACTCAGACCTGTAAACCTGTTTTTTTTTTTTTTTTAGATTATCATAAATATGGACTGATTGGGGCGTGTGGTGATGCAGATCAGGAAGATTTTATTGTCCAGTTTGATGATGAACAGTTGGCACACGTGGACTTCAAAGAGCAGAAAGATGTTATTACATTACCTGAATTTGCTGGTCAGGCTGTGCTTCCGCCAATATATGTGGATGCTAAAAGGGCAGAATTCAATTGCAAAGCCTACCTGGCTGTGCTTAGAGAGGTGTATGCCAGTTCACCTGAAGTACTTG[G/A]TAAGACAAAAATAGGGATAAAAATGAGTCACACTTTATGATAAGTTTGCAATATTTACTAACATGAGCTAGGAATAATACAGCAACAGATTCTTGTTTGTTAATATCAGTTAATGCACCGTGAGTTAACAAGAAGTAACAAAAAAAAAAAAAAAAAACGTTTATTAACTATCATTACAAAAGATGAATCAATACTGTTATAAATATTCTTCATCATTTGTTTGTGATAGTAAATACGATAACTTATACAATCTTATTATAAAGTCTTAACAAAAAAATGTTTTAGTAAAATGTTTAAAATGGTGGTTGATCTAATCTTTGCCAGAACCTCCCTGGAGCTCAATTTATCCTAAAAGTGATCCACAATTAAATCTCAAGAACACTCTGATCTGTCATGTGACTGGATTCTTCCCTCCGCCGGTCAGAGTCTTGTGGACCAAGAACAATGTGAATGTGACAGACGGATCAACCATCAGCAGATATTACCCTAACAAAGATGGC

Associated Phenotype:

Not determined