Busch Lab

ZMP

pcca

Ensembl ID:
ENSDARG00000028982
ZFIN ID:
ZDB-GENE-040718-246
Description:
propionyl-CoA carboxylase alpha chain, mitochondrial [Source:RefSeq peptide;Acc:NP_001002746]
Human Orthologue:
PCCA
Human Description:
propionyl CoA carboxylase, alpha polypeptide [Source:HGNC Symbol;Acc:8653]
Mouse Orthologue:
Pcca
Mouse Description:
propionyl-Coenzyme A carboxylase, alpha polypeptide Gene [Source:MGI Symbol;Acc:MGI:97499]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa1201 Essential Splice Site F2 line generated Not yet available
sa5937 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa17977 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa1201
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000034097 Essential Splice Site 432 709 15 23
ENSDART00000133905 Essential Splice Site 444 721 15 23
ENSDART00000135252 None None 152 None 7
ENSDART00000136786 None None 159 None 7
Genomic Location (Zv9):
Chromosome 1 (position 28854758)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 29105587
GRCz11 1 29909518
KASP Assay ID:
554-1110.1 (used for ordering genotyping assays)
KASP Sequence:
TTCAAGAAGGAAGCGACATCAGTATTTATTATGACCCTATGATTTCTAAG[G/A]TAATCAATGACCATCATGAAAGTCTAATTTCAATTAAGATGTCAGTTTGT
Long Flanking Sequence:
TTTTTATTTTAGAAATCCACACACATAAAGGGATACAGATGAGCTTTAAATGTCTAAAGAAAGCAAACATCACTGAGGAGATTAACAATGGTCTTTTATTTGTAGGTAGGGCCAAAAAAGATAACATTGTGTGATGTTCTTAGTGGTTATTTATAGTTTTGTGTTGTTTTGAAGGGTTAGTTCACACACAAATAAAAAAAAAATTTGCTCACCATTGACCCTTAAGTGGTAATTTTTTGTGTGTTAAATGCTAAAAATTATTGTTTGAAGAATGTTGGAAACTTACAACTATTGGAATCCATAGTATAAAAAAACTACCATACTATTGAAGTATTTATTAGAACTATCCCTAAGGTGAGGGTTAAAGTATGTAAGTAAATACTTCATGTGTAAGTGTTTTAATTCGATTTTTTTTTTTGCTTCTCCTGTAGGTTCGAGTGGACAGCGGAATTCAAGAAGGAAGCGACATCAGTATTTATTATGACCCTATGATTTCTAAG[G/A]TAATCAATGACCATCATGAAAGTCTAATTTCAATTAAGATGTCAGTTTGTTTCATTTTATATATTGTTTTATAGCTGGTCACGTATGGCAAAACACGGGAGGAAGCTCTGAAGAAAATGGAAGAAGCACTTGATAATTACGTGGTCAGAGGTAAATGGCCTCCGAAAGAATTATGACAAATGAAGGTGAAAACATTTCAGATCATAGACTGCTTCTCTTGTTGGCACAGGTGTAACACATAACATACCTCTACTGAGAGAGATCATTGTTCATCCTCGGTTTGTGTCTGGTGATATCAGTACTAAGTTTCTCCCGGAGGTGTATCCTGATGGGTTCAAAGGTCACATGTTAACAGCAGGAGAAAGACAGGAGCTGCTTGCTACGGCTGCGGCACTCTATACAGCAGCACAGCTCCGCTCTCAGAGGTTCCTGGGGGATCTCAGGTGAGACAAAGATGGAGCAACTTCCAGCTAGGGATATATTTTACACTCTTTTGTCAT
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa5937
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000034097 Essential Splice Site 458 709 16 23
ENSDART00000133905 Essential Splice Site 470 721 16 23
ENSDART00000135252 None None 152 None 7
ENSDART00000136786 None None 159 None 7
Genomic Location (Zv9):
Chromosome 1 (position 28854910)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 29105739
GRCz11 1 29909670
KASP Assay ID:
554-3742.1 (used for ordering genotyping assays)
KASP Sequence:
GAAGCTCTGAAGAAAATGGAAGAAGCACTTGATAATTACGTGGTCAGAGG[T/C]AAATGGCCTCCKAAAGAATTATGACAAATGAAGGTGAAAACATTTCAGAT
Long Flanking Sequence:
ATAGTTTTGTGTTGTTTTGAAGGGTTAGTTCACACACAAATAAAAAAAAAATTTGCTCACCATTGACCCTTAAGTGGTAATTTTTTGTGTGTTAAATGCTAAAAATTATTGTTTGAAGAATGTTGGAAACTTACAACTATTGGAATCCATAGTATAAAAAAACTACCATACTATTGAAGTATTTATTAGAACTATCCCTAAGGTGAGGGTTAAAGTATGTAAGTAAATACTTCATGTGTAAGTGTTTTAATTCGATTTTTTTTTTTGCTTCTCCTGTAGGTTCGAGTGGACAGCGGAATTCAAGAAGGAAGCGACATCAGTATTTATTATGACCCTATGATTTCTAAGGTAATCAATGACCATCATGAAAGTCTAATTTCAATTAAGATGTCAGTTTGTTTCATTTTATATATTGTTTTATAGCTGGTCACGTATGGCAAAACACGGGAGGAAGCTCTGAAGAAAATGGAAGAAGCACTTGATAATTACGTGGTCAGAGG[T/C]AAATGGCCTCCGAAAGAATTATGACAAATGAAGGTGAAAACATTTCAGATCATAGACTGCTTCTCTTGTTGGCACAGGTGTAACACATAACATACCTCTACTGAGAGAGATCATTGTTCATCCTCGGTTTGTGTCTGGTGATATCAGTACTAAGTTTCTCCCGGAGGTGTATCCTGATGGGTTCAAAGGTCACATGTTAACAGCAGGAGAAAGACAGGAGCTGCTTGCTACGGCTGCGGCACTCTATACAGCAGCACAGCTCCGCTCTCAGAGGTTCCTGGGGGATCTCAGGTGAGACAAAGATGGAGCAACTTCCAGCTAGGGATATATTTTACACTCTTTTGTCATTTCGCTAAAGGAATTTGTGCAGCATATTATTACAACTAATGTGACATCGTTGAGAAAACAAAAGTTAAGAAAGCATCTAGCATCAAGTTAATTTACAGACAAAATTATCAACCCTGAAATTTAAATTGTTTTTTTAAAATGTTTTCCAAGTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa17977
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000034097 Nonsense 514 709 17 23
ENSDART00000133905 Nonsense 526 721 17 23
ENSDART00000135252 None None 152 None 7
ENSDART00000136786 None None 159 None 7
Genomic Location (Zv9):
Chromosome 1 (position 28855157)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 29105986
GRCz11 1 29909917
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TTAACAGCAGGAGAAAGACAGGAGCTGCTTGCTACGGCTGCGGCACTCTA[T/A]ACAGCAGCACAGCTCCGCTCTCAGAGGTTCCTGGGGGATCTCAGGTGASA
Long Flanking Sequence:
TAATTCGATTTTTTTTTTTGCTTCTCCTGTAGGTTCGAGTGGACAGCGGAATTCAAGAAGGAAGCGACATCAGTATTTATTATGACCCTATGATTTCTAAGGTAATCAATGACCATCATGAAAGTCTAATTTCAATTAAGATGTCAGTTTGTTTCATTTTATATATTGTTTTATAGCTGGTCACGTATGGCAAAACACGGGAGGAAGCTCTGAAGAAAATGGAAGAAGCACTTGATAATTACGTGGTCAGAGGTAAATGGCCTCCGAAAGAATTATGACAAATGAAGGTGAAAACATTTCAGATCATAGACTGCTTCTCTTGTTGGCACAGGTGTAACACATAACATACCTCTACTGAGAGAGATCATTGTTCATCCTCGGTTTGTGTCTGGTGATATCAGTACTAAGTTTCTCCCGGAGGTGTATCCTGATGGGTTCAAAGGTCACATGTTAACAGCAGGAGAAAGACAGGAGCTGCTTGCTACGGCTGCGGCACTCTA[T/A]ACAGCAGCACAGCTCCGCTCTCAGAGGTTCCTGGGGGATCTCAGGTGAGACAAAGATGGAGCAACTTCCAGCTAGGGATATATTTTACACTCTTTTGTCATTTCGCTAAAGGAATTTGTGCAGCATATTATTACAACTAATGTGACATCGTTGAGAAAACAAAAGTTAAGAAAGCATCTAGCATCAAGTTAATTTACAGACAAAATTATCAACCCTGAAATTTAAATTGTTTTTTTAAAATGTTTTCCAAGTAATGTTTAACTGAACAAGGAATATTTTTCACAGTATTTAGTATTATAATTTTCTTCTAGATATATTCTTATTACTTGTAGTTTGGTTGTAATAAAAAAAAAAAAAACAATATATAATGAACAAGACATTGTCGTCCAATTAATTTAACTTGCCAAGGCAACCTAATTAACGGTAATGTTTAAATTGCCCTTTAAGCTGAATACTAGTGTGTAGCAGTCACTAGTAAATTATTATATACTGTCATCATG
Associated Phenotype:
Not determined