ZMP
top1l
Ensembl ID:
ZFIN ID:
Description:
topoisomerase (DNA) I, like [Source:RefSeq peptide;Acc:NP_001037789]
Human Orthologue:
TOP1
Human Description:
topoisomerase (DNA) I [Source:HGNC Symbol;Acc:11986]
Mouse Orthologue:
Top1
Mouse Description:
topoisomerase (DNA) I Gene [Source:MGI Symbol;Acc:MGI:98788]
Alleles
There are 3 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa21911 | Essential Splice Site | Available for shipment | Available now |
| sa5843 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa2597 | Nonsense | Confirmed mutation in F2 line | Not yet available |
Mutation Details
Allele Name:
sa21911
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000065949 | Essential Splice Site | 601 | 758 | 17 | 21 |
| ENSDART00000065949 | Essential Splice Site | 601 | 758 | 17 | 21 |
The following transcripts of ENSDARG00000070545 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 11 (position 26240238)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 11 | 25069063 |
| GRCz11 | 11 | 25306679 |
KASP Assay ID:
554-3661.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TACAACGCCTCCATCACACTACAGCAGCAGCTGAACGAACTCACTAACTG[T/G]AAGTCCTGCACGCACCAGATTGAGCAGAGCTGCTGGAAACGCATCATATG
Long Flanking Sequence:
AGGTTTTGCTGTTTGCAATCAATTTTTGTGTGTGTTTGGGGTTGTGGTCTTTTGTGCTCTTCAACTGTCCTTGAGTTTGTGAAAGGCTCTGCGCGAATCAAATGTTCACCAGTTTACTGTGCCCTAGTACAAATTGAAATCTTCTCATCTGAGGGCTATTGATTAGCATGGTCGTGTGTTCTGCTTCTGCCTTTTGTGTAAAATCCCTTTTAAATGTTACAGGTTTTCAAAAATCTCCAGCTTTTCATGGAGGATAAGGAGCCAGAGGATGACCTCTTTGACCGTCTCAATGTAAGCAGTCACTTTCACCAGTCTGTTATTTATGGCATGCAGAGGAGAATCTCAATTCTGAATGCATCTCATTAATTGTAAACCATCTTGCAGACCTCCATTTTAAACAAGCATCTTCAGGAGTTGATGGACGGCCTTACGGCTAAAGTGTTCCGTACTTACAACGCCTCCATCACACTACAGCAGCAGCTGAACGAACTCACTAACTG[T/G]AAGTCCTGCACGCACCAGATTGAGCAGAGCTGCTGGAAACGCATCATATGTGACGCTTGTGTGTTTGTTTAGCTGAAGATAATGTTCCTGCGAAGATCCTCTCCTACAATCGGGCCAACCGAGCGGTAGCCATCCTGTGTAACCACCAGAGGGCACCACCAAAGACCTTTGAAAAGTCCATGCAGAATCTTCAGACCAAGGTATGAGACGTTGGCGAACTTGTCCTTATTGTTGTCTTCATGCTGGTATTTCTTTGTTAGCGCAGGGTCTGTTGGACCATCTAAATGTTTGCCTTTCCCGCATTCACTTGTTCATTAAAACCAGATTGACGCAAAGAAGGAGCAGCTTGTTGAAGCTAAAAGAGAGCTGAAAGGTGCCAAGGCTGACGCCAAAGTACGCAAAGATGAGAAATTCAAGAAGTGAGTGTCAAAATATTTGCTTGAAGGGCGCCCAACTGAATTTGGCCTCTTTGTCGCTCATTGTGCATTCGTATGTGATTG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa5843
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000065949 | Essential Splice Site | 601 | 758 | 17 | 21 |
| ENSDART00000065949 | Essential Splice Site | 601 | 758 | 17 | 21 |
The following transcripts of ENSDARG00000070545 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 11 (position 26240238)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 11 | 25069063 |
| GRCz11 | 11 | 25306679 |
KASP Assay ID:
554-3661.1 (used for ordering genotyping assays)
KASP Sequence:
TACAACGCCTCCATCACACTACAGCAGCAGCTGAACGAACTCACTAACTG[T/A]AAGTCCTGCACGCACCAGATTGAGCAGAGCTGCTGGAAACGCATCATATG
Long Flanking Sequence:
AGGTTTTGCTGTTTGCAATCAATTTTTGTGTGTGTTTGGGGTTGTGGTCTTTTGTGCTCTTCAACTGTCCTTGAGTTTGTGAAAGGCTCTGCGCGAATCAAATGTTCACCAGTTTACTGTGCCCTAGTACAAATTGAAATCTTCTCATCTGAGGGCTATTGATTAGCATGGTCGTGTGTTCTGCTTCTGCCTTTTGTGTAAAATCCCTTTTAAATGTTACAGGTTTTCAAAAATCTCCAGCTTTTCATGGAGGATAAGGAGCCAGAGGATGACCTCTTTGACCGTCTCAATGTAAGCAGTCACTTTCACCAGTCTGTTATTTATGGCATGCAGAGGAGAATCTCAATTCTGAATGCATCTCATTAATTGTAAACCATCTTGCAGACCTCCATTTTAAACAAGCATCTTCAGGAGTTGATGGACGGCCTTACGGCTAAAGTGTTCCGTACTTACAACGCCTCCATCACACTACAGCAGCAGCTGAACGAACTCACTAACTG[T/A]AAGTCCTGCACGCACCAGATTGAGCAGAGCTGCTGGAAACGCATCATATGTGACGCTTGTGTGTTTGTTTAGCTGAAGATAATGTTCCTGCGAAGATCCTCTCCTACAATCGGGCCAACCGAGCGGTAGCCATCCTGTGTAACCACCAGAGGGCACCACCAAAGACCTTTGAAAAGTCCATGCAGAATCTTCAGACCAAGGTATGAGACGTTGGCGAACTTGTCCTTATTGTTGTCTTCATGCTGGTATTTCTTTGTTAGCGCAGGGTCTGTTGGACCATCTAAATGTTTGCCTTTCCCGCATTCACTTGTTCATTAAAACCAGATTGACGCAAAGAAGGAGCAGCTTGTTGAAGCTAAAAGAGAGCTGAAAGGTGCCAAGGCTGACGCCAAAGTACGCAAAGATGAGAAATTCAAGAAGTGAGTGTCAAAATATTTGCTTGAAGGGCGCCCAACTGAATTTGGCCTCTTTGTCGCTCATTGTGCATTCGTATGTGATTG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa2597
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000065949 | Nonsense | 612 | 758 | 18 | 21 |
The following transcripts of ENSDARG00000070545 do not overlap with this mutation:
Genomic Location (Zv9):
Chromosome 11 (position 26240345)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 11 | 25069170 |
| GRCz11 | 11 | 25306786 |
KASP Assay ID:
554-2781.1 (used for ordering genotyping assays)
KASP Sequence:
TTGTGTGTTTGTTTAGCTGAAGATAATGTTCCTGCGAAGATCCTCTCCTA[C/A]AATCGGGCCAAYCGAGCGGTAGCCATCCTGTGTAACCACCAGAGGGCACC
Long Flanking Sequence:
ACCAGTTTACTGTGCCCTAGTACAAATTGAAATCTTCTCATCTGAGGGCTATTGATTAGCATGGTCGTGTGTTCTGCTTCTGCCTTTTGTGTAAAATCCCTTTTAAATGTTACAGGTTTTCAAAAATCTCCAGCTTTTCATGGAGGATAAGGAGCCAGAGGATGACCTCTTTGACCGTCTCAATGTAAGCAGTCACTTTCACCAGTCTGTTATTTATGGCATGCAGAGGAGAATCTCAATTCTGAATGCATCTCATTAATTGTAAACCATCTTGCAGACCTCCATTTTAAACAAGCATCTTCAGGAGTTGATGGACGGCCTTACGGCTAAAGTGTTCCGTACTTACAACGCCTCCATCACACTACAGCAGCAGCTGAACGAACTCACTAACTGTAAGTCCTGCACGCACCAGATTGAGCAGAGCTGCTGGAAACGCATCATATGTGACGCTTGTGTGTTTGTTTAGCTGAAGATAATGTTCCTGCGAAGATCCTCTCCTA[C/A]AATCGGGCCAACCGAGCGGTAGCCATCCTGTGTAACCACCAGAGGGCACCACCAAAGACCTTTGAAAAGTCCATGCAGAATCTTCAGACCAAGGTATGAGACGTTGGCGAACTTGTCCTTATTGTTGTCTTCATGCTGGTATTTCTTTGTTAGCGCAGGGTCTGTTGGACCATCTAAATGTTTGCCTTTCCCGCATTCACTTGTTCATTAAAACCAGATTGACGCAAAGAAGGAGCAGCTTGTTGAAGCTAAAAGAGAGCTGAAAGGTGCCAAGGCTGACGCCAAAGTACGCAAAGATGAGAAATTCAAGAAGTGAGTGTCAAAATATTTGCTTGAAGGGCGCCCAACTGAATTTGGCCTCTTTGTCGCTCATTGTGCATTCGTATGTGATTGTATTCTGCTTTAATGTTGATTCTTTTGGCAACGCAGAGCTGTGGAGGCCAAGAAGAAAGCGCTTCAGAGGGTGGAGGAGCAGCTGATGAAGCTGGAGGTTCAGGCCA
Associated Phenotype:
This allele has been associated with this phenotype by genetic linkage analysis and may not be causal.
See FAQs for more info.
See FAQs for more info.
| Stage | Entity | Quality | Tag |
|---|---|---|---|
| Hatching:Pec-fin ZFS:0000034 |
eye ZFA:0000107 |
decreased size PATO:0000587 |
abnormal PATO:0000460 |
| Hatching:Pec-fin ZFS:0000034 |
head ZFA:0001114 |
decreased size PATO:0000587 |
abnormal PATO:0000460 |
| Hatching:Pec-fin ZFS:0000034 |
inner ear ZFA:0000217 |
decreased size PATO:0000587 |
abnormal PATO:0000460 |
| Hatching:Pec-fin ZFS:0000034 |
pericardium ZFA:0000054 |
edematous PATO:0001450 |
abnormal PATO:0000460 |