ZMP

chek1

Ensembl ID:

ENSDARG00000014385

ZFIN ID:

ZDB-GENE-040426-896

Description:

serine/threonine-protein kinase Chk1 [Source:RefSeq peptide;Acc:NP_956487]

Human Orthologue:

CHEK1

Human Description:

CHK1 checkpoint homolog (S. pombe) [Source:HGNC Symbol;Acc:1925]

Mouse Orthologue:

Chek1

Mouse Description:

checkpoint kinase 1 homolog (S. pombe) Gene [Source:MGI Symbol;Acc:MGI:1202065]

Alleles

There are 3 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa45737	Nonsense	Mutation detected in F1 DNA	Not yet available
sa25158	Nonsense	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa45737

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000065538	Nonsense	244	410	7	11
ENSDART00000101776	Nonsense	293	459	8	12
ENSDART00000137423	Nonsense	244	410	8	12
ENSDART00000138666	Nonsense	214	225	8	9
ENSDART00000145977	Nonsense	293	351	9	10

Genomic Location (Zv9):

Chromosome 21 (position 21677722)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	21	22526132
GRCz11	21	22562778

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

AGGGCATCACACCAGCAGCCAAGATTCAACGGGCTGACTCTGAGCTGAGA[C/T]GAAAAAACAGGTCAGTATGATAAATACATACAGTGCATCCAGAAAGAATT

Long Flanking Sequence:

AGTTACCCTGGGATCAGCCGAGTGAAAACTGTCAGGAGTATTTGGACTGGCTGGAAAGAAAGACCTACCTTACGCCCTGGAAGAAAATTGATGCGGTACCCCTTAGTAAGTATCTTCGACTTGCTAAATTTGACAATATTTAAATATTTATTATAGATTTCACTTTGGCCGGAAAGCAGCCACTCAAAACTACTGCATACAAACATTCAGAACACCTCTGATGTTAAGAAGTTTTGTTTGTTTTTGATCAGGTCTGTTGTCTAAGATATTACTGCACAATCCAGAAGACAGGTTCACCATTCCTGAAATTAAGAAACACCGCTGGTTTAGCAGAAGTTTCAAATCAGGTACTGTTTCAAACATCAGCTCAGTAGCTCTGCAAGTGCTTTAAGAGTGTTTGTGTTTGTGATTGTTTTGCGTCTGAATTTTTGACCACAGCAGTACAACGTCAGGGCATCACACCAGCAGCCAAGATTCAACGGGCTGACTCTGAGCTGAGA[C/T]GAAAAAACAGGTCAGTATGATAAATACATACAGTGCATCCAGAAAGAATTCACAGCGCTTTACTTTTTCCACAGGTGTGCCAAACTTGTGGCATCATATTTAAAAAGACATGAGGCTGTAATTGCTGCCAAAAGTGCATCAACAAAGTATTGAGCAAAGGCTGTGAATACTTATGAACAGGGCTTTTCAGCTTTTTTATTTTTAATAAATTTGCAACAATTTCAAAAAATCTTTTTCACATTGTCATTATGGCGTATTGTGTGTAGAATTTTAAAGAAATACATGAATTTAATCCATTTTGGAATAAAGCTGTAACATGAAAAATTAAAGCACTATAAATATTTTCCGGATGCACTGTATGTTGCCTTAATGACTGTTTAGTATTGAGCAAAACTCATGAGCTATTTTCTGCTATAAGGGGCACATAATCACTACCTGTGTGTTTCCTCAGTGATGACCGAGCGCAGATCTCAAGCTCTCAGCCTGAGCCACAGGGATTA

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa25158

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

T > A

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000065538	Nonsense	384	410	11	11
ENSDART00000101776	Nonsense	433	459	12	12
ENSDART00000137423	Nonsense	384	410	12	12
ENSDART00000138666	None	None	226	None	9
ENSDART00000145977	None	None	351	None	10

Genomic Location (Zv9):

Chromosome 21 (position 21679818)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	21	22528200
GRCz11	21	22564805

KASP Assay ID:

554-7883.1 (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

TGTAACTGATTTGATTAAAGCTCTGTTTTTTGTATTCTAGGGGGATGGTT[T/A]GGAATTCAAGCGAATATTCCTGAAACTCAAACAGAAGCTGTCTGACATTA

Long Flanking Sequence:

ACATCTGAAATGTTGTTTTGGTCATTCTAAAATCCTGTAACCATTTTAGTATTTATGTTATTATATTATTAATGACCTCCAGAATTGTGTGCTCCGCATCTCACGCCTTTAAATGCCACCACACATTCATTGCGTATCATTCTGAGACGCAAGTAATTTATTAAATAAAAAAAAGTATTAAAACAGCTTCTTCAACCGCTGCAAGTTCTGTTTTTACTTTTGATATTTGGCGGCAGTTAATCAGGAAGTGACGATTTTATTCTCTTTGACTACTTGGTAGGAAAAGCTGCTTTATTTGCATTTCTTATGAGCGATATTCCAGTTTTGCGCATCAATTTACTTAGCATCTTTTGATGGACACATAGGTACTGACTTGTTAATCAACACAACTAAAATAATCAGATTATTGAAATGCAAACAATAACCATAGCATTTTAAAATGATAAACAATGTAACTGATTTGATTAAAGCTCTGTTTTTTGTATTCTAGGGGGATGGTT[T/A]GGAATTCAAGCGAATATTCCTGAAACTCAAACAGAAGCTGTCTGACATTATTAGCAACCAAAAGGTTTTGCCATTGATTTGATGCATATACACATTTTACCATGCAAAGCCTGCCTTCACATGTGCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTAAATTGTTATATGTTTGTGGTATGTGTTGTGATCTGTTTGTCTGAAGTTGTATATGTCTGTTTTGTTGATCCACGAGTGAAGGAATGAAGAGAAATTGTCAGGTATAGTTTGTCTGTTCATGTTTCGTTACCGTGACAAAGAGGGTTTTAGTTTTCTACCTCCTAAATAGATTGTAGGGTTCAGAACATCACAAAAAATTGAAAATAAATCCACTTTTAATAACTCTGTTTGGCTTCGGTTTTAAATTATAAAAAGTATGATCTGTAAGAAACATCACATTAACTTCCAGTCCTGTTCAGCTTTTGTTTTA

Associated Phenotype:

Not determined