ZMP

dnmt6

Ensembl ID:

ENSDARG00000015566

ZFIN ID:

ZDB-GENE-050314-3

Description:

DNA (cytosine-5)-methyltransferase 3A [Source:RefSeq peptide;Acc:NP_001018150]

Human Orthologues:

DNMT3A, DNMT3L

Human Descriptions:

DNA (cytosine-5-)-methyltransferase 3 alpha [Source:HGNC Symbol;Acc:2978]
DNA (cytosine-5-)-methyltransferase 3-like [Source:HGNC Symbol;Acc:2980]

Mouse Orthologues:

Dnmt3a, Dnmt3l

Mouse Descriptions:

DNA (cytosine-5-)-methyltransferase 3-like Gene [Source:MGI Symbol;Acc:MGI:1859287]
DNA methyltransferase 3A Gene [Source:MGI Symbol;Acc:MGI:1261827]

Alleles

There are 3 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa45614	Nonsense	Mutation detected in F1 DNA	Not yet available
sa36471	Essential Splice Site	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa45614

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

T > A

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000005239	Nonsense	401	731	10	18
ENSDART00000126823	Nonsense	401	731	10	18
ENSDART00000127557	Nonsense	648	978	14	22

Genomic Location (Zv9):

Chromosome 17 (position 37124475)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	17	37009372
GRCz11	17	36956957

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

GGTCCTGGTGCGGCGCAGGCAGCTATTAAAGAAGACCCATGGAATTGCTA[T/A]ATGTGTGGACTGAAGACTCAGTATGGCCTGTTGGAGCGCCGGGCTGATTG

Long Flanking Sequence:

TGGTCAAACTCAACTGTATAACTCTATGTACTCAAAAAGGGTGTGTTCCTTTAAGATAAGCAGTTTTTTGGAAGTGATTTCATAAAGTACAATGTTTTGGAAGTTTTTTAAATATAAACTGCAAACTCCCAGAAAGAAGTCCTCTCATCAGTACATGCCGATATTCCAGCTTTCTTCTATTTGGCAATCCTCTATAAACAAATGAACTTTTTATGCGTTTGTCCTTTTATAGAACTGCTTTCTAGAATGTGCGTATCAATACGATGACGATGGCTACCAGTCCTACTGTACCATCTGCTGTGGAGGGAGGGAAGTGCTCATGTGCGGAAACAATAACTGTTGCAGGTAAAACTGAACTCTGATGCTCAGTTTTTCTATACTGTCCTTCAGTCCTTCACCTCTAAGTTGTCCTGCAGGTGTTTCTGTGTAGAGTGTGTGGATTTGTTGGTGGGTCCTGGTGCGGCGCAGGCAGCTATTAAAGAAGACCCATGGAATTGCTA[T/A]ATGTGTGGACTGAAGACTCAGTATGGCCTGTTGGAGCGCCGGGCTGATTGGCCTTGCAGACTGCAGCACTTCTTTGCCAACAATCACGACCAAGAATTTGTAAGTGACATATACTGTTTTATATCTTAATATTGGCAGTTTGAGCGAGCCCTGTCTTAAAATCAGCTCTGACTAATAGGGCTGCACAATATATCGTTTTTGCATCAATGACGCAATGTGTGCATTCACAATAATCACATCACAAGATATGCAATGTTGAGTCGGAATTATAGTTGACCAGGAGCTACAGAATTGTATTTACTTACTATATTTAAACGAAATTTAGATATGAGCTAAAAACCTTATTTAATATTTTTGTCTTGTTTTTAGTCCAAATATCTTCAATTCAAAGCAAAAACAAAGTTATTTTTCTTGCCCACTGACATAGTTTTGTTTGTTTTCAGGAAAAACTTAAAATAATAAAAAGTTGAAAACAAATAATATTTTTACTTATTTTTAGA

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa36471

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

T > C

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000005239	Essential Splice Site	591	731	14	18
ENSDART00000126823	Essential Splice Site	591	731	14	18
ENSDART00000127557	Essential Splice Site	838	978	18	22

Genomic Location (Zv9):

Chromosome 17 (position 37114629)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	17	36999526
GRCz11	17	36947111

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

GGTGGCCATGGGCGTCAGCGACAAAAGGGACATCTCTCGCTTTTTAGAGG[T/C]TTACAGCGATTGATATCATTATTTTTGTTCTGGTTGAGATGAAATTGTAC

Long Flanking Sequence:

AATACATTAATCAGCTGATGAGTCAAGAACCATGATTAACTACGCTTAAAATAGAGAAATTGCACGTAATAGACAATATTAACAGAATAATCCAATAAAATCACATAGATATTTAAAAACAAGATTTTATTATCGCTGTGCCAATGGTTTCCCCTAAAGAATTAGTAAAAAAAATTGTAATAACAGTAATAAATGCAAGATATAGATGGCAACAAAATGTTAGCAATCCTAAACATTTAAACACTAGTGTATATCTTACTTATATTTTATAACACAGCTCATATATATGTATTTATTTGACATTTGTCATATTGAGTTTCTATAATGTCTTGTTTTTTTGTCTTTTTCAGAGGGCACCGGTCGGCTCTTCTTCGAGTTTTATCGGCTGTTACACGAGGCCCGACCTAAAGAAGGAGATACCAGGCCGTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTCAGCGACAAAAGGGACATCTCTCGCTTTTTAGAGG[T/C]TTACAGCGATTGATATCATTATTTTTGTTCTGGTTGAGATGAAATTGTACTTAATGACCTCACATAATGATCTCCTACAGTCAGTCCGGCATTGATATACTATAAACCAATAGATTTTGCTGCCACCTAGTGGTGTAATGAAGTGATGTGCAGGAAAAAAATAAGTCTTGTGTGTTTTTTATGTAAGTTTATTTTATATATATATATATACATATATACACACACACACACAAATCCAAGGGAAAATAGGCCAGTTAAACACATTGAATCTAAAACCAACCTAAAAATGTTAATAAAAAAATATCTAAATAAAAAAAACATTTATGAACTGTGTGCAGAATCACAATTTTGGAATATCTATTGCAGATAGACATCTGCAAAATTTAATTCTTTGAAAGTTTTATGAAAATGTTTATTGTTATCGAATTAATTGTAAAATAAAAATAAAACATTTGCATTCCTGATGCTATTTTTCTGTACAGCACAAAGTCCCAAACATA

Associated Phenotype:

Not determined