Busch Lab

ZMP

LOXL2 (2 of 3)

Ensembl ID:
ENSDARG00000091492
Description:
lysyl oxidase-like 2 [Source:HGNC Symbol;Acc:6666]
Human Orthologue:
LOXL2
Human Description:
lysyl oxidase-like 2 [Source:HGNC Symbol;Acc:6666]
Mouse Orthologue:
Loxl2
Mouse Description:
lysyl oxidase-like 2 Gene [Source:MGI Symbol;Acc:MGI:2137913]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa34883 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa34882 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa31777 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa45401 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa34883
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000127848 Essential Splice Site 262 648 4 12
Genomic Location (Zv9):
Chromosome 10 (position 20457861)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 20466644
GRCz11 10 20424025
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGGATTCGGAAGCGCCAAAGAGGCTCTCACTGGAGCCAAGTTAGGACAAG[G/A]TTTGTGTGGCTTTTCATGCATGATATGTTTTATCAGTGCTTGTAAAACTG
Long Flanking Sequence:
TGGAAGGAATTGTTTTCCTGGAAATAACGTTTTCCTGTAGATCATCATGTTCTCTCAGGCTGGATGTCAGGGTGACACTTGAAAAAATCATGTAGTACATTAAATCATGCTTCCTTTTGGATAAAAAGAAGATTGCATAATATTTAAACATGGCCTCAGAGAGCTGAAGTGAGATTGTTTATACAGGCAAATGGGGGGAAAAAATCATCTGAATCACCTGGATCCAGAGACCGAGAGAGCTAGACTGTACAAACATGGGTCACCGAGGGTGTGTGAATTGATCATCCTGCTAATTTTTCCCTCTCTGATTCCTTAGCAACCCCTGGTGCGTCTGCGGGGTGGTGCAAATGTTGGCGAAGGCAGAGTGGAGGTGCTGAAGAATGGTGTTTGGGGAACAGTGTGTGATGATAACTGGAATCTAAAGGCTGCAACTGTAGTGTGTCGAGAGCTGGGATTCGGAAGCGCCAAAGAGGCTCTCACTGGAGCCAAGTTAGGACAAG[G/A]TTTGTGTGGCTTTTCATGCATGATATGTTTTATCAGTGCTTGTAAAACTGAAATGATTTGGAGGCACTGAGAATCAAGACTGAACACTCTTACCTTAGTTACCAAACTACTACATGTCCTAAAAGTTGGTGTTGGAGTTGGTGACTTTTTTTATCTTTAGCTTATTTTTATCTTTTGTCCGTAGTGATTCATAAAGTGCAAGTCAGGGGATTTTGACACTCACTCACTATCCACAGTGGAATGAACGGCCAATTACTCTGAAAAAGGTTTTGTGCAGGGGGTGCCCCTCCAGCTGCAACCCAACACTGGAAAATACCCAAACACTCACATTCACACGCACGCTCATACACTATGGCCAATTATGTTATTATGTCTACCACATACCTTTGGACTGTTGGGGAAACCCACGCGAACACAGGGAACACATACAAATTCCACACAGGATTGCTCCTAGCCCAGCCGGGACAAAAAAAAAAACAGCAACCTTCTTGCTGTGTGGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34882
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000127848 Essential Splice Site 314 648 6 12
Genomic Location (Zv9):
Chromosome 10 (position 20453517)
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CGCTCATGAATCGGTATGATTGTGAAACACTGTTTGCTTTTGACTACAAC[A/C]GATACGACTAAGTGGAGGAAGAAACCCATTTGAAGGACGTGTGGAAGTTC
Long Flanking Sequence:
GAAAATTTCAGATGGCACAGAGGTTTTTGCATCTGAACTCTTCAAATAGACACATCCTTTGGTACCTTTTGGTGCCTGAAGCATTAACAAGAATTCAGTATCAACCACATGTCAAACACAGATATCTTCTACCAGGGTAATTTCTTTTTTTTGCATCAGAACTCAGAATTTCTTATTCATGAACACTATTTTGGATAATAATGCCCCATTTAATGTACACAATGTATTTAATGTGTACTTTTTTTGTCAGGAATGGGTCCGGTCCACATGAATGAGGTGGAGTGCTCTGGATTTGAGAAATCTCTCACTGACTGCTACTTTAATAATGATGCGCTGGGATGCAGTCATGAGGAGGACGCAGCTGTTCGCTGTAATGTACCTGCTATGGGCTTTCAGAAAAGGGTGAGGATTTTTAAAATATAATTTACATATTAATTAGCAATAGTTTTACGCTCATGAATCGGTATGATTGTGAAACACTGTTTGCTTTTGACTACAAC[A/C]GATACGACTAAGTGGAGGAAGAAACCCATTTGAAGGACGTGTGGAAGTTCTCGCTGAGAAGAACGGTTCTCTCGTTTGGGGAACAGTTTGTAGTGAAAACTGGGGGATTATAGAGGCTATGGTGGTCTGCAGACAGCTGGGATTAGGCTTTGCCAGCCATGCGTTCCAGGTAAGACTACTTACTAAATGTGAAAGTCCTTCAAAATTGAAAATCGAATGGGTTTAAACAGTCACAAAATACAAGCTACTATTCTACTGAACACATGATCACTATGAAAAAGTGCATTTAAACAATAAATTCATATTTCATAGTATTGTACTTGCCATTTAAATTCACCTTTTCATTCATTTTCTTTCACACACACTCTAAAGCAAGTAGTATTTATGCATCACACTAAGCTCTTCTGCTAAAATGATGTAGAGGGAAACAAAATAACAGTGAAGGGTCTTGATTCAATCTAAACATAAGTGGTCACAAGAGTCACATTTGAATTCATGTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa31777
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000127848 Essential Splice Site 314 648 6 12
Genomic Location (Zv9):
Chromosome 10 (position 20453516)
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCTCATGAATCGGTATGATTGTGAAACACTGTTTGCTTTTGACTACAACA[G/A]ATACGACTAAGTGGAGGAAGAAACCCATTTGAAGGACGTGTGGAAGTTCT
Long Flanking Sequence:
AAAATTTCAGATGGCACAGAGGTTTTTGCATCTGAACTCTTCAAATAGACACATCCTTTGGTACCTTTTGGTGCCTGAAGCATTAACAAGAATTCAGTATCAACCACATGTCAAACACAGATATCTTCTACCAGGGTAATTTCTTTTTTTTGCATCAGAACTCAGAATTTCTTATTCATGAACACTATTTTGGATAATAATGCCCCATTTAATGTACACAATGTATTTAATGTGTACTTTTTTTGTCAGGAATGGGTCCGGTCCACATGAATGAGGTGGAGTGCTCTGGATTTGAGAAATCTCTCACTGACTGCTACTTTAATAATGATGCGCTGGGATGCAGTCATGAGGAGGACGCAGCTGTTCGCTGTAATGTACCTGCTATGGGCTTTCAGAAAAGGGTGAGGATTTTTAAAATATAATTTACATATTAATTAGCAATAGTTTTACGCTCATGAATCGGTATGATTGTGAAACACTGTTTGCTTTTGACTACAACA[G/A]ATACGACTAAGTGGAGGAAGAAACCCATTTGAAGGACGTGTGGAAGTTCTCGCTGAGAAGAACGGTTCTCTCGTTTGGGGAACAGTTTGTAGTGAAAACTGGGGGATTATAGAGGCTATGGTGGTCTGCAGACAGCTGGGATTAGGCTTTGCCAGCCATGCGTTCCAGGTAAGACTACTTACTAAATGTGAAAGTCCTTCAAAATTGAAAATCGAATGGGTTTAAACAGTCACAAAATACAAGCTACTATTCTACTGAACACATGATCACTATGAAAAAGTGCATTTAAACAATAAATTCATATTTCATAGTATTGTACTTGCCATTTAAATTCACCTTTTCATTCATTTTCTTTCACACACACTCTAAAGCAAGTAGTATTTATGCATCACACTAAGCTCTTCTGCTAAAATGATGTAGAGGGAAACAAAATAACAGTGAAGGGTCTTGATTCAATCTAAACATAAGTGGTCACAAGAGTCACATTTGAATTCATGTTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45401
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000127848 Nonsense 557 648 10 12
Genomic Location (Zv9):
Chromosome 10 (position 20444277)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 20453058
GRCz11 10 20410439
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCTTTGGACTAGGTATTTCGAAGCGGTACCATTGTGCTAACTTTGGTGAA[C/T]AGGGCATCACTGTTGGCTGCTGGGACACTTACAGACATGACATTGATTGT
Long Flanking Sequence:
CTCTTCCAAAGGCTTTAACTGACACAGTAAAACTGACACCATTGTTACTGTCCATTTGTCTGATTTTACTGATGACCAATCAGAGCAGAGGAGAGGTTTAAAGAGACTTTAATTTTAGACACTGAGAGAAAAGAGCTTTAATATTTGCTATTTATGAGTAAATAAAGTGCTTTTTGACCTTGAACTGACCTTTAAAATAGCACAACTGGGGCACTTAATTATGATACACAATAAAACTCTCACATTGTATTGTTGTGTGTCTGCACAGGCATTATCACAGCATGGAGGTCTTTACTCATTATGACCTGCTGAGCTTAAACGGCACCAAGGTAGCAGAGGGTCACAAAGCCAGTTTCTGTCTAGAGGACACTCATTGTGATGAAGGTGAGAATGCGAGGGCTGATCCCCTGAACTTTATTCAGTTCAAGCTGAATTCCTAACTGGTTGTTTTCTTTGGACTAGGTATTTCGAAGCGGTACCATTGTGCTAACTTTGGTGAA[C/T]AGGGCATCACTGTTGGCTGCTGGGACACTTACAGACATGACATTGATTGTCAGTGGATTGATGTGACGGATGTCAAACCAGGAGACTACATTTTCCAGGTACAGTTTCAAATCACTGTTGGTGTGAATTTTAGACAATGAGTTTTTGAGGGAATTCTCTTATGTTCACCGTAGGTGGATTTATTAAGTTAAGACATTCAATTCAATCAGTTGTAATTTACAAGTTGGATTAAGTGTATTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTATTTATTTCTTCCTGTCATGCAAAGCTTTTCCTGCATCTAGTCCTCACATGATCATCGAGAAATCATTTATGCTAATTGTGTTCTCAAGAAACATATTATTATTATTTATTTTTTTTAAAATAAATTTTAGAAACTGCTTTTTTATATATTTTGTAAACTGATACATGCCATTTTAAACTG
Associated Phenotype:
Not determined