Busch Lab

ZMP

mad1l1

Ensembl ID:
ENSDARG00000033852
ZFIN ID:
ZDB-GENE-040426-1081
Description:
mitotic spindle assembly checkpoint protein MAD1 [Source:RefSeq peptide;Acc:NP_957206]
Human Orthologue:
MAD1L1
Human Description:
MAD1 mitotic arrest deficient-like 1 (yeast) [Source:HGNC Symbol;Acc:6762]
Mouse Orthologue:
Mad1l1
Mouse Description:
mitotic arrest deficient 1-like 1 Gene [Source:MGI Symbol;Acc:MGI:1341857]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa19431 Nonsense Available for shipment Available now
sa45064 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa14241 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa19431
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048610 Nonsense 374 717 10 17
ENSDART00000103478 None None 323 None 9
ENSDART00000103479 None None 323 None 9
ENSDART00000147904 Nonsense 374 717 11 18

The following transcripts of ENSDARG00000033852 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 8897163)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9136968
GRCz11 1 9821079
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGTTCGCTCTGTGGAAAAGGCCCGCTCTGAGCTCCTGACCGAGATTGCT[C/T]AGCTGCGCGCCAAGGCTCAAGAAGAACAGAAGAAACGAGAGAACCAGGAC
Long Flanking Sequence:
AACAGACGTTTAAAAATGTATACAGAATACATATATGGTCTTTTTATGCTGACAACAAGGTCCTCAATATGAGAAATATTGCAGTCCTGGCAATACTGGTCTCAAATGAGAACCAAACTGAAGTGTGCACATTCAGACTAGTTGGTGCCCATTTAGAAAAATATTGTATGGATTAATCACCATCAGACATACACATTCATTTACCGTCCCCAGGGCTTTATTCAGGTCTCTTTCAAAGAATTGTTTATGGCTCACTGTCTTTCAAACATTGTGCACCATTTCCCTGAATGGCCCAGCAACAAAGACCGTATACTCTACTGTGAACACTGAGAAGGCAGCTTTTATGTTATAAGGAAATGACCTTCCAGGATGTAGAGGATGCAGTTCTTTGTGTTCTCCCCAGAGCTGCTCCATCTTAATGTTCTGGCTTTTTTCTATCTGTCTCTTTCAGTGTTCGCTCTGTGGAAAAGGCCCGCTCTGAGCTCCTGACCGAGATTGCT[C/T]AGCTGCGCGCCAAGGCTCAAGAAGAACAGAAGAAACGAGAGAACCAGGACTCACTGGTCCGTCGCTTGCAGAAGAGAGTCTTACTGCTCACCAAGGTAATACAAAAAGTATTGGTTTCCACATTTAGTTACACTTGTCAAAACTAACTGGTTTAAACTTCCTAGTTTAAATAGATAAACTATTGCTTTTAAGCAAGTGAAATAGCCATGAGAGGTCTGATATGACCCATTATCTCCTAGCTGTACCTCTTATAGAAATCTAGATCATGTCCTTCCTCCTGACTTAAAGTTTTCTCCAAAGGCAAGGATGAGTTGTAGATAAATTACTGTGGCAGAAACTCATTGGACTCGCGAATAATACTCCTTGTTCTTTGTTTGTCAACAGCTTGCTTAATTAGTAATTAACCAAAGCCTTCAATAAACTCCAATCATGTTTCCTAAATGGGTGGTATATGTTTTAATGAGGTCAGTGCTTGAGTGTAATGATGTCTACACTGGAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45064
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048610 Essential Splice Site 502 717 13 17
ENSDART00000103478 None None 323 None 9
ENSDART00000103479 None None 323 None 9
ENSDART00000147904 Essential Splice Site 502 717 14 18

The following transcripts of ENSDARG00000033852 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 8884379)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9124184
GRCz11 1 9808295
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATGCCGAGAGAAGCAGCTCAGTGACAGCAGAGGAAATCAGCTCTCTCAGG[T/C]AACACAGATGGAAGAAATTAAACTTCATGTATGTTTCATCTGATGGAACG
Long Flanking Sequence:
CTTTGTAATCAAGGACTTTATGCTTTACTATCTTACTTTGTGTTTTTATGGGAATAATCTGTTTCACTCTGATAGACTCAACTGTCCAAAGCCCAGGAGGAGGCTGGCTCCTTCAAATTACAAGCTCAGATGGTAAGTCACATCTATCACCATGGGAACTTCCTTTTGGCATTTATGCGCTTATCCCAGCTAGCGCTTCGATCCTGAATAATTGATTAAAATTTGCACTGTAATGCATGCAAGAAATGAAAAAACCACATAAGGCGAGAAGTCGAGATATTAGAGGGGTATTACATTGCGCCAAGGCTGCAGGTGTTTCATTTGCTCCGATTTACAGTCAGTGGCTGTTTTTTGACATACAGTACTGATGGTTTTGTTATTCATTATGTTTTTCATCTCTTGCTCAGGTGGCTGCTGAACTTGAGGCTCTGAAAGAGCAGCAGGTGTCTAATGCCGAGAGAAGCAGCTCAGTGACAGCAGAGGAAATCAGCTCTCTCAGG[T/C]AACACAGATGGAAGAAATTAAACTTCATGTATGTTTCATCTGATGGAACGTTTTTTATGTTTGATCTGATCGTTATTTAAGCCTGTTTCTGCTGACTTGTTCAGAGTTTCAGATATGAAGTCTAAAACTGGATTCTTAACATTTGTTTACTGTTCAATTTCACTATCTTTACGTTATGTTCATGAACATATGTTCATAGGTTGTTTTCACATAACTCGCAAAAGTTAGATAGGGTGGAGGAACTGGTTCTTCTACATAGGAATCGCTATCAGAACATCAAAACATTTCTGTTTTATGTTTTTTATAATTGTTTAAATCGGCCAAAATAAGAAATGCCAAACTGCGTTTATAGCCTTCCTAGAGTTTTTGCTCTTAATGGGGGGAAAGTTCAAGAAACTGGCTGAAAAACAGGAGAAAAGATGCCATTTAATACACATTTATTTAGTACATCCATGTTTACAAGCTTTTTGTGAATGCAATAGTTTGACAGCAATAAAGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14241
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048610 Nonsense 568 717 15 17
ENSDART00000103478 Nonsense 174 323 7 9
ENSDART00000103479 Nonsense 174 323 7 9
ENSDART00000147904 Nonsense 568 717 16 18

The following transcripts of ENSDARG00000033852 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 8869337)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9109142
GRCz11 1 9793253
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ATGGCAAAGCAGCAGCGRGCGGATGAGGTGGAGCAGCTCAGGGTGGAGTG[T/A]CAGCGTTTGAGGGACCGACTCCGCAAAATCGARRTGGCTGGTGGCATGAC
Long Flanking Sequence:
AATTTCTTTGCTCTGTTAAACATCATTTGGGAAATATAAAAAAATCAAAGGGTGCTAATAATTCTGACTTCAACTGTATAGGCAATATGTCTGAATGGTAACGAACTCAACTAATAAAAGATGATGTCCGCCATTCTCTAATTCTCGTACAGCTATCTCAACAAAAATGCTTGCTGTAAACCAACAGCTTTATTGTATTGGCCCTGACAGCATGGCGGGGAAAAACATGCAACAAACCCCGTGCATCATGGAAACAAACTCGTACGACTAGGCATAGTACGAGTTTCAAGGTTTACTGCGGTTTGGAAAAGTCAAGATTTTAAAACCGCAAAAATTACCACATATTAATTGAATCCCAATTTTCAGACTCTCTGCATCTCTTTCCTTCATTAGGGAGACTACGACCCTGTTAAGACGAAGGTGGTCCACCTGCAGATGAACCCCACCAGCATGGCAAAGCAGCAGCGGGCGGATGAGGTGGAGCAGCTCAGGGTGGAGTG[T/A]CAGCGTTTGAGGGACCGACTCCGCAAAATCGAAGTGGCTGGTGGCATGACAACAGATGACACTACCCTCATCATCCCACCGTCACAGGAAATACTGGGTAAATACCTTTTTTACACAAGCCTTTAAAGCATGAGATTTATGGTAAAGACAATCCATCACATTTAGTTGTCTATTCTTAATACCATTGCTGGCTTTCTTTTCTCTGTTCACCAGAAGTTGATGTAAAACATGTTGTGCCTCAAAATATAATTATTGGGTTTTGTTTAAATTACAGAACAAAATACATAAAACAAATAAATTAAATTAAATAAATACAATACATTAAATTATTTAAAAATATCTATAAAATTATAAAATAAAAACTTTTGAAATATTGAAACATCAGGAATTGTTACAAATTGTTAAAAAAGGTGAAAATAAATATATAAATAGATTCTAACAATATATAATAAAAAAAATAATAAATAACACCGTTCAGTTTATATTTTTGTATAAAAAAA
Associated Phenotype:
Not determined