ZMP

hcn2

Ensembl ID:

ENSDARG00000061665

ZFIN ID:

ZDB-GENE-030131-8228

Description:

Novel protein similar to hyperpolarization activated cyclic nucleotide-gated potassium channel famil

Human Orthologue:

HCN2

Human Description:

hyperpolarization activated cyclic nucleotide-gated potassium channel 2 [Source:HGNC Symbol;Acc:4846

Mouse Orthologue:

Hcn2

Mouse Description:

hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Gene [Source:MGI Symbol;Acc:MGI:1298210]

Alleles

There are 3 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa43812	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa43813	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa6705	Nonsense	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa43812

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

A > G

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000088193	Essential Splice Site	234	979	2	8
ENSDART00000136390	Essential Splice Site	130	875	2	8

Genomic Location (Zv9):

Chromosome 22 (position 19190275)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	22	18941210
GRCz11	22	18966188

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

CAATGAACTCAAATATTCAGTAACTAAACTAATGTGCTCATTCTCCTCTT[A/G]GGTTCTACTGGGATTTCACAATGCTAATGTTCATGGTGGGCAACTTGATT

Long Flanking Sequence:

TTTTATTTTTTTTACCTTTGCGACTCTATTTCTCCTACTTACATGTTTATAGGATTTCTTGGAGTTTAAATCTTAAAATTCCGACCTTTTAGCCCTGAATTTTGATTTCTTGCAATTCTGATGGTTCTGTAAATTGCAACATTATTTGCTTCCTCAAAAATTACAATTTGTCACAAATCTGAAAAGACATGTCAAAATTGTGAATTGACTGCTAAAGGTATGAATTGCTAAACTTAAATATGGAATCTAAACGCAGTTCTGTGAAAAAATAATTATGGTATTTAACTTGGACTTAACTATATTTAACTATAGCAATTTTCCATATAAACTCTCGCAATAGCAAGACAAAGCCAGAAAAGTCACAATAACCTTTTTTTATATTGTATTTTTATTGTTATAAAAATTTAATCTATAAAATAATATCTACATGCTTTTCATCATGTGTGTTGTCAATGAACTCAAATATTCAGTAACTAAACTAATGTGCTCATTCTCCTCTT[A/G]GGTTCTACTGGGATTTCACAATGCTAATGTTCATGGTGGGCAACTTGATTATCATTCCTGTGGGCATCACCTTCTTCAAGGAGGAAACCACCACCCCTTGGATTATCTTTAATGTTGTGTCCGACACATTCTTCCTCATGGACCTGGTACTGAACTTTCGTACGGGCATAGTGTACGAAGACAACACAGAGATAATACTGGACCCTGAAAAGATCAAGAAGAAGTACCTTAAGACGTGGTTCGTGGTGGACTTTGTCTCATCCATCCCGGTGGATTATATCTTTCTCATCGTAGAGAAAGGCATTGACTCTGAGGTTTACAAAACGGCCAGGGCACTGCGAATAGTGCGTTTCACCAAGATCCTCAGTTTACTGCGACTTCTCAGATTGTCCAGGCTGATTCGTTACATCCATCAATGGGAAGAGGTAAGATGATGCTCCAATGACAAAATCAAGAAGGGTCTTTTACATTTGGCACTTTAAAAAATAAGACAAACAATC

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa43813

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

G > A

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000088193	Essential Splice Site	687	979	8	8
ENSDART00000136390	Essential Splice Site	583	875	8	8

Genomic Location (Zv9):

Chromosome 22 (position 19230665)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	22	18981600
GRCz11	22	19006578

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

TTATGGACACTTAGAAAAAATAAGATATAACTTATCATCTTTTCTTTACA[G/A]GAAAGAAGAACTCCATCCTGATGCACAAAGTACAACATGATCTCAATTCT

Long Flanking Sequence:

TTGCTGTTCACAGGGAAGTGGCTAACCAATCTTACGTTTGGAAAAAAATAGTGTCTAAGGCCATGTGTGCTAGTGAGTAAGACATAATACAGGGGTCTTAAGACATGTTTAGAAAACAGTCAAGGAGACCTTGATTAGTTAATTCAGGTGTTTATTAATGAATTGTATACAGCTAAACCCTACTTAAAAAGGGCCCTCCAGGAGCAGGATTGAAACCAGGATGGATCTGGATTACAATTGTGATTCATACCTTCACCTGGAAAATTTGACAAAATTAGGTGAAGTATGATGGTTTAGAATAAGACAATGCTTCATTGTGTCTGACAATTACTAAAGCCACAGGGTGCAATAGAGTACAGTTTAATGAATTCACTGTAACAAGAAATAAACATTTAGGTAATTGCCATTATTATTAATCATCCTTAACTTCAGGATTACTAGCTACAGTAGTTATGGACACTTAGAAAAAATAAGATATAACTTATCATCTTTTCTTTACA[G/A]GAAAGAAGAACTCCATCCTGATGCACAAAGTACAACATGATCTCAATTCTGGTGTTTTCAACAACCGTGAGAATGAGATGATCCAGGAGATTGTGAAATACGATAGGGAAATGGTTAAACTGGTTAAACAAGGGGACATGCAGAGGCCCAGGGCCATGTCCATGACTCCGTCAACTCATGGGAGTATGTTTGGACCTTCTAGTCAACCCTCTACAAGTTCTGCCATTGCTACTCTCCAGCAAGCTGTTGCCATGAGCTTCTGTCCCCAGATGGGTAACCCTCTAATGGGTTCTGGATCTGTCCAGTCTCCCCGTATGGTGCGGCGATTCCAGGTCGTCCAGACTCAGACACCCCCAGGTTCCCAGTACTCAACCTTAGCCCGTGCCTCTGCTCTTGCAAGCACACCTGTCCATAGTCCTCTGGCAACTACTGCTCGAACATTCCAGTATGGTTCAAGCCCCCCGGGTGCACCCTCAGGCTCCCAGTTATCCCTTGTACAG

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa6705

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000088193	Nonsense	968	979	8	8
ENSDART00000136390	Nonsense	864	875	8	8

Genomic Location (Zv9):

Chromosome 22 (position 19231508)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	22	18982443
GRCz11	22	19007421

KASP Assay ID:

554-5472.1 (used for ordering genotyping assays)

KASP Sequence:

ATTCAGGTCTTCCCAAGAAGGATTCAATAAGCAGCCTCCCAGAAACAGAA[C/T]AACATCACATCAGATCTAGATTATCTTCAAATTTGTGACCTCAATAGCGT

Long Flanking Sequence:

CTCAGACACCCCCAGGTTCCCAGTACTCAACCTTAGCCCGTGCCTCTGCTCTTGCAAGCACACCTGTCCATAGTCCTCTGGCAACTACTGCTCGAACATTCCAGTATGGTTCAAGCCCCCCGGGTGCACCCTCAGGCTCCCAGTTATCCCTTGTACAGCAACTTGTCCCTAGTCCCACACATCGACCAGCAGTCCACAGGAGCACTCTCACCCAGGACGCACGTGCCCTTTCCGCCTCCCAGCCATCCTTACGCCCAGACATGATTCAGCCAGTTGCCCCAAGTCCTCCCCAGTCTACCCGAGTCTCTTCTACTTCCATCGGTCCCCCTCAGAACCTCCCAGGTCCCACTGGTCTTAGGGGAAGTATCCCACCTAGAATGGCACTAACACACCAAATGTCTGTAGGTGCATTTCCTCCTGCCTCCCTACCCCAGATGAGACCTAGCTTGGATTCAGGTCTTCCCAAGAAGGATTCAATAAGCAGCCTCCCAGAAACAGAA[C/T]AACATCACATCAGATCTAGATTATCTTCAAATTTGTGACCTCAATAGCGTTGGTGGTCTCTGCTTCAGTCAGGAACATATGGACCTTTGTTCTCCAAGAACTTCTCCCGAACCCTAGTCACACCTTTGGATTTTACTCTCAGAATGTATGTGATTGTGACTGGCCACAAGGGCAAACAAACCCTCAAAACTTTCTAGCATAAAACAAACATGTCTGTATCATTCTTACCGCAATTGGGACAATTGATTCCATTGTCTCATGATATAAACATCAATGTAGCTTCCACCCTCACACTTTGCCTCTTTGAAATGGTTTTCTTTATTGTAGCTGTTCACAGAGATTACAAATGTACCCACACCCTTTTATATACTGTAGTACAAATGATGCAAGCTGATGTGTGTCTAAATACCGGGACTTAGCAGTTTGCTGCTGATCACAATGTAGGAGCTTACTTCCTCTTCTCAACTTGAACCGGCTAGACATTAGATATATAACCTATA

Associated Phenotype:

Not determined