Busch Lab

ZMP

leo1

Ensembl ID:
ENSDARG00000055357
ZFIN ID:
ZDB-GENE-040426-2435
Description:
RNA polymerase-associated protein LEO1 [Source:UniProtKB/Swiss-Prot;Acc:Q6NYV9]
Human Orthologue:
LEO1
Human Description:
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:3040
Mouse Orthologue:
Leo1
Mouse Description:
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Gene [Source:MGI Symbol;Acc:

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa29073 Nonsense Mutation detected in F1 DNA Not yet available
sa2979 Nonsense F2 line generated Not yet available
sa43155 Nonsense Mutation detected in F1 DNA Not yet available
sa44895 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa29073
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077694 Nonsense 50 696 2 11
Genomic Location (Zv9):
Chromosome 18 (position 37756723)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 39338426
GRCz11 18 39319434
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GACCAAGATCTGCCAGCAACGCTTCTGGAAGCGAGAGTGCTCAGAGTGAC[C/T]GAGATCATGATGATGATGAAGATGAAGATGGCGGAAAGCCTAGCAATAAA
Long Flanking Sequence:
TTCTCTCCTAAGACTGCTGCCCCCGAGACCCGGCCCCGGATAAGCGGATGAAAATAATAATGATGATGATGATGATAATGATGGTCTACTGATTATTTGCCGGCACAAATGTGAGAGCATTTAGTGACTTTTCCCCATGCATTATTAACTATTGTAAAATCGTTAATGACGATACTATTGTTTACAAACTACAGAGGCACCACTTGTATTTTGGACCCATAGTGTCGCGGTGCTACCGAAGTACCGGTAAAACGTGCAACTCTAATGGTTTAGAACCACTTGAGGGAGATTAAATAGTGAGGAAATGTTCATTTTAGTGAAAACTCCGTTTTTTTTGGTCTGCGTTCTGTGTATAACTAAACAAAGTAACACGTTAGTAAATTATTATATCAATTCATGTGTTTTCTCCAGATTCCGGCTCTGGTTCTGGCTCTGATTCGGATCATGAGAGACCAAGATCTGCCAGCAACGCTTCTGGAAGCGAGAGTGCTCAGAGTGAC[C/T]GAGATCATGATGATGATGAAGATGAAGATGGCGGAAAGCCTAGCAATAAAGAGCTGTTTGGAGACGACAGTGAAGATGAGCACGGCAGCCAGCACAGCGGGAGCCAGCACAGCGGCAGCCGGCACAGCGGCAGCCGGCACAGCGGCAGCAGGCACAGTGGCAGTAGGCACAGTGGCAGCCAGCACAGCGGGAGCCAATCAGAGCGATCGGGCAACCAATCAGACGCCACCATGCACTCTGACAATGAACACAGCATGTCTGAGGCCCATCGTGGTGAGCAGGATGATGAGGATGATGATGACAGAGGCCACAGGTCAGACGTAGGCAGTCCAGCCTCAGGAGCAGGAAGCCGCAGGTCGGACAGAGGAAGTGGAAGTCCAGGGTCAGAGGCGGGAAGTCCACGCTCAGAAGCTGGAAGTGGTCATTCGGATCCTGGAACCCCACATACAGATGGAGAGGGGTCAGGGAAAGATGCCCATTCTGGAGATGAGAAGTGGGGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa2979
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077694 Nonsense 118 696 2 11
ENSDART00000077694 Nonsense 118 696 2 11
Genomic Location (Zv9):
Chromosome 18 (position 37756519)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 39338222
GRCz11 18 39319230
KASP Assay ID:
554-3266.1 (used for ordering genotyping assays)
KASP Sequence:
ACAGTGGCAGYAGGCACAGTGGCAGCCAGCACAGCGGGAGCCAATCAGAG[C/T]GATCGGGCAACCAATCAGACGCCACCATGCACTCTGACAATGAACACAGC
Long Flanking Sequence:
TGTATTTTGGACCCATAGTGTCGCGGTGCTACCGAAGTACCGGTAAAACGTGCAACTCTAATGGTTTAGAACCACTTGAGGGAGATTAAATAGTGAGGAAATGTTCATTTTAGTGAAAACTCCGTTTTTTTTGGTCTGCGTTCTGTGTATAACTAAACAAAGTAACACGTTAGTAAATTATTATATCAATTCATGTGTTTTCTCCAGATTCCGGCTCTGGTTCTGGCTCTGATTCGGATCATGAGAGACCAAGATCTGCCAGCAACGCTTCTGGAAGCGAGAGTGCTCAGAGTGACCGAGATCATGATGATGATGAAGATGAAGATGGCGGAAAGCCTAGCAATAAAGAGCTGTTTGGAGACGACAGTGAAGATGAGCACGGCAGCCAGCACAGCGGGAGCCAGCACAGCGGCAGCCGGCACAGCGGCAGCCGGCACAGCGGCAGCAGGCACAGTGGCAGTAGGCACAGTGGCAGCCAGCACAGCGGGAGCCAATCAGAG[C/T]GATCGGGCAACCAATCAGACGCCACCATGCACTCTGACAATGAACACAGCATGTCTGAGGCCCATCGTGGTGAGCAGGATGATGAGGATGATGATGACAGAGGCCACAGGTCAGACGTAGGCAGTCCAGCCTCAGGAGCAGGAAGCCGCAGGTCGGACAGAGGAAGTGGAAGTCCAGGGTCAGAGGCGGGAAGTCCACGCTCAGAAGCTGGAAGTGGTCATTCGGATCCTGGAACCCCACATACAGATGGAGAGGGGTCAGGGAAAGATGCCCATTCTGGAGATGAGAAGTGGGGTGGAGATGGAAAAAGTGACCAGTCGGAGGACGAGGACAAACAGCAGAACTCTGATGATGAGAGGGAGCGATCTGATGAAGAAGGGGAGAGGCAGAAATCAGGTGAGGTCTATTAAAATGATCCAAATAATTCAAATATAGTCTGTGTTAGTAAATGCAAGGCTATTTATACAGTTGTACCGATACTAGTTGGCATGCACTGATAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43155
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077694 Nonsense 211 696 2 11
Genomic Location (Zv9):
Chromosome 18 (position 37756240)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 39337943
GRCz11 18 39318951
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGGAACCCCACATACAGATGGAGAGGGGTCAGGGAAAGATGCCCATTCT[G/T]GAGATGAGAAGTGGGGTGGAGATGGAAAAAGTGACCAGTCGGAGGACGAG
Long Flanking Sequence:
AGAGTGCTCAGAGTGACCGAGATCATGATGATGATGAAGATGAAGATGGCGGAAAGCCTAGCAATAAAGAGCTGTTTGGAGACGACAGTGAAGATGAGCACGGCAGCCAGCACAGCGGGAGCCAGCACAGCGGCAGCCGGCACAGCGGCAGCCGGCACAGCGGCAGCAGGCACAGTGGCAGTAGGCACAGTGGCAGCCAGCACAGCGGGAGCCAATCAGAGCGATCGGGCAACCAATCAGACGCCACCATGCACTCTGACAATGAACACAGCATGTCTGAGGCCCATCGTGGTGAGCAGGATGATGAGGATGATGATGACAGAGGCCACAGGTCAGACGTAGGCAGTCCAGCCTCAGGAGCAGGAAGCCGCAGGTCGGACAGAGGAAGTGGAAGTCCAGGGTCAGAGGCGGGAAGTCCACGCTCAGAAGCTGGAAGTGGTCATTCGGATCCTGGAACCCCACATACAGATGGAGAGGGGTCAGGGAAAGATGCCCATTCT[G/T]GAGATGAGAAGTGGGGTGGAGATGGAAAAAGTGACCAGTCGGAGGACGAGGACAAACAGCAGAACTCTGATGATGAGAGGGAGCGATCTGATGAAGAAGGGGAGAGGCAGAAATCAGGTGAGGTCTATTAAAATGATCCAAATAATTCAAATATAGTCTGTGTTAGTAAATGCAAGGCTATTTATACAGTTGTACCGATACTAGTTGGCATGCACTGATACTATTTGTTTACCAATCCAATCTCGAAACCAACATTATGGTTATCGACTGATATAGATCCGATCCTGATACTGCAATATTTTTACATTTTTTGACATAATACAGTTTCTAAAGTTCTGTTGATAACATAATAATCAAATAATTTAGCTTCTTTAGTAACAATAACAGACCTATAGGCCTACTTTAAATGTCAGACGGCACAATCTAGCTAAAAACATGATGCTTGCTGTAAACTAGGCTACATTATTTGAGCATCCGTTATGACATTGATATGATATGTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa44895
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000077694 Essential Splice Site 315 696 4 11
Genomic Location (Zv9):
Chromosome 18 (position 37753519)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 39335222
GRCz11 18 39316230
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTCGTCAGACAGCGATGCAGAGAAACCTCTCACACCTGGCCAACCATTGG[T/C]GAGACATTTACATGCTTAACTTCTGATTCAATTTAAACTGCTGGAAAGCA
Long Flanking Sequence:
CAGACAAAACATGAAATATTTTGTGTTCATATTGTTTATATTTTGTGGTCATATTGTTTATATTTTGTGTTCATATTGTTTGCAATGAAATACAAGTCAAAGTACATTAAGGAATCACTGCTTTCTTTTTTTTATTAGCAATTTCCATACTTTCTCACCTTTTCTGATTAAGGCTTGTATTAATAATGTAAAAGCCATATGTTATTCTTAATTTCAGAGTCGATTAAGGGCAGTGACAGCGAGGATGATTTCACACGCAAGAAAAAGAAAAAGATTGCTTCGGACTCGGACTCAGACTCTGATGCTGAAACACAGGGTGGTGAGTGACAGACGCTCGCTATGATTAAAACACAGTGTCATACACTACACACAGCAGCTCTGTTGAACTGTTTGTGTGTTTGTAGGTAAGAAGCCTGCAGCAAATGATCTTTTTGGGGAGGCAGATGATATTTCGTCAGACAGCGATGCAGAGAAACCTCTCACACCTGGCCAACCATTGG[T/C]GAGACATTTACATGCTTAACTTCTGATTCAATTTAAACTGCTGGAAAGCAAATTTGATACATTTTTTTAAGATTTACACTGTAAAAAATGCTGGGTTCCACACAATCGGTTTGTGTTAGGGCAACATAAAGGAATTAAGTTAACTTATTAGTTTTTACGAATTTCAGTGGATCAAACATTTAACATAACTCAAGAATTGTGTTGCTTCAGCTCCATTTAAAGAAGTAGTTTGAACAAACAGCAAATGTCAATTTTTAGTGTAGCTCAAGCCCTAACTAAACCATCTTATTTAGTAGATAGATTGTAATATGATTTATTTTATTATTGCAAATCAAGACACAATATGACAAGAAAAGTGTGTTGAAACATGTTCCTGCAGTGACAGACGCTTCAAACATTGTATTTGTCAGCTGTGTGTCCTGCTGAGTTTAGCTCCAACTTGCTTCAGCACAATTGCCAGGAAGTTTCTAGTATATCTAGTAAGAGCTTGATTAGCTGCT
Associated Phenotype:
Not determined