ZMP

si:ch211-235e18.3

Ensembl ID:

ENSDARG00000058606

ZFIN ID:

ZDB-GENE-030131-9446

Description:

serine/threonine-protein kinase SIK1 [Source:RefSeq peptide;Acc:NP_001119855]

Human Orthologue:

SIK1

Human Description:

salt-inducible kinase 1 [Source:HGNC Symbol;Acc:11142]

Mouse Orthologue:

Sik1

Mouse Description:

salt inducible kinase 1 Gene [Source:MGI Symbol;Acc:MGI:104754]

Alleles

There are 3 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa34563	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa38724	Nonsense	Mutation detected in F1 DNA	Not yet available
sa41359	Nonsense	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa34563

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

G > A

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000083033	Essential Splice Site	218	811	5	13
ENSDART00000127164	Essential Splice Site	188	437	5	11

The following transcripts of ENSDARG00000058606 do not overlap with this mutation:

Genomic Location (Zv9):

Chromosome 9 (position 9172670)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	9	9138168
GRCz11	9	9116498

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

CAGAGGTCTTTGAGGGCAAAGAGTATGAGGGGCCACAGTTAGACATTTGG[G/A]TATGTTCATCATTTTCATTTTTACATGACATGTTATAAAAAATATAATAG

Long Flanking Sequence:

AGTTTTGGCAGATTCTGACGGCGGTGGACTACTGTCATAGGCACCACATAGTCCACAGAGATCTCAAAACTGAAAACCTGCTGCTAGATGCCAACATGAACATCAAGCTTGCAGGTGAGCAGCGAAAATACGCTTTACATTTTGGTGTTTCATTCTCAAATACATCAGTGCAAAACTAGAGTGAGGGTCTTAAAAAAGAAAGTAATTGTTGTATCTACAATTAGGTTTGGTGATAAAATTAAGTAATCACATTAGTCTGCTTCTCTGCACTCAAATAATTCATTATACACTTTATTTTAAGGAATGCACACCATTTGAAGTAGTTTTATGAGTGAATAGTCAACAAAGAACTCACTTCTGTTTCATTTTTTCAAGACTTTGGATTTGGAAACTTCTATAATGCTGGGGAACCTCTCTCCACATGGTGTGGAAGTCCTCCATATGCTGCCCCAGAGGTCTTTGAGGGCAAAGAGTATGAGGGGCCACAGTTAGACATTTGG[G/A]TATGTTCATCATTTTCATTTTTACATGACATGTTATAAAAAATATAATAGATAATGTTGTTCTTTTCTGCCTTGCAAATGCTAGGACAAATGTAAATCTAACACATGCTCTAAATATCTTTCACAGAGTTTAGGCGTGGTTCTGTATGTGCTGGTGTGTGGGTCACTGCCCTTTGATGGGGACAGTCTTCCAGCTCTGAGACAAAGAGTGACGGAGGGCCGCTTCAGAATACCATTCTTCATGTCACAAGGTATAATTCTACACTCCTTCTATTCATCTATCTAATTGTGTAAAACCTATTATTAACTGAGACCTCCCTGTTTCTTTGTCCAGACTGTGAAAATCTCATTCGTAAGATGCTGGTTGTTGATCCAGCCAAGAGAATCACCATCGCTCAGATCAAGCAGCACCGCTGGATGCTTGCAGATCCCAGTGCACCCCACCAGACCCTTTCCCTTTCCCTTACCGACTACAACTCCAACCTGGGAGACTACAGTGAA

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa38724

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

A > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000083033	Nonsense	353	811	8	13
ENSDART00000127164	Nonsense	323	437	8	11

The following transcripts of ENSDARG00000058606 do not overlap with this mutation:

Genomic Location (Zv9):

Chromosome 9 (position 9173679)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	9	9139177
GRCz11	9	9117507

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

AGAACAGCAGCTACAATCACTTCTCAGCTATCTATTACCTGCTGCTCGAA[A/T]GAGTGAAGGAGCACCGCAGCCAACAGATTAGCCGTCAATGTGGGGCCTGG

Long Flanking Sequence:

GGGTATCATGCAGACCCTTGGCATTGACCGGCAGAGGACTGTGGAGGTGAGAAAATGTGGCATATGGTGCAATGGGAGTATAGAGACAGGTTGTATATTACAAATAGTATAAGCAGTTATTTCCAGCCGGGAATGGCTTGTTTGCTAGATCAAGGGTTAATAGATGTTGTTCAAAGAATTGAATTGTCAATTTGTCACCTAAGAATATAAACAACACCCTTTCCAGCTACCCGCAGCTTTAAACATTCTCCTTAGTTGGCATCGAAAGGATAAACACAGTAGCATCTGTTTTGAAAGCTGTCATGCTGTGTTGCTTTAAGCTTTCACTAAAATCCTTTAAGAAGTTAATTCTTGACGCACACTGCCTGAGTTTCATTACACCTGTTAATGTGAAGCGCAGTATGGCTACTGTGTCTAAAACAGTTTTTCAATTCCCTCCACAGTCTCTCCAGAACAGCAGCTACAATCACTTCTCAGCTATCTATTACCTGCTGCTCGAA[A/T]GAGTGAAGGAGCACCGCAGCCAACAGATTAGCCGTCAATGTGGGGCCTGGAATCAGAGGTCGAGGACAGCGTCTGATTCCTCCACCCCAGAGGTGAGTGTCAAAGTGAGGCCAAGATCATCTACTGTTTGAGATGAAATATCTGCCTGCTAACTCTGCTCTTCCTCTGTCCATCTCATTTTCAAGGTGATCATGGAGTCATCTGACAGCTTCAGAAACTCTGCCTTCCCTGTCGCCACCAAGGTGAATGCTCCTATCCATTCAGAGATGGAATGTGAACAAGGAGGTCTATTTCAGGTCAGTATTTCTTTTAGTTTAACCTAATTCCTCTCTAGACTATGGACAGGCAACTCTGACTTTTGTGGTCCATGGAAGGTTTAGCTTCATCTCAGATCAAACATACCTGAACAAGCTAATCAAGGTTGTCAGGATAACCGTATTTGATTAGGCTTGGAGCTAAACTCTGCAACTGTGCTCGAAACCTCAAGGGTCAGACTTGCC

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa41359

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000083033	Nonsense	712	811	13	13
ENSDART00000127164	None	None	437	None	11

The following transcripts of ENSDARG00000058606 do not overlap with this mutation:

Genomic Location (Zv9):

Chromosome 9 (position 9175481)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	9	9140979
GRCz11	9	9119309

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

CCCCAACTCAAGCAATTCTCCCTCCATGCCAGAAGACCTCCATCGCCTTC[C/T]AGCACAACCTGTGGCAACAACAGCAGTCTTTCGACTCCTCTTCCTCATCG

Long Flanking Sequence:

CAGTCTGTGAAAATTTCTTTAGGTCTAAAAGCATTCAGACAGCAGCTGAGGAAGAACACTCGTGCGAAAGGCTTACTGGGGTTAAACAAAATCAAAGGTTTGGCCCGACAAGTGTGCCCACCGTCTTCATGCTCCAGAGGCAGCCGAGGGTCGCTTGGTCCAACTATGTGCCCTCCCTCAAGCCTCCAGAGTTCTAGTGGGCCCCGTGAACGCCGTAGCATGTTGGAGGAAGTTCTGCACCAGCAGAGGTAAGAAAAAATCTGTTCAAAGCAGACATCCAAACACTTAGATACATTTTTGCAATGTACCTAAACTCTGTTCTTCTTTCATCTTTCAGAATGCTGCAGATTCAGCACCAGCCTCAACCCCAAGTCCAATTTCTCTCACAGTCTCACCCTTCATCTCCTCCCTCCAACAATCTCTTTGCTCCTGCTGCTCTGTTTTCCAACCCCCCAACTCAAGCAATTCTCCCTCCATGCCAGAAGACCTCCATCGCCTTC[C/T]AGCACAACCTGTGGCAACAACAGCAGTCTTTCGACTCCTCTTCCTCATCGCTATCTCCAGTGGCATCTGCTGCCCATCTGCTGGAGGCACGTCTGCACATCAGCCAACGTTCACATCTCCACCCTCAGTCCCCACAGCACCTGCAGATCCAGCCCAACCTCCCATCCCAGGGGCCTTTCTCTCTCCTGCCCCACCCAGGCAGTTGGAGCCTGAGCACCAGCACAGAACCCGAGCCTAATGTCCAGGAGCTGATTTGTGCCAGTCAAAAACAACAACTCAGCAACTGTGTCATGGTCAAGTAAAGAAGGTAAAGACCTTGATGAAGAAGTTTGACTCTTTCTCTACCAATCTAGAGTCTAGAGTGAACCAATTGACAATGGTGTTGAGCATCAGAGCCAGAAGGCATCTCATTTTGATGATGCTTTTAGAAGGTTTCCAATGCAAAGGAGAGACAGTTATATTCTCTCTGGACACACAATTCCAAAGCTTTGTTTGTATGT

Associated Phenotype:

Not determined