si:busm1-228j01.5

Ensembl ID:

ENSDARG00000079593

ZFIN ID:

ZDB-GENE-030616-395

Description:

Novel protein similar to MHC class II alpha chain [Source:UniProtKB/TrEMBL;Acc:Q95HJ5]

Human Orthologues:

HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DRA, XXbac-BPG181M17.5

Human Descriptions:

Major histocompatibility complex, class II, DM beta [Source:UniProtKB/TrEMBL;Acc:A2AAT6]
major histocompatibility complex, class II, DM alpha [Source:HGNC Symbol;Acc:4934]
major histocompatibility complex, class II, DM beta [Source:HGNC Symbol;Acc:4935]
major histocompatibility complex, class II, DO alpha [Source:HGNC Symbol;Acc:4936]
major histocompatibility complex, class II, DP alpha 1 [Source:HGNC Symbol;Acc:4938]
major histocompatibility complex, class II, DQ alpha 1 [Source:HGNC Symbol;Acc:4942]
major histocompatibility complex, class II, DQ alpha 2 [Source:HGNC Symbol;Acc:4943]
major histocompatibility complex, class II, DR alpha [Source:HGNC Symbol;Acc:4947]

Mouse Orthologues:

H2-Aa, H2-DMa, H2-DMb1, H2-DMb2, H2-Oa

Mouse Descriptions:

histocompatibility 2, O region alpha locus Gene [Source:MGI Symbol;Acc:MGI:95924]
histocompatibility 2, class II antigen A, alpha Gene [Source:MGI Symbol;Acc:MGI:95895]
histocompatibility 2, class II, locus DMa Gene [Source:MGI Symbol;Acc:MGI:95921]
histocompatibility 2, class II, locus Mb1 Gene [Source:MGI Symbol;Acc:MGI:95922]
histocompatibility 2, class II, locus Mb2 Gene [Source:MGI Symbol;Acc:MGI:95923]

Allele Name	Consequence	Status	Availability
sa6151	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa41280	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa27256	Nonsense	Mutation detected in F1 DNA	Not yet available

Allele Name:

sa6151

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

A > T

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000061132	Essential Splice Site	67	240	3	6

Genomic Location (Zv9):

Chromosome 8 (position 45769182)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	8	44374375
GRCz11	8	44367794

KASP Assay ID:

554-3727.1 (used for ordering genotyping assays)

KASP Sequence:

AAAGGAAAAACTAGTTTTCACACYACCTGATATGGTAAACTCCTTTTTAA[A/T]TGCAAATCCTCAATATTCTCTGAATGATCTAAGACTCAATRATGTTGGAA

Long Flanking Sequence:

TCAAACCAGAATTTCCAGTTTATGACTGACCACAGTGGCAAACTGAAGGATCCAACTGCTCTGACTGGACTTCAAACATGTTTAAAACATTTTCTGGAATAACATTTTTTATTTTCTGTTTAATTCATACTGAAGGCCAAAGTAAGTAAATCTTGAAGTGCAATTTGTAATTAATGTAAATGTAATGTAAAAAGCGACATATTTATTATAAATATTTTATTACAAATATATTAACTAAAAAAATTACAGTATTTGTATACTTCTTGTAATAGTTATTTTTAAACAATTGCTTCATTATAGAAAAGAGATGTGATATTGTGTATGCATTTCTGAAATTCTGAAACCTTTAGGTTATCCTGAATTTGGCTTCATAGAAACATGCAGGGGATCATCATATGATAAAATTGTCTTCATTTTGGATACTGAAGAGGCTGCATATAAAGACATAGAAAAGGAAAAACTAGTTTTCACACTACCTGATATGGTAAACTCCTTTTTAA[A/T]TGCAAATCCTCAATATTCTCTGAATGATCTAAGACTCAATGATGTTGGAATACCAGCTTTCTGCACAGAGATTTACCACAAGATACTCTCTTTGAATGTGTCTGAAGACACTGAACCTCTTGGTGAGTTTTTTTTTTTACTCCACACAGCTGACATCTACTGAAACACACGTGGTTTGAACATTTATCACTGCTAGTTCAATAAGAAGTATCTGTAATGTCCAAATATTTTTCAGATAAAATTCAAACATCGACAACAAATTTGTTTTTTTTTTTATTACATATTATGTATTTTATTAGACATATTATTATCTTCCAGAACCTCCTTGGACCACAGTTTACTCCCGGAATGATGTGAAATTAAATGTCAAGAACACTCTGATCTGTCATGTGACTGGATTCTTTCCCCCGCCGGTCAGAGTCTTGTGGACCAAGAACAATGTGAATGTGACAGACGGATCAACTATCAGCAGATATTACCCTAACAAAGATGGCACAATG

Associated Phenotype:

Not determined

Allele Name:

sa41280

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

A > T

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000061132	Essential Splice Site	201	240	5	6

Genomic Location (Zv9):

Chromosome 8 (position 45768512)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	8	44375045
GRCz11	8	44368464

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

TCACATGTAATCGCTTATAAAACACATAAATGTTTGTGTGCGTTGTGTGC[A/T]GATGTGGAGGTACAGCAGCCCAGCATTGGTCCATCTGTGTTCTGTGGAGT

Long Flanking Sequence:

CGTGGTTTGAACATTTATCACTGCTAGTTCAATAAGAAGTATCTGTAATGTCCAAATATTTTTCAGATAAAATTCAAACATCGACAACAAATTTGTTTTTTTTTTTATTACATATTATGTATTTTATTAGACATATTATTATCTTCCAGAACCTCCTTGGACCACAGTTTACTCCCGGAATGATGTGAAATTAAATGTCAAGAACACTCTGATCTGTCATGTGACTGGATTCTTTCCCCCGCCGGTCAGAGTCTTGTGGACCAAGAACAATGTGAATGTGACAGACGGATCAACTATCAGCAGATATTACCCTAACAAAGATGGCACAATGAACGTCTTTTCTCGACTGAGCTTCATTCCAGAGGAAGGAGACGTTTATGGTTGTTCAGTTGAGCACAAAGCTCTTCAACAACCTCAGACCAGAACATGGGGTGAGTGCTTATTTAACATTCACATGTAATCGCTTATAAAACACATAAATGTTTGTGTGCGTTGTGTGC[A/T]GATGTGGAGGTACAGCAGCCCAGCATTGGTCCATCTGTGTTCTGTGGAGTTAGTCTTGCTCTTGGGCTTTTTGGTTTTGCAACTGGAGTCCTTTTCATTGCCAAAGGAAAAAAATGGATATAATTATACATAAGTCAACATTAAAAGTGGATCAGACCCTTTCATCAAAGTTGTCCTAAATCTACCGAGCAGCACGGATTCTTGAAAAATAGTTTTGATCCACTTCAAATGTTGATTACTAAATAATGATGGAAAAAAAAAAAAAAACATTTTGGTGTTACACTGTAAAAAATAAGATGACAAAAAGTGATGACAAATGCATTTTTGTTACTTTAAGGTATTTCAATGTGTTGATCCAGCTCTAACCCTGATATATATTATATATAATTATATATTGTATTTTAGTTATGCAAAGATTAACTTGATATTTTTAGTCAATTTGACATGTAAATTGACATGACTAGAAAAACTAAAAGCTAAAGAAACAGGAAGATGGCACG

Associated Phenotype:

Not determined

Allele Name:

sa27256

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000061132	Nonsense	206	240	5	6

Genomic Location (Zv9):

Chromosome 8 (position 45768496)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	8	44375061
GRCz11	8	44368480

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

ATAAAACACATAAATGTTTGTGTGCGTTGTGTGCAGATGTGGAGGTACAG[C/T]AGCCCAGCATTGGTCCATCTGTGTTCTGTGGAGTTAGTCTTGCTCTTGGG

Long Flanking Sequence:

ATCACTGCTAGTTCAATAAGAAGTATCTGTAATGTCCAAATATTTTTCAGATAAAATTCAAACATCGACAACAAATTTGTTTTTTTTTTTATTACATATTATGTATTTTATTAGACATATTATTATCTTCCAGAACCTCCTTGGACCACAGTTTACTCCCGGAATGATGTGAAATTAAATGTCAAGAACACTCTGATCTGTCATGTGACTGGATTCTTTCCCCCGCCGGTCAGAGTCTTGTGGACCAAGAACAATGTGAATGTGACAGACGGATCAACTATCAGCAGATATTACCCTAACAAAGATGGCACAATGAACGTCTTTTCTCGACTGAGCTTCATTCCAGAGGAAGGAGACGTTTATGGTTGTTCAGTTGAGCACAAAGCTCTTCAACAACCTCAGACCAGAACATGGGGTGAGTGCTTATTTAACATTCACATGTAATCGCTTATAAAACACATAAATGTTTGTGTGCGTTGTGTGCAGATGTGGAGGTACAG[C/T]AGCCCAGCATTGGTCCATCTGTGTTCTGTGGAGTTAGTCTTGCTCTTGGGCTTTTTGGTTTTGCAACTGGAGTCCTTTTCATTGCCAAAGGAAAAAAATGGATATAATTATACATAAGTCAACATTAAAAGTGGATCAGACCCTTTCATCAAAGTTGTCCTAAATCTACCGAGCAGCACGGATTCTTGAAAAATAGTTTTGATCCACTTCAAATGTTGATTACTAAATAATGATGGAAAAAAAAAAAAAAACATTTTGGTGTTACACTGTAAAAAATAAGATGACAAAAAGTGATGACAAATGCATTTTTGTTACTTTAAGGTATTTCAATGTGTTGATCCAGCTCTAACCCTGATATATATTATATATAATTATATATTGTATTTTAGTTATGCAAAGATTAACTTGATATTTTTAGTCAATTTGACATGTAAATTGACATGACTAGAAAAACTAAAAGCTAAAGAAACAGGAAGATGGCACGAATGTTTAAAGTGCCG

Associated Phenotype:

Not determined

ZMP

Alleles

Mutation Details

Mutation Details

Mutation Details