Busch Lab

ZMP

tln2

Ensembl ID:
ENSDARG00000017901
ZFIN ID:
ZDB-GENE-040724-263
Description:
Putative uncharacterized proteinZgc:152648 [Source:UniProtKB/TrEMBL;Acc:Q0V975]
Human Orthologue:
TLN2
Human Description:
talin 2 [Source:HGNC Symbol;Acc:15447]
Mouse Orthologue:
Tln2
Mouse Description:
talin 2 Gene [Source:MGI Symbol;Acc:MGI:1917799]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa40914 Nonsense Mutation detected in F1 DNA Not yet available
sa45280 Nonsense Mutation detected in F1 DNA Not yet available
sa34090 Nonsense Mutation detected in F1 DNA Not yet available
sa3330 Essential Splice Site F2 line generated Not yet available

Mutation Details

Allele Name:
sa40914
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018142 Nonsense 13 289 3 10
ENSDART00000134068 Nonsense 13 115 4 5
ENSDART00000136555 Nonsense 13 2157 3 49
Genomic Location (Zv9):
Chromosome 7 (position 31226849)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 29619191
GRCz11 7 29890341
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TAAGCCGTCAGGATGGTGGCGCTGTCTCTGAAGATCTGTGTGAGGCAGTG[T/A]AATGTGGTGAAGACCATGCAGTTTGAGCCCTCAACGGCTGTATATGACGC
Long Flanking Sequence:
GCTGCAATGATTATAAAAGTACATAATCATCATCAGACAATTAACTCTTGCATTAAAATATTACAAACTGTGTTGAAAAAAATGGAAACAAAAATTCTGGGAAAGTGAATTTATGGGTATTCACCATATACTGTACGTTAACGAAACTAACTAAAGGATTATTTTTTTAAATGGCCATTCAAATCATGACCATTTTTTTAATGGTGTAATAATATTTAGCATATTTTTTTACTTATGTTACATTTCTGTTTTACTATATTACTTTTTTTTTGCTGTTTTCTAAATTATTATATTGCATAGAGGAAACTAACTGCCGACAATCAAAAATGAATGTATTTGTAGTAGCTAACAATTAAAGTCTTCAACATCATTTTTGTGAATGTTGATTTAAATCCTAAAATCTCTAACACTCTGTCTGTTTCTCACAGGTGCAGAGTTGTTGGTGACCCTTAAGCCGTCAGGATGGTGGCGCTGTCTCTGAAGATCTGTGTGAGGCAGTG[T/A]AATGTGGTGAAGACCATGCAGTTTGAGCCCTCAACGGCTGTATATGACGCATGCCGGGTCATCAGAGAGAGGGTTCCAGAAGCCCAGACAGGACAAGGTTTGTCATCACGCCTTCTTGATTCTATACTATGTTCAGACTGAGAATAAATCTCAGTTTGTTTGACTAAGTTCTAATGGCGTGTGTTGTTTTTCCTCAGCTTCAGAATATGGGCTGTTTCTGTCAGACGAAGACCCTAGGAAAGGCATCTGGCTAGAAGGAGGCCGGACGCTGGATTATTACATGCTGAGAAATGGAGTAAGCGCTTTGATCATTTGTTTTACAAGCTCCTGTCAAATGTTCTGTGTCATGGCTTTGCACTGTTGTCTTTGTTTTGTGACATGTTTTTTAATTTTTTATGCTGAAGGGTGAGAAGTGGTCTAAACTGCTTTTGATTTTATTTTATAATCAGTGCGTGCGTGCACACGTTGTCACTTATCCGAGACAAACTACACTGATGTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45280
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018142 None None 289 None 10
ENSDART00000134068 Nonsense 90 115 5 5
ENSDART00000136555 None None 2157 None 49
Genomic Location (Zv9):
Chromosome 7 (position 31227180)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 29619522
GRCz11 7 29890672
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATGCTGAGAAATGGAGTAAGCGCTTTGATCATTTGTTTTACAAGCTCCTG[T/A]CAAATGTTCTGTGTCATGGCTTTGCACTGTTGTCTTTGTTTTGTGACATG
Long Flanking Sequence:
TGTATTTGTAGTAGCTAACAATTAAAGTCTTCAACATCATTTTTGTGAATGTTGATTTAAATCCTAAAATCTCTAACACTCTGTCTGTTTCTCACAGGTGCAGAGTTGTTGGTGACCCTTAAGCCGTCAGGATGGTGGCGCTGTCTCTGAAGATCTGTGTGAGGCAGTGTAATGTGGTGAAGACCATGCAGTTTGAGCCCTCAACGGCTGTATATGACGCATGCCGGGTCATCAGAGAGAGGGTTCCAGAAGCCCAGACAGGACAAGGTTTGTCATCACGCCTTCTTGATTCTATACTATGTTCAGACTGAGAATAAATCTCAGTTTGTTTGACTAAGTTCTAATGGCGTGTGTTGTTTTTCCTCAGCTTCAGAATATGGGCTGTTTCTGTCAGACGAAGACCCTAGGAAAGGCATCTGGCTAGAAGGAGGCCGGACGCTGGATTATTACATGCTGAGAAATGGAGTAAGCGCTTTGATCATTTGTTTTACAAGCTCCTG[T/A]CAAATGTTCTGTGTCATGGCTTTGCACTGTTGTCTTTGTTTTGTGACATGTTTTTTAATTTTTTATGCTGAAGGGTGAGAAGTGGTCTAAACTGCTTTTGATTTTATTTTATAATCAGTGCGTGCGTGCACACGTTGTCACTTATCCGAGACAAACTACACTGATGTTATTAAAGACATTTGTCATTGCCGCATGTGGTTTATGTTTGTGTTTGTTAAGTCCCTGTGCTCGCGTGTGCGTGTGCGAGTGCGTGTGCGTGTGTGTGTGTGTGTGTGCGTGTGTGTACGTGTGTGTGTGTGTGTGCGCGCGCGCGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGCGCGCGTATAAAAAGAAAAGCAGATGCTTGTTTTCAGGAAGGTATAAAAAAGTGTGTGGTATAAATTAAGAAGCGTTAAATGATGTTTTCATCAGGAGCTTTTTTTTTTTTGTTTATCAAAAAACCTCTTCTTCATTCATTCATATACTGTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34090
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018142 Nonsense 246 289 8 10
ENSDART00000134068 None None 115 None 5
ENSDART00000136555 Nonsense 246 2157 8 49
Genomic Location (Zv9):
Chromosome 7 (position 31236573)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 29628915
GRCz11 7 29900065
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTCATCCGGTGTCGTTTGACAAGGCTTGTGAGTTTGGGGGAATTCAAACG[C/T]AGATCCAGTTCGGTCCTCATATTGAACATAAACACAAGACTGGATTTCTG
Long Flanking Sequence:
GGAAAGTGAAACATTACTTTTGAGACGAAAGTTCTTCTACTCCGATCAAAACGTGGACTCGCGAGATCCTGTGCAGCTCAATCTGCTCTACGTGCAGGTCAAACTTTCCTCATGCCACTTCATTTATCATAGCAAAAGCCATAATGCTCATCCAGCATTGGTTGACCTTAATGATCTGTTTCCATATAGGTCTTTACATATCAGTTCAATATAGAGGTTAAAATGCTGTAAATCTCTTATTGACACTTGCGCCTAAAAGCCTTTCTGAGTGCAGCACTAACATGCTGATGTACACATTGTATCGATCTGTTAAGTAGTGCAGTCCCTGTTTTCTTTATATCAGCTCTTCTTCTGTCAGTTGCTGATCTGGATTTAGTTGCATTTCTGTGGATTGGTAATAAAAGTCTGTTTGCATGTTTATCCAGGCACGTGATGACATTCTGAACGGTTCTCATCCGGTGTCGTTTGACAAGGCTTGTGAGTTTGGGGGAATTCAAACG[C/T]AGATCCAGTTCGGTCCTCATATTGAACATAAACACAAGACTGGATTTCTGGAGTAAGACATCATTCATTCAGAGCTTTCGGTTGTAGAGTGATGGAAAGAATCAAAGGACAGATTGAAAATTCTCAGATTTTCTGTATTTGCAATTTATGGTTATGTGATTTGAGTTAAATGTCATTTTTGTTTTATTCTATAAATGACAAGTGACTTTTATTTATAACAAAAAGTTGGCATGATTATATGAATTTTTAGACTACACACTTACAATGTTTTAACTCCAAAACTGTTACACAATCAATATTTGTTGGAATAAGCCAAATGTTTTTAACCACAACAACTGAAACATTAGTAATTCTGACCTATTGTCATTTTCTGGAAAATAAAAACCCATAAATGACAATATTTCTTTTCAAATTTGGAGGAAATGATATCAGACGTTTATACAGGGATCCCAAAACCTTGAGATTTAGAGGGTTGTTATCAGGTCTTGACAGAAAAGCTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa3330
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000018142 None None 289 None 10
ENSDART00000134068 None None 115 None 5
ENSDART00000136555 Essential Splice Site 668 2157 18 49
Genomic Location (Zv9):
Chromosome 7 (position 31249090)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 29641432
GRCz11 7 29912582
KASP Assay ID:
554-2649.1 (used for ordering genotyping assays)
KASP Sequence:
AGATCTGCTCAGACAGATTGGAGAGAATGAAACCGATGAGCGCTTCCAGG[T/A]ACACAGGCGTCTAATAAAGTATACAATGCATGACGCGTGTTTATCACCCT
Long Flanking Sequence:
CATCCATTATTCCATTCATTCATTCATTCATGCAGTTTCTTTCATTCATGGTTTTATTTATTGTTTGCTTTTTCATTTATTCATTCGTTCGTTCGTTCATTCATTCATTGTTTCATTTATTGTTTGTTTTTTCATTCATTCATTCATTCATTGTTTCATGATTTTTTATTTCCCATGTTTAAATGCACAGTTTGTTAACTTGGTTTTACTTTTATAACTGATTTGCATGTTTTTCTATGTGACGTTTTCTTTCCAGATGTCAAATGTAACATTTTGAGTATTTTTTTATTCATTTCATTATTATCCCTGTATTAAATTTCATTAGAATTCCAGCAACACTGCACTACTATGAAGCTTGAGAGAGAAATCTATATTTACTAGTTTATGTTCTGTCACTCAGCCTCGACAGACTGTTCTGACTGCAGCTGGCAGCATCGGTCAGGCCAGTGGAGATCTGCTCAGACAGATTGGAGAGAATGAAACCGATGAGCGCTTCCAGG[T/A]ACACAGGCGTCTAATAAAGTATACAATGCATGACGCGTGTTTATCACCCTGAGCCTGTATATATGTGTCTGTTTTAGGATGTGCTGATGAACTTGGCAAAAGCTGTGGCCAATGCAGCAGCTATGATGGTTCTAAAGGCCAAGAACGTGGCGCAGGTTTCTGAAGACAGCGTGATGCAGAACAGGGTTATCGCTGCTGCCACCCAGTGTGCCCTTTCCACTTCACAACTAGTGGCCTGTGCCAAGGTGAAAACACACACACACACACAGTCATAATTGAGGTGGAAATCACAGATTAAAGGGATTATTCCCCCCAAAAATAGACTCATTAATTACTTAAAAAAAACTTTTGGTTTTCCAACTAGTGAAATCAGATTGTTTTTATTCATTGTCACTCCAAGACAACATACAAGTTTTTAATACTTGGAGAAGATCCTCCCTCCTGTTCGATTTGTAAAAGCACTTTAACTATGAAGCATGTTCTGTTGGATTGTGTTTCAG
Associated Phenotype:
Not determined