ZMP

mcm2

Ensembl ID:

ENSDARG00000015911

ZFIN IDs:

ZDB-GENE-020419-24, ZDB-GENE-020419-24

Description:

DNA replication licensing factor MCM2 [Source:RefSeq peptide;Acc:NP_775364]

Human Orthologue:

MCM2

Human Description:

minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:6944]

Mouse Orthologue:

Mcm2

Mouse Description:

minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Gene [Source:MGI Symbol;Acc:MGI:10538

Alleles

There are 2 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa38176	Essential Splice Site	Mutation detected in F1 DNA	Not yet available
sa38175	Nonsense	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa38176

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

T > C

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000006598	Essential Splice Site	122	884	3	22
ENSDART00000049626	Essential Splice Site	122	889	3	16
ENSDART00000114363	Essential Splice Site	122	876	3	20

Genomic Location (Zv9):

Chromosome Zv9_NA237 (position 29574)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	22	5621712
GRCz11	22	5651558

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

AGAGAACAAGGCCTTGGCATGGGCCGCATCGGACGTGGACTCCTTTACGG[T/C]AGGTGGTTAAATCCAGTGAATTTTATTTTAATGTATTGATTATAGTATAT

Long Flanking Sequence:

AAATGGAATTAGTTCGAATTTTATGTAATGATGTGGAATTTGTTCTTGTTTTATGTAAAGTGATAAAATTTGTTCTTTTTATGTGGAGTGATGAATTTGTTCGATTTTTATGTAAGGTTATGGAATTGTTTTTAATTAACGTTCCGAAATTGTACTTAATGTAAAGTGATGAATTAAATTTTTTGTTTTATGCAAGGATACAAATTTGTTTTTTATTTTAATTAAAGTTTCAAACACTTTCATTTGCAATTGCTTCATGCAAATTCCAGTTCACAATTTAGCATGGCAGCGTAGTTAACAAAATATGTTTTATTGTATTTTCGCAGAGACTACCGTGTAATCCCAGAGCTGGACCGCTATGAAGCGGAGGGTCTGGATGAGGATGAAGATCTGAGTGAACTTTCACCCAGCGCTCGTGCCGAGGCAGAAGCGGCGATGAGGAGACGCGACAGAGAACAAGGCCTTGGCATGGGCCGCATCGGACGTGGACTCCTTTACGG[T/C]AGGTGGTTAAATCCAGTGAATTTTATTTTAATGTATTGATTATAGTATATTTATTAAAATGTTGAAGAATGTATCTAAATTTATATAATTTATATTTATAATAATTTATAATTAATTTCAATCTGGTTTAAACAGATTTGTACTTATCATTTCAAATTGATTATATAGTTTTAATTGTTTCTTTTATACTAACTTTTTTGCATTTTAAACTATTTTATTAATCATGCATTCATAATTTCTCATTTTTATTATGAAAATTTTAGCTTTTTTCTTTTTTTCTCAAGCATTTCCATCGAACATTTCCTGAGATGTTTTGTATCTAAGAACTAGCTTTCTAGGAAGTAATGGTTTTTGTTTTTGAAAACACATGAAATAAAAATAATAATAATTATTGTTGTTTTGCAAGTGATGTACAGTATATAAATTGTGTTCTCTTAAATCTGTAAAATTGGGTAGAAACAGTGAGATTACATATATATATATATATATATATATATATA

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa38175

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000006598	Nonsense	532	884	16	22
ENSDART00000049626	Nonsense	537	889	10	16
ENSDART00000114363	Nonsense	524	876	14	20

Genomic Location (Zv9):

Chromosome Zv9_NA237 (position 17958)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	22	5610526
GRCz11	22	5640372

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

TCCTGAAGTACGTGGAGAAGGTGGCGAGTCGAGCGGTGTTCACCACAGGA[C/T]AGGGAGCCTCCGCTGTGGGTCTGACGGCTTACGTGCAGCGGCATCCCGTC

Long Flanking Sequence:

GCGCAGAAAAGAGCGCAATTGCTCTGTTCACATACGCCAAACGAACTGCGCTAACTGGGCAATCGAGACACGTTCCGAAACAAAAGTGTAGGTGTGAAAGCACCCTTAAATACCAGCCACTGCACTCCCAGCAAAGTAATAAAGAATGCGTTCAAACTCTCATCGTTAAACAAAGCCCATAATCAGTACCTGAGGTGATCATTGTCATAGTAGTTTATGCTGTTATTGTGCCGTGACATTGCAGAAGTAGAAACTATAGACAAAAGCTCCTTTTAACATAGAATCCATTGATTTTATCGCATCACGGCATTGGGTGTAGTAAGTAAATATTGGAAATGTACAGGCAATTACATGATCACATCTGTGTGTTTTGGTCAGGTGGGAAGCACAAGGTGCGTGGTGATATAAACGTCCTCCTGTGTGGAGATCCCGGCACGGCTAAATCTCAGTTCCTGAAGTACGTGGAGAAGGTGGCGAGTCGAGCGGTGTTCACCACAGGA[C/T]AGGGAGCCTCCGCTGTGGGTCTGACGGCTTACGTGCAGCGGCATCCCGTCAGCCGAGAGTGGACGCTGGAGGCCGGAGCGTTAGTGCTGGCGGACAGAGGAGTGTGTCTTATTGATGAGTTCGATAAGGTGAGAGAAACAGCCCTCAAATACTGTAAATGTAGATTTTATTTTGGTGTTTGCTTAGGAATAAGAAGAGCTCGACGTATCGTGGCTGTTTATTGTTGATGTATTGCATTTTTAAAGTTTGCATTTCATTGATTTCACTCGATACATATTGAAGCCGTTAGCTACAAAATCTGAATTGTAGATGTTTTTGATGCTCTGTTTGGGATCATTTTATACAATTGTTTTTGCAATTACATGCAAGTAAATCTGTTTTATTTCCTCTTCTGTGCTCTCTAGATGAACGATCAGGACAGAACCAGCATCCACGAGGCGATGGAGCAGCAGAGCATCTCCATTTCCAAAGCAGGAATCGTGACTTCTCTCCAGGCCCGC

Associated Phenotype:

Not determined