Busch Lab

ZMP

si:ch211-89p3.3

Ensembl ID:
ENSDARG00000016464
ZFIN IDs:
ZDB-GENE-041014-372, ZDB-GENE-080219-17
Description:
serine/threonine-protein kinase MRCK alpha [Source:RefSeq peptide;Acc:NP_001038559]
Human Orthologue:
CDC42BPA
Human Description:
CDC42 binding protein kinase alpha (DMPK-like) [Source:HGNC Symbol;Acc:1737]
Mouse Orthologue:
Cdc42bpa
Mouse Description:
CDC42 binding protein kinase alpha Gene [Source:MGI Symbol;Acc:MGI:2441841]

Alleles

There are 8 alleles of this gene:

Allele Name Consequence Status Availability
sa23762 Nonsense Available for shipment Available now
sa37106 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa37107 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa37108 Nonsense Mutation detected in F1 DNA Not yet available
sa8673 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa13720 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa23762
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Nonsense 519 1716 12 37
ENSDART00000113773 Nonsense 519 1768 12 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35186847)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35259360
GRCz11 20 35162239
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CAGACTCTGGTCAGATGGAGCAGCAGTTGGAGAACGCCAGCACAGCTAGA[A/T]GAGACCTGGAAGACTCGTCCAAGGTCGTCAGGAACTTAGAGAAACAGCTG
Long Flanking Sequence:
CACGCTGTCAGATCGAGGGTGTTTGCGGGAATCGGTCGGACCTGCACAGGTTGATGCTCATGTTCAGCGTAGCCTGGAGGAGAGCCTGGCCTCTGAAGCCTATGAGAGGAGAATTCGACGTTTAGAGCAGGAGAAAACCGAACTTACCCGTAAACTACAGGGTGAGGACACCAACACATCCGCACTAAATCCCATCATTTTTTCCGCGTCTCTGAAACACCTTTTTGTCCCTATAGAGTCTACGCAAACGGTGCAAGCACTGCAGTACCCTGATTCAGACGCCCCAGTGAATGCTAATAAAGAGGTAGAGATAAGGAGTTTAAAGAGTGAGATCGACATCCTGAAGAAACAGATAGCAGGTAAGAGCTCGAAACTAGATTGAAGTGCAGTCAAGCTTCTTTATTGTACTCCATTGATTACTCTTTGATTGTGGTGACATTTTTGTCATGTCAGACTCTGGTCAGATGGAGCAGCAGTTGGAGAACGCCAGCACAGCTAGA[A/T]GAGACCTGGAAGACTCGTCCAAGGTCGTCAGGAACTTAGAGAAACAGCTGAAGAGTGTCACACAAGAGAAAGATGATCTGCACAAGGTATCTGTTCTGGTAGCTAACTTCAATAGTCTGTGGTATTATCATTCAGGTCAAAATATTTGGGAAATATTTACTTGGTATATGGTTTAAACTGGTCTAGCTGATTTTCAAGCCTGGCCAAGCCAAAGTTTAGGGAGTCGACCTTTTAAAAAACAGACAGAAACTTCTCTAAAACCACTTAAACAAGTGTTTAGCTAGATTGGGAAACCAGGCAACACATTTAAGGGGATTGTTCATCCAAATATAAAAATTCCACCATCATTTACTCATTCTTCGCCTGTTCCAAACTGGTTTGAGTTTCTTTCTCATGTTGAACATTTTAGAGGATATACTGAAGAATGTTGGGGGAAAAAAGCAGCCATCGACTTCCATAATATGTTTTTGTTCCTACTATGGATGTCAGTAGCTGATTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37106
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Essential Splice Site 784 1716 16 37
ENSDART00000113773 Essential Splice Site 784 1768 16 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35195912)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35268425
GRCz11 20 35171304
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGCCCATCTGACAGACGAAAACAAGAAGCTGAGTGCCGAAGTGGAGAAGG[T/A]AAGATCTCTATCGCTTTCAACAACACATGTGCTCATGATATTCATTATGC
Long Flanking Sequence:
TATTTAGCAACTCTCGAAGCTAAAAACACCACAAGCGTTGTGTGTAGTGTCACTATGTAAAGTAAAACAAACAACGTTTATTCACAGACATGCAAAACATACAGACATATTTGGTCCGGTTTTATTTTATTATTCTCATACACAGCACTACTTTTTCATCCGAATCTGTCTGAATTTTGTCAGATCATGGAAATCATACATCCCTAATGCAACACACTGAAAAAAAAATAAACTGTGGTTTGTGGAGAGCTCATTCTCATGATATATGAAGTCCTTCATCAGTTTTGTTGAGTCACCAAAGAGTTTCTGTACATTGAATTGTTTATATTAAATAACCTAATGGAATGCGAGTGTACCATAAACACCTCCTGTACGGTATTGTGTTTTCAACAGTCAAGTCGAGCGAGAAGAATTTGTGTGCGAGTACAAGCAGAAGTACGAGAGGGAAAAAGCCCATCTGACAGACGAAAACAAGAAGCTGAGTGCCGAAGTGGAGAAGG[T/A]AAGATCTCTATCGCTTTCAACAACACATGTGCTCATGATATTCATTATGCGTCTCTCTCTCTCATCACGAAAGGCATACATCAAACCCCCCTATTCTGTAATTCCCCCTTCCCTCTGGCACCCTTTCTCCAAATCCGCTGACATTCCTAGAGAGAGATCGCAACCGCACACACTTACACTGAATTGCTTCTTGGCTCAGCCACTGTTTTCTTTGGACCGCGGGGTAAAATCGGAATAAGCCAGTCAAATAATTCTGCAAGTTTGGACGTATCAGATATTAAAGGACTCCTTATTTTTGGTGGCATGGATATTAAGCATTATTCATTCCGCAAAAAAAGAAATACCTGGAAACCTAAAACACAAAAGGCAGTTTAAAACAATAGCGGAGCAGGCCAGGGCTGTCATGTCAAATGCCAGATTGGACGGGGTTTAGAAACATAAGCAAGAACGATGGCATTTGGAAGGAATTGAAGCAGGATGTGAGGTGGTTGAATAAATTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37107
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Essential Splice Site 967 1716 21 37
ENSDART00000113773 Essential Splice Site 967 1768 21 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35203071)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35275584
GRCz11 20 35178463
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCTTTTTGGCTTTCCTCAATGCGCCCACTTCTGCACTGGATCAGTTTGAT[G/T]TAAGTTTGAGATGCCAGGTGTTGTTCATGAGCACATCTGCATAGAGGTTT
Long Flanking Sequence:
AAGTATCATACATAATAAAATATCATTGTCACAGTGCAACCCTGAAAAAATCCTTCAAATCACTACAAACCATCGACTTTTTAAATGCTTAAAAAAATACTAACTCTAATTTTGACATAAATATAGAATGCTGAACAGTTTCTTGTATGTAATAGGCATTTTAAATTTTTTAATTAGAAAATTACCTTTGTAAATTGAATTTGATGTACATATCAAAATCATGTCTCGTAGTTGACCCTTATTTTTACCCATCAGTTTTATTTCAATGAACAAAACTATTTCAGTTAATAGTAACAATATTGAGGTAATAATCAATTATCCACACTACCCACAACTATTATCATTGCTTAATACACAGTTATTGCATTGCTGTCTATATGGTGGTAAAATTATGCCTTTTCTTTATAAAAATCTCACTTGTAGGCGTGAAGCACCAGGATTCCCAAAATTCCTTTTTGGCTTTCCTCAATGCGCCCACTTCTGCACTGGATCAGTTTGAT[G/T]TAAGTTTGAGATGCCAGGTGTTGTTCATGAGCACATCTGCATAGAGGTTTAATCTTGTTTTATTTTCTTAATTTTTCTTCATGATTTTTTGACATATATTCTGTATTATTCTGATGCCTCCTGATCTGTTTTATTTGTTTCAGAATTTTGTCATAATGTGAATGGTCTTTTTTTTTTTCTTTCTTTATTCTGTTGTCTATCAGGACTCATTTTCTTCCTCTTCATCTTCTTTAGTTGAATTTTGGGAAGATGTAAGTTCTCCAGCCATGTTATTGCAGAAGTGTCTTTGATTTTATACATTTAAAAGCAGATGAGCAAAAACCAGATACTCCAGTAATGAAACTCTTCAAGGAAAAAAATCACCATACCAATGCAACTCACTTGCAATTGATTTGACATGTTGCTGAGCTAATAGCAAAAAATGTGACTTTCCAACGGGCGCTTTGATGTCAAAACAACATCAAATTGACATAAATAAATGCAAATCGATGTCAAAATCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37108
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Nonsense 1270 1716 29 37
ENSDART00000113773 Nonsense 1322 1768 31 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35215651)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35288164
GRCz11 20 35191043
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGTGCATCATGTAGAACTGATGCCCACGGAGCACATACTGGCCGTCATCT[C/A]GGGCAGGAACCGACAAGTATGTCTGGTCTCCATGGCGGGTCTCGACGGGA
Long Flanking Sequence:
AAATCTGGTCCCACGTCTCATCCTCGAATGCAAGATTGAGGTCTCACTCCCACTGTTGTTTAATAAAGGAAAGAGAGGGAGTAGAGAAAGAGGAGACCAACCTGTATAAAATAGACATTATACCTTTTTTATCTATGGGTACTTCAAACATTTTGTCAAGGAAAATCTGGAAATGAGTTTTGAGCAGTTTCTAAGTTGCAAGTATCTAATGAAATGAGTGCTAGGAAGAGAAAAAATATGTATTAATTGGGAAAAGCTGGGAAAAATATTATCGATATAAATATCACTGACAGTCTAAATTTCTGCTCTCTGCCCAGTATTAAATGCTGATTTATTATTTTTGAGAACGTATTTAAGGTTTACTTTTGATTTAAATGGATATAAACCAATGTAAGACTCAACATCTTTGCTCTTTCTTCCAGAAATCATTCGTGTGGGTGATGTCAAGAAGGTGCATCATGTAGAACTGATGCCCACGGAGCACATACTGGCCGTCATCT[C/A]GGGCAGGAACCGACAAGTATGTCTGGTCTCCATGGCGGGTCTCGACGGGAGGGAGGTCGACAAGAATAAGGTGGCAGATACTAAAAACTGCCAGTTGCTGGTGTCCGGTGTGGTTCGCAATGTCACCTGCTTCTGCCTCGCCATTAAACGGCAGATCTCATGCTTCGAAATTAACAAGAGCAAGTCACGACACTCCCATCTCGTGGACATACAAGTACAGTCTCCAAAACCTCTTCCTTTCCGATCATACTGATGTGAAATCTTAAAGGGATAGTTCACCAGAATAAGTATGCATTAGTTTCTTTCTTTCTTCTGTTGAACACTAGAGAAGATATTTTAAAGAAAGCTGAAAACCTGTAACCATTGACAATAGTAGGAAAAAAACTTGCTATAAAGGTCAATGGTTACAGGTTTTTAAATATCTTCTTTTGTGTTCAACAAAAGGTTGAGTAAATGATGATGGAATTTTCAGTGTTGGGTGAACTATTTCTTTAAGTGTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8673
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Essential Splice Site 1341 1716 29 37
ENSDART00000113773 Essential Splice Site 1393 1768 31 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35215867)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35288380
GRCz11 20 35191259
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CGAAATTAACAAGAGCAAGTCACGACACTCCCATCTCGTGGACATACAAG[T/C]ACAGTCTCCAAAACCTCTTCCTTTYMGATCATACTRATGTGAAATCTTAA
Long Flanking Sequence:
AGTGCTAGGAAGAGAAAAAATATGTATTAATTGGGAAAAGCTGGGAAAAATATTATCGATATAAATATCACTGACAGTCTAAATTTCTGCTCTCTGCCCAGTATTAAATGCTGATTTATTATTTTTGAGAACGTATTTAAGGTTTACTTTTGATTTAAATGGATATAAACCAATGTAAGACTCAACATCTTTGCTCTTTCTTCCAGAAATCATTCGTGTGGGTGATGTCAAGAAGGTGCATCATGTAGAACTGATGCCCACGGAGCACATACTGGCCGTCATCTCGGGCAGGAACCGACAAGTATGTCTGGTCTCCATGGCGGGTCTCGACGGGAGGGAGGTCGACAAGAATAAGGTGGCAGATACTAAAAACTGCCAGTTGCTGGTGTCCGGTGTGGTTCGCAATGTCACCTGCTTCTGCCTCGCCATTAAACGGCAGATCTCATGCTTCGAAATTAACAAGAGCAAGTCACGACACTCCCATCTCGTGGACATACAAG[T/C]ACAGTCTCCAAAACCTCTTCCTTTCCGATCATACTGATGTGAAATCTTAAAGGGATAGTTCACCAGAATAAGTATGCATTAGTTTCTTTCTTTCTTCTGTTGAACACTAGAGAAGATATTTTAAAGAAAGCTGAAAACCTGTAACCATTGACAATAGTAGGAAAAAAACTTGCTATAAAGGTCAATGGTTACAGGTTTTTAAATATCTTCTTTTGTGTTCAACAAAAGGTTGAGTAAATGATGATGGAATTTTCAGTGTTGGGTGAACTATTTCTTTAAGTGTTCATACCCAAAAGCTCACCACAAGCATCAACAGCTCTTTTTTTGTATCTCAGGCTCCAGGAACTGTCCAATGGATGGCGCTGTTCAACCAGCAGTTGTGTGTTGGTTACCCATCAGGCTTCATGCGCTACAGTTTGTATGGAGAAACACCTCCAGCCAGCTTACTTCATCCAGATGACCCCACACTGGCATTTATTAAAACAGACAACCTGGATGCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa13720
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040456 Nonsense 1605 1716 35 37
ENSDART00000113773 Nonsense 1657 1768 37 39
ENSDART00000114262 None None 306 None 2
Genomic Location (Zv9):
Chromosome 20 (position 35222710)
Other Location(s):
Assembly Chromosome Position
GRCz10 20 35295223
GRCz11 20 35198102
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACCGTGCTGGATTCAGCGGCTCCGTCAGCATCCCCTCCATTACAAAAMAY[A/T]GAGCAGARCCAGGGCGATCCATGAGCGCAAGCAGTGGCCTAGGAATGCGT
Long Flanking Sequence:
AAATAGCTTTATCACTGGGCACTCTTTCCCATTTAGTATGAAGTATATTTTTCTATAACATTTATTCTAAGGCCTTTATAAAATGTAGCAATGACTCCCTTGTACTGTTAACGTCCTACTTATGTCAAATAAATGCAGCTTTGATAAGCAAAAGCAACTTCTTTCAGGAGTATAAAATCCTGTTCCAAACTTTTGTACTGTAGTGTACATCAGTACACAGTTCTCTGTTCTCTACATTCACTAATACATCACAATTCATTTACAGGTCCTCAATTAATATGTTCATTCATGGCATGGTAATATCTTGAAAATCACTATGTAACCGTCATAGAATGTTTTCATCATCTCATGTCTGCCGCACTCATTGCATGTTTGTGTGTCCCTGCTCTGTGTGTGTATGTGTGTGTGTTGTTTCTTTGTATAACCGGTAGAATGTACGTGCTCAGGACAACCGTGCTGGATTCAGCGGCTCCGTCAGCATCCCCTCCATTACAAAAAAC[A/T]GAGCAGAACCAGGGCGATCCATGAGCGCAAGCAGTGGCCTAGGAATGCGTAAGCACACACACACACACATTTTCCTCATAGGGATGAAAAAGGTCCCCACAATGTCAACTTTAACTGGTATTGCTATACTATTACATTTGATTCTATTTTTCAGTCTTATGCATTTTGCATATTTTTTTATTTCAAGCAACTAAACATTGATATTTGTAGCAATGAGAAAAGCAATCAAATATGTTATATTTATAATATCATGGCATGCAATAACTTCAAACAATGGTATAAAGCTAAAATCAAACAAAAAGTGCTTCGGGGTTAATTAATGTGTCTGTGTTCTTCGGATAAGGGATTCTTAAAGATTAACAACAAAATCACTTACATTTCAAATGCCTTGAACTTAGGATTTTATGGTATAAAGCAATTTAAAACATCCATAAATGTACATTGTAATAATTGCACTTACAATTTCATTTGAAATTTTAATGCTTCTCTTTCACATTCTC
Associated Phenotype:
Not determined