Busch Lab

ZMP

zwilch

Ensembl ID:
ENSDARG00000057100
ZFIN ID:
ZDB-GENE-050420-101
Description:
Protein zwilch homolog [Source:UniProtKB/Swiss-Prot;Acc:A5WWB6]
Human Orthologue:
ZWILCH
Human Description:
Zwilch, kinetochore associated, homolog (Drosophila) [Source:HGNC Symbol;Acc:25468]
Mouse Orthologue:
Zwilch
Mouse Description:
Zwilch, kinetochore associated, homolog (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:1915264]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa36630 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa43087 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa36631 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa43088 Nonsense Mutation detected in F1 DNA Not yet available
sa538 Essential Splice Site Confirmed mutation in F2 line Not yet available

Mutation Details

Allele Name:
sa36630
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079695 Essential Splice Site 30 583 None 19
ENSDART00000079695 Essential Splice Site 30 583 None 19

The following transcripts of ENSDARG00000057100 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 18 (position 19237630)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 19467853
GRCz11 18 19456919
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGTTTTAGGTTATGCCAAGATGAAAGTAAAGACAACTGCACGTATATGG[T/G]AAAACGCATGTGATATAAACGAATAGACAAATTGGTGTTGAAAAGTATTT
Long Flanking Sequence:
TATATGATTAGAGGAAGCAGGCGGGTGGGGAACTACTTTCAGTAATTAATTACAATATTTGTAAATGTTTGGATTTTTTAGTTTTTCATTAGTTAAATCACAAAAATGATACTGAACAAAAAAAATAAAGAAAGAAAATGTCTAAAGATATTTTTTCTTTCAAAGTGGGAGTGGCACAAGTACGTTTGCGTCGTGACGCTTTTGACGTGCATTTGCCGCGCTGTAATCAAAGTTTTCTGTCGTCTTGGCGTTTCAACAAGTACAATTTGCTACTAGAATTCTGTCAATCGAAGGCAATGGGATCCAAAATAGTTTCGGACGCCAACGCTTTTGTTAAATTTCTGAAGTAAGTACTTGTCCATTGACTGAACTTGAATGTTAGTCGACAGATCTGCCATGTTTTGTTACGTGCATCAAATGTAATATGCACTGTTTACCATTTCTCTCTGTCTGTTTTAGGTTATGCCAAGATGAAAGTAAAGACAACTGCACGTATATGG[T/C]AAAACGCATGTGATATAAACGAATAGACAAATTGGTGTTGAAAAGTATTTATGGATGTATTGGTTTTTAATTTTAGGATGACGTTTCAGTGCTGCTTGTGAAGAAGGAACAGCTTTTGCACGACATAATCGGTGAAAAAAATCAGCCCATCTTCATCTGCGAGAAAGCAGTAAGTGAACATATAATGGTCCCCATGTAAATATTATGAGCTATTATTTTTCACATTTTACATCACTTAATGTAAACACGGTGGCTCAGTGGTTAGCACTGTCGTCTCACAGCAAGAAGGTCGCCGGTTCGAGCCCTGACTGGGTCAGTTGGCATCTCTGTGTAGAATTTGCATGTTTTCCCTGTGTTCACGTGGGTTTCCTCCAGGTGCTCTTGTTTCCCACACAGTCCAAAGACATGTGCTATAGGTGAATTGAATAAACTAAATTGGCTGTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43087
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079695 Essential Splice Site 30 583 None 19
ENSDART00000079695 Essential Splice Site 30 583 None 19

The following transcripts of ENSDARG00000057100 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 18 (position 19237630)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 19467853
GRCz11 18 19456919
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGTTTTAGGTTATGCCAAGATGAAAGTAAAGACAACTGCACGTATATGG[T/G]AAAACGCATGTGATATAAACGAATAGACAAATTGGTGTTGAAAAGTATTT
Long Flanking Sequence:
TATATGATTAGAGGAAGCAGGCGGGTGGGGAACTACTTTCAGTAATTAATTACAATATTTGTAAATGTTTGGATTTTTTAGTTTTTCATTAGTTAAATCACAAAAATGATACTGAACAAAAAAAATAAAGAAAGAAAATGTCTAAAGATATTTTTTCTTTCAAAGTGGGAGTGGCACAAGTACGTTTGCGTCGTGACGCTTTTGACGTGCATTTGCCGCGCTGTAATCAAAGTTTTCTGTCGTCTTGGCGTTTCAACAAGTACAATTTGCTACTAGAATTCTGTCAATCGAAGGCAATGGGATCCAAAATAGTTTCGGACGCCAACGCTTTTGTTAAATTTCTGAAGTAAGTACTTGTCCATTGACTGAACTTGAATGTTAGTCGACAGATCTGCCATGTTTTGTTACGTGCATCAAATGTAATATGCACTGTTTACCATTTCTCTCTGTCTGTTTTAGGTTATGCCAAGATGAAAGTAAAGACAACTGCACGTATATGG[T/G]AAAACGCATGTGATATAAACGAATAGACAAATTGGTGTTGAAAAGTATTTATGGATGTATTGGTTTTTAATTTTAGGATGACGTTTCAGTGCTGCTTGTGAAGAAGGAACAGCTTTTGCACGACATAATCGGTGAAAAAAATCAGCCCATCTTCATCTGCGAGAAAGCAGTAAGTGAACATATAATGGTCCCCATGTAAATATTATGAGCTATTATTTTTCACATTTTACATCACTTAATGTAAACACGGTGGCTCAGTGGTTAGCACTGTCGTCTCACAGCAAGAAGGTCGCCGGTTCGAGCCCTGACTGGGTCAGTTGGCATCTCTGTGTAGAATTTGCATGTTTTCCCTGTGTTCACGTGGGTTTCCTCCAGGTGCTCTTGTTTCCCACACAGTCCAAAGACATGTGCTATAGGTGAATTGAATAAACTAAATTGGCTGTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa36631
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079695 Essential Splice Site 62 583 4 19

The following transcripts of ENSDARG00000057100 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 18 (position 19238298)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 19468521
GRCz11 18 19457587
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTTAAGGAAATTGAATGAATGACTAAATATTTGTTTGTTATTCATAATAA[G/T]CAAACCAAGTATGAACCCGAAGCTACAGAAACGTCAGCAGACACCAGTGA
Long Flanking Sequence:
CAGTAAGTGAACATATAATGGTCCCCATGTAAATATTATGAGCTATTATTTTTCACATTTTACATCACTTAATGTAAACACGGTGGCTCAGTGGTTAGCACTGTCGTCTCACAGCAAGAAGGTCGCCGGTTCGAGCCCTGACTGGGTCAGTTGGCATCTCTGTGTAGAATTTGCATGTTTTCCCTGTGTTCACGTGGGTTTCCTCCAGGTGCTCTTGTTTCCCACACAGTCCAAAGACATGTGCTATAGGTGAATTGAATAAACTAAATTGGCTGTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGAGTGTCCAAGTACTGGGTTGCAGCTGGAATGGCATCCGCTGTGTAAAACATATGATGGATAAGTTGGCAGTTCATTGTGCTGTGTTGACCCCTGATGAATGAAAGGACTAAGCTTAAGGAAATTGAATGAATGACTAAATATTTGTTTGTTATTCATAATAA[G/T]CAAACCAAGTATGAACCCGAAGCTACAGAAACGTCAGCAGACACCAGTGATGTTGAAGACGTTCTCTTTAAAGTGGAGCAGGATCCGGGGCCACAGCCTCTCTCCATCATGAAAGCAAGGTGCAAAGCGTGTAGTGTCTATTACTATACTGCATTTATAATTTAAATCAAATGAACATTGTGTTTATATATAATGATAACTTGCCATCTTCAACCAGACAACTGTTGTCATGGTACACCATGGCTCATAACCCCAACATGAGCCGACTGAAAGCCCCAGAGAATCTGCACCCTCTCTGGGTTCGTTGTGACAAGTCGGACCCATGTGCCACTGCCTGGCTTGGAGTAGAAATCACCTACAGTGGGAACAAAACCAGTGGTGTCAAATTGTACACGGTCTGCTGCAAAGGTAACTCTTTTGTTATTTATACATTACTTAACCATTTTTAATCCTCACATTTCACTAGACATGATAATATTTAAATGATGTGTCATTGGTAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43088
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079695 Nonsense 341 583 11 19

The following transcripts of ENSDARG00000057100 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 18 (position 19244278)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 19474501
GRCz11 18 19463567
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGCCTTTAGTTCAATGGTAATTGAGAGAGGAGACCTTGACTTTACAGAA[C/T]AACTGTGGGAGAAGATGAGAAAGAGTAAAAGAGCTTTTTTATTATTATTA
Long Flanking Sequence:
ATAACTGTTCTGCTGTTTGATTTTTGAAAACGACTACTACTGTAGTTATCATTATGGTTATTGTCCTTGCTGTGAAATGGCTTTATAAGTATACTGTGTAAATTGAGGAAAATTTGGTGTTTTTGTATTTAATGTAAGTTTAAGTAATTTTTCCTGATTTTAGAGCTTGAGAACCTTGCGCATGGAGTGCCAGGACATTCTGCCAAAGCTTCTGAGGTAAATCAATAGTAAAATATAATATCGGAAGCTCTAGTTCTCATTTACTTTCATTAGATTTAAGTATATACACAACAGTTTTTGTCCACAACATACAATAATCTTTTTGTGTCATCCACTGAAGAAAGAACATCATGTATTTTGAATTCAGAATAACATTAGGGAGTGAATTCATCAACTGGTGAATTTTTCCCCTTAATCTTTTATAACAGAAGCAGAAAGCTAAACCAGATGCTGCCTTTAGTTCAATGGTAATTGAGAGAGGAGACCTTGACTTTACAGAA[C/T]AACTGTGGGAGAAGATGAGAAAGAGTAAAAGAGCTTTTTTATTATTATTATTCATTTTAACTTCCTCACTAAAATACACCAAAACTATTTCTTTCTAACTGTGGATGTTTTGTTTTCTCATAGGTGTAACTTCGTATCAAGACATAACAGAATGCATGAAAATTGTTGTCAAAGCAGTGAAACTTGGCAAAATCAAACCATGGGTGCATATCTTAATTAAAAAAAAAATCTTATTCTTAATAATTATTTCAAAATGATGTGTAATGCGGGTATTTCTCTTCCTCAGATTCATAAAGACAGCAATAGCACTCTCAGCAAGTTGATCCTGCAGTCGTACCAGCAGCAGATTGACAGCGTTCCTCTCACTGGTCTCGCACCCGCTAATATGCTGCTAGAATTGGGCCTGGACAAGATCAGGAAAGACTTCATCAACTACCTTGTTGGTACATTGATTTTTGATTCATTGTTTATTTTGTAATCAGATTTTTGGCATACTTTGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa538
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079695 Essential Splice Site 438 583 15 19

The following transcripts of ENSDARG00000057100 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 18 (position 19247135)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 19477358
GRCz11 18 19466424
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCTATGCGCTAATTTTTTTTAAAAATGTGTTTTTTTTTTCTAAACTTTC[A/G]GAGTTACTACTTAGACACTGAGGTGGATCTGCAGGAGCAGGTGGTTAGAG
Long Flanking Sequence:
AATGATCCACTGAGTGCTCTAATACGCTCACTCATTGCATTCACTACTTCAAGTAGACTAGATTAGTGGAATAATGCAGGAAATAGGGAATGGGGTACAGGGGACTTACAGTATATGCATATATGCCTATTTATACATACAGCATATGTGTTCAAATTCAAACTACTAAAACACTTCATACATGTCCCAAAAAATCATTAAATCATAAATCGACCATAACAAAGGTTTTTAACCCAATAAACACACATTAGCATTCATACTGTGAAACAATGACTTTAGGAAAGAAGCACTTGCTTACTAAACAAGAATGAAAATGTTAATTATAACTATCAATTAACAGTATTGTATTACTTTCAAATGTAAAAAAAATGCTTTGCATGTTTGTTGTGTTCGTTAAAATTTAAACCTATTTGAAAACGTTTTTAAAACCATCTGTTAGTGTGCAAAGTCACCTATGCGCTAATTTTTTTTAAAAATGTGTTTTTTTTTTCTAAACTTTC[A/G]GAGTTACTACTTAGACACTGAGGTGGATCTGCAGGAGCAGGTGGTTAGAGTGAGAAAACTGCACCACCTGCTGGAGATCCTGGGCACCTGCAGCACTTTCCTCAGTCTTCCTCACGAGCGCCTTTTCCTTTTCACTCAGTGAGTTTCTCGTCTTCTCCGAGAGTCTTATATTAATCAAATAGTGATTTAAGGGCTAATAAATCATACCATTTTTTTCCACAGAGAATTGTGATTTATGATACATGAAGGTGCACTTTTCTATTAGAGAGCACTGCAGATTTCTTGATTGCACTAGGGATGGTACTTTGAAAGAGATTAAAATGTAGTTATATCTTGTTCTAACCGTGATATTTGATGTCAGGTCCTGTTTGCAGTACTATAAAACATCCAACTATGATGAGGACCACATCTTCCAGTTGCAAATTAAACCGGCGCTCATTAGCTACTTTTATGAGAAGTGAGTTCTTTCTGTATGGTGTTTTCATGTATTATGTGCTGAA
Associated Phenotype:
Not determined