Busch Lab

ZMP

rps6kb1

Ensembl ID:
ENSDARG00000058230
ZFIN ID:
ZDB-GENE-040426-2038
Description:
ribosomal protein S6 kinase beta-1 [Source:RefSeq peptide;Acc:NP_998241]
Human Orthologue:
RPS6KB1
Human Description:
ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Source:HGNC Symbol;Acc:10436]
Mouse Orthologue:
Rps6kb1
Mouse Description:
ribosomal protein S6 kinase, polypeptide 1 Gene [Source:MGI Symbol;Acc:MGI:1270849]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa30991 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa9785 Nonsense Available for shipment Available now
sa45534 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa12915 Essential Splice Site Available for shipment Available now
sa35849 Nonsense Mutation detected in F1 DNA Not yet available
sa17324 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa30991
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Essential Splice Site 78 502 None 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16429106)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17474069
GRCz11 15 17410091
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGAGTGCTTTGAGCTTCTCCGTGTTTTAGGGAAAGGAGGTTATGGAAAGG[T/A]AATATTATTATCATTATTATTTTTTTTTTTTGTAGGACATGTCAAGGCAA
Long Flanking Sequence:
TTCCCAACGTATGTCCTATTTTACATTTTTAGAGAAGAATCCAAAAACAGCCACATATTAAATAATGTTATGACAGCTGTTTTAACTTTAAGTTATGATTGAATTGCTTATTCTTACAATTAGAAAATAGTTTGATAACAAGGAAATGTTCATGGGCCAATGACATGACCATATTGAAATGGTCTATATCATTCAGGAAATATTGCAGGTTTAAAAGGTTAAATGTACAAAATGTTCACAAGAATGCACAAGTGTAAATAAAAAAACCCCCACTCATGACAAAAAATGGACTTGGGAGCAATAAACAGATTCACGAATTTGATGCTGATTCTGAATGATGCACATGATCAATAGTTTTGTGGTTTGTTGTTATTACAGTAACATGGATGACTGTGAGAAGATTGAGATATCAGAGGACAATGTGAACCAAGGCACAGAGAACATCCGTCCGGAGTGCTTTGAGCTTCTCCGTGTTTTAGGGAAAGGAGGTTATGGAAAGG[T/A]AATATTATTATCATTATTATTTTTTTTTTTTGTAGGACATGTCAAGGCAATTTGTTTTTACATTGTTGAATGTTATAAGATATTTTTTTCTTCTTTCAATTCAGAAGTTTATTTAAAGGTGCTGTATGTAGGATTTTGACTCTTCTAAAGCATAAAAATAAAATATGTTTGTAGATATTTAAGAAACAGGGCAAGTGAACATTCTTGTTTATCTGAAAAACAATGCTGAAATCAGCTATTCTGCTTTGAAAATGTGAGTTATGTGCCGGAATGTCTGTTTTTGTTTTGGTCTCTTTAACCCCCCCATTGCCACTTTAGGCAATTATATTTCAGCACCCCGGGTTGCCTTGATGGAAAACGCGTATTTCATTCCTTCATTCATAAAGGCTCTCTAAGCATGCGCTAGTGACCGAAATGCGACCTCCAGTGCACAGTAGCAGACTCCGAAATCAGACGCAGATTCAGAGTTTTTACATAAGGTTATTAATTAGCAAATAATA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9785
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Nonsense 99 502 4 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16430842)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17475805
GRCz11 15 17411827
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TCGGAAAGTATCTGGTGCTGCAACAGGAAAAATATTTGCAATGAAAGTCT[T/A]GAAGAAGGTTCAACATTCCTTGAATTCCCAATGCTAATTCATTTAGTTAT
Long Flanking Sequence:
ATTTCTCAGCATTTTACTTTACTCTTAATTCAATTAATACATTTTTGTATTGAAATTGTTGAATTTATTGCATTTTTTTAGCTTATTGTTGATAAATAAAAAATTGCTTTTGAAAGATCTTTTTTGCATTATAGCACTTATTAATATCAAGTGCATGTAGCATCAGGGTTTTTATCATTAGCTTGATCTATGATTACAAATTGACAAAAGTGACTTTTACAGAAAGCACAAGTGAAGTTCTGCTTCAATTTTTCAAATAACGTTTGTAAAATCTTTTTTTAAATTTCTTTTAAAGTTACATTTTTACATTTTCTTTACTTGAATTGGACACCTACAATTATATGAATAATTTTTAACCAATGTAAACAATTTCAAAATTAATTTTGTGGTATGCTGATTTATTTCATTTTAAAGTAAATGTATTTATTTGTTTTTGTAGGTTTTCCAAGTTCGGAAAGTATCTGGTGCTGCAACAGGAAAAATATTTGCAATGAAAGTCT[T/A]GAAGAAGGTTCAACATTCCTTGAATTCCCAATGCTAATTCATTTAGTTATGTCATGTCTTATTAGATATGTAGATGTAAGTGCCTCAATGTCACCTTTATCTTTCTGTTTGTAGGCTATGATTGTACGCAACGCCAAGGACACAGCGCATACTAAAGCAGAACGGAACATCTTAGAGGAAGTCAAGCATCCTTTCATCGTTGATCTAATCTATGCCTTTCAGACGGGCGGCAAGCTTTACCTCATCCTTGAATACCTAAGTGGTCTGTGAATCAAGAGCAACCTTTGTTTCTTAGAGATAGACAACTTCTCATTCTTTCCACACTCCTTTTGTTGCTGTGGAGTTGCTAAGGGATTAATTCAACCTCTTAGTGCCAGTCTTTTCTTTTAAATTTCTTTATTTTTTTATTTGTATGGAGGAAATATATTTAAAAGAACACTCCACATTTTTGTAAATAGTCTCATTTTACAATTCCATTAGAGTTGAACATTAGAGTTTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45534
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Essential Splice Site 300 502 10 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16438520)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17483483
GRCz11 15 17419505
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAACCTCCCACCCTACCTCACACAAGAAGCCAGGGACCTTCTCAAAAGGG[T/C]AGGCCAACATTGATCTCATTTCCTCCCCCAGTAAGATGTATTGTGGTGTT
Long Flanking Sequence:
TTCTATCCGTATTAGACAGAACTGAATAACAACGGTGAGCAAAAGGGAGAATGTTAGCTTAGCTATGCTGGCGTCAAAATAAAAGTCCCGTCTCAAACACATCTGCCAAACAGAAAAGCTTATTGGCCAATATTTGAAAAATTACAAATATCGATTGACCCCTAATATTAACTCTTAAAAACAGCATCTTCTTTTTTACATTTATTTATAGTACAATGTAAACACAAGGAAATCATATTTGGATTGAAAACCATTCATCTGGTCAATATTAGAATTGGTTTAGGTTTTTGAACCTTACTGCAATAAATAAATTACTTTTTGATTTTGATGTTGTTGTTGTTGTTGTTTTTGTTCTCATTCATTTATTTATTTATTTTTTTTGCTTTTCCAGCCTCCTTTTACAGGAGAGAACCGGAAAAAAACCATTGACAAAATTCTTAAATGCAAACTGAACCTCCCACCCTACCTCACACAAGAAGCCAGGGACCTTCTCAAAAGGG[T/C]AGGCCAACATTGATCTCATTTCCTCCCCCAGTAAGATGTATTGTGGTGTTGCTTTATTTGGTATTTTATTTTGTAACACCAATGCATTTCAGCTACTGAAAAGAAGTGCCTCATCTCGGCTTGGGGCTGGACCTGGAGATGCAACAGAAGTACAGGTTTGTTTGCATAAAGGTCAACATCAATGGTTAAAGTCAACATAAAAATGGTAACACTTTAAATCCTAACAAACTGTTCATAGTGAAAAGCCTTTTTTTTTAAAGAAAAATGTTTACTTTAGTTCTTTTCCTTGCCCAAAAAGTATAAACTATTAGCTATGAGATGGCAGAATTGAACAATAAGGTCTTTGGGGTACAAAAAGAAGTATATCATTAACTTAACCTATTGATTTTTGGTACAACTGAACATTTAACCACATTTCATAATTTAGAAGGAATTGCTGAGCTTTTGTTTTGGTTTAATGTGTTTTAATTTGTCTCCTAGACTCATCCCTTTTTCCGACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12915
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Essential Splice Site 347 502 12 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16439080)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17484043
GRCz11 15 17420065
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGATGATCTTCTTGCACGCAAAGTAGAACCACCATTCAAGCCTTTCTTGG[T/C]AACTATATTCATGTTTTGGGGTGTTTTGCTGGATCCTATTGGTTAAKAGT
Long Flanking Sequence:
GGTATTTTATTTTGTAACACCAATGCATTTCAGCTACTGAAAAGAAGTGCCTCATCTCGGCTTGGGGCTGGACCTGGAGATGCAACAGAAGTACAGGTTTGTTTGCATAAAGGTCAACATCAATGGTTAAAGTCAACATAAAAATGGTAACACTTTAAATCCTAACAAACTGTTCATAGTGAAAAGCCTTTTTTTTTAAAGAAAAATGTTTACTTTAGTTCTTTTCCTTGCCCAAAAAGTATAAACTATTAGCTATGAGATGGCAGAATTGAACAATAAGGTCTTTGGGGTACAAAAAGAAGTATATCATTAACTTAACCTATTGATTTTTGGTACAACTGAACATTTAACCACATTTCATAATTTAGAAGGAATTGCTGAGCTTTTGTTTTGGTTTAATGTGTTTTAATTTGTCTCCTAGACTCATCCCTTTTTCCGACATGTTAATTGGGATGATCTTCTTGCACGCAAAGTAGAACCACCATTCAAGCCTTTCTTGG[T/C]AACTATATTCATGTTTTGGGGTGTTTTGCTGGATCCTATTGGTTAAGAGTACACATGAAGTAGGTGACCTGATGTCTTGTATTGGCAGCAATCTGCTGAGGATGTGAGCCAGTTTGATTCAAAGTTCACCAGCCAGACTCCCGTTGACAGTCCTGATGACTCCACACTGAGCGAAAGTGCAAATCAGGTCTTTTTGGTAAGGCAGCCAAGTCATGATTTCAGTGTCCTCTATGAAAGCCTGTTTTTGCCATAGAATACAGATAAAAAGGGACTTGCAATTTGGACTTTTCTCTCTCTTTTAAGAATTGAGTTGCCACATTTTAGCATTTTGAAAGTTAGTTGGGTAACATTTTTTTATATTGGGTAACATTTGGAGGTTTTTTTTTTGCAGAATACTTTCTTGCATTTAAGGATTTATTTGGAAAAATGTGTAACATGGTATCTGTGGGACCTTAAAATGTCTTAAATTTTAAAAAACAAAATTTTAATTTTTAAAACAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa35849
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Nonsense 355 502 13 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16439190)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17484153
GRCz11 15 17420175
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTAGGTGACCTGATGTCTTGTATTGGCAGCAATCTGCTGAGGATGTGAGC[C/T]AGTTTGATTCAAAGTTCACCAGCCAGACTCCCGTTGACAGTCCTGATGAC
Long Flanking Sequence:
AGGTCAACATCAATGGTTAAAGTCAACATAAAAATGGTAACACTTTAAATCCTAACAAACTGTTCATAGTGAAAAGCCTTTTTTTTTAAAGAAAAATGTTTACTTTAGTTCTTTTCCTTGCCCAAAAAGTATAAACTATTAGCTATGAGATGGCAGAATTGAACAATAAGGTCTTTGGGGTACAAAAAGAAGTATATCATTAACTTAACCTATTGATTTTTGGTACAACTGAACATTTAACCACATTTCATAATTTAGAAGGAATTGCTGAGCTTTTGTTTTGGTTTAATGTGTTTTAATTTGTCTCCTAGACTCATCCCTTTTTCCGACATGTTAATTGGGATGATCTTCTTGCACGCAAAGTAGAACCACCATTCAAGCCTTTCTTGGTAACTATATTCATGTTTTGGGGTGTTTTGCTGGATCCTATTGGTTAAGAGTACACATGAAGTAGGTGACCTGATGTCTTGTATTGGCAGCAATCTGCTGAGGATGTGAGC[C/T]AGTTTGATTCAAAGTTCACCAGCCAGACTCCCGTTGACAGTCCTGATGACTCCACACTGAGCGAAAGTGCAAATCAGGTCTTTTTGGTAAGGCAGCCAAGTCATGATTTCAGTGTCCTCTATGAAAGCCTGTTTTTGCCATAGAATACAGATAAAAAGGGACTTGCAATTTGGACTTTTCTCTCTCTTTTAAGAATTGAGTTGCCACATTTTAGCATTTTGAAAGTTAGTTGGGTAACATTTTTTTATATTGGGTAACATTTGGAGGTTTTTTTTTTGCAGAATACTTTCTTGCATTTAAGGATTTATTTGGAAAAATGTGTAACATGGTATCTGTGGGACCTTAAAATGTCTTAAATTTTAAAAAACAAAATTTTAATTTTTAAAACAGATAAATTCGCTGAAATATGGTGTTGGACGCCTTAGTCATGTTAAACAGTTCTTATTTTTTTTTTGACTTTCAACCAAACCAAAAAAGAAGTTACCCTTATCAACTCCATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa17324
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000081059 Essential Splice Site 383 502 None 15

The following transcripts of ENSDARG00000058230 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 15 (position 16439278)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 17484241
GRCz11 15 17420263
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CAGTCCTGATGACTCCACACTGAGCGAAAGTGCAAATCAGGTCTTTTTGG[T/C]AAGGCAGCCAAGTCATGATTTCASTGTCCTCTATGAAAGCCTGTTTTTGC
Long Flanking Sequence:
AAGAAAAATGTTTACTTTAGTTCTTTTCCTTGCCCAAAAAGTATAAACTATTAGCTATGAGATGGCAGAATTGAACAATAAGGTCTTTGGGGTACAAAAAGAAGTATATCATTAACTTAACCTATTGATTTTTGGTACAACTGAACATTTAACCACATTTCATAATTTAGAAGGAATTGCTGAGCTTTTGTTTTGGTTTAATGTGTTTTAATTTGTCTCCTAGACTCATCCCTTTTTCCGACATGTTAATTGGGATGATCTTCTTGCACGCAAAGTAGAACCACCATTCAAGCCTTTCTTGGTAACTATATTCATGTTTTGGGGTGTTTTGCTGGATCCTATTGGTTAAGAGTACACATGAAGTAGGTGACCTGATGTCTTGTATTGGCAGCAATCTGCTGAGGATGTGAGCCAGTTTGATTCAAAGTTCACCAGCCAGACTCCCGTTGACAGTCCTGATGACTCCACACTGAGCGAAAGTGCAAATCAGGTCTTTTTGG[T/C]AAGGCAGCCAAGTCATGATTTCAGTGTCCTCTATGAAAGCCTGTTTTTGCCATAGAATACAGATAAAAAGGGACTTGCAATTTGGACTTTTCTCTCTCTTTTAAGAATTGAGTTGCCACATTTTAGCATTTTGAAAGTTAGTTGGGTAACATTTTTTTATATTGGGTAACATTTGGAGGTTTTTTTTTTGCAGAATACTTTCTTGCATTTAAGGATTTATTTGGAAAAATGTGTAACATGGTATCTGTGGGACCTTAAAATGTCTTAAATTTTAAAAAACAAAATTTTAATTTTTAAAACAGATAAATTCGCTGAAATATGGTGTTGGACGCCTTAGTCATGTTAAACAGTTCTTATTTTTTTTTTGACTTTCAACCAAACCAAAAAAGAAGTTACCCTTATCAACTCCATTTGTCATTTTGGTTTAACTATCTTCCTTACTCTAACAGTTGTTTAAAAGTTCTCCATGTATTAATAGTTACCTGGTGAGGACACTAATC
Associated Phenotype:
Not determined