ZMP

tlx2

Ensembl ID:

ENSDARG00000011273

ZFIN ID:

ZDB-GENE-020208-1

Description:

T-cell leukemia homeobox protein 2 [Source:RefSeq peptide;Acc:NP_705937]

Human Orthologues:

TLX2, TLX3

Human Descriptions:

T-cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:5057]
T-cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:13532]

Mouse Orthologues:

Tlx2, Tlx3

Mouse Descriptions:

T-cell leukemia, homeobox 2 Gene [Source:MGI Symbol;Acc:MGI:1350935]
T-cell leukemia, homeobox 3 Gene [Source:MGI Symbol;Acc:MGI:1351209]

Alleles

There are 2 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa22417	Nonsense	Available for shipment	Available now
sa35628	Essential Splice Site	Mutation detected in F1 DNA	Not yet available

Mutation Details

Allele Name:

sa22417

Status:

Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Order Allele From ZIRC

Mutation:

C > T

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000012116	Nonsense	204	301	2	4

The following transcripts of ENSDARG00000011273 do not overlap with this mutation:

ENSDART00000144539

Genomic Location (Zv9):

Chromosome 14 (position 5676101)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	14	5363098
GRCz11	14	5669932

KASP Assay ID:

2260-7225.1 (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

CGTCGTTCAGCCGCGTGCAGATCTGCGAGCTGGAGAAACGCTTTCACCGG[C/T]AGAAATATCTGGCGTCCGCGGAGCGCGCCACACTCGCCAAGGCCTTGAAG

Long Flanking Sequence:

AACACACAGAAAAATGATTTCTGCATAATTGTTGCAAAATTTGTGTTGAATTGAAACAAATTAAAATTAGTAATGTTAATTTGTTTGTTTAAATTTAGGTCAAATAAATTGTTTATAACCACCTAACTTAAAAAATAGTAAACCCAAGGAATCATCTTTAAATAATTTATTTTAGTGCTCTTACTTTACATTTTTTTAGTAAATCCAATAAATATATTTTTCAGTGATAGCTACAGGGCCCACCATAAATATAATTATCAATTATGTCATTACTTATTGGCTTTTTGAATGTTACTGGAAATGTTACAGATTACATTTTATTTTTGAATGTTATACTCACACATAGTTCCTCTTTTTCCCTCTCAGCTGCTCTGTCCCCGTTCTCCGTCACACGGCGGATCGGTCATCCGTACCAGAACCGGACACCACCGAAGCGAAAAAAGCCGCGTACGTCGTTCAGCCGCGTGCAGATCTGCGAGCTGGAGAAACGCTTTCACCGG[C/T]AGAAATATCTGGCGTCCGCGGAGCGCGCCACACTCGCCAAGGCCTTGAAGATGACAGACGCTCAAGTCAAAACCTGGTTTCAAAACAGAAGAACAAAATGGAGGTCAGTGAATACAAGGACCATTTCAAATACATCATTTCAAAACGGTGTCTAATAAATACTGCAAAGAAAATTGATTTAAATATTCTTGTCAAGTTGTTATTGACAATTTTATAGCCCAACAATATACCACGAGCAGTTTTACTGAGTAGAATTGAAGTTTATTTGCTCATTTTTATTTCAGTTTCATTTGCGGACCCTGTTTATTCAGAGCTAAAATTTCTCGGCTTGTTTTGTTTCTACAGACTTGTCGAAATGTGTTTATTTTTAATGAAATCTCTTACTCTCTAAAGCTGCATTAACTGCTCAACACATATTGAAACAGAAACATTTAGAACGTATTATTATAATTTATAAAGCCTGTTTACAATGCAGTTTATGATTATGATGAACAGTTTCG

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa35628

Status:

Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Not yet available

Mutation:

A > C

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000012116	Essential Splice Site	238	301	None	4

The following transcripts of ENSDARG00000011273 do not overlap with this mutation:

ENSDART00000144539

Genomic Location (Zv9):

Chromosome 14 (position 5665707)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	14	5352704
GRCz11	14	5659538

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

None

Flanking Sequence:

AAAAAATAAGGCAGCAGTGTAATTATGTTGACTTAAATATCTCTGCTGAC[A/C]GGAGGCAGACAGCGGAGGAGAGGGAGGCCGAGCGACAGCAAGCCAACCGT

Long Flanking Sequence:

TTTATTCTGGTTTAAAGAACAGACTATTTACAGTTTCTCAAAATAGCAACGCGCCAAAACACGCCTGCTTTTTTAGACCAGAACGTCTATGGGCGCACATTTGAGCGCAAATGCATTTGCTATTTAAACAGTGTGGTGCAATGCCTCAAAATGACCCTTGCGCCGAGCTGAAAGTAGCAAATAACAATTGCGTTGCGCCTTGCGCCACATTGCGCCAGGTGTATGATAGGGCCCATTGTGTTTAGAGCAGAAAATTCCAACATTCTGTAAGGTATGATAAAATATCTGATGGGTATTTTGAGCTGAAACTTTACAAACCCATTCTGGAGACACAAAAGACTTCTCTTAAATCTTAAAAAAGGGTAAAATAGTTGCCCTTTAACTTAACATTTTTAGTCAGTTTGAATAATGTAAGTCGAGATGACTAGAAAAGTTCATTTGATTCAACTGAAAAAATAAGGCAGCAGTGTAATTATGTTGACTTAAATATCTCTGCTGAC[A/C]GGAGGCAGACAGCGGAGGAGAGGGAGGCCGAGCGACAGCAAGCCAACCGTCTGATGCTGCAGCTTCAGCAGGAGGCCTTTCAGAAGACCCTGAGTCAGCCGCTCCAACAAGACCCGCTCTGCCTTCACAACTCCTCGCTTTATGCCCTGCAGAACTTACAGCCCTGGGCAGAGGACAATAAGGTGACGTCGGTCACCTCAGTCGCATCTGTGGTCTGACCCGCAGCTCTCATTGTGTGTGCTATAGTTAACCGAGAACGGATTTATAGTGCTTAACGTAATTTGGGTGGATCTGGCATCCTGATTGGGACTCACGAAGCCATAAGATTTTTTGTTTTCAGTGAGACCTAAAAAAAAAATCTTTTTTCAATCATATAGCTACTGTGTGGAATTAATAGCCTCAGTAGCATGAGGTTAAAATCACTAAACAATCCCGGTAAAATAATAAACTGTATTTATTTATTTGTGTGTTTAATTATCAGTTTTTCCCCAACACAAACA

Associated Phenotype:

Not determined