ZMP
si:ch211-1n9.7
Ensembl ID:
ZFIN ID:
Description:
Novel protein similar to vertebrate DNA replication helicase 2 homolog (Yeast) (DNA2) [Source:UniPro
Human Orthologue:
DNA2
Human Description:
DNA replication helicase 2 homolog (yeast) [Source:HGNC Symbol;Acc:2939]
Mouse Orthologue:
Dna2
Mouse Description:
DNA replication helicase 2 homolog (yeast) Gene [Source:MGI Symbol;Acc:MGI:2443732]
Alleles
There are 5 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa42185 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa35475 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa35476 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa773 | Nonsense | Confirmed mutation in F2 line | Not yet available |
| sa8393 | Nonsense | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa42185
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000109798 | Essential Splice Site | 13 | 1378 | 1 | 22 |
| ENSDART00000135424 | Essential Splice Site | 13 | 237 | 1 | 3 |
| ENSDART00000144094 | None | None | 1020 | None | 20 |
Genomic Location (Zv9):
Chromosome 13 (position 22962251)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 13 | 22691589 |
| GRCz11 | 13 | 22822039 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTATTCACACATGTCTACAATGATGAAGTGCAAATCCAGCCGATCATCT[G/A]TGAGTATTTAAATAAGTTCGTTTGCTGCTATATTGTTAGATGTTTTTAAG
Long Flanking Sequence:
TCTTGGTAATCATAAATTTATCTCTCGTTACAAAAAACAACAACGATATAATTGTTGGTTTTGTTGTTTATGTATGATATAATGATCACTGCAAAACGACTCGACTGACTGATAGGACTGTCACTGGGTGGCAGTGTGTCTGCAACGGCGTTGGAAGTTCCGCAAACAAGAAACAACGAAGAAGAAGTTGCTTATCATGTGATGTTTATTAATTCTACGCGGGAATCTGTTTCACTGCACAGATGAATCAAAGGTTATTTACGCCAGCAATTGCTTTTAATTAATGTGAAAGTAACAGTTACGTTCAGATGTCCGTCTGGCTGTAAGAATAACGTCATCAGTTTCTGGACGAAGTTCATCTTTTAGAGCAGCTTTACAGTGGTGTGAGATGCTTGAAGTTTTTGAATGAGTGTTATGCTTTTCTGCAAAGAACAAAACGCCTTCAGTCATTTTATTCACACATGTCTACAATGATGAAGTGCAAATCCAGCCGATCATCT[G/A]TGAGTATTTAAATAAGTTCGTTTGCTGCTATATTGTTAGATGTTTTTAAGTTGTGAAAATCGGGTTGCCTTAACTAACATATTTTCCTTTTAATCTTAGATGGTCAGTGGAGTTCAATCAAACATTTCTTCATTTTTCCTCTCAAAGGTAAGGACACGACTGACAGGGACAGTTCAACATTTAAATGATGATACGTCATCATTATTTACTCACACTTATGTTGTTTCATACTTCAATGTTTATTCTGTACAGCACAAAAGGATGTTTGAAGGTTAGAGACCGATAGCTCTGATCACAATTCACTTTCCTTACATTTTATTTATGAAAAAAACGTTTAACAGTCAGTATCCCGGTATTGTAATTATTGCTCCAAAGTATATTCTTTTTAAATTTCTTGGTAAAAAACAAAACCTTTTTCCCCTTTAAATTCAATATATTCTTTTTTTTTTTTTTTTGAAAGATTTATGTTTTTTTGGAGCAGTAAACATGTCAGACTATAT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa35475
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000109798 | Essential Splice Site | 514 | 1378 | 6 | 22 |
| ENSDART00000135424 | None | None | 237 | None | 3 |
| ENSDART00000144094 | Essential Splice Site | 160 | 1020 | 3 | 20 |
Genomic Location (Zv9):
Chromosome 13 (position 22969336)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 13 | 22698674 |
| GRCz11 | 13 | 22829124 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGACATTTGCCACGGAGGCCTTAAGAAGCCCCAACTACCTCGGACAAATG[T/A]AAGTACTCTCCTGTAACTGTCAACTCCACCTTTAGTGGCAAACTTGGGCT
Long Flanking Sequence:
TTAGCTGTAATAAGTAATGTGAAGTCTAAATGTCAATTTAGCTTTTATTTCAGTGCTGATTGTCAGTTTAGTGTAGCAGTTCATTTTAAACATTAACTTTATTATTAATTATTATTTATTATTATTAAGTATTATTCTAACTTTTAGAGTTTTCCGTATTTAGCATATATAAGCACATTAAATCTGGAAGTTACATTTTAATGAAAGTAATGTGAAAATGTGTTGTTGTTTTTTTTTTTTGTCTGTTTTAAAGAGTAAGATGGTATACATTAGTAATATATTATTTTTAAAAGTAACTTTACTCAACACTGAAAAATTGTTGTGTGTGTGGTGTTGCTGTTTTTAAACAGGCATTTGATGGTGGATCCAAGCAGATGTTAAATGGTACAATAGTTCATGATATCTTTCAAAAAGCAGCCATGTCCTCAGATTTCTCCTCAGAGAAGATACAGACATTTGCCACGGAGGCCTTAAGAAGCCCCAACTACCTCGGACAAATG[T/A]AAGTACTCTCCTGTAACTGTCAACTCCACCTTTAGTGGCAAACTTGGGCTGCCATTTGTACTTGTTTGCCTTAAATTTTAGTAAAGCAGCTTTTGACCATCGTAATACTATATGTTATGATATTGCCTTGAAATGGATGTAAATGACACAACTGGCTATATATTGTGTTTTTTCATGTTTCATTAAATTAGGTACAGTCTAAAGCTGACTCAGGCTGACATGAGACAGGAAGTTGAAGAATATCTTCCCTCTATATCTGAATGGGCAAAACAATACCTCCACACTTCCCCACAGGCAGGACAAAAACAGCTGACTCTAAAACTGTGAGTGTATTATTTATATACTTCTTTTAACAAATGTTTATTGGATGTGTCATGCAGTCTGCTGTCAGCATTTTCTGGTTTCTTCAATGTAATATTATGGATGAAGTTAATGGTTTATGTGGTTCTTTGTTGTTAGCCCTAGTGATGGGGCTCTGAGCAAACAAGATGCTTCCAGTA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa35476
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000109798 | Essential Splice Site | 674 | 1378 | 9 | 22 |
| ENSDART00000135424 | None | None | 237 | None | 3 |
| ENSDART00000144094 | Essential Splice Site | 320 | 1020 | 6 | 20 |
Genomic Location (Zv9):
Chromosome 13 (position 22970292)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 13 | 22699630 |
| GRCz11 | 13 | 22830080 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAGACTGGCAGTCTACATCCTGTTGTGGGCAATCACATGGACAGGAGAGG[T/C]TAGATTTATATAGAGGTTTATACTTGTAAAGGACAGAAATGAAGATTCTG
Long Flanking Sequence:
TTAGCCCTAGTGATGGGGCTCTGAGCAAACAAGATGCTTCCAGTAGCGTGATGGTTACTGATTTTGTGGACATTGAGGAGAACATTTGGTGTCCACGTTTTGGTCTGAAGGGAAAGATTGATGTCACAGCTGGAGTTAAGATTCACCGGAGAGGCAGGAAGCCCATGGAAAGAATTGTGCCACTGGAGCTGAAAACTGGCAAAGAGTCTAACTCCATTGAGCATCGCAGTCAGGTACAAAAACACAATCACCTATGGAGAAAAAAATAATTAAATTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATCACTACTTGTTGCTTGATGCTTGACATATTGTTTGTATTTTAGGTTATTCTGTACACACTGATGAGCTCAGCTAGACGTTGTGATCCAGAGGCAGGTTTCCTTGTCTACTTGAAGACTGGCAGTCTACATCCTGTTGTGGGCAATCACATGGACAGGAGAGG[T/C]TAGATTTATATAGAGGTTTATACTTGTAAAGGACAGAAATGAAGATTCTGTTTACATTTATGCATTCTCATGTTGTTTTAAATACAAAAGACATTCTTCCACCTTTGAAACCTAAATTAAGATATCTAATCTATGGGAAGTCTTTCCTTACATTTAAAGACTATTGACCCAATACTCTCTGACACTTCAGAACATCAATCAAGAGGAAAAAAGGTGATTGCTTCATAAATTGAATCAAGGGATTTTATTTAGATATAAACATTTGTCAGCAAACAATGTTTGCAGCCTTCAGTTTTGTTCACATAAGCTCAAGCGTTCTTGCTTGGTGTATGAGAATAATGAGGTTCATTCATTCCTGTCAGTCCAACGCATTTGACCTTCAGCATGAACCTATGAGGTGTGTTCATATGTGAATAAAGGCCTGAATTATATCTGTTCATTAGGTCTTTGCATGTCTTCAGAAAACTTTGATTAAATATCTTGAATTTTTATAATGATCA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa773
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000109798 | Nonsense | 710 | 1378 | 10 | 22 |
| ENSDART00000135424 | None | None | 237 | None | 3 |
| ENSDART00000144094 | Nonsense | 356 | 1020 | 7 | 20 |
Genomic Location (Zv9):
Chromosome 13 (position 22971011)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 13 | 22700349 |
| GRCz11 | 13 | 22830799 |
KASP Assay ID:
554-0678.1 (used for ordering genotyping assays)
KASP Sequence:
TGGATGGGAAAAGTCAAATGGCCCAATTGCCTGCCATTGTATCTGACCAG[C/T]AAACTTGCAAATATTGTCCTCAGAAAAGGAACTGTGCAATTTACAACAGG
Long Flanking Sequence:
TGCTTCATAAATTGAATCAAGGGATTTTATTTAGATATAAACATTTGTCAGCAAACAATGTTTGCAGCCTTCAGTTTTGTTCACATAAGCTCAAGCGTTCTTGCTTGGTGTATGAGAATAATGAGGTTCATTCATTCCTGTCAGTCCAACGCATTTGACCTTCAGCATGAACCTATGAGGTGTGTTCATATGTGAATAAAGGCCTGAATTATATCTGTTCATTAGGTCTTTGCATGTCTTCAGAAAACTTTGATTAAATATCTTGAATTTTTATAATGATCAAATGTTTTGCTTTCATTTGTGTTCTGAAGATGATCAGATTATGGGTTTGGAATAACATGAGACAAAGTAATTTTTTGTTGAACTAACCCTTCAGTATTTTCCTTATCATAGAGCTGATTAAAATAAGGAACTCATTGGCCCATCACATTGGCAACAACCTGATCAAGGTGGATGGGAAAAGTCAAATGGCCCAATTGCCTGCCATTGTATCTGACCAG[C/T]AAACTTGCAAATATTGTCCTCAGAAAAGGAACTGTGCAATTTACAACAGGTGCCATTTTCTACTCTTTGCATGTTCTCTTCACAATTGAAAAGTCAAACAGTTCTTTAATGTCATTGAGCTACTGCCAAAATCTATCATTTGTTTAGAGCTGTGGAGAGAGATCCTGTGGAGAAGTGCAGTGAAAATCCACAGGCCTTTGTGCAGTCAGAGAGTGAACACCTCAGTCAGGTGCACCTCCAGTACTTTAGCCACTGGCTGCTGCTCTGCTCACTGGAGGCTCTCACCATGGAGAATAAAGGAGGTCGGCGTAATATCTGGCTTCAGACTGCTCAACAGAGGTGGGTGTTTTTACTTAATTAATTCTCAGAAAAAGGTACATTATTTAATCATTTACTCACTCTAATGTCATTCTAAGTCTACCTGAAAGCCTTTCTATTCACCTTTGAAGTGCAAAATAAAGATATTTATAGTTAAAGCTGAGGGATTTCTTTTTCTCCAG
Associated Phenotype:
This allele has been associated with this phenotype by genetic linkage analysis and may not be causal.
See FAQs for more info.
See FAQs for more info.
| Stage | Entity | Entity | Quality | Tag |
|---|---|---|---|---|
| Larval:Day 5 ZFS:0000037 |
eye ZFA:0000107 |
decreased size PATO:0000587 |
abnormal PATO:0000460 |
|
| Larval:Day 5 ZFS:0000037 |
head ZFA:0001114 |
malformed PATO:0000646 |
abnormal PATO:0000460 |
|
| Larval:Day 5 ZFS:0000037 |
larval locomotory behavior GO:0008345 |
disrupted PATO:0001507 |
abnormal PATO:0000460 |
|
| Larval:Day 5 ZFS:0000037 |
swim bladder ZFA:0000076 |
aplastic PATO:0001483 |
abnormal PATO:0000460 |
|
| Larval:Day 5 ZFS:0000037 |
whole organism ZFA:0001094 |
anterior/posterior axis BSPO:0000013 |
increased length PATO:0000573 |
abnormal PATO:0000460 |
Mutation Details
Allele Name:
sa8393
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000109798 | Nonsense | 931 | 1378 | 14 | 22 |
| ENSDART00000135424 | None | None | 237 | None | 3 |
| ENSDART00000144094 | Nonsense | 577 | 1020 | 11 | 20 |
Genomic Location (Zv9):
Chromosome 13 (position 22972492)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 13 | 22701830 |
| GRCz11 | 13 | 22832280 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TRGAATTCAGGCCTCCTCAGTTCATTGACAGCCTCAGCAGTGTTTTGCCA[C/T]GAGATGCCAAGGACATTGTGKCCAACATTCTGAAAGGTGCATTCATACAC
Long Flanking Sequence:
GATTGTTGTCAGTGATCAGGACTCTGTGCTCATTGGCCTGTCCACCGGATACGTCACAGAAATTGCAGTTAACCGAGTTACTTGCTCGCTGGACAAGTAAGTATCTTCTTGTGATTTTTGTTCTTTTTTTGTTTTGTTATTAATTTACTAGAATCTATCAAGTATTCAAGTTAGGCTACAAAATACCTTTATTCTACATTCAAATTGTTGCAGAAACCTTTCCAAGTATTCCTCAAACACTGTTTTCCGACTGGACCAGGATGAAGGTGCAGGTGGTCTTAGCACTCATCTCGGAAACCTTTCTATGTTAATGGAAAACACTCCAACAAGGTCTGAACATCACCTTAGTTCTGTTTTCCATCTTTAAGTGTTTCACTGCTAATGTTTTTGATACCATTTCAAACTACATATGTTTATATTTATGCAGTGAAAGACTGAGAGAGTTGATTGTGGAATTCAGGCCTCCTCAGTTCATTGACAGCCTCAGCAGTGTTTTGCCA[C/T]GAGATGCCAAGGACATTGTGTCCAACATTCTGAAAGGTGCATTCATACACTGCCTTCACCCGAGAATCTTATTACATTTAATAGCAATAAGCTGACTTTTTCTGCAGTGAGCTGCTTTAAAGCGTGCCCTTGATGTGCTAATTTGAATAATAGAGCTTCTCCACTCCTACTTAATGTGTTTTAATTAAATGCTGCCTCACAGGACTCAACAAACCCCAGAAACAAGCAATGAAAAAAGTGCTTCTGTCTAAAGATTACACGCTTATTGTGGGAATGCCGGGTACTGGGAAAACTACCACCATCTGTACACTGGTAAGCTTATCATGATTTGAAATTATTATGTTTAGTCACTAGCTGATGTATGCGACTTTTGGGTTTAATATTTGGTCTGTATGTTACACAAGACTTTTTATTCCACTTGAAGTCAGCCAAGGTTTTTTGCACTAAAAAGTCATTTTCTTTACATGACTTTTACTTCTAGAAATGACCACATTTCTAGA
Associated Phenotype:
Not determined