Busch Lab

ZMP

cflar

Ensembl ID:
ENSDARG00000055966
ZFIN IDs:
ZDB-GENE-030826-3, ZDB-GENE-030826-3
Description:
CASP8 and FADD-like apoptosis regulator [Source:RefSeq peptide;Acc:NP_919380]
Human Orthologue:
CFLAR
Human Description:
CASP8 and FADD-like apoptosis regulator [Source:HGNC Symbol;Acc:1876]
Mouse Orthologue:
Cflar
Mouse Description:
CASP8 and FADD-like apoptosis regulator Gene [Source:MGI Symbol;Acc:MGI:1336166]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa2599 Nonsense Available for shipment Available now
sa27805 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa11641 Nonsense Available for shipment Available now
sa41869 Nonsense Mutation detected in F1 DNA Not yet available
sa27804 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa2599
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000078378 Nonsense 54 461 3 11
ENSDART00000108494 Nonsense 54 418 1 9
Genomic Location (Zv9):
Chromosome 11 (position 31215340)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 30092702
GRCz11 11 30339886
KASP Assay ID:
554-2867.1 (used for ordering genotyping assays)
KASP Sequence:
TGGAAGAACTGAGAGGAGATTTGCTGGCCTTTGCCCAACAGAACCCCAAT[C/T]AAGCAGGTCAACCTCATTCTGGAAATGCTCTGCTGATGGAGCTCATGTTT
Long Flanking Sequence:
GCTCCAAATTAAGGTCACTGAAGGTAATTCAGCCTTTTACAGGTATCTTTCATTTGTTGATGTTTTTTTTTATTTATTTTTTTATTTTTTTGCTAAATTGGGTGTTCTGTTTGTCTTTTACAGGTGTAAATCCAAAGTGGCTACATTCTTCCATTCTGTCAAGATAAATGCAATTTTCATTCATTGATTGCAAAAAAAAAAGAAAAAGAAAAGAAAAAGAAAATACAGCCCTTTTTCTAGACTAACTTAATTAGATTTTAAAAATGCATAGAAAATTCAATTCTGCTTTTAAAATGACCCAAACTATTACCTAAAGTATTTATACAACACCATACGGTGAAATGGCAGATGGATTTTCTACTCTGGTTAACAAAGTGACCGCATCTCTTAGCAGCGACGAGTCTAAGATCCTGCTGTATCTTTGCACTGATTTGTTCAACAACAGTTGTGTGGAAGAACTGAGAGGAGATTTGCTGGCCTTTGCCCAACAGAACCCCAAT[C/T]AAGCAGGTCAACCTCATTCTGGAAATGCTCTGCTGATGGAGCTCATGTTTCAAATGAAGCGCTATGATTTACTACGCAAAGTTTTTGGCACCAACAAACAACAGGTAGAAGGAATTCTCAGAAAGGAGCGCGTCATCTCAGATTACAGGTAATTTATTCTTCAAATGAACACATTTCAGATATTTCCTAACCCATGACCCATGTGGTGGAAAAATACAATTTTAGTAAAGAAGAACTATTTTAGAGCTTGACATTTGTTTGTTTTTTTAGGTCATTAGAGCAGTTTCATTAGAAATACCCATGTAGAAATACCCATGTGTGTTATTTACACTCTCTTTTGCAGTACGATTATTGAATTGATTACTTTTATACAGGGTTCTAATGGCAGATGTGAGTGAAAACTTGGATAAAGAGGATTTACAATCTCTTATCTTCCTCCTAAGCAGTATCCTGCCCAAAGAAAGATCAACTAGAGCTACTGTAAGACCTTACTGAATATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa27805
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000078378 Essential Splice Site 218 461 7 11
ENSDART00000108494 Essential Splice Site 218 418 5 9
Genomic Location (Zv9):
Chromosome 11 (position 31214212)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 30091574
GRCz11 11 30338758
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTCAGCCTTTTGAAAAGCAAGTGAGACAATCACAGTGCTTCAATCATGG[T/G]GAGTTAATATGTAGGTATGTACAGTATGTGTAAAGCGGGTGTAAAGGGAT
Long Flanking Sequence:
AGATGTGGTGGTGGAGTTGGAGAAATTAAATGAAGTATCTTGTGAGAAGCTGGACTTTCTTGAAAAGTGTCTTAAAAATATTCGCAGAAATGACCTTGTCAAAAAAATTCAGGCGTACAGGAATAGAGGTCAGTCCCTTTTGAAAGAAAGTAAAAGAGAAAATCTTCTGCAAAAAAAAAACATGCATTTCTATAACGCACCACAAAGCTCTTAATTTGGCAACTAGACTCAGTTATTTTATTTACTAATATATATCAAATAAAGCAATTACGTGATTAAATTTACTAAATAAAAATTATTTAGGTCAGAACATGCCATGTGCCGCTCCAAATACCTTTAAGGTAAGACATTTAAACAAATATATTGATACAGTATATGAAAAGTATATAAAGCATATTTTTAAACTCTTTGTTTTTCTACTTTTTAAAATTTCAGTTCACCCCTATGCAGTGTCAGCCTTTTGAAAAGCAAGTGAGACAATCACAGTGCTTCAATCATGG[T/G]GAGTTAATATGTAGGTATGTACAGTATGTGTAAAGCGGGTGTAAAGGGATAGTTCAAACAAAATTCTGTCATTATTTACTCACACTTCACATTTCACAAAACTAATTGAGGTTCCTTTTTCTGTTGAACCCAAACTTTATTTTGAAAAATGTTGGAAAGCTTATACCACTGACTTCCCTTGTATTTGCTCTTCTTTCTGGGCAAGTCATTGGTCACAGGTTTCAATTTCCAACATCCTTCAAAATAACTTCTGTGTTCAACAGATGAAAAATGAGCTCATAAAGGTTGGGAAGAAACCATTCGAGAATGAGTACATGATGACAGAATCAAACATTTGATTTGCTTAATTATCACTTTATTTTTGACCCTGTGATCTTCTTCTAGAGTTCAACAAATTGAAGCTTTCTGTGCCTGAAACAGGGATTCACTATCAACAGGTAAGTTATCAGCTTCTCGGCTGACTAAAAACAATTAAAATAGAAATTGCCATTCTTTTAAAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11641
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000078378 Nonsense 222 461 8 11
ENSDART00000108494 Nonsense 222 418 6 9
Genomic Location (Zv9):
Chromosome 11 (position 31213815)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 30091177
GRCz11 11 30338361
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ATTATCACTTTATTTTTGACCCTGTGATCTTCTNNNAGAGTTCAACAAAT[T/A]GAAGCTTTCTGTGCCTGAAACAGGGATTCACTATCAACAGGTAAGWTATC
Long Flanking Sequence:
TTTTAAACTCTTTGTTTTTCTACTTTTTAAAATTTCAGTTCACCCCTATGCAGTGTCAGCCTTTTGAAAAGCAAGTGAGACAATCACAGTGCTTCAATCATGGTGAGTTAATATGTAGGTATGTACAGTATGTGTAAAGCGGGTGTAAAGGGATAGTTCAAACAAAATTCTGTCATTATTTACTCACACTTCACATTTCACAAAACTAATTGAGGTTCCTTTTTCTGTTGAACCCAAACTTTATTTTGAAAAATGTTGGAAAGCTTATACCACTGACTTCCCTTGTATTTGCTCTTCTTTCTGGGCAAGTCATTGGTCACAGGTTTCAATTTCCAACATCCTTCAAAATAACTTCTGTGTTCAACAGATGAAAAATGAGCTCATAAAGGTTGGGAAGAAACCATTCGAGAATGAGTACATGATGACAGAATCAAACATTTGATTTGCTTAATTATCACTTTATTTTTGACCCTGTGATCTTCTTCTAGAGTTCAACAAAT[T/A]GAAGCTTTCTGTGCCTGAAACAGGGATTCACTATCAACAGGTAAGTTATCAGCTTCTCGGCTGACTAAAAACAATTAAAATAGAAATTGCCATTCTTTTAAAGTTTATAAGTTGTCTTTATATCTGCTAGGCTATTACAGAGGAGTATCAAATGAATCCCGAACAAAGAGGCCTGTGTGTGATTATTGACTGTGTTGGCTATGATGGAGGTAAGTGTGTGTCATACTCTCAAAATAAAGGTACGAAAGCTGTCACTGGGGCTTTTGTACCAGGGCCACATTGGTACTTTAAAGGTACACTTTAATACTTTTTAGGTACTAGTATGTACAGTCACAGTACAACTGAGGGACTGTTTGGTAACACACACTTAAAAAAAAAAAGGTACTGCCACAGTGATTTTTGTACTTCTATTTCTGAAAGTCTTTCTCTTTTGTATTTGTTCTAGAGAATCATCTAGAGAAAGTGACCTTAAGGTCCTCATTTAACTAATAAAATACTAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41869
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000078378 Nonsense 251 461 9 11
ENSDART00000108494 Nonsense 251 418 7 9
Genomic Location (Zv9):
Chromosome 11 (position 31213637)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 30090999
GRCz11 11 30338183
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TAGGCTATTACAGAGGAGTATCAAATGAATCCCGAACAAAGAGGCCTGTG[T/A]GTGATTATTGACTGTGTTGGCTATGATGGAGGTAAGTGTGTGTCATACTC
Long Flanking Sequence:
TTTACTCACACTTCACATTTCACAAAACTAATTGAGGTTCCTTTTTCTGTTGAACCCAAACTTTATTTTGAAAAATGTTGGAAAGCTTATACCACTGACTTCCCTTGTATTTGCTCTTCTTTCTGGGCAAGTCATTGGTCACAGGTTTCAATTTCCAACATCCTTCAAAATAACTTCTGTGTTCAACAGATGAAAAATGAGCTCATAAAGGTTGGGAAGAAACCATTCGAGAATGAGTACATGATGACAGAATCAAACATTTGATTTGCTTAATTATCACTTTATTTTTGACCCTGTGATCTTCTTCTAGAGTTCAACAAATTGAAGCTTTCTGTGCCTGAAACAGGGATTCACTATCAACAGGTAAGTTATCAGCTTCTCGGCTGACTAAAAACAATTAAAATAGAAATTGCCATTCTTTTAAAGTTTATAAGTTGTCTTTATATCTGCTAGGCTATTACAGAGGAGTATCAAATGAATCCCGAACAAAGAGGCCTGTG[T/A]GTGATTATTGACTGTGTTGGCTATGATGGAGGTAAGTGTGTGTCATACTCTCAAAATAAAGGTACGAAAGCTGTCACTGGGGCTTTTGTACCAGGGCCACATTGGTACTTTAAAGGTACACTTTAATACTTTTTAGGTACTAGTATGTACAGTCACAGTACAACTGAGGGACTGTTTGGTAACACACACTTAAAAAAAAAAAGGTACTGCCACAGTGATTTTTGTACTTCTATTTCTGAAAGTCTTTCTCTTTTGTATTTGTTCTAGAGAATCATCTAGAGAAAGTGACCTTAAGGTCCTCATTTAACTAATAAAATACTATAATTTCTTTATTGACTTTTTTCATAAGTTAAAAGAGGATCATAAGGTCACTTTCTGTTTTAGGTGGGGAAAAAATACCATGACAGTTTACACTTTCTGAATACTTGTTTTGCCCCTGGTTTCATTGACACTCTTTATTCCGACAAGTGTGCTCAGAGTAAAATAAAAAAAATCCTATA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa27804
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000078378 Essential Splice Site 262 461 9 11
ENSDART00000108494 Essential Splice Site 262 418 7 9
Genomic Location (Zv9):
Chromosome 11 (position 31213604)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 30090966
GRCz11 11 30338150
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAACAAAGAGGCCTGTGTGTGATTATTGACTGTGTTGGCTATGATGGAGG[T/C]AAGTGTGTGTCATACTCTCAAAATAAAGGTACGAAAGCTGTCACTGGGGC
Long Flanking Sequence:
GAGGTTCCTTTTTCTGTTGAACCCAAACTTTATTTTGAAAAATGTTGGAAAGCTTATACCACTGACTTCCCTTGTATTTGCTCTTCTTTCTGGGCAAGTCATTGGTCACAGGTTTCAATTTCCAACATCCTTCAAAATAACTTCTGTGTTCAACAGATGAAAAATGAGCTCATAAAGGTTGGGAAGAAACCATTCGAGAATGAGTACATGATGACAGAATCAAACATTTGATTTGCTTAATTATCACTTTATTTTTGACCCTGTGATCTTCTTCTAGAGTTCAACAAATTGAAGCTTTCTGTGCCTGAAACAGGGATTCACTATCAACAGGTAAGTTATCAGCTTCTCGGCTGACTAAAAACAATTAAAATAGAAATTGCCATTCTTTTAAAGTTTATAAGTTGTCTTTATATCTGCTAGGCTATTACAGAGGAGTATCAAATGAATCCCGAACAAAGAGGCCTGTGTGTGATTATTGACTGTGTTGGCTATGATGGAGG[T/C]AAGTGTGTGTCATACTCTCAAAATAAAGGTACGAAAGCTGTCACTGGGGCTTTTGTACCAGGGCCACATTGGTACTTTAAAGGTACACTTTAATACTTTTTAGGTACTAGTATGTACAGTCACAGTACAACTGAGGGACTGTTTGGTAACACACACTTAAAAAAAAAAAGGTACTGCCACAGTGATTTTTGTACTTCTATTTCTGAAAGTCTTTCTCTTTTGTATTTGTTCTAGAGAATCATCTAGAGAAAGTGACCTTAAGGTCCTCATTTAACTAATAAAATACTATAATTTCTTTATTGACTTTTTTCATAAGTTAAAAGAGGATCATAAGGTCACTTTCTGTTTTAGGTGGGGAAAAAATACCATGACAGTTTACACTTTCTGAATACTTGTTTTGCCCCTGGTTTCATTGACACTCTTTATTCCGACAAGTGTGCTCAGAGTAAAATAAAAAAAATCCTATATTATACCCCTGATTTTCCTAACAAATTCATAAT
Associated Phenotype:
Not determined