ZMP
mpll
Ensembl ID:
ZFIN ID:
Description:
thrombopoietin receptor [Source:RefSeq peptide;Acc:NP_001003858]
Human Orthologue:
MPL
Human Description:
myeloproliferative leukemia virus oncogene [Source:HGNC Symbol;Acc:7217]
Mouse Orthologue:
Mpl
Mouse Description:
myeloproliferative leukemia virus oncogene Gene [Source:MGI Symbol;Acc:MGI:97076]
Alleles
There are 3 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa20736 | Nonsense | Available for shipment | Available now |
| sa881 | Nonsense | F2 line generated | Not yet available |
| sa26776 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa20736
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000057297 | Nonsense | 304 | 655 | 8 | 13 |
| ENSDART00000124917 | Nonsense | 277 | 614 | 7 | 12 |
Genomic Location (Zv9):
Chromosome 6 (position 33670542)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 6 | 33988207 |
| GRCz11 | 6 | 33972897 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGGAAGTTGTGTCCCAATTGCAATAACTCCATCCATCAGTGTGTCCTGTA[T/A]GGCCAGAAGTCCAATGTCTTTAAGTTTTACCTCAATACAGGGTTGCAACC
Long Flanking Sequence:
TACTGTACACTTTTAGAGAGACTACTGCATACTTTTAAAGAATACAAAATCTTTTATCATTTATAATTAGTTACATTATTTATAATACCAATTATTCATAATACCAATTAGTTTTACAATAGTAAATAATGACTAAACGTTCATTTTCTGAGAAAACTAAAAAATCTACATTGGTGAAAATATCAGTTAAATGCCCATTCACAATTCAGTATCTTTTGAATTTTCAGGTGACATAGAGTTCAGGTGCCACACTTCTGATCTGATTCAAATCATTTGCAAATGGAGGGGAGACTTATATAAGGACAATACATACAGCTTCTACTATAAACAATTAAACAGGTGTCATTTTTTTATATATCTTCTGTCTGAAACATTTAATAAAAACACTGAAAAGGTAGCTTACTAACTTTGATCCTTCTTGTCTGGTGTTTCAGAAGTTCATGGAGCAGTTGGAAGTTGTGTCCCAATTGCAATAACTCCATCCATCAGTGTGTCCTGTA[T/A]GGCCAGAAGTCCAATGTCTTTAAGTTTTACCTCAATACAGGGTTGCAACCATTCAGCCGAACATTTTATGCAGAGACTTTCTATATGAACAGTAAAGGTAAGTGTGAAGGAAGAATTGCAGAAAGTCATGTTAGATATGGTTTCTTACATTTAATTTTGATGGTCTCACAGACTGTCAAGTTACTCTCTTTAGTAAGCATTATCACACAGTAAGGTTAAGACTTGAGTGAGGTTATGTTAAGTATATTATGTTGACATATACTCAATGTTGGTTCGTAGACAATCAAAATAAAGTATTAGCTGATTTTAAAGGGATTTTCACCCAAATATAAAATGTCATTACAATTAACTCATACTCTAATGCATAGGTCTCGAACTCAATGCCTGGAGGGCCGCAGCTCTGCAATTTGCTCCAACCCTAATCAAACACAGCTGATCCAATTAATCAAGTGCTCAAGAATACTAGAGACTACTAAGCAGGTGTGAGTTGGAGGTGGTTG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa881
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000057297 | Nonsense | 346 | 655 | 9 | 13 |
| ENSDART00000124917 | Nonsense | 321 | 614 | 8 | 12 |
Genomic Location (Zv9):
Chromosome 6 (position 33652540)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 6 | 33970205 |
| GRCz11 | 6 | 33954895 |
KASP Assay ID:
554-0788.1 (used for ordering genotyping assays)
KASP Sequence:
CTTTTCTGTTTTTGACAGTTCAGACAAGGCCTCCAGAAGGTCTGAAGGTA[C/T]AGATTGGGGAAGAAAGGCTTTGTTTGACATGGGATTCACCATTTCTGATC
Long Flanking Sequence:
AGCTTTAAATGTTGAACCGGCCGACAGCGTAAATCTTACAATAGACAGACAGTAATATGCAATAAAGCTGACAGCAAACAAATACATTATAACAGATAAATTTACCTGATGATATAACAAATAACAATCTTCAAATGTTAAACAAAATAGCAATATACAAATGAAGCATACAAACAAGCAAAAATATTGTATCTATTGGTCTACCAATCTGACAACATAACAAATGGCATTCTATGATTAAAAACAGGCTACTAAAGAAGATAACAATACACAAACTAGAATTAAAATTATATCAAAAGTCATCTACATTATATTAAAAGTCATGTTATCTACAAAAAATATGCTTTAAGAAACATCTTTACATACCACTAATGTCAGCGATAGTCTATGCTGCATTGTAATGACACTTAGTGTAATGGCACTGGCAGTGAAAGCTCAGTTAGTCTGTCTCTTTTCTGTTTTTGACAGTTCAGACAAGGCCTCCAGAAGGTCTGAAGGTA[C/T]AGATTGGGGAAGAAAGGCTTTGTTTGACATGGGATTCACCATTTCTGATCATTTCTAAGCATCTAATGTACCAGATCCGTTATCAGCATCATGAAGAGAATCAGTGGAAGGTGAGTTTAAATAAATAATGAGAAATGAAAAATTCACTTATTATGGAAAGATAATATGAACTCATTTATTGCCATTATGTCTTTTTTTTTTGCTTTAAATCATTTATGCAAATAACTGCAAATGTTATGGTGAAATATAATTTTTGTGTCAGGGTTTTAAAGCTTCTGGATCCAAGACCAGCACTTGTCTAGATGTGCACAGAGGGGGTCGATACACCATCCAGGTTCGAGCACAACCCAATGGATCTGTGTACAGCGGAAACTGGAGTGACTGGTCAAAACCTGTTACAACCAACCTACCTTTAAGCAAAGGTTAACATTCTATTCATAATGTTAAATGTGCCTACTAGATACTTTCTGACAAAATAATGTGCTAAAGGAAATAGAATA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa26776
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000057297 | Essential Splice Site | 436 | 655 | 10 | 13 |
| ENSDART00000124917 | Essential Splice Site | 411 | 614 | 9 | 12 |
Genomic Location (Zv9):
Chromosome 6 (position 33652116)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 6 | 33969781 |
| GRCz11 | 6 | 33954471 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGGAGTGACTGGTCAAAACCTGTTACAACCAACCTACCTTTAAGCAAAGG[T/G]TAACATTCTATTCATAATGTTAAATGTGCCTACTAGATACTTTCTGACAA
Long Flanking Sequence:
GCAGTGAAAGCTCAGTTAGTCTGTCTCTTTTCTGTTTTTGACAGTTCAGACAAGGCCTCCAGAAGGTCTGAAGGTACAGATTGGGGAAGAAAGGCTTTGTTTGACATGGGATTCACCATTTCTGATCATTTCTAAGCATCTAATGTACCAGATCCGTTATCAGCATCATGAAGAGAATCAGTGGAAGGTGAGTTTAAATAAATAATGAGAAATGAAAAATTCACTTATTATGGAAAGATAATATGAACTCATTTATTGCCATTATGTCTTTTTTTTTTGCTTTAAATCATTTATGCAAATAACTGCAAATGTTATGGTGAAATATAATTTTTGTGTCAGGGTTTTAAAGCTTCTGGATCCAAGACCAGCACTTGTCTAGATGTGCACAGAGGGGGTCGATACACCATCCAGGTTCGAGCACAACCCAATGGATCTGTGTACAGCGGAAACTGGAGTGACTGGTCAAAACCTGTTACAACCAACCTACCTTTAAGCAAAGG[T/G]TAACATTCTATTCATAATGTTAAATGTGCCTACTAGATACTTTCTGACAAAATAATGTGCTAAAGGAAATAGAATATCAGAATTTAAAAGCATTGCATGCAGTCTCAGCTTGCTTGGGCAACCGGTCTGCAGCCAAACCCTTCAGAATTTTTTTAAATATATACACAAAAAGTACTTAAATTCATATTCACCATATTCATATGCTTTTTAATGTTCAGATTAAAAGGTAGAATATTTAAAAAACAAATTGACTAGGGATCACTTTTTCAAAACAATACTGAAGACCAGGGGCGGATTTAACCAATAAGGAAGGTAAGCAGCCCAAATAAATACCTAGAAGTATAAACAATACCTATAAATTATTTATAACATTGTTTTCTATCATAATTTGTACAGTGAGGGTCTACATTTTTTAGTTCAAATTTAATTATTACATCTGCACAAATGTGTCCCACTTCTTAAAATCATTTAGCAGTTCAGCAGTCAAATTAGTAAAGATT
Associated Phenotype:
Not determined