ZMP
arhgef18
Ensembl ID:
ZFIN ID:
Description:
rho/rac guanine nucleotide exchange factor (GEF) 18 [Source:RefSeq peptide;Acc:NP_999983]
Human Orthologue:
ARHGEF18
Human Description:
Rho/Rac guanine nucleotide exchange factor (GEF) 18 [Source:HGNC Symbol;Acc:17090]
Mouse Orthologue:
Arhgef18
Mouse Description:
rho/rac guanine nucleotide exchange factor (GEF) 18 Gene [Source:MGI Symbol;Acc:MGI:2142567]
Alleles
There are 8 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa1637 | Nonsense | F2 line generated | Not yet available |
| sa25861 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa16319 | Essential Splice Site | Available for shipment | Available now |
| sa19819 | Nonsense | Available for shipment | Available now |
| sa38343 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa39886 | Nonsense | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa1637
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Nonsense | 41 | 940 | 5 | 21 |
| ENSDART00000133951 | Nonsense | 41 | 68 | 4 | 4 |
| ENSDART00000143496 | Nonsense | 41 | 73 | 6 | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37247605)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37544315 |
| GRCz11 | 2 | 37526772 |
KASP Assay ID:
554-1577.1 (used for ordering genotyping assays)
KASP Sequence:
ATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTG[G/T]AGTCCGATGCTCGGGACTTTGAGGCTCCSACCWGGAGTTTAGCTGTTGAC
Long Flanking Sequence:
TAAATCAGCCAAGGTGACCGCACAAAAACACACTAAGCTAAAAAATGGATTAACTGCAGTATTTGAATTACCACAAAATATTAGGTTATACTTTTCTCTGTCAATATGGGACCTAGCAAGAACGTTTATTAAACTGATCAGGGTATTTCTATTGCTACAAAAGCTTCAAAAAATGGTCTTTTGAATTAACCATTTTTCAAAAAATCCTTAAAGCATTAATAATTTATTGAGAGAAAATAGCACATCCAGTCTTGACTTTCTTTTTGTTTTTCAGAGCATAAGATGGATGATATTGATTATTACAGAAGCAAGCCTCTGGCAGAGGAATCAAATTTCCAGACCACAAACTATGACGCCATCAGTATTGACGGTTGGACACGTCACCTGTTTAATTGATGTTACATGTGTATTATCATCACAGCACTTGTTTGTTGACACTAAGGCAAGTGTATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTG[G/T]AGTCCGATGCTCGGGACTTTGAGGCTCCGACCTGGAGTTTAGCTGTTGACCCACAATATTTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGGTAAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATGAAATAATTTGAGCCATATTTATTTTAAATGGCTGTTAATGTTGTTCTCGCAGAGCTGATTCAGACAGAAATCAACCATGTGCGGACGCTAAAGATAGTTTTGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACACGACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAGTTTTTCCTTGACAATCTTAAACTGCGAAGACTTGACTCTATGGAGCCTGGAAGCTCCCAGAATTACTGCATCCACAATCTTGGGGACATCCTTATCACACAGGTACCATTATTATATAACTGCTGTAGGATATTTATAG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa25861
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Essential Splice Site | 77 | 940 | 5 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
| ENSDART00000025841 | Essential Splice Site | 77 | 940 | 5 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37247495)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37544205 |
| GRCz11 | 2 | 37526662 |
KASP Assay ID:
554-6245.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGG[T/A]AAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATG
Long Flanking Sequence:
ACCTAGCAAGAACGTTTATTAAACTGATCAGGGTATTTCTATTGCTACAAAAGCTTCAAAAAATGGTCTTTTGAATTAACCATTTTTCAAAAAATCCTTAAAGCATTAATAATTTATTGAGAGAAAATAGCACATCCAGTCTTGACTTTCTTTTTGTTTTTCAGAGCATAAGATGGATGATATTGATTATTACAGAAGCAAGCCTCTGGCAGAGGAATCAAATTTCCAGACCACAAACTATGACGCCATCAGTATTGACGGTTGGACACGTCACCTGTTTAATTGATGTTACATGTGTATTATCATCACAGCACTTGTTTGTTGACACTAAGGCAAGTGTATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTGGAGTCCGATGCTCGGGACTTTGAGGCTCCGACCTGGAGTTTAGCTGTTGACCCACAATATTTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGG[T/A]AAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATGAAATAATTTGAGCCATATTTATTTTAAATGGCTGTTAATGTTGTTCTCGCAGAGCTGATTCAGACAGAAATCAACCATGTGCGGACGCTAAAGATAGTTTTGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACACGACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAGTTTTTCCTTGACAATCTTAAACTGCGAAGACTTGACTCTATGGAGCCTGGAAGCTCCCAGAATTACTGCATCCACAATCTTGGGGACATCCTTATCACACAGGTACCATTATTATATAACTGCTGTAGGATATTTATAGATTACAAATGTGATTCCGGACCACAAAAGCAGTCTTATGTGCAAATTGTCCTGAAAGCTGAATACATAATCTTTCCGTTGATGTTTAGTTTATTAGGATGTGAGCGGAGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa16319
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Essential Splice Site | 77 | 940 | 5 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
| ENSDART00000025841 | Essential Splice Site | 77 | 940 | 5 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37247495)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37544205 |
| GRCz11 | 2 | 37526662 |
KASP Assay ID:
554-6245.1 (used for ordering genotyping assays)
KASP Sequence:
TTGAAAAACTTTTCCAAAGATGCCGWCAAAAGACAGGATGTAATACACGG[T/G]AAGGGACTGTGGTCTWTTTTTKTTNGTTTATTTGTTTATTTGTTTTWCATG
Long Flanking Sequence:
ACCTAGCAAGAACGTTTATTAAACTGATCAGGGTATTTCTATTGCTACAAAAGCTTCAAAAAATGGTCTTTTGAATTAACCATTTTTCAAAAAATCCTTAAAGCATTAATAATTTATTGAGAGAAAATAGCACATCCAGTCTTGACTTTCTTTTTGTTTTTCAGAGCATAAGATGGATGATATTGATTATTACAGAAGCAAGCCTCTGGCAGAGGAATCAAATTTCCAGACCACAAACTATGACGCCATCAGTATTGACGGTTGGACACGTCACCTGTTTAATTGATGTTACATGTGTATTATCATCACAGCACTTGTTTGTTGACACTAAGGCAAGTGTATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTGGAGTCCGATGCTCGGGACTTTGAGGCTCCGACCTGGAGTTTAGCTGTTGACCCACAATATTTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGG[T/G]AAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATGAAATAATTTGAGCCATATTTATTTTAAATGGCTGTTAATGTTGTTCTCGCAGAGCTGATTCAGACAGAAATCAACCATGTGCGGACGCTAAAGATAGTTTTGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACACGACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAGTTTTTCCTTGACAATCTTAAACTGCGAAGACTTGACTCTATGGAGCCTGGAAGCTCCCAGAATTACTGCATCCACAATCTTGGGGACATCCTTATCACACAGGTACCATTATTATATAACTGCTGTAGGATATTTATAGATTACAAATGTGATTCCGGACCACAAAAGCAGTCTTATGTGCAAATTGTCCTGAAAGCTGAATACATAATCTTTCCGTTGATGTTTAGTTTATTAGGATGTGAGCGGAGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa19819
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Nonsense | 110 | 940 | 6 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37247294)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37544004 |
| GRCz11 | 2 | 37526461 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACA[C/T]GACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAG
Long Flanking Sequence:
GCCTCTGGCAGAGGAATCAAATTTCCAGACCACAAACTATGACGCCATCAGTATTGACGGTTGGACACGTCACCTGTTTAATTGATGTTACATGTGTATTATCATCACAGCACTTGTTTGTTGACACTAAGGCAAGTGTATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTGGAGTCCGATGCTCGGGACTTTGAGGCTCCGACCTGGAGTTTAGCTGTTGACCCACAATATTTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGGTAAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATGAAATAATTTGAGCCATATTTATTTTAAATGGCTGTTAATGTTGTTCTCGCAGAGCTGATTCAGACAGAAATCAACCATGTGCGGACGCTAAAGATAGTTTTGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACA[C/T]GACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAGTTTTTCCTTGACAATCTTAAACTGCGAAGACTTGACTCTATGGAGCCTGGAAGCTCCCAGAATTACTGCATCCACAATCTTGGGGACATCCTTATCACACAGGTACCATTATTATATAACTGCTGTAGGATATTTATAGATTACAAATGTGATTCCGGACCACAAAAGCAGTCTTATGTGCAAATTGTCCTGAAAGCTGAATACATAATCTTTCCGTTGATGTTTAGTTTATTAGGATGTGAGCGGAGTGGAGCAGCAAGAATTTCCACGCTCAAACTATTTTCTCTCTGTCTCCACTCCTCTCCGGGTTTTCCATCCGCATATGTATTTCAACAATAAATGCATTGTAAAAATAAATTCATTTAAGTGTAAGTACACATTAGTTAAGGCCACCTGTAATAAAGTGTGAGCGTTTTTAAAACATGTAGTGTTGCATTACTTAAACTTACT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa38343
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Essential Splice Site | 331 | 940 | 9 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37242456)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37539166 |
| GRCz11 | 2 | 37521623 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCTCAACTGGAGGGTCACGAACAACAAAGGCAAAGGTGATAAGCATACAG[G/A]TGAGATAAAAATTACAGCTGGATTATCTAGTAGTTGTTTACCAATCTTGA
Long Flanking Sequence:
TTTGTCAACACCCCTGTATTTAATTGGCACATCAAAGGTACATCTAAGGTTTTGTTTGTCTTCCCTTTTGCTTGACTTGAGATTAAACCATGTTTTTTCAGAACAGAGAGATTCCCGTGTTTCTGTGTAATTGATGCTCATTGTAACAAACACAACCAGAACATGCAGGTTCATTAGACAGCATCAATGAGAGTGCATGATTACGTTTTTTTTCCTTGTTCTTTTGACAGATGAGTCAGAAGAACAAATGGACCTGATAAAAGGGCTGGACTTTCTGAAGGACACCATAGCACAAGTGAATGCTCATGTGGACGAGGCTGAGAAAGAGGCACGACTGAGAGAACTTAGCAGTAAACTGGAGCCCAAGTCCCAGGTGAAGATGACCAGTGGGAGGGTGTTTCGTCGAGAGGACATGCTGCAGGGAAAGAGGAAGCTGCTTCATGAGGGCATGCTCAACTGGAGGGTCACGAACAACAAAGGCAAAGGTGATAAGCATACAG[G/A]TGAGATAAAAATTACAGCTGGATTATCTAGTAGTTGTTTACCAATCTTGATTTTAAATGACCGATTCCTGCAAATTCCAATAAAAACATGAGAACAAGCAGTTTATTTGCTGAAATATCTGCAGTCATTTTAAATTACAAGCACTGTGATGACACTCCATTAGCTTTGATAATTGGAAAATTAGGTTGTATAATTTTAAAATCTAAAATAAAAGCATAATGATTTGACTAGCTTTTTGAAATTATTCTACATAAAAACAAAGGGACATAACACAAAAAAATTGATGAGCTGAATAAAAATGCTAATTTACTCTCTTCCATTAGGTGGTACTAAACAGCAGGTAGAGTGGTGTATATGCTTGTATTCCAAATGCATTATTTTAAGGAAATAATAGTTTATTTTTCTCAACTAGAAATATCCAGCTCCAATGACATGATCGGAAATCGGGCCCGATTACATGGTTTTAGACTCAATCAAAATCGGATGTTACCTCCTGATCA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa39886
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000025841 | Nonsense | 491 | 940 | 13 | 21 |
| ENSDART00000133951 | None | None | 68 | None | 4 |
| ENSDART00000143496 | None | None | 73 | None | 6 |
Genomic Location (Zv9):
Chromosome 2 (position 37235649)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 2 | 37532359 |
| GRCz11 | 2 | 37514816 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGAGCGCCATCCGCTACGTGGGAATGCAGCAGAGCCCCTGCAGGGAGAA[C/T]GACTACTCACCGGAGCCCTGAAAGATGGTGAGATTTACACTGCACAGTAC
Long Flanking Sequence:
TTAATGGGTCAAGATTTATTGTAAATGTTAGCTAAATATTAATATTGTTTCTAACATTTCTTTTTTGACGCCACTCTAAGCTAATGATAATCTATGGTCAAAAGGTCAATCAGGCGGTTATGATGCCTGTTAATGGGTCAAGATTTATTGTAAATGTTAGCTAAATATTGTTTCAGCTGTCCAGACGTAAAGGAAGAAGAGCCAGAAGAACTCCCTAAGAAGATCTGGGAATTTCAAAGTAATGTGCAGATTTACTCATTCACAGTCTGGGATTTTAGTCTTCCATTTTTCTTCAGTAAAATGAACAGATGTCAGTTTTAACACTTGCTTTTTTCTGAGTAGGAAAGCTGTGTGTGCACGATGCCTCGATAGAGCAGCACCTGACAGAGAAGCTGAAGTTATTCTCCAGCATAGCAGCTTCAGTGACTGGTGTTTCTGACACCTCGACGAGTGAGCGCCATCCGCTACGTGGGAATGCAGCAGAGCCCCTGCAGGGAGAA[C/T]GACTACTCACCGGAGCCCTGAAAGATGGTGAGATTTACACTGCACAGTACAAATGAGAATTTCACTATTGACCCCTTAATGCTTTTTTCAGTCCTTTGTGCATTTTAAAAATGGGTTGCGAGTTCTCAGCTGATTCAGTAAGACAACAGCCATACAACTATGCACATATGAGCTTGTTTAGCCCAGTACACAGCATTGTTTGGATTAATTTACTTTTTTTTATTCAATTCAATCACCTTATGTTTCAATTAAATACATTTTCCTAGGTTGGGCATTCCTTTGGGCCACTACTGAATAAAATATTAAAGCATGGTGAATTTTAATTGAAAGTTTCAATCCCTTTCTACAGTGGAGAATCTACAGAACTTGCTGGTGATGTGTGAGCAGGGCCCAACTCCTTTCACTAGTAAGGCAACAGATCTGGTCCTGAAGAAGCCCCATGCTGACACAGGCTTGGAGAACAATACTCACATGTTACCTGAAAGTAAGACAAGCTTTCT
Associated Phenotype:
Not determined