ZMP
si:dkey-1h6.1
Ensembl ID:
ZFIN ID:
Description:
Novel protein similar to vertebrate methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methe
Human Orthologue:
MTHFD1
Human Description:
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase
Mouse Orthologue:
Mthfd1
Mouse Description:
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase,
Alleles
There are 8 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa32295 | Nonsense | Available for shipment | Available now |
| sa1702 | Essential Splice Site | Available for shipment | Available now |
| sa43457 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa32296 | Essential Splice Site | Available for shipment | Available now |
| sa23722 | Nonsense | Available for shipment | Available now |
| sa37049 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa14993 | Nonsense | Available for shipment | Available now |
Mutation Details
Allele Name:
sa32295
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | None | None | 935 | None | 30 |
| ENSDART00000141697 | Nonsense | 14 | 900 | 2 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27677085)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27748388 |
| GRCz11 | 20 | 27647478 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGTGCAGACATGTTTTCTGTCAGTGCTGCTGTGCTACGGCGAGGTGTTT[T/A]AAGGTACAGATGGGACAGATGCTGTGCGCTTGCAACAGTTGTTTCTGGAA
Long Flanking Sequence:
GCTTAGCAGATCACATGCTGCAGTTTTTTGACGGCGAAGAAGAGGAGGAGACCGACTAAACTCACAGTCCCAGGAATGTTTCTTTTCTCACCCACAAGACCTCTGATTGGCTGCCTGCTCCTCGCTGAACAGCCTACCTGCTCCACTTGCCAGTAGTTGTATTTTAACCTCTCTTGCATTGTGCAGGCTTTTTCCACAAACCATGTGATTGTTTGAGCTTGTCTGAGTTTTGCAGCCTCTACTTTTATCAGCTCACATCCCGACTCGTGCTGGAATAGTCTGGACAGCTGGATGCATTGATAAGACTGCACAGTGAAAGCAGGAGGAGTGACTGTACTGACTTCATACAGTTCATACAATACAGGTGGTGATATCTCTGTGATGTAGAGAAACAGCTTTGTTTGAAGATTTTTTTCCTGTATGTTGTCCAACTGACTTTGACACTGTGTTGTGTGCAGACATGTTTTCTGTCAGTGCTGCTGTGCTACGGCGAGGTGTTT[T/A]AAGGTACAGATGGGACAGATGCTGTGCGCTTGCAACAGTTGTTTCTGGAAACAAGACCTCACAGTGAGTTTGAGTGTGTTTGAGGGCTCTTGTTGATGTAGGACTCAGGAGCTTTTACACATTATCAAGCATTTGATGCTTTTTAAATTTAGTTTATTGTGTTTATTCTAAGCCTTTTAACAATATGCTTGTAATATAATAATGTACTTAATTTAAAATGGAAACACCTTATAATAACTATTCATTTGTAAACCTTGGGAACTTACAATATAAAGTGCTCAGCATAATTGAATACACTCCATTTTGAAAATAAATATTTTTATCCATTTCTCTGTGAATATAGGCAATGTATTTTGGTGCCCTAAACAAAACCAATTTATTAAACATCTATATTTATTAAAATAATATTTATTTTATGCACCAATATTTAGCCACCAAACATATTTAGGAAGTGAAAGATAATACAATTAAGTGCAAGCTAAATTATTATTTTTTTTATC
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa1702
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Essential Splice Site | 80 | 935 | 4 | 30 |
| ENSDART00000141697 | Essential Splice Site | 101 | 900 | 5 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27681819)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27753122 |
| GRCz11 | 20 | 27652212 |
KASP Assay ID:
554-1648.1 (used for ordering genotyping assays)
KASP Sequence:
AATCAATGCGAACCACATCAGGCTTCCTGAAACAGCCACTGAAAATGAAG[T/A]AAGAGAAACACAATAAATAACAACGTTTATCCATATATCATTGTTTTAAT
Long Flanking Sequence:
ATATGCCGTAATAGTTGACAAAGCCAAAGGAAAATTAATAAATTAATTTATTTAAAATCACTCAGAAATGTTGCTTAACACTATTAAATATTTAAATATTTTCACAAAATAAAATATTTCTAATTAAACCCTTGCAAAACAAATATCTGCACAAAAATTTCTAATTGCATTTTTATATTCATAAACAGCAACATTTTGAAGATTAAGTAGTTTTCTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTCAAAGGTTGGAGACAGAGAAGACTCAAACCTCTACATCAGTATGAAGCTCAAAGCTGCGGCTGAGGTTCAGTGAGCTGATTTAATAAACTGAAGTCTTGTTTATCATAAACCTCTCACTCACACTGTCTCTCTCCTTGGTTTAGATTGGAATCAATGCGAACCACATCAGGCTTCCTGAAACAGCCACTGAAAATGAAG[T/A]AAGAGAAACACAATAAATAACAACGTTTATCCATATATCATTGTTTTAATCTTAATTAGAAGTCTTTTGTTTTAATCAACGCTGAAAAAATACAGCAACCAATCTATTGCAAAGCCATCATAGAAAAATGATGAAAGATCCAATGCCCTCATCAGTTTGATAGAGTTTATCCTTTAAAATTACAAAACAGTCTGTCTGGGTTAATTGTAACACCTTTATTACATTTCCTAAACCACCTACTGACTAACCTTCAGTTCCGATTTAGTTTTGTAAGGAAGTTGCAATTGATCATTAGTATAATTAATAAATGTCGCACACAGCAGATTAAACTATTTTGTGAGAAATATGATTTAAGGACTGGTCTTCTTTAGGTCCTACGCAACATAGTTGCGGTGAATGAGAATCCTGCATTTCATGGGCTCATTGTGCAGCTGCCGCTCGACTCCATCAACCCAATAAACACTGAGAAAATCACCAATGCTGTCGCTCCAGAGAAAGAT
Associated Phenotype:
Normal
| Stage | Entity | Quality | Tag |
|---|---|---|---|
| Larval:Day 5 ZFS:0000037 |
whole organism ZFA:0001094 |
quality PATO:0000001 |
normal PATO:0000461 |
Mutation Details
Allele Name:
sa43457
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Essential Splice Site | 475 | 935 | 14 | 30 |
| ENSDART00000141697 | Essential Splice Site | 494 | 900 | 15 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27695507)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27766810 |
| GRCz11 | 20 | 27665900 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGACACTGTTAAAGCATATGCTCACTATGAGACCAAACTCTCGGAAAAGG[T/C]CAGGCTTGTGTTTGATATGTGGGTGTTTCTATAATTGGAGATACAGTTGG
Long Flanking Sequence:
TATGTGGTAAAAATACATATTTGACAAATGAGAGTAAACATGAAACTGAGCAAAGTCATAAATAAGAGATAAAAAGACATTGTTGACATACAAAATTGATTGATGTTCTATTGTCAGTTGTTTGAAACATTTAGAAGTTCATTTCTCATTTTTTTTTCTCAAATTTCTCAAAAAAAATCTTTTTTTAACTCTAAACTGAAATAAAACATCTTACATGAGTTTGCTTATTGATTTATTTGAGGTCCTGTTTGCTTTTTGTCCACAGGGCCTGCTGTTGGAGGAGGATACTCTCAAATTATCCCACTGGAGGAGGTAAGTTTAAGTCTTCCTTGTAGCAAAGATTTGAAAGTATCAAATTAAAAATGAATATCATCCAACACACTGATCCCAGGTCAGCCTTCAGCCTTCAGGCCAGAATGAGCTCGTCTCTGCTGCCGGTAGACTGGTGATGGACACTGTTAAAGCATATGCTCACTATGAGACCAAACTCTCGGAAAAGG[T/C]CAGGCTTGTGTTTGATATGTGGGTGTTTCTATAATTGGAGATACAGTTGGAACAAAAAAAATGTTTCAGTTGCAGAAATTCTTTGCAATAAGTTACTGACAACAGATTTAACAATTCCCTTCTTGCCAAAGACAGGTTATGTCTTTTTTTTACGTTTAATAAAAACTCTCGTTTTGCTGTCAGCTATGGTACACACTGTCAGTTTTGTTACTCTTGTATGGAGACCAGGAACGTGATGGTGGGGATTAAAAATGGGTTGGAGAAAAAAAAAACAGAGTTATAGAAAAATATATATTTTGTTACCACAAACACTTCCTGTTCACTTCATACATGTCAACTAGAGATGTGCGGTTGGCGGTTATAGCCGCGGATCGGGCGGATGACGTTACGAAAAAATAATATTTTAATTAAATTCCGGCGGGTGGCGGGCGGTTGTACTGTTTTTATAGGCATAGCTGGCGCACCAACGAAAAAGCCTAGGACTGACTTCACAGAATGGG
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa32296
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Essential Splice Site | 725 | 935 | 23 | 30 |
| ENSDART00000141697 | Essential Splice Site | 716 | 900 | 22 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27701910)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27773213 |
| GRCz11 | 20 | 27672303 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTCATAGATCCAAGCAGGTTTGCCCCTTCCAAAAGAGTACTTACAAGAGG[T/C]AATACACTTTTACTACTGACAACATTGTGATAGATAGATAGATAGATAGA
Long Flanking Sequence:
TTTAATATTTTATAACAGCTATTTTACTTTTGATCAAATGAATGCATACTAGCATATGAGAGTTTTTTTTTCAGAGGCACTGAAAAATATTACTAACTTCAAACTTACATTAAAATATAAAAAATATGGTCAGATTTCTGTAATATCAACAACAAAAATATAATCTGGTTCTATCTGTATTTCAGTCACAGAGTCGGGTCATGGAGCTGATGTTGGCTTGGAGAAGTTTTTCAACATTAAATGCCTCTACTCAGGTCTTCAGCCAGATGTGCTAGTGATGGTGGCAACCATTCGTACATTGAAGATGCAAGGTGGAGCACCTCCTGTGAGTAACACAACACACATTCATAATGGATTGGTTAGCCATTTAAAACTATTAGACATCAACACATCCATTGTGTTCATTAAAATATCTGTTTTGTGCTTCAGACTGCAATTATATTCTTTCTGTTCATAGATCCAAGCAGGTTTGCCCCTTCCAAAAGAGTACTTACAAGAGG[T/C]AATACACTTTTACTACTGACAACATTGTGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGACTATGCATGTTCCTATTACCTGTTTAAACACAAATGTTTTTTTATACACATTTATTCTATATTTGAAGTTTTAATAAACTTGCATAACATATAATAATTGTAATACATAACACATTATACATAAAACCATATGAAATAAATAATGTAGATGCTATTAAAATTGTACATAATGGATATACATTTTTCTATTGGCTTCAGCACACACATATCTGAAA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa23722
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Nonsense | 757 | 935 | 24 | 30 |
| ENSDART00000141697 | Nonsense | 748 | 900 | 23 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27702725)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27774028 |
| GRCz11 | 20 | 27673118 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGGTGGAAAAAGCACAAGCATTCGGCTTGCCGGTGATCGTAGCTGTCAAC[A/T]AATTCAGGTAAAGCAGCAAGCAGCCAACAATGAAATATTTTGCTATTTGA
Long Flanking Sequence:
ACAAATGTTTTTTTATACACATTTATTCTATATTTGAAGTTTTAATAAACTTGCATAACATATAATAATTGTAATACATAACACATTATACATAAAACCATATGAAATAAATAATGTAGATGCTATTAAAATTGTACATAATGGATATACATTTTTCTATTGGCTTCAGCACACACATATCTGAAAACTATATGTAGCCTTCTATCTCACAAGGTCACTATTGATATAGGTCAATATGGCATATAATAGAGTTTTGAATGGTGTAGTATTTCAAATATATTTAGAACCTAATTAACTGACAAATGTGGTCAATTGTTTTATGTACACTTATTGACTGTAGGAGACACTGCTGTTTAGATTGATTTAGTGTGTGCATCACTTGAAGTGAAGTATTTTCTCCAATGCAGAACCTCAAGCAGCTGGAAAGAGGCTGTTGTCATATGAGGAGGCAGGTGGAAAAAGCACAAGCATTCGGCTTGCCGGTGATCGTAGCTGTCAAC[A/T]AATTCAGGTAAAGCAGCAAGCAGCCAACAATGAAATATTTTGCTATTTGAGACTTTTCATACATTATCATTAGAATAAAATAGATTATCTTTAATGTCATTGCATGGAGTATACAACCAAATTTGCTCGACAAAAATTTTGGTTTGATCAAGTTAAAGTTTAGTTAGTCAATATTAAAACATATTTCAAGTGATTAAAGATTCATTAAACAATCACGTAAAAAATGTATATGTGGTCAATGTTGTAAATGTAAAACAAAGTTACTTTTTGGAACATCTCTGCAAAAAGGATGCATGGAAAGTGAAGGAAAATATTGTATTAATCTTATAGTAGTGTAAAATCAGAAATAGGGTAAATATTTCTTTAAATTTATATTTAGTCATTAAGCAGACACTTTAGTTCAAAGTGACTTACAATTGAGGAGGCATTCAGTGATTCAACAAGAAGAGGCAATGCACACAAGAAGTTTTAATTAAACAAATGAACTGTTAATGCTAGGA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa37049
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Nonsense | 787 | 935 | 25 | 30 |
| ENSDART00000141697 | Nonsense | 778 | 900 | 24 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27704788)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27776091 |
| GRCz11 | 20 | 27675181 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGGCCAGGCGAGGCAGGCTGGTGCCTTTGATGCAGTGCAGTGCAGCAGCT[G/A]GTCTGAAGGGGGCGCTGGAGCTCTGGCTCTGGCCGAGACGGTTCAGAGAG
Long Flanking Sequence:
CTAGAATATTAAATAAGGTTTTTAACTGAAACCCTGATCCTTTGAGATGTAAATGCAAGTCAACAGCTTCCAACACTAAAAAAAACATCTACAGGCAAAACAAAATTAATACCCGTGGGTCATGACTTATGGAGCTTATGGAACACAACACTTGGTCTGTTCAAGAAGCTGAACATAATTATTTAATGCAATAGTATTGCATTCATATGAATCCATAAAATCAGAAAAACAACCAGTCCTAATATCTTTCAGTTTTATTCAGTGTCACTGATATATATCTAGTTATGATCTAGTAGATGATTTTTTTTGTCCTTTGTACACTAATCGTATGCTCATGAGCCAAGTTAAACCACACACAACACTCCCACTCTGAGTGAATGTGTGTATGAATATGGACTCTGATTGTGTTTGGCGTAGCTCTGATACTGACGCTGAGCTGGAGCTGGTATGTGGCCAGGCGAGGCAGGCTGGTGCCTTTGATGCAGTGCAGTGCAGCAGCT[G/A]GTCTGAAGGGGGCGCTGGAGCTCTGGCTCTGGCCGAGACGGTTCAGAGAGCAGCAAAACTACCTGCCTGCTTCAAGTTCCTCTATGACTTGCAGGTAAAAAATGGCAAAGTGGGTAATATTTGCACTGATAACCTAAAGGATGCTAAGGCAAGAGATTTATTTTTTTTTTTTTTTTTGGCAAAGAGTAATATCATGCCATATTTTCCCAGTTAATTGATTATCAATGTCAAATATCAAATATTTAAATGCTGTGTTATTTAATTACACATTACACAACTTGTAAATCTAAGCATAAGTTAATTTAATATTTTTATTAGAATTGATTGTTTTTGCATATTAGAGTCGGAGGTGTTAAGGTGAACTTGAGAATCTCCTTTTATCACTTCATAATTTAGAAAATACTGCTAATGGCCTGCAGATACAATAACAACATATGAACATATTTCTGGGTAAAAACCTTCCAGATTTGTGATAAAACACAAAATCGTTTGGGGTATGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa14993
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000008199 | Nonsense | 787 | 935 | 25 | 30 |
| ENSDART00000141697 | Nonsense | 778 | 900 | 24 | 26 |
Genomic Location (Zv9):
Chromosome 20 (position 27704789)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 20 | 27776092 |
| GRCz11 | 20 | 27675182 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGCCAGGCGAGGCAGGCTGGTGCYTTTGATGCAGTGCAGTGCAGCAGCTG[G/A]TCTGAAGGGGGCGCTGGAGCTCTGGCTCTGGCCGAGACGGTTCAGAGAGC
Long Flanking Sequence:
TAGAATATTAAATAAGGTTTTTAACTGAAACCCTGATCCTTTGAGATGTAAATGCAAGTCAACAGCTTCCAACACTAAAAAAAACATCTACAGGCAAAACAAAATTAATACCCGTGGGTCATGACTTATGGAGCTTATGGAACACAACACTTGGTCTGTTCAAGAAGCTGAACATAATTATTTAATGCAATAGTATTGCATTCATATGAATCCATAAAATCAGAAAAACAACCAGTCCTAATATCTTTCAGTTTTATTCAGTGTCACTGATATATATCTAGTTATGATCTAGTAGATGATTTTTTTTGTCCTTTGTACACTAATCGTATGCTCATGAGCCAAGTTAAACCACACACAACACTCCCACTCTGAGTGAATGTGTGTATGAATATGGACTCTGATTGTGTTTGGCGTAGCTCTGATACTGACGCTGAGCTGGAGCTGGTATGTGGCCAGGCGAGGCAGGCTGGTGCCTTTGATGCAGTGCAGTGCAGCAGCTG[G/A]TCTGAAGGGGGCGCTGGAGCTCTGGCTCTGGCCGAGACGGTTCAGAGAGCAGCAAAACTACCTGCCTGCTTCAAGTTCCTCTATGACTTGCAGGTAAAAAATGGCAAAGTGGGTAATATTTGCACTGATAACCTAAAGGATGCTAAGGCAAGAGATTTATTTTTTTTTTTTTTTTTGGCAAAGAGTAATATCATGCCATATTTTCCCAGTTAATTGATTATCAATGTCAAATATCAAATATTTAAATGCTGTGTTATTTAATTACACATTACACAACTTGTAAATCTAAGCATAAGTTAATTTAATATTTTTATTAGAATTGATTGTTTTTGCATATTAGAGTCGGAGGTGTTAAGGTGAACTTGAGAATCTCCTTTTATCACTTCATAATTTAGAAAATACTGCTAATGGCCTGCAGATACAATAACAACATATGAACATATTTCTGGGTAAAAACCTTCCAGATTTGTGATAAAACACAAAATCGTTTGGGGTATGTA
Associated Phenotype:
Not determined